P46197

PR
Gene name
NPR2
Protein name
Atrial natriuretic peptide receptor 2
Names
Atrial natriuretic peptide receptor type B, ANP-B, ANPR-B, NPR-B, Guanylate cyclase B, GC-B
Species
Bos taurus (Bovine)
KEGG Pathway
bta:281357
EC number
4.6.1.2: Phosphorus-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

462-539 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P46197

Entry ID Method Resolution Chain Position Source
AF-P46197-F1 Predicted AlphaFoldDB

196 variants for P46197

Variant ID(s) Position Change Description Diseaes Association Provenance
rs455851632 4 P>L No EVA
rs444628254 4 P>S No EVA
rs444628254 4 P>T No EVA
rs472766973 6 L>I No EVA
rs432867910 7 L>Q No EVA
rs457102125 10 V>A No EVA
rs479710540 11 A>G No EVA
rs479710540 11 A>V No EVA
rs463041816 12 A>G No EVA
rs480588178 13 L>P No EVA
rs440620820 14 A>G No EVA
rs457733316 15 G>R No EVA
rs453174062 17 V>G No EVA
rs435285051 17 V>L No EVA
rs433148414 18 R>G No EVA
rs462180730 19 P>A No EVA
rs480124984 21 G>R No EVA
rs439896001 22 A>G No EVA
rs439896001 22 A>V No EVA
rs463368591 23 R>H No EVA
rs434595730 24 N>T No EVA
rs452280156 25 L>M No EVA
rs469309999 25 L>P No EVA
rs446920825 27 L>P No EVA
rs464772613 28 A>P No EVA
rs133926865 29 V>A No EVA
rs133926865 29 V>G No EVA
rs459414822 30 V>G No EVA
rs443496535 34 H>P No EVA
rs476584763 35 N>S No EVA
rs453241175 40 W>R No EVA
rs464722011 43 P>L No EVA
rs482568322 45 V>G No EVA
rs477189119 50 A>V No EVA
rs474760898 52 A>G No EVA
rs454641712 52 A>S No EVA
rs452598422 54 E>G No EVA
rs434869538 54 E>Q No EVA
rs470394755 55 A>E No EVA
rs482581229 59 A>E No EVA
rs458678738 59 A>S No EVA
rs442671932 62 V>A No EVA
rs442671932 62 V>E No EVA
rs459672785 63 D>E No EVA
rs470993352 67 V>A No EVA
rs437304582 68 S>I No EVA
rs455173843 70 E>D No EVA
rs466506450 77 E>K No EVA
rs449717219 78 Y>* No EVA
rs431926294 78 Y>D No EVA
rs478690959 87 L>F No EVA
rs438700274 87 L>P No EVA
rs458885681 89 L>F No EVA
rs436617366 103 Y>S No EVA
rs454366953 112 A>S No EVA
rs437640035 114 H>P No EVA
rs448917679 115 W>R No EVA
rs466738785 117 L>H No EVA
rs478200799 118 P>S No EVA
rs461418852 121 T>S No EVA
rs439074313 126 A>G No EVA
rs455954273 127 S>A No EVA
rs467216757 128 G>C No EVA
rs445033851 129 F>I No EVA
rs469285198 133 S>R No EVA
rs482984757 141 R>S No EVA
rs460736048 143 G>R No EVA
rs472046664 145 S>P No EVA
rs473114190 151 E>V No EVA
rs432951819 153 V>E No EVA
rs450780273 154 V>G No EVA
rs467759954 156 L>R No EVA
rs479132760 158 G>V No EVA
rs462989764 159 H>L No EVA
rs445343893 159 H>N No EVA
rs474351701 161 N>Y No EVA
rs440021209 162 W>R No EVA
rs451263432 166 A>S No EVA
rs475555314 174 R>C No EVA
rs446755872 175 T>S No EVA
rs478157418 177 D>H No EVA
rs451035341 177 D>V No EVA
rs439273437 180 H>Y No EVA
rs457104945 184 I>T No EVA
rs474815399 188 F>L No EVA
rs434681243 195 N>T No EVA
rs451719769 199 Q>L No EVA
rs464615577 200 H>P No EVA
rs464615577 200 H>R No EVA
