P43563
PR
Gene name |
MOB2 (YFL034C-B, YFL035C, YFL035C-A) |
Protein name |
CBK1 kinase activator protein MOB2 |
Names |
MPS1 binder 2, Maintenance of ploidy protein MOB2 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YFL034C-B |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 variants for P43563
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s06-63395 | 162 | T>A | No | SGRP | |
| s06-63178 | 234 | F>Y | No | SGRP |
No associated diseases with P43563
No regional properties for P43563
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P43563 | |||
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cellular bud | A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated. |
| cellular bud neck | The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding. |
| cellular bud tip | The end of a cellular bud distal to the site of attachment to the mother cell. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mating projection tip | The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| serine/threonine protein kinase complex | A protein complex which is capable of protein serine/threonine kinase activity. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein kinase activator activity | Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| budding cell apical bud growth | Growth at the tip of a bud, in a cell that reproduces by budding. |
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| establishment or maintenance of cell polarity | Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. |
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| septum digestion after cytokinesis | The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P40484 | MOB1 | DBF2 kinase activator protein MOB1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| Q95RA8 | mats | MOB kinase activator-like 1 | Drosophila melanogaster (Fruit fly) | SS |
| Q70IA8 | MOB3C | MOB kinase activator 3C | Homo sapiens (Human) | SS |
| Q96BX8 | MOB3A | MOB kinase activator 3A | Homo sapiens (Human) | SS |
| Q86TA1 | MOB3B | MOB kinase activator 3B | Homo sapiens (Human) | SS |
| Q9H8S9 | MOB1A | MOB kinase activator 1A | Homo sapiens (Human) | EV |
| Q7L9L4 | MOB1B | MOB kinase activator 1B | Homo sapiens (Human) | SS |
| Q8BJG4 | Mob3c | MOB kinase activator 3C | Mus musculus (Mouse) | SS |
| Q8BSU7 | Mob3a | MOB kinase activator 3A | Mus musculus (Mouse) | SS |
| Q8VE04 | Mob3b | MOB kinase activator 3B | Mus musculus (Mouse) | SS |
| Q8VI63 | Mob2 | MOB kinase activator 2 | Mus musculus (Mouse) | EV |
| Q921Y0 | Mob1a | MOB kinase activator 1A | Mus musculus (Mouse) | SS |
| Q8BPB0 | Mob1b | MOB kinase activator 1B | Mus musculus (Mouse) | EV |
| Q3T1J9 | Mob1a | MOB kinase activator 1A | Rattus norvegicus (Rat) | SS |
| Q8GYX0 | MOB1B | MOB kinase activator-like 1B | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHI1 | MOB1A | MOB kinase activator-like 1A | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSFFNFKAFG | RNSKKNKNQP | LNVAQPPAMN | TIYSSPHSSN | SRLSLRNKHH | SPKRHSQTSF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PAQKSTPQSQ | QLTSTTPQSQ | QQEASERSES | QQIMFLSEPF | VRTALVKGSF | KTIVQLPKYV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DLGEWIALNV | FEFFTNLNQF | YGVVAEYVTP | DAYPTMNAGP | HTDYLWLDAN | NRQVSLPASQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YIDLALTWIN | NKVNDKNLFP | TKNGLPFPQQ | FSRDVQRIMV | QMFRIFAHIY | HHHFDKIVHL |
| 250 | 260 | 270 | 280 | ||
| SLEAHWNSFF | SHFISFAKEF | KIIDRKEMAP | LLPLIESFEK | QGKIIYN |