P46734
SS
Gene name |
MAP2K3 (MEK3, MKK3, PRKMK3, SKK2) |
Protein name |
Dual specificity mitogen-activated protein kinase kinase 3 |
Names |
MAP kinase kinase 3 , MAPKK 3 , EC 2.7.12.2 , MAPK/ERK kinase 3 , MEK 3 , Stress-activated protein kinase kinase 2 , SAPK kinase 2 , SAPKK-2 , SAPKK2 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:5606 |
EC number |
2.7.12.2: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues) |
Protein Class |
|
Descriptions
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) is annotated based on its experimentally validated activation loop, which is expected to act as accessory element in the autoinhibition of MAP2K3.
Autoinhibitory domains (AIDs)
Accessory elements
207-229 (Activation loop from InterPro)
Target domain |
64-326 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
1 structures for P46734
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P46734-F1 | Predicted | AlphaFoldDB |
392 variants for P46734
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1236281089 CA398250606 |
2 | E>* | No |
ClinGen gnomAD |
|
|
rs555847635 CA398250622 |
4 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs555847635 CA8449993 |
4 | P>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs968308259 CA288952354 |
4 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA8449994 rs769870063 |
6 | S>L | No |
ClinGen ExAC gnomAD |
|
|
rs1421142599 CA398250630 |
6 | S>P | No |
ClinGen gnomAD |
|
|
rs764298409 CA8449998 |
7 | S>R | No |
ClinGen ExAC gnomAD |
|
|
rs762132100 CA8449999 |
8 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768042835 CA8450000 |
9 | P>A | No |
ClinGen ExAC gnomAD |
|
|
CA288952377 rs768042835 |
9 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA8450002 rs750892990 |
10 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450001 rs750892990 |
10 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450003 rs778416374 |
12 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA398250670 rs778416374 |
12 | M>I | No |
ClinGen ExAC gnomAD |
|
|
rs1567654365 CA398250666 |
12 | M>L | No |
ClinGen Ensembl |
|
|
rs1282207373 CA398250690 |
15 | S>C | No |
ClinGen gnomAD |
|
|
CA398250696 rs1345986872 |
16 | K>R | No |
ClinGen gnomAD |
|
|
CA8450140 rs535050080 |
19 | S>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8450141 rs535050080 |
19 | S>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1485988424 CA398252719 |
20 | K>R | No |
ClinGen TOPMed |
|
|
rs748633910 CA8450143 |
21 | R>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA398252759 rs953801481 |
24 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
rs953801481 CA288967614 |
24 | D>Y | No |
ClinGen TOPMed gnomAD |
|
|
CA398252778 rs1355867861 |
25 | L>P | No |
ClinGen TOPMed |
|
|
CA8450149 rs749070324 |
26 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs779727093 CA8450148 |
26 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768450668 CA8450150 |
27 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1340112579 CA398252792 |
27 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1275616285 CA398252808 |
28 | S>Y | No |
ClinGen gnomAD |
|
|
rs761908122 CA8450152 |
29 | C>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA398252822 rs761908122 |
29 | C>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774158814 CA8450151 |
29 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
rs370914287 CA8450154 |
30 | M>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8450153 rs772121244 |
30 | M>K | No |
ClinGen ExAC gnomAD |
|
|
rs1265176318 CA398252827 |
30 | M>L | No |
ClinGen TOPMed gnomAD |
|
|
rs760802049 CA8450155 |
31 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs1158820883 CA398252858 |
32 | K>R | No |
ClinGen TOPMed |
|
|
rs1391649195 CA398252871 |
33 | P>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs1403197048 CA398252885 |
34 | P>R | No |
ClinGen gnomAD |
|
|
rs368729510 CA398252892 |
35 | A>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs368729510 COSM1710022 CA8450160 |
35 | A>T | skin [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs758965481 CA398252933 |
38 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450161 rs758965481 |
38 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1381511 rs77066538 CA8450162 RCV000892940 |
39 | T>I | large_intestine [Cosmic] | No |
ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs77066538 CA398252944 |