rs447058209 206 E>G No EVA
rs457646722 207 P>R No EVA
rs481836438 209 G>V No EVA
rs441748229 210 P>L No EVA
rs470943559 211 E>G No EVA
rs457234884 212 Q>H No EVA
rs433119007 212 Q>P No EVA
rs447071223 214 T>A No EVA
rs464836095 214 T>I No EVA
rs447071223 214 T>S No EVA
rs481773939 215 H>L No EVA
rs481773939 215 H>P No EVA
rs448182101 219 A>G No EVA
rs459463624 220 N>K No EVA
rs470796765 221 G>W No EVA
rs443498901 222 R>G No EVA
rs465956445 223 I>M No EVA
rs475159866 223 I>V No EVA
rs443488417 227 C>W No EVA
rs475144271 232 M>R No EVA
rs452787715 235 E>G No EVA
rs441413605 235 E>K No EVA
rs469797276 236 I>F No EVA
rs436074311 237 L>R No EVA
rs109560900 246 T>I No EVA
rs447320143 248 G>E No EVA
rs441962179 273 P>A No EVA
rs448405937 278 R>L No EVA
rs471179953 279 T>P No EVA
rs443895136 280 R>P No EVA
rs455239982 284 Q>P No EVA
rs472005406 288 E>A No EVA
rs472005406 288 E>V No EVA
rs432090951 290 F>C No EVA
rs449830892 291 Q>H No EVA
rs481435153 332 L>I No EVA
rs447794141 333 I>V No EVA
rs483334858 357 T>A No EVA
rs442346674 370 G>A No EVA
rs453640093 371 R>* No EVA
rs439740089 408 A>G No EVA
rs457621630 414 A>D No EVA
rs474576271 418 I>L No EVA
rs434398128 421 T>A No EVA
rs445732632 421 T>R No EVA
rs481156738 423 R>L No EVA
rs458123353 427 W>S No EVA
rs475998365 428 V>L No EVA
rs470647258 429 K>N No EVA
rs453590138 429 K>Q No EVA
rs448159189 432 P>A No EVA
rs479850622 433 P>S No EVA
rs446075903 441 F>S No EVA
rs463867037 442 D>H No EVA
rs481626880 444 D>A No EVA
rs876048237 480 K>N No EVA
rs436149056 481 L>P No EVA
rs436149056 481 L>R No EVA
rs470257563 482 M>K No EVA
rs436588269 483 L>M No EVA
rs447947335 484 E>G No EVA
rs465517684 485 K>E No EVA
rs442538160 488 A>S No EVA
rs471646329 490 M>I No EVA
rs460335973 490 M>L No EVA
rs443638787 496 W>C No EVA
rs876109634 496 W>R No EVA
rs476673412 497 E>K No EVA
rs436520990 507 C>F No EVA
rs454148039 513 S>R No EVA
rs465456255 514 R>G No EVA
rs448951013 515 L>I No EVA
rs460255680 518 S>A No EVA
rs460473156 524 Y>S No EVA
rs471791763 525 G>D No EVA
rs456055516 527 L>P No EVA
rs466596385 528 M>L No EVA
rs432808984 531 H>P No EVA
rs450548740 533 K>E No EVA
rs470445270 664 G>D No EVA
rs466286123 687 T>N No EVA
rs448459527 690 E>G No EVA
rs437196512 696 P>A No EVA
rs453787685 704 K>N No EVA
rs442532514 705 A>D No EVA
rs458481094 721 S>R No EVA
rs447952839 721 S>R No EVA
rs481703260 723 P>A No EVA
rs446005813 725 Y>F No EVA
rs472507202 726 L>F No EVA
rs454703874 727 E>G No EVA
rs470554854 729 L>R No EVA
rs442241748 730 D>A No EVA
rs482131100 730 D>E No EVA
rs442241748 730 D>G No EVA
rs464413885 731 L>F No EVA
rs446817440 731 L>P No EVA
rs469942879 732 S>N No EVA
rs436289051 732 S>R No EVA
rs469942879 732 S>T No EVA
rs452255364 735 E>K No EVA
rs455922765 737 V>F No EVA
rs438132080 744 Q>H No EVA
rs471877846 745 R>W No EVA
rs43557658 861 T>P No EVA
rs452802411 982 D>H No EVA
rs444240601 1029 G>R No EVA

