Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P45771

Entry ID Method Resolution Chain Position Source
AF-P45771-F1 Predicted AlphaFoldDB

No variants for P45771

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P45771

No associated diseases with P45771

4 regional properties for P45771

Type Name Position InterPro Accession
domain DNA topoisomerase, type IA, zn finger 13 - 49 IPR013498-1
domain DNA topoisomerase, type IA, zn finger 62 - 98 IPR013498-2
domain DNA topoisomerase, type IA, zn finger 104 - 142 IPR013498-3
domain DNA topoisomerase, type IA, zn finger 145 - 167 IPR013498-4

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

4 GO annotations of molecular function

Name Definition
DNA topoisomerase type I (single strand cut, ATP-independent) activity Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
iron ion binding Binding to an iron (Fe) ion.
single-stranded DNA binding Binding to single-stranded DNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAKSALFTVR NNESCPKCGA ELVIRSGKHG PFLGCSQYPA CDYVRPLKSS ADGHIVKVLE
70 80 90 100 110 120
GQVCPACGAN LVLRQGRFGM FIGCINYPEC EHTELIDKPD ETAITCPQCR TGHLVQRRSR
130 140 150 160 170
YGKTFHSCDR YPECQFAINF KPIAGECPEC HYPLLIEKKT AQGVKHFCAS KQCGKPVSAE