P46935
PR
Gene name |
Nedd4 |
Protein name |
E3 ubiquitin-protein ligase NEDD4 |
Names |
HECT-type E3 ubiquitin transferase NEDD4, Neural precursor cell expressed developmentally down-regulated protein 4, NEDD-4 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:17999 |
EC number |
2.3.2.26: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P46935
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3M7F | X-ray | 200 A | B | 71-246 | PDB |
| AF-P46935-F1 | Predicted | AlphaFoldDB |
29 variants for P46935
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389055170 | 110 | P>Q | No | EVA | |
| rs3389058163 | 123 | I>F | No | EVA | |
| rs3389051862 | 158 | R>I | No | EVA | |
| rs3389055173 | 192 | P>S | No | EVA | |
| rs217502550 | 243 | P>Q | No | EVA | |
| rs3389058994 | 252 | P>H | No | EVA | |
| rs3389058172 | 269 | N>D | No | EVA | |
| rs3389065418 | 275 | T>S | No | EVA | |
| rs3389060891 | 339 | A>V | No | EVA | |
| rs3389045623 | 364 | V>E | No | EVA | |
| rs3389055371 | 375 | T>A | No | EVA | |
| rs3389025250 | 376 | S>R | No | EVA | |
| rs3389058804 | 396 | T>K | No | EVA | |
| rs3389003530 | 452 | G>V | No | EVA | |
| rs3389049758 | 465 | G>V | No | EVA | |
| rs3389064830 | 651 | M>V | No | EVA | |
| rs3389055189 | 679 | D>N | No | EVA | |
| rs3389064749 | 681 | T>M | No | EVA | |
| rs3389003547 | 687 | F>Y | No | EVA | |
| rs3389049763 | 710 | V>I | No | EVA | |
| rs3389033287 | 727 | R>* | No | EVA | |
| rs3389064819 | 775 | W>R | No | EVA | |
| rs3389055140 | 787 | M>I | No | EVA | |
| rs3389045606 | 799 | V>I | No | EVA | |
| rs3389060801 | 830 | G>D | No | EVA | |
| rs3389065402 | 858 | L>P | No | EVA | |
| rs3389065344 | 859 | D>H | No | EVA | |
| rs3389033328 | 860 | L>P | No | EVA | |
| rs3389059044 | 874 | Q>* | No | EVA |
No associated diseases with P46935
5 regional properties for P46935
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 58 - 183 | IPR000008 |
| domain | HECT domain | 530 - 886 | IPR000569 |
| domain | WW domain | 249 - 282 | IPR001202-1 |
| domain | WW domain | 405 - 438 | IPR001202-2 |
| domain | WW domain | 460 - 493 | IPR001202-3 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.26 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
16 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| dendritic spine | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| membrane raft | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
| microvillus | Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic cytosol | The region of the cytosol consisting of all cytosol that is part of the postsynapse. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| ubiquitin ligase complex | A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. |
13 GO annotations of molecular function
| Name | Definition |
|---|---|
| beta-2 adrenergic receptor binding | Binding to a beta-2 adrenergic receptor. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| ionotropic glutamate receptor binding | Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. |
| phosphoserine residue binding | Binding to a phosphorylated serine residue within a protein. |
| phosphothreonine residue binding | Binding to a phosphorylated threonine residue within a protein. |
| proline-rich region binding | Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein. |
| protein C-terminus binding | Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
| protein domain specific binding | Binding to a specific domain of a protein. |
| RNA polymerase binding | Binding to an RNA polymerase molecule or complex. |
| sodium channel inhibitor activity | Binds to and stops, prevents, or reduces the activity of a sodium channel. |
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
40 GO annotations of biological process
| Name | Definition |
|---|---|
| adaptive immune response | An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). |
| blood vessel morphogenesis | The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. |
| cellular response to UV | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. |
| endocardial cushion development | The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. |
| establishment of localization in cell | Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. |
| formation of structure involved in a symbiotic process | The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction. |
| glucocorticoid receptor signaling pathway | The series of molecular signals initiated by glucocorticoid binding to its receptor. |
| lysosomal transport | The directed movement of substances into, out of or within a lysosome. |
| negative regulation of sodium ion transmembrane transporter activity | Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity. |
| negative regulation of sodium ion transport | Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage | Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus. |
| negative regulation of vascular endothelial growth factor receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. |
| neuromuscular junction development | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. |
| neuron projection development | The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| outflow tract morphogenesis | The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. |
| positive regulation of nucleocytoplasmic transport | Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. |
| positive regulation of phosphatidylinositol 3-kinase signaling | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. |
| positive regulation of protein catabolic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
