P46551

PR
Gene name
cdk-12
Protein name
Cyclin-dependent kinase 12
Names
Cell division cycle 2-related protein kinase 7, Cell division protein kinase 12
Species
Caenorhabditis elegans
KEGG Pathway
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-310 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

461-484 (Activation loop from InterPro)

Target domain

311-605 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P46551

Entry ID Method Resolution Chain Position Source
AF-P46551-F1 Predicted AlphaFoldDB

No variants for P46551

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P46551

No associated diseases with P46551

3 regional properties for P46551

Type Name Position InterPro Accession
domain Protein kinase domain 311 - 605 IPR000719
active_site Serine/threonine-protein kinase, active site 440 - 452 IPR008271
binding_site Protein kinase, ATP binding site 317 - 340 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
cyclin/CDK positive transcription elongation factor complex A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.
euchromatin A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin binding Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

5 GO annotations of biological process

Name Definition
nematode larval development The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
phosphorylation of RNA polymerase II C-terminal domain The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
positive regulation of transcription elongation by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
protein phosphorylation The process of introducing a phosphate group on to a protein.
transcription elongation by RNA polymerase II promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q09437 cdk-11.1 Cyclin-dependent kinase 11.1 Caenorhabditis elegans PR
F4I114 At1g09600 Probable serine/threonine-protein kinase At1g09600 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZVM9 At1g54610 Probable serine/threonine-protein kinase At1g54610 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEISPGSSTH ERDRKGSYGH RERTRSHSGS PSRFYSKDKR GSSRQGVRPR DRDSKDSISP
70 80 90 100 110 120
QYKQRNWSRG GGGGGRDRGR NDFSYRKKGK DYNKRRDKRS RSRSRHRSPK RSGSSKKSKR
130 140 150 160 170 180
RNSSGSSSSD LMDTSLMSEL KKHGDYGSSS KSKKKSRKRR KHSSSSSSSS GEAMDLPVSS
190 200 210 220 230 240
NGMNVTAIPP PPSFNINPFQ PMFSQPPPPP LPPNSQFMTP PPRPPPAPFS IPPPSVDIHF
250 260 270 280 290 300
AATASFSLSS IPPPPPQTDG GASSSKRQDP LPMPPDSKRI ATRPVITTRR GHATNRPSDS
310 320 330 340 350 360
DSWYKTNLTH YTMLDQIGEG TYGQVYKAVN NLTGEQVALK RVRLENEKEG FPITAIREIK
370 380 390 400 410 420
ILRQLHHKNI VRLMDIVIDD ISMDELKRTR ANFYLVFEYV DHDLIGLLES KELVDFNKDQ
430 440 450 460 470 480
ICSLFKQLLE GLAYIHNTGF LHRDIKCSNI LVNNKGELKI ADLGLARLWE KESRLYTNRV
490 500 510 520 530 540
ITLWYRPPEL LLGDERYGPA IDVWSTGCML GELFTRKPLF NGNNEFGQLE LISKVCGSPN
550 560 570 580 590 600
VDNWPELTEL VGWNTFRMKR TYQRRIREEF EHIMPREAVD LLDKMLTLNP EKRISAKEAL
610 620 630 640 650 660
NHPWIRSLEH TTVQPLKLPQ HQDCHEMWSK KQKKSARLGR QAEGSSGSGH SIRATSHPRA
670 680 690 700 710 720
PTQPSTTTTK SNGSSNHHHH HHHSHHHASS LPPSGGHAPP PPPPPTQASS TSHNNHQPVP
QSQYQSVFFK