P43298

PR
Gene name
TMK1
Protein name
Receptor protein kinase TMK1
Names
BARK1-like kinase 1, Transmembrane kinase 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G66150
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

873-942 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

734-758 (Activation loop from InterPro)

Target domain

588-869 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

2 structures for P43298

Entry ID Method Resolution Chain Position Source
4HQ1 X-ray 155 A A 1-469 PDB
AF-P43298-F1 Predicted AlphaFoldDB

63 variants for P43298

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH13741905 8 L>I No 1000Genomes
tmp_1_24631537_T_A 12 F>Y No 1000Genomes
tmp_1_24631573_A_G 24 D>G No 1000Genomes
ENSVATH05076796 34 S>L No 1000Genomes
tmp_1_24631637_C_G 45 F>L No 1000Genomes
tmp_1_24631716_G_A 72 G>R No 1000Genomes
ENSVATH14426244 75 G>S No 1000Genomes
ENSVATH01479181 86 N>S No 1000Genomes
ENSVATH01479181 86 N>T No 1000Genomes
tmp_1_24631799_C_A 99 N>K No 1000Genomes
ENSVATH05076798 103 P>H No 1000Genomes
tmp_1_24631866_A_C 122 N>H No 1000Genomes
ENSVATH00125668 136 S>L No 1000Genomes
tmp_1_24631920_G_T 140 V>L No 1000Genomes
tmp_1_24631933_A_G 144 N>S No 1000Genomes
ENSVATH13741907 147 F>L No 1000Genomes
tmp_1_24631941_T_G 147 F>V No 1000Genomes
tmp_1_24631949_T_G 149 S>R No 1000Genomes
ENSVATH01479182 205 S>R No 1000Genomes
ENSVATH05076801 224 D>E No 1000Genomes
ENSVATH05076803 243 K>E No 1000Genomes
tmp_1_24632235_T_C 245 S>P No 1000Genomes
ENSVATH01479183 247 P>S No 1000Genomes
ENSVATH14426256 248 L>I No 1000Genomes
ENSVATH05076805 266 S>A No 1000Genomes
tmp_1_24632316_C_T 272 P>S No 1000Genomes
ENSVATH05076807 273 A>T No 1000Genomes
ENSVATH13741908 279 E>D No 1000Genomes
ENSVATH05076810 307 D>E No 1000Genomes
tmp_1_24632445_T_A 315 L>M No 1000Genomes
ENSVATH05076815 339 P>H No 1000Genomes
ENSVATH05076820 352 T>I No 1000Genomes
tmp_1_24632593_T_A 364 I>N No 1000Genomes
ENSVATH13741909 384 A>G No 1000Genomes
ENSVATH05076826 384 A>S No 1000Genomes
ENSVATH13741909 384 A>V No 1000Genomes
ENSVATH05076828 395 I>V No 1000Genomes
tmp_1_24632697_A_T 399 T>S No 1000Genomes
ENSVATH13741910 435 V>L No 1000Genomes
ENSVATH05076832 442 D>E No 1000Genomes
ENSVATH05076833 460 G>V No 1000Genomes
tmp_1_24632901_A_G 467 N>D No 1000Genomes
tmp_1_24632904_G_A 468 G>S No 1000Genomes
tmp_1_24632926_T_A 475 M>K No 1000Genomes
ENSVATH05076836 484 I>V No 1000Genomes
ENSVATH01479188 493 L>F No 1000Genomes
ENSVATH13741913 511 K>E No 1000Genomes
ENSVATH14426259 512 R>S No 1000Genomes
tmp_1_24633097_A_G 532 D>G No 1000Genomes
tmp_1_24633133_G_A,C 544 S>N No 1000Genomes
tmp_1_24633133_G_A,C 544 S>T No 1000Genomes
ENSVATH05076840 553 T>P No 1000Genomes
tmp_1_24633501_C_T 667 P>S No 1000Genomes
tmp_1_24633687_A_G 729 M>V No 1000Genomes
tmp_1_24633987_A_C 801 S>R No 1000Genomes
tmp_1_24634051_C_T 822 A>V No 1000Genomes
tmp_1_24634158_A_G 858 M>V No 1000Genomes
ENSVATH13741919 873 K>R No 1000Genomes
ENSVATH05076862 882 I>V No 1000Genomes
ENSVATH14426262 909 S>F No 1000Genomes
ENSVATH13741920 913 S>T No 1000Genomes
ENSVATH01479189 914 L>P No 1000Genomes
ENSVATH14426263 927 T>I No 1000Genomes