39 | T>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1363198122 CA398252938 |
39 | T>P | No |
ClinGen gnomAD |
|
|
CA8450163 rs77066538 |
39 | T>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs33911218 CA398253037 |
40 | P>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs775653621 CA8450195 |
40 | P>H | No |
ClinGen ExAC gnomAD |
|
|
CA398253042 rs775653621 |
40 | P>L | No |
ClinGen ExAC gnomAD |
|
|
RCV000947780 rs33911218 CA8450194 VAR_046062 |
40 | P>T | No |
ClinGen ClinVar UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
CA398253055 rs1411037459 |
41 | P>L | No |
ClinGen gnomAD |
|
|
CA8450201 rs139443409 |
42 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8450200 rs767884956 |
42 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765002445 CA8450204 |
44 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs752337832 CA8450205 |
45 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450209 rs746787964 |
47 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450208 rs746787964 |
47 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777780137 CA8450207 |
47 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs140668299 CA8450210 |
48 | T>I | No |
ClinGen ESP ExAC gnomAD |
|
|
rs745994827 CA8450211 |
49 | F>C | No |
ClinGen ExAC gnomAD |
|
|
rs1166933352 CA398253159 |
50 | I>L | No |
ClinGen TOPMed gnomAD |
|
|
rs373525024 CA8450212 |
50 | I>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8450214 rs187946780 |
52 | I>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
RCV000885055 CA8450213 rs187946780 |
52 | I>T | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1356564972 CA398253181 |
52 | I>V | No |
ClinGen gnomAD |
|
|
COSM1318530 CA8450215 rs75306459 |
54 | D>E | haematopoietic_and_lymphoid_tissue [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP TOPMed gnomAD |
|
CA398253210 rs1329877028 |
54 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
rs36047035 CA398253241 |
55 | R>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8450218 rs774743496 |
55 | R>S | No |
ClinGen ExAC gnomAD |
|
|
CA8450217 rs36047035 VAR_061742 RCV000947781 |
55 | R>T | No |
ClinGen ClinVar UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
rs1597816060 CA398253975 |
57 | F>C | No |
ClinGen Ensembl |
|
|
rs1339445140 CA398253991 |
58 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1455533812 CA398254007 |
59 | V>A | No |
ClinGen TOPMed |
|
|
CA8450265 rs767174366 |
59 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1327033661 CA398254011 |
60 | E>K | No |
ClinGen gnomAD |
|
|
rs1486227430 CA398254059 |
62 | D>N | No |
ClinGen gnomAD |
|
|
CA8450267 rs760418674 |
62 | D>V | No |
ClinGen ExAC gnomAD |
|
|
CA288970653 rs1011375302 |
63 | D>H | No |
ClinGen TOPMed gnomAD |
|
|
CA8450269 rs753716912 |
65 | V>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755054165 CA8450270 |
66 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1454899646 CA398254166 |
67 | I>V | No |
ClinGen gnomAD |
|
|
CA8450271 VAR_046063 rs34105301 RCV000947782 |
68 | S>P | No |
ClinGen ClinVar UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
rs1401085699 CA398254232 |
70 | L>M | No |
ClinGen gnomAD |
|
|
CA398254240 rs1207412878 |
70 | L>R | No |
ClinGen TOPMed |
|
|
CA8450272 rs752806793 |
71 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200914153 CA8450274 |
72 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8450275 rs747410898 |
72 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs200914153 CA8450273 |
72 | R>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1288901484 CA398254288 |
73 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1288901484 CA398254290 |
73 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1318579056 CA398254306 |
74 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA398254348 rs1344632491 |
75 | Y>* | No |
ClinGen TOPMed gnomAD |
|
|
CA8450277 rs781769054 |
75 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450278 rs746313676 |
76 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746313676 CA398254357 |
76 | G>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA398254371 rs1482278537 |
77 | V>A | No |
ClinGen gnomAD |
|
|
CA398254385 rs773794838 |
78 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA8450280 rs773794838 |
78 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs747661001 CA8450281 |
79 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs771651753 CA8450283 |