No associated diseases with P46197

5 regional properties for P46197

Type Name Position InterPro Accession
domain Protein kinase domain 513 - 786 IPR000719
domain Adenylyl cyclase class-3/4/guanylyl cyclase 825 - 1037 IPR001054
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 540 - 783 IPR001245
domain Receptor, ligand binding region 45 - 397 IPR001828
conserved_site Adenylyl cyclase class-4/guanylyl cyclase, conserved site 968 - 991 IPR018297

Functions

Description
EC Number 4.6.1.2 Phosphorus-oxygen lyases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

8 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTP binding Binding to GTP, guanosine triphosphate.
guanylate cyclase activity Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
identical protein binding Binding to an identical protein or proteins.
natriuretic peptide receptor activity Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.
peptide hormone binding Binding to a peptide with hormonal activity in animals.
peptide receptor activity Combining with an extracellular or intracellular peptide to initiate a change in cell activity.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

11 GO annotations of biological process

Name Definition
bone development The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
cellular response to granulocyte macrophage colony-stimulating factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.
cGMP biosynthetic process The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
negative regulation of meiotic cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle.
negative regulation of oocyte maturation Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation.
ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
protein phosphorylation The process of introducing a phosphate group on to a protein.
receptor guanylyl cyclase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

27 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O02740 GUCY2F Retinal guanylyl cyclase 2 Bos taurus (Bovine) PR
P51841 GUCY2F Retinal guanylyl cyclase 2 Homo sapiens (Human) PR
Q02846 GUCY2D Retinal guanylyl cyclase 1 Homo sapiens (Human) PR
P20594 NPR2 Atrial natriuretic peptide receptor 2 Homo sapiens (Human) PR
P52785 Gucy2e Retinal guanylyl cyclase 1 Mus musculus (Mouse) PR
Q5SDA5 Gucy2f Retinal guanylyl cyclase 2 Mus musculus (Mouse) PR
Q6VVW5 Npr2 Atrial natriuretic peptide receptor 2 Mus musculus (Mouse) PR
P51840 Gucy2e Retinal guanylyl cyclase 1 Rattus norvegicus (Rat) PR
P18910 Npr1 Atrial natriuretic peptide receptor 1 Rattus norvegicus (Rat) PR
P51842 Gucy2f Retinal guanylyl cyclase 2 Rattus norvegicus (Rat) PR
P16067 Npr2 Atrial natriuretic peptide receptor 2 Rattus norvegicus (Rat) PR
Q09435 gcy-1 Receptor-type guanylate cyclase gcy-1 Caenorhabditis elegans PR
O16544 gcy-19 Receptor-type guanylate cyclase gcy-19 Caenorhabditis elegans PR
Q18331 gcy-11 Receptor-type guanylate cyclase gcy-11 Caenorhabditis elegans PR