No associated diseases with P43298

4 regional properties for P43298

Type Name Position InterPro Accession
domain Protein kinase domain 330 - 603 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 331 - 596 IPR001245
domain WIF domain 63 - 196 IPR003306
active_site Tyrosine-protein kinase, active site 461 - 473 IPR008266

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
transmembrane receptor protein serine/threonine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

49 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q91044 NTRK3 NT-3 growth factor receptor Gallus gallus (Chicken) SS
Q91987 NTRK2 BDNF/NT-3 growth factors receptor Gallus gallus (Chicken) SS
Q91009 NTRK1 High affinity nerve growth factor receptor Gallus gallus (Chicken) SS
Q5IS37 NTRK3 NT-3 growth factor receptor Pan troglodytes (Chimpanzee) SS
O15146 MUSK Muscle, skeletal receptor tyrosine-protein kinase Homo sapiens (Human) EV
P04629 NTRK1 High affinity nerve growth factor receptor Homo sapiens (Human) EV
Q16288 NTRK3 NT-3 growth factor receptor Homo sapiens (Human) SS
Q16620 NTRK2 BDNF/NT-3 growth factors receptor Homo sapiens (Human) EV
P55144 Tyro3 Tyrosine-protein kinase receptor TYRO3 Mus musculus (Mouse) SS
Q61006 Musk Muscle, skeletal receptor tyrosine-protein kinase Mus musculus (Mouse) SS
Q00993 Axl Tyrosine-protein kinase receptor UFO Mus musculus (Mouse) PR
Q60805 Mertk Tyrosine-protein kinase Mer Mus musculus (Mouse) SS
Q3UFB7 Ntrk1 High affinity nerve growth factor receptor Mus musculus (Mouse) SS
P09581 Csf1r Macrophage colony-stimulating factor 1 receptor Mus musculus (Mouse) SS
P21803 Fgfr2 Fibroblast growth factor receptor 2 Mus musculus (Mouse) SS
P16092 Fgfr1 Fibroblast growth factor receptor 1 Mus musculus (Mouse) SS
Q03142 Fgfr4 Fibroblast growth factor receptor 4 Mus musculus (Mouse) PR
P05622 Pdgfrb Platelet-derived growth factor receptor beta Mus musculus (Mouse) SS
Q00342 Flt3 Receptor-type tyrosine-protein kinase FLT3 Mus musculus (Mouse) SS
Q61851 Fgfr3 Fibroblast growth factor receptor 3 Mus musculus (Mouse) PR
P24786 NTRK3 NT-3 growth factor receptor Sus scrofa (Pig) SS
P35739 Ntrk1 High affinity nerve growth factor receptor Rattus norvegicus (Rat) SS
Q03351 Ntrk3 NT-3 growth factor receptor Rattus norvegicus (Rat) SS
Q63604 Ntrk2 BDNF/NT-3 growth factors receptor Rattus norvegicus (Rat) SS
Q9TZM3 lrk-1 Leucine-rich repeat serine/threonine-protein kinase 1 Caenorhabditis elegans SS
P43293 PBL11 Probable serine/threonine-protein kinase PBL11 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E8W4 ANX2 Receptor-like protein kinase ANXUR2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LPS5 SERK5 Somatic embryogenesis receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN94 At5g59670 Receptor-like protein kinase At5g59670 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LPZ9 SD113 G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 Arabidopsis thaliana (Mouse-ear cress) SS
C0LGG3 At1g51820 Probable LRR receptor-like serine/threonine-protein kinase At1g51820 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGI2 At1g67720 Probable LRR receptor-like serine/threonine-protein kinase At1g67720 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQR3 At2g14510 Leucine-rich repeat receptor-like serine/threonine-protein kinase At2g14510 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWW0 ALE2 Receptor-like serine/threonine-protein kinase ALE2 Arabidopsis thaliana (Mouse-ear cress) PR