80 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1376541785 CA398254425 |
81 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
CA398254451 rs759527241 |
82 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450287 rs759527241 |
82 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450285 rs766095224 |
82 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA398254483 rs200944510 |
83 | H>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA398254455 rs1298472395 |
83 | H>Y | No |
ClinGen TOPMed gnomAD |
|
|
CA398254491 rs2305873 |
84 | A>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
VAR_046064 rs2305873 CA8450290 RCV000947785 |
84 | A>T | No |
ClinGen ClinVar UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
CA8450291 rs764245258 |
85 | Q>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs530302955 CA8450292 |
85 | Q>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA398254505 rs764245258 |
85 | Q>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1029598403 CA288970804 |
86 | S>G | No |
ClinGen TOPMed gnomAD |
|
|
CA8450293 rs757705153 |
86 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1588762 rs1204923291 CA398254542 |
87 | G>S | endometrium [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
CA398254547 rs1252212211 |
87 | G>V | No |
ClinGen gnomAD |
|
|
rs1481928966 CA398254563 |
88 | T>I | No |
ClinGen gnomAD |
|
|
CA398254559 rs1481928966 |
88 | T>N | No |
ClinGen gnomAD |
|
|
rs746225381 CA8450295 |
89 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1266125913 CA398254571 |
89 | I>V | No |
ClinGen gnomAD |
|
|
CA8450296 rs36076766 VAR_046065 RCV000969919 |
90 | M>I | No |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1597816368 CA398254592 |
90 | M>K | No |
ClinGen Ensembl |
|
|
CA398254601 rs1172598370 |
91 | A>P | No |
ClinGen TOPMed gnomAD |
|
|
rs780568273 CA8450297 |
91 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746731299 CA398254615 |
92 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA8450301 rs746731299 |
92 | V>E | No |
ClinGen ExAC gnomAD |
|
|
CA398254612 rs772854520 |
92 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA8450300 rs772854520 |
92 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs56067280 CA8450327 VAR_046066 |
94 | R>L | No |
ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
rs56067280 CA398254692 |
94 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1482045827 CA398254706 |
95 | I>M | No |
ClinGen gnomAD |
|
|
VAR_046067 CA8450328 rs56216806 |
96 | R>W | No |
ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
rs1257931374 CA398254741 |
98 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1156837659 CA398254743 |
99 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
rs1400193440 CA398254765 |
100 | N>S | No |
ClinGen gnomAD |
|
|
CA8450333 rs55796947 |
102 | Q>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA398254789 rs1228109961 |
103 | E>D | No |
ClinGen TOPMed |
|
|
rs1312694093 CA398254791 |
104 | Q>* | No |
ClinGen gnomAD |
|
|
rs754138163 CA8450334 |
104 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA8450336 rs779360419 |
106 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450335 rs370241403 |
106 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8450337 rs751101797 |
107 | L>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1322230590 CA398254814 |
108 | L>F | No |
ClinGen TOPMed |
|
|
CA8450338 rs535902224 |
109 | M>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA8450339 rs780836688 |
112 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs780836688 CA398254858 |
112 | D>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1486525497 CA398254884 |
114 | N>H | No |
ClinGen gnomAD |
|
|
rs1250999700 CA398254901 |
115 | M>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1470443771 CA398254906 |
115 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
CA8450341 rs769330208 |
116 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450342 rs374662792 |
116 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA398254922 rs374662792 |
116 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8450343 rs749017209 |
117 | T>M | No |
ClinGen ExAC gnomAD |
|
|
CA8450346 rs761995933 |
119 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs373365578 CA8450347 |
119 | D>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA398254967 rs2230435 |
120 | C>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs761014197 CA8450349 |
