Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P43333

Entry ID Method Resolution Chain Position Source
AF-P43333-F1 Predicted AlphaFoldDB

7 variants for P43333

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_3161571_T_A 11 K>N No 1000Genomes
ENSVATH10856869 12 S>I No 1000Genomes
tmp_1_3161406_A_G 33 V>A No 1000Genomes
ENSVATH01028614 110 A>S No 1000Genomes
ENSVATH01028613 129 A>P No 1000Genomes
ENSVATH00014059 148 I>V No 1000Genomes
ENSVATH04546107 173 K>E No 1000Genomes

No associated diseases with P43333

1 regional properties for P43333

Type Name Position InterPro Accession
domain U2A'/phosphoprotein 32 family A, C-terminal 128 - 146 IPR003603

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
Cajal body A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

1 GO annotations of molecular function

Name Definition
U2 snRNA binding Binding to a U2 small nuclear RNA (U2 snRNA).

1 GO annotations of biological process

Name Definition
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P09661 SNRPA1 U2 small nuclear ribonucleoprotein A' Homo sapiens (Human) PR
P57784 Snrpa1 U2 small nuclear ribonucleoprotein A' Mus musculus (Mouse) PR
10 20 30 40 50 60
MVKLTADLIW KSPHFFNAIK ERELDLRGNK IPVIENLGAT EDQFDTIDLS DNEIVKLENF
70 80 90 100 110 120
PYLNRLGTLL INNNRITRIN PNLGEFLPKL HSLVLTNNRL VNLVEIDPLA SIPKLQYLSL
130 140 150 160 170 180
LDNNITKKAN YRLYVIHKLK SLRVLDFIKI KAKERAEAAS LFSSKEAEEE VKKVSREEVK
190 200 210 220 230 240
KVSETAENPE TPKVVAPTAE QILAIKAAII NSQTIEEIAR LEQALKFGQV PAGLIIPDPA
TNDSAPMEE