P93050 BSH Probable LRR receptor-like serine/threonine-protein kinase RKF3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRP3 At3g17420 Probable receptor-like protein kinase At3g17420 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LIG2 At3g21340 Receptor-like protein kinase At3g21340 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SNA3 At3g46340 Putative receptor-like protein kinase At3g46340 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M2S4 LECRKS4 L-type lectin-domain containing receptor kinase S.4 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWZ5 SD25 G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 Arabidopsis thaliana (Mouse-ear cress) PR
C0LGW2 PAM74 Probable LRR receptor-like serine/threonine-protein kinase PAM74 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN93 At5g59680 Probable LRR receptor-like serine/threonine-protein kinase At5g59680 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SXB4 At1g11300 G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 Arabidopsis thaliana (Mouse-ear cress) PR
Q84JQ4 PRK2 Pollen receptor-like kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q93ZS4 NIK3 Protein NSP-INTERACTING KINASE 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AG2 SERK1 Somatic embryogenesis receptor kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
O64477 At2g19130 G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 Arabidopsis thaliana (Mouse-ear cress) SS
Q9XIC7 SERK2 Somatic embryogenesis receptor kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
O13146 epha3 Ephrin type-A receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MKKRRTFLLF SFTFLLLLSL SKADSDGDLS AMLSLKKSLN PPSSFGWSDP DPCKWTHIVC
70 80 90 100 110 120
TGTKRVTRIQ IGHSGLQGTL SPDLRNLSEL ERLELQWNNI SGPVPSLSGL ASLQVLMLSN
130 140 150 160 170 180
NNFDSIPSDV FQGLTSLQSV EIDNNPFKSW EIPESLRNAS ALQNFSANSA NVSGSLPGFL
190 200 210 220 230 240
GPDEFPGLSI LHLAFNNLEG ELPMSLAGSQ VQSLWLNGQK LTGDITVLQN MTGLKEVWLH
250 260 270 280 290 300
SNKFSGPLPD FSGLKELESL SLRDNSFTGP VPASLLSLES LKVVNLTNNH LQGPVPVFKS
310 320 330 340 350 360
SVSVDLDKDS NSFCLSSPGE CDPRVKSLLL IASSFDYPPR LAESWKGNDP CTNWIGIACS
370 380 390 400 410 420
NGNITVISLE KMELTGTISP EFGAIKSLQR IILGINNLTG MIPQELTTLP NLKTLDVSSN
430 440 450 460 470 480
KLFGKVPGFR SNVVVNTNGN PDIGKDKSSL SSPGSSSPSG GSGSGINGDK DRRGMKSSTF
490 500 510 520 530 540
IGIIVGSVLG GLLSIFLIGL LVFCWYKKRQ KRFSGSESSN AVVVHPRHSG SDNESVKITV
550 560 570 580 590 600
AGSSVSVGGI SDTYTLPGTS EVGDNIQMVE AGNMLISIQV LRSVTNNFSS DNILGSGGFG
610 620 630 640 650 660
VVYKGELHDG TKIAVKRMEN GVIAGKGFAE FKSEIAVLTK VRHRHLVTLL GYCLDGNEKL
670 680 690 700 710 720
LVYEYMPQGT LSRHLFEWSE EGLKPLLWKQ RLTLALDVAR GVEYLHGLAH QSFIHRDLKP
730 740 750 760 770 780
SNILLGDDMR AKVADFGLVR LAPEGKGSIE TRIAGTFGYL APEYAVTGRV TTKVDVYSFG
790 800 810 820 830 840
VILMELITGR KSLDESQPEE SIHLVSWFKR MYINKEASFK KAIDTTIDLD EETLASVHTV
850 860 870 880 890 900
AELAGHCCAR EPYQRPDMGH AVNILSSLVE LWKPSDQNPE DIYGIDLDMS LPQALKKWQA
910 920 930 940
YEGRSDLESS TSSLLPSLDN TQMSIPTRPY GFAESFTSVD GR