121 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA8450350 rs766487476 |
121 | F>S | No |
ClinGen ExAC gnomAD |
|
|
rs759854704 CA398254993 |
122 | Y>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750313752 CA288971058 |
123 | T>A | No |
ClinGen Ensembl |
|
|
CA398255005 rs1367510527 |
123 | T>I | No |
ClinGen TOPMed |
|
|
CA398255011 rs1273790684 |
124 | V>L | No |
ClinGen TOPMed |
|
|
CA8450355 rs756764700 |
128 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749891984 CA398255076 |
129 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749891984 CA8450357 |
129 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1385261269 CA398255804 |
134 | G>R | No |
ClinGen gnomAD |
|
|
rs749679371 CA8450416 |
136 | V>E | No |
ClinGen ExAC gnomAD |
|
|
rs749679371 CA8450415 |
136 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs770045688 CA8450414 |
136 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770045688 CA8450413 |
136 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1435533376 CA398255833 |
137 | W>S | No |
ClinGen gnomAD |
|
|
CA398255844 rs774768696 |
138 | I>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450417 rs774768696 |
138 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA398255858 rs1314519598 |
139 | C>F | No |
ClinGen gnomAD |
|
|
CA8450419 rs141291947 |
140 | M>V | No |
ClinGen ESP ExAC TOPMed |
|
|
rs1260172726 CA398255877 |
141 | E>K | No |
ClinGen gnomAD |
|
|
rs776319905 CA8450420 |
142 | L>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450423 rs752339522 |
143 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450422 rs765004158 |
143 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs1189011101 CA398255925 |
145 | T>I | No |
ClinGen gnomAD |
|
|
CA8450425 rs763864227 |
146 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762812560 CA8450424 |
146 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1265141106 CA398255944 |
147 | L>F | No |
ClinGen TOPMed |
|
|
rs757193395 CA8450427 |
148 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs751357548 CA8450426 |
148 | D>G | No |
ClinGen ExAC TOPMed |
|
|
rs1363851432 CA398255948 |
148 | D>N | No |
ClinGen gnomAD |
|
|
rs368763343 CA8450428 |
149 | K>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1374404589 CA398255976 |
150 | F>L | No |
ClinGen gnomAD |
|
|
CA8450432 rs148304866 COSM3402667 |
152 | R>Q | central_nervous_system [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
rs143272108 CA8450431 |
152 | R>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1390715738 CA398256006 |
153 | K>E | No |
ClinGen gnomAD |
|
|
CA398256021 rs1597819586 |
154 | V>G | No |
ClinGen Ensembl |
|
|
rs755211258 CA8450433 |
154 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA398256029 rs1398447545 |
155 | L>P | No |
ClinGen TOPMed |
|
|
COSM1479333 CA8450435 rs748513234 |
156 | D>Y | breast [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA398256047 rs1597819623 |
157 | K>E | No |
ClinGen Ensembl |
|
|
rs772485005 CA8450437 |
158 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs113110874 CA288972516 |
160 | T>A | No |
ClinGen Ensembl |
|
|
CA8450438 rs773806671 |
160 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs773806671 CA398256088 |
160 | T>K | No |
ClinGen ExAC gnomAD |
|
|
rs745383124 CA8450439 |
162 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA398256142 rs1567669619 |
165 | I>N | No |
ClinGen Ensembl |
|
|
CA398256153 rs775135517 |
166 | L>H | No |
ClinGen ExAC gnomAD |
|
|
CA8450441 rs775135517 |
166 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA398256162 rs1221576051 |
167 | G>E | No |
ClinGen gnomAD |
|
|
RCV000890370 CA8450443 rs141390631 |
169 | I>T | No |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs774056960 CA8450444 |
170 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1183708815 CA398256284 |
174 | V>A | No |
ClinGen gnomAD |
|
|
rs201593726 CA398256278 |
174 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs201593726 CA8450487 |
174 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs201593726 CA8450486 |
174 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8450490 rs747851232 |
175 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450491 rs747851232 |
175 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
VAR_014208 rs1339756947 CA8450488 |
175 | R>W | colon cancer [UniProt] | No |
ClinGen UniProt TOPMed dbSNP |
|
rs891388633 CA398256327 |
178 | E>D | No |
