AiPD: Autoinhibited Protein Database

Gene name	KIN14M
Protein name	Kinesin-like protein KIN-14M
Names	AtKIN14c, Kinesin-like protein KatB
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT4G27180
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

318-407 (Predicted disordered autoinhibitory region) PR

318-407 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P46864-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH06783537	127	A>S	No	1000Genomes
ENSVATH06783534	164	I>L	No	1000Genomes
tmp_4_13617888_G_C	171	T>R	No	1000Genomes
tmp_4_13617700_A_C	209	D>E	No	1000Genomes
tmp_4_13617587_G_A	247	A>V	No	1000Genomes
tmp_4_13617435_C_T	271	V>I	No	1000Genomes
ENSVATH14301210	281	D>E	No	1000Genomes
tmp_4_13616999_C_A	355	E>D	No	1000Genomes
tmp_4_13616765_C_T	405	E>K	No	1000Genomes
tmp_4_13616587_C_G	439	V>L	No	1000Genomes
ENSVATH00540761	490	D>N	No	1000Genomes
tmp_4_13616210_A_G	503	F>S	No	1000Genomes
ENSVATH14301206	505	T>K	No	1000Genomes
ENSVATH12254653	535	S>T	No	1000Genomes
ENSVATH02929843	538	K>R	No	1000Genomes
tmp_4_13615883_C_T	587	R>Q	No	1000Genomes
ENSVATH06783511	621	Q>H	No	1000Genomes
ENSVATH02929842	641	G>R	No	1000Genomes
tmp_4_13615202_A_C	698	F>C	No	1000Genomes
tmp_4_13615077_A_T	740	Y>N	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Kinesin motor domain	385 - 732	IPR001752
conserved_site	Kinesin motor domain, conserved site	624 - 635	IPR019821

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
kinesin complex	Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.
microtubule motor activity	A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.

Name	Definition
microtubule-based movement	A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
spindle assembly	The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9P2E2	KIF17	Kinesin-like protein KIF17	Homo sapiens (Human)	EV
Q99PW8	Kif17	Kinesin-like protein KIF17	Mus musculus (Mouse)	SS
Q9SV36	KINUC	Kinesin-like protein KIN-UC	Arabidopsis thaliana (Mouse-ear cress)	PR