Q10029 gcy-2 Receptor-type guanylate cyclase gcy-2 Caenorhabditis elegans PR
X5M8U1 gcy-17 Receptor-type guanylate cyclase gcy-17 Caenorhabditis elegans PR
Q23682 gcy-5 Receptor-type guanylate cyclase gcy-5 Caenorhabditis elegans PR
Q9M2S4 LECRKS4 L-type lectin-domain containing receptor kinase S.4 Arabidopsis thaliana (Mouse-ear cress) PR
O81292 LECRK43 L-type lectin-domain containing receptor kinase IV.3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M345 LECRK42 L-type lectin-domain containing receptor kinase IV.2 Arabidopsis thaliana (Mouse-ear cress) PR
O81291 LECRK44 L-type lectin-domain containing receptor kinase IV.4 Arabidopsis thaliana (Mouse-ear cress) PR
O80939 LECRK41 L-type lectin-domain containing receptor kinase IV.1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M1G4 LECRK15 Probable L-type lectin-domain containing receptor kinase I.5 Arabidopsis thaliana (Mouse-ear cress) PR
Q96285 LECRK55 L-type lectin-domain containing receptor kinase V.5 Arabidopsis thaliana (Mouse-ear cress) PR
Q93ZS4 NIK3 Protein NSP-INTERACTING KINASE 3 Arabidopsis thaliana (Mouse-ear cress) PR
P93050 BSH Probable LRR receptor-like serine/threonine-protein kinase RKF3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSR8 LECRK19 L-type lectin-domain containing receptor kinase I.9 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MALPSLLLVV AALAGGVRPP GARNLTLAVV LPEHNLSYAW AWPRVGPAVA LAMEALGRAL
70 80 90 100 110 120
PVDLRFVSSE LDGACSEYLA PLRAVDLKLY HDPDLLLGPG CVYPAASVAR FASHWRLPLL
130 140 150 160 170 180
TAGAVASGFS AKSEHYRTLV RTGPSAPKLG EFVVMLHGHF NWTARAALLY LDARTDDRPH
190 200 210 220 230 240
YFTIEGVFEA LQGSNLSVQH QVYAREPGGP EQATHFIRAN GRIVYICGPL EMLHEILLQA
250 260 270 280 290 300
QRENLTNGDY VFFYLDVFGE SLRAGPTRSM GRPWQDNRTR EQAQALREAF QTVLVITYRE
310 320 330 340 350 360
PPNPEYQEFQ NRLLIRARED FGVELAPSLM NLIAGCFYDG ILLYAEVLNE TIQEGGTRED
370 380 390 400 410 420
GLRIVEKMQG RRYRGVTGLV VMDKNNDRET DFVLWAMGDL VSGDFQPAAH YSGAEKQIWW
430 440 450 460 470 480
TGRPIPWVKG VPPLDNPPCA FDMDDPSCDK TPLSTLAIVA LGTGITFIMF GVSSFLIFRK
490 500 510 520 530 540
LMLEKELASM LWRIRWEELQ FGNSERCHKG AGSRLTLSLR GSSYGSLMTA HGKYQIFANT
550 560 570 580 590 600
GHFKGNVVAI KHVNKKRIEL TRQVLFELKH MRDVQFNHLT RFIGACIDPP NICIVTEYCP
610 620 630 640 650 660
RGSLQDILEN DSINLDWMFR YSLINDLVKG MAFLHNSIIA SHGSLKSSNC VVDSRFVLKI
670 680 690 700 710 720
TDYGLASFRS TAEPDDSHAL YAKKLWTAPE LLSGNPLPTT GMQKADVYSF GIILQEIALR
730 740 750 760 770 780
SGPFYLEGLD LSPKEIVQKV RNGQRPYFRP SIDRTQLNEE LVLLMERCWA QDPAERPDFG
790 800 810 820 830 840
QIKGFIRRFN KEGGTSILDN LLLRMEQYAN NLEKLVEERT QAYLEEKRKA EALLYQILPH
850 860 870 880 890 900
SVAEQLKRGE TVQAEAFDSV TIYFSDIVGF TALSAESTPM QVVTLLNDLY TCFDAIIDNF
910 920 930 940 950 960
DVYKVETIGD AYMVVSGLPG RNGQRHAPEI ARMALALLDA VSSFRIRHRP HDQLRLRIGV
970 980 990 1000 1010 1020
HTGPVCAGVV GLKMPRYCLF GDTVNTASRM ESNGQALKIH VSSTTKDALD ELGCFQLELR
1030 1040
GDVEMKGKGK MRTYWLLGER KGPAGLL