ClinGen TOPMed |
|
|
CA8450493 rs760420455 COSM1710026 |
178 | E>K | skin [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs770874878 CA8450494 |
179 | H>Q | No |
ClinGen ExAC |
|
|
rs765424344 CA8450497 |
185 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA288973560 rs765424344 |
185 | S>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA398256753 rs1196458610 |
191 | V>M | No |
ClinGen gnomAD |
|
|
rs768792966 CA8450536 |
192 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450537 rs774573159 |
193 | P>S | No |
ClinGen ExAC |
|
|
rs1164944855 CA398256776 |
195 | N>D | No |
ClinGen gnomAD |
|
|
rs767600120 CA8450539 |
196 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs1326801604 CA398256817 |
201 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA398256825 rs1401545996 |
202 | G>S | No |
ClinGen gnomAD |
|
|
rs1354689052 CA398256838 |
203 | H>Q | No |
ClinGen gnomAD |
|
|
rs377202574 CA8450542 |
204 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8450545 rs763652051 |
206 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA8450544 rs755472008 |
206 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA8450546 rs751046606 |
207 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
CA8450547 RCV000892941 rs138917253 |
208 | D>V | No |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs370011459 CA8450549 |
210 | G>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs755810709 CA8450550 |
212 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA398256912 rs1232429710 |
214 | Y>* | No |
ClinGen Ensembl |
|
|
rs989026404 VAR_014209 CA398256914 |
215 | L>V | colon cancer [UniProt] | No |
ClinGen UniProt TOPMed dbSNP gnomAD |
|
RCV000203042 CA249248 rs74575904 |
215 | L>W | No |
ClinGen ClinVar ExAC dbSNP gnomAD |
|
|
CA398256922 rs1457628071 |
216 | V>L | No |
ClinGen TOPMed |
|
|
rs1243698443 CA398256930 |
217 | D>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs1421313006 CA398256947 |
218 | S>P | No |
ClinGen gnomAD |
|
|
rs774609917 CA8450553 |
218 | S>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1162647513 CA398256965 |
219 | V>A | No |
ClinGen TOPMed |
|
|
rs748134030 CA8450554 |
220 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA398256989 rs1414373733 |
221 | K>R | No |
ClinGen TOPMed |
|
|
rs58609466 CA398257003 |
222 | T>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs58609466 RCV000947789 CA8450556 |
222 | T>M | No |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
rs58609466 CA8450557 |
222 | T>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8450561 COSM1381515 rs139594289 |
223 | M>I | large_intestine [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA8450560 rs760085339 |
223 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs776965903 CA8450559 |
223 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767215287 CA8450564 |
226 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450563 rs149487222 |
226 | G>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA398257067 rs1258791233 |
227 | C>G | No |
ClinGen gnomAD |
|
|
rs1435584008 CA398257093 |
228 | K>N | No |
ClinGen gnomAD |
|
|
CA398257126 rs1180403428 |
231 | M>V | No |
ClinGen gnomAD |
|
|
rs749979842 CA8450565 |
232 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450614 rs757259243 |
234 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs781404369 CA8450615 |
235 | R>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781404369 CA398257282 |
235 | R>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1185963849 CA398257340 |
238 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs746144760 CA8450616 |
238 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1187474562 CA398257346 |
239 | E>G | No |
ClinGen TOPMed |
|
|
CA288975422 rs868386503 |
239 | E>K | No |
ClinGen Ensembl |
|
|
CA398257362 rs1597824627 |
241 | N>K | No |
ClinGen Ensembl |
|
|
CA8450617 rs756321508 |
241 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs1167184206 CA398257367 |
242 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
CA8450618 rs780318706 |
242 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs1419499841 CA398257388 |
243 | K>N | No |
ClinGen gnomAD |
|
|
rs148612005 CA8450619 RCV000887086 |
244 | G>V | No |
ClinGen ClinVar ExAC dbSNP gnomAD |
|
|
rs1413452966 CA398257409 |
245 | Y>C | No |
ClinGen gnomAD |
|
|
rs774858402 CA8450621 |
246 | N>H | No |
ClinGen ExAC gnomAD |
|
|
rs746534193 CA8450622 |
