P45442
Gene name |
lag-2 |
Protein name |
Protein lag-2 |
Names |
Lethal protein 461 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_Y73C8B.4 |
EC number |
|
Protein Class |
DELTA/SERRATE/LAG-2 DOMAIN PROTEIN (PTHR22669) |
Descriptions
LAG-2 is a putative ligand for LIN-12 and GLP-1 receptors and regulates cell fates during development. The deletions of EGF-like repeats or intracellular (IC) domain recovered the activity of LAG-2. Membrane association is critical for the activation of LAG-2 and may function to limit the diffusion of LAG-2 and also to increase its local concentration.
Autoinhibitory domains (AIDs)
Target domain |
103-169 (DSL domain) |
Relief mechanism |
Ligand binding |
Assay |
Deletion assay |
Target domain |
103-169 (DSL domain) |
Relief mechanism |
Ligand binding |
Assay |
Deletion assay |
Target domain |
103-169 (DSL domain) |
Relief mechanism |
Ligand binding |
Assay |
Deletion assay |
Target domain |
103-169 (DSL domain) |
Relief mechanism |
Ligand binding |
Assay |
Deletion assay |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P45442
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P45442-F1 | Predicted | AlphaFoldDB |
No variants for P45442
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P45442 | |||||
No associated diseases with P45442
3 regional properties for P45442
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EGF-like domain | 165 - 216 | IPR000742-1 |
| domain | EGF-like domain | 229 - 266 | IPR000742-2 |
| domain | Delta/Serrate/lag-2 (DSL) protein | 103 - 169 | IPR001774 |
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR22669 | DELTA/SERRATE/LAG-2 DOMAIN PROTEIN |
| PANTHER Subfamily | PTHR22669:SF8 | PROTEIN LAG-2 |
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell projection membrane | The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuronal cell body membrane | The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| Notch binding | Binding to a Notch (N) protein, a surface receptor. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| cell fate specification | The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. |
| gonad development | The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones. |
| maintenance of dauer | Maintenance of a nematode during the facultative diapause of the dauer (enduring) larval stage of nematode development. |
| nematode larval development | The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. |
| Notch signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| positive regulation of stem cell proliferation | Any process that activates or increases the frequency, rate or extent of stem cell proliferation. |
| regulation of basement membrane organization | Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane. |
| regulation of germ cell proliferation | Any process that modulates the frequency, rate or extent of germ cell proliferation. |
| regulation of mesodermal cell fate specification | Any process that modulates the frequency, rate or extent of mesoderm cell fate specification. |
| regulation of vulval development | Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. |
| sleep | Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIAYFLLLLT | CLPVLQARVE | VHQEFISSKR | VSVRFEIVTE | SHSPNRPVTF | DLFPRGPKTN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IILLDTFNPV | FNFSIQLVQP | FTGQPLGDRI | YRKVQFSGTN | QPWINDTFTT | TSGISLSVAT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EVTCARNYFG | NRCENFCDAH | LAKAARKRCD | AMGRLRCDIG | WMGPHCGQAV | DPRKCSCEND |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GICVSSMIHP | SQPNQTSSNE | QLICECTNGF | TGTRCEIFGF | NQFQLTAPRP | DACSVKDACL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NGAKCFPNGP | KVFCSCAVGF | IGEFCEISLT | TTTPTTVEIT | VSTSGYSSAV | YITVALFVIF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SIIIGCFKYK | FKPMRQQALA | RGQVPEPYKM | PETKSMLIDP | EASEAQKKVF | TIEGSVQKID |
| 370 | 380 | 390 | 400 | ||
| EEVRYTSAPR | KYESNNEYAV | IQKSTPPPPS | LSPPSIPACH | YV |