| progesterone receptor signaling pathway | The series of molecular signals initiated by progesterone binding to its receptor in the cytoplasm. |
| proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| protein K63-linked ubiquitination | A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. |
| protein monoubiquitination | Addition of a single ubiquitin group to a protein. |
| protein polyubiquitination | Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. |
| protein targeting to lysosome | The process of directing proteins towards the lysosome using signals contained within the protein. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| receptor catabolic process | The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
| receptor internalization | A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. |
| regulation of dendrite morphogenesis | Any process that modulates the frequency, rate or extent of dendrite morphogenesis. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
| regulation of membrane potential | Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
| regulation of postsynaptic neurotransmitter receptor internalization | Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse. |
| regulation of potassium ion transmembrane transporter activity | Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity. |
| regulation of protein catabolic process at postsynapse, modulating synaptic transmission | Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse. |
| regulation of synapse organization | Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). |
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| T cell activation | The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
| ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. |
| viral budding | A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P39940 | RSP5 | E3 ubiquitin-protein ligase RSP5 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9Y0H4 | Su(dx) | E3 ubiquitin-protein ligase Su | Drosophila melanogaster (Fruit fly) | SS |
| Q9V853 | Smurf | E3 ubiquitin-protein ligase Smurf1 | Drosophila melanogaster (Fruit fly) | SS |
| Q9HAU4 | SMURF2 | E3 ubiquitin-protein ligase SMURF2 | Homo sapiens (Human) | EV |
| O00308 | WWP2 | NEDD4-like E3 ubiquitin-protein ligase WWP2 | Homo sapiens (Human) | EV |
| Q9HCE7 | SMURF1 | E3 ubiquitin-protein ligase SMURF1 | Homo sapiens (Human) | PR |
| O95817 | BAG3 | BAG family molecular chaperone regulator 3 | Homo sapiens (Human) | PR |
| Q96PU5 | NEDD4L | E3 ubiquitin-protein ligase NEDD4-like | Homo sapiens (Human) | PR |
| O60861 | GAS7 | Growth arrest-specific protein 7 | Homo sapiens (Human) | PR |
| Q9H0M0 | WWP1 | NEDD4-like E3 ubiquitin-protein ligase WWP1 | Homo sapiens (Human) | EV |
| Q96J02 | ITCH | E3 ubiquitin-protein ligase Itchy homolog | Homo sapiens (Human) | EV |
| P46934 | NEDD4 | E3 ubiquitin-protein ligase NEDD4 | Homo sapiens (Human) | EV |
| Q60780 | Gas7 | Growth arrest-specific protein 7 | Mus musculus (Mouse) | PR |
| Q8BZZ3 | Wwp1 | NEDD4-like E3 ubiquitin-protein ligase WWP1 | Mus musculus (Mouse) | SS |
| Q9CUN6 | Smurf1 | E3 ubiquitin-protein ligase SMURF1 | Mus musculus (Mouse) | PR |
| Q9DBH0 | Wwp2 | NEDD4-like E3 ubiquitin-protein ligase WWP2 | Mus musculus (Mouse) | SS |
| A2A5Z6 | Smurf2 | E3 ubiquitin-protein ligase SMURF2 | Mus musculus (Mouse) | SS |
| Q8C863 | Itch | E3 ubiquitin-protein ligase Itchy | Mus musculus (Mouse) | EV |
| Q3U0D9 | Hace1 | E3 ubiquitin-protein ligase HACE1 | Mus musculus (Mouse) | SS |
| Q8CFI0 | Nedd4l | E3 ubiquitin-protein ligase NEDD4-like | Mus musculus (Mouse) | PR |
| Q62940 | Nedd4 | E3 ubiquitin-protein ligase NEDD4 | Rattus norvegicus (Rat) | PR |
| Q9N2Z7 | wwp-1 | E3 ubiquitin-protein ligase wwp-1 | Caenorhabditis elegans | SS |
| A9JRZ0 | smurf2 | E3 ubiquitin-protein ligase SMURF2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSDMAADES | EAPVLSEDEV | WEFCLDKTED | GGGSPGSDVT | DTCEPPCGCW | ELNPNSLEEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HVLFTADPYL | ELHNDDTRVV | RVKVIAGIGL | AKKDILGASD | PYVRVTLYDP | MSGILTSVQT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KTIKKSLNPK | WNEEILFRVL | PQRHRILFEV | FDENRLTRDD | FLGQVDVPLY | PLPTENPRME |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RPYTFKDFVL | HPRSHKSRVK | GYLRLKMTYL | PKNGSEDENA | DQAEELEPGW | VVLDQPDAAT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HLPHPPEPSP | LPPGWEERQD | VLGRTYYVNH | ESRRTQWKRP | SPDDDLTDED | NDDMQLQAQR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AFTTRRQISE | DVDGPDNRES | PENWEIVRED | ENTEYSGQAV | QSPPSGHIDV | QTHLAEEFNT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RLAVCGNPAT | SQPVTSSNHS | SRGGSLQTCI | FEEQPTLPVL | LPTSSGLPPG | WEEKQDDRGR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SYYVDHNSKT | TTWSKPTMQD | DPRSKIPAHL | RGKTDSNDLG | PLPPGWEERT | HTDGRVFFIN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HNIKKTQWED | PRLQNVAITG | PAVPYSRDYK | RKYEFFRRKL | KKQTDIPNKF | EMKLRRANIL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EDSYRRIMGV | KRADLLKARL | WIEFDGEKGL | DYGGVAREWF | FLISKEMFNP | YYGLFEYSAT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DNYTLQINPN | SGLCNEDHLS | YFKFIGRVAG | MAVYHGKLLD | GFFIRPFYKM | MLQKLITLHD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MESVDSEYYS | SLRWILENDP | TELDLRFIID | EELFGQTHQH | ELKTGGSEIV | VTNKNKKEYI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| YLVIQWRFVN | RIQKQMAAFK | EGFFELIPQD | LIKIFDENEL | ELLMCGLGDV | DVNDWREHTK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| YKNGYSMNHQ | VIHWFWKAVW | MMDSEKRIRL | LQFVTGTSRV | PMNGFAELYG | SNGPQSFTVE |
| 850 | 860 | 870 | 880 | ||
| QWGTPDKLPR | AHTCFNRLDL | PPYESFDELW | DKLQMAIENT | QGFDGVD |