246 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA398257437 rs1597824669 |
247 | V>A | No |
ClinGen Ensembl |
|
|
CA398257454 rs770625051 |
248 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs1229469947 CA398257444 |
248 | K>T | No |
ClinGen gnomAD |
|
|
CA398257464 rs1305410810 |
249 | S>C | No |
ClinGen TOPMed |
|
|
CA398257456 rs1352475563 |
249 | S>P | No |
ClinGen gnomAD |
|
|
CA398257468 rs1484682426 |
250 | D>A | No |
ClinGen gnomAD |
|
|
COSM3402669 rs759303256 CA8450625 |
250 | D>N | central_nervous_system [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA8450628 rs150613942 |
251 | V>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs150613942 CA8450627 RCV000951140 |
251 | V>I | No |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1427823788 CA398257495 |
252 | W>C | No |
ClinGen TOPMed |
|
|
rs751438940 CA398257526 |
254 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs751438940 CA8450631 |
254 | L>R | No |
ClinGen ExAC gnomAD |
|
|
rs757171269 CA398257539 |
255 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs1382544404 CA398257531 |
255 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
CA8450632 rs757171269 |
255 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs750467980 CA8450634 |
257 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA398257580 rs1433036479 |
258 | M>R | No |
ClinGen TOPMed |
|
|
CA398257584 rs1433036479 |
258 | M>T | No |
ClinGen TOPMed |
|
|
rs778493330 CA8450696 |
260 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA398258254 rs771917013 |
263 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450698 rs771917013 |
263 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs772881322 CA8450699 |
265 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1197448393 CA398258266 |
265 | R>W | No |
ClinGen gnomAD |
|
|
CA8450701 rs770752770 |
266 | F>C | No |
ClinGen ExAC gnomAD |
|
|
CA398258270 rs1398761406 |
266 | F>L | No |
ClinGen gnomAD |
|
|
CA8450703 rs776797051 |
266 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs765561073 CA8450704 |
268 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA398258294 rs763253789 |
269 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs368095963 CA8450708 |
270 | S>A | No |
ClinGen ESP ExAC TOPMed |
|
|
CA8450709 rs751837128 |
270 | S>C | No |
ClinGen ExAC gnomAD |
|
|
CA8450710 rs751837128 |
270 | S>Y | No |
ClinGen ExAC gnomAD |
|
|
rs767860294 CA398258302 |
271 | W>* | No |
ClinGen ExAC gnomAD |
|
|
rs767860294 CA8450712 |
271 | W>L | No |
ClinGen ExAC gnomAD |
|
|
CA8450713 rs753415767 |
272 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs754414832 CA8450714 |
273 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA398258322 rs1254611514 |
274 | P>L | No |
ClinGen gnomAD |
|
|
CA398258321 rs1254611514 |
274 | P>R | No |
ClinGen gnomAD |
|
|
CA8450718 rs777673763 |
277 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs777673763 CA8450719 |
277 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
rs770932904 CA8450721 |
278 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA398258350 rs1462982083 |
279 | K>E | No |
ClinGen gnomAD |
|
|
CA8450723 rs745957434 |
283 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA8450725 rs376891281 |
284 | E>K | No |
ClinGen ESP ExAC gnomAD |
|
|
CA8450724 rs376891281 |
284 | E>Q | No |
ClinGen ESP ExAC gnomAD |
|
|
rs371545792 CA8450726 COSM1381521 |
285 | P>L | large_intestine [Cosmic] | No |
ClinGen cosmic curated ESP ExAC gnomAD |
|
CA398258394 rs371545792 |
285 | P>R | No |
ClinGen ESP ExAC gnomAD |
|
|
CA8450729 rs762040308 |
287 | P>H | No |
ClinGen ExAC gnomAD |
|
|
rs1254789558 CA398258408 |
288 | Q>* | No |
ClinGen gnomAD |
|
|
rs768070212 CA8450730 |
289 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs756613703 CA8450732 |
291 | A>D | No |
ClinGen ExAC gnomAD |
|
|
rs756613703 CA8450733 |
291 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs758070523 CA8450735 |
292 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450736 rs777252658 |
293 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450738 rs35206134 RCV000947797 VAR_046068 |
293 | R>H | No |
ClinGen ClinVar UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
rs35206134 CA398258437 |
293 | R>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8450737 rs777252658 |
293 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1377036792 CA398258445 |
294 | F>L | No |
ClinGen gnomAD |
|
|
CA398258443 rs1196428815 |
294 | F>S | No |
ClinGen gnomAD |
|
|
CA398258452 rs1466464125 |
295 | S>F | No |
ClinGen gnomAD |
|
|
rs370462268 CA288979846 |
296 | P>S | No |
ClinGen ESP TOPMed |
|
|
CA8450740 rs572893701 |
297 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs780328276 CA8450742 |
299 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA8450744 rs768951364 |
303 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1326797498 CA398258505 |
304 | Q>* | No |
ClinGen gnomAD |
|
|
CA8450770 rs771434728 |
305 | C>* | No |
ClinGen ExAC gnomAD |
|
|
CA398258514 rs1234597456 |
305 | C>R | No |
ClinGen gnomAD |
|
|
CA398258538 rs1305305084 |
307 | R>K | No |
ClinGen gnomAD |
|
|
rs777065859 CA8450771 |
308 | K>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8450772 rs777065859 |
308 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1399913936 CA398258547 |
308 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1399913936 CA398258548 |
308 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
CA398258552 rs1233709187 |
309 | N>T | No |
ClinGen TOPMed |
|
|
rs144440258 CA398258558 |
310 | P>A | No |
ClinGen ESP ExAC gnomAD |
|
|
CA8450774 rs144440258 |
310 | P>S | No |
ClinGen ESP ExAC gnomAD |
|
|
CA398258564 rs55740804 |
311 | A>S | No |
ClinGen 1000Genomes ESP ExAC gnomAD |
|
|
CA8450776 rs55740804 |
311 | A>T | No |
ClinGen 1000Genomes ESP ExAC gnomAD |
|
|
rs767229142 CA8450778 |
312 | E>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767229142 CA398258576 |
312 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750272526 CA8450779 |
313 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs376163246 CA8450780 |
313 | R>H | No |
ClinGen ESP ExAC gnomAD |
|
|
CA8450781 rs376163246 |
313 | R>P | No |
ClinGen ESP ExAC gnomAD |
|
|
CA398258593 rs753881799 |
314 | M>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754917550 CA8450783 |
314 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs753881799 CA8450782 |
314 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1486901884 CA398258610 |
315 | S>N | No |
ClinGen gnomAD |
|
|
rs1180149007 CA398258626 |
316 | Y>C | No |
ClinGen gnomAD |
|
|
CA398258649 rs748212878 |
318 | E>A | No |
ClinGen ExAC gnomAD |
|
|
CA8450785 rs748212878 |
318 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA398258654 rs1165924614 |
319 | L>M | No |
ClinGen gnomAD |
|
|
CA8450787 rs777906236 |
320 | M>I | No |
ClinGen ExAC gnomAD |
|
|
rs1455270580 CA398259872 |
321 | E>K | No |
ClinGen gnomAD |
|
|
rs750711278 CA8450847 |
322 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1278160340 CA398259921 |
323 | P>L | No |
ClinGen TOPMed |
|
|
rs780504964 CA8450848 |
323 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754209897 CA8450849 |
326 | T>N | No |
ClinGen ExAC gnomAD |
|
|
CA8450851 rs547952800 |
327 | L>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA398259976 rs1330040800 |
327 | L>V | No |
ClinGen gnomAD |
|
|
rs149799475 CA8450852 |
328 | H>R | No |
ClinGen ESP ExAC |
|
|
CA398259996 rs1359324940 |
328 | H>Y | No |
ClinGen TOPMed |
|
|
CA8450855 rs201112044 |
331 | K>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1371305788 CA398260039 |
331 | K>R | No |
ClinGen gnomAD |
|
|
rs1273519236 CA398260055 |
332 | K>N | No |
ClinGen gnomAD |
|
|
CA8450856 rs769307504 |
333 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs35755743 CA8450857 |
333 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
COSM1520428 rs774212609 CA8450860 |
334 | D>N | lung [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs761720851 CA8450861 |
335 | I>F | No |
ClinGen ExAC gnomAD |
|
|
rs760983046 CA8450864 |
336 | A>S | No |
ClinGen ExAC gnomAD |
|
|
rs766473365 CA8450865 |
336 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA398260109 rs1376947736 |
337 | A>T | No |
ClinGen gnomAD |
|
|
rs186277389 CA8450866 |
337 | A>V | No |
ClinGen 1000Genomes ESP ExAC gnomAD |
|
|
rs765684474 CA8450868 |
338 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs780805421 CA8450871 |
339 | V>A | No |
ClinGen ExAC gnomAD |
|
|
RCV000947799 VAR_046069 rs2363198 CA8450870 |
339 | V>M | No |
ClinGen ClinVar UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
rs1393442926 CA398260163 |
341 | E>D | No |
ClinGen gnomAD |
|
|
rs1059421 CA288983175 |
341 | E>K | No |
ClinGen Ensembl |
|
|
rs745313836 CA8450872 |
342 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA398260195 rs1597510242 |
345 | E>K | No |
ClinGen Ensembl |
|
|
rs779615271 CA398260209 |
346 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs779615271 CA8450875 |
346 | D>Y | No |
ClinGen ExAC gnomAD |
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CA398260229 rs1257454593 |
348 | S>E | No |
ClinGen gnomAD |
1 associated diseases with P46734
Without disease ID
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.12.2 | Dual-specificity kinases (those acting on Ser/Thr and Tyr residues) |
| Subcellular Localization |
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| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| MAP kinase kinase activity | Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
| protein tyrosine kinase activity | Catalysis of the reaction |
20 GO annotations of biological process
| Name | Definition |
|---|---|
| cardiac muscle contraction | Muscle contraction of cardiac muscle tissue. |
| cellular response to lipopolysaccharide | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
| cellular response to sorbitol | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus. |
| cellular response to vascular endothelial growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. |
| cellular senescence | A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. |
| heart development | The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers |
| negative regulation of hippo signaling | Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling. |
| p38MAPK cascade | An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| positive regulation of blood vessel endothelial cell migration | Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| positive regulation of nitric-oxide synthase biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme. |
| positive regulation of protein kinase activity | Any process that activates or increases the frequency, rate or extent of protein kinase activity. |
| regulation of cytokine production | Any process that modulates the frequency, rate, or extent of production of a cytokine. |
| response to ischemia | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| stress-activated protein kinase signaling cascade | The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9X2 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | Bos taurus (Bovine) | EV |
| O14733 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | Homo sapiens (Human) | PR |
| P52564 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | Homo sapiens (Human) | EV |
| P45985 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | Homo sapiens (Human) | EV |
| Q13163 | MAP2K5 | Dual specificity mitogen-activated protein kinase kinase 5 | Homo sapiens (Human) | PR |
| P36507 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens (Human) | EV |
| Q02750 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens (Human) | EV |
| P70236 | Map2k6 | Dual specificity mitogen-activated protein kinase kinase 6 | Mus musculus (Mouse) | EV |
| O09110 | Map2k3 | Dual specificity mitogen-activated protein kinase kinase 3 | Mus musculus (Mouse) | PR |
| Q8CE90 | Map2k7 | Dual specificity mitogen-activated protein kinase kinase 7 | Mus musculus (Mouse) | PR |
| P47809 | Map2k4 | Dual specificity mitogen-activated protein kinase kinase 4 | Mus musculus (Mouse) | EV |
| G5EDF7 | sek-1 | Dual specificity mitogen-activated protein kinase kinase sek-1 | Caenorhabditis elegans | PR |
| G5EDT6 | jkk-1 | Dual specificity mitogen-activated protein kinase kinase jkk-1 | Caenorhabditis elegans | PR |
| Q21307 | mek-1 | Dual specificity mitogen-activated protein kinase kinase mek-1 | Caenorhabditis elegans | PR |
| Q9DGE0 | map2k6 | Dual specificity mitogen-activated protein kinase kinase 6 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESPASSQPA | SMPQSKGKSK | RKKDLRISCM | SKPPAPNPTP | PRNLDSRTFI | TIGDRNFEVE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ADDLVTISEL | GRGAYGVVEK | VRHAQSGTIM | AVKRIRATVN | SQEQKRLLMD | LDINMRTVDC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FYTVTFYGAL | FREGDVWICM | ELMDTSLDKF | YRKVLDKNMT | IPEDILGEIA | VSIVRALEHL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HSKLSVIHRD | VKPSNVLINK | EGHVKMCDFG | ISGYLVDSVA | KTMDAGCKPY | MAPERINPEL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NQKGYNVKSD | VWSLGITMIE | MAILRFPYES | WGTPFQQLKQ | VVEEPSPQLP | ADRFSPEFVD |
| 310 | 320 | 330 | 340 | ||
| FTAQCLRKNP | AERMSYLELM | EHPFFTLHKT | KKTDIAAFVK | EILGEDS |