P43294

PR
Gene name
MHK (At4g13020, F25G13.110)
Protein name
Serine/threonine-protein kinase MHK
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G13020
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

301-443 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

149-171 (Activation loop from InterPro)

Target domain

12-291 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P43294

Entry ID Method Resolution Chain Position Source
AF-P43294-F1 Predicted AlphaFoldDB

38 variants for P43294

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00497135 87 F>L No 1000Genomes
tmp_4_7604572_A_G 101 R>G No 1000Genomes
tmp_4_7604576_A_T 102 E>V No 1000Genomes
ENSVATH06639222 104 P>S No 1000Genomes
ENSVATH06639223 105 F>L No 1000Genomes
ENSVATH06639224 108 G>E No 1000Genomes
tmp_4_7604628_A_T 119 Q>H No 1000Genomes
ENSVATH00497138 126 K>R No 1000Genomes
ENSVATH00497138 126 K>T No 1000Genomes
tmp_4_7604792_T_C 145 I>T No 1000Genomes
tmp_4_7604798_A_T 147 K>I No 1000Genomes
ENSVATH06639232 163 Y>F No 1000Genomes
ENSVATH11604383 179 L>V No 1000Genomes
ENSVATH06639233 183 L>F No 1000Genomes
ENSVATH00497150 229 T>A No 1000Genomes
tmp_4_7605454_C_T 234 A>V No 1000Genomes
ENSVATH02808876 240 I>V No 1000Genomes
tmp_4_7605489_A_G 246 T>A No 1000Genomes
ENSVATH06639243 289 P>S No 1000Genomes
tmp_4_7605823_T_G 291 F>V No 1000Genomes
ENSVATH06639244 294 A>T No 1000Genomes
ENSVATH11604630 295 T>M No 1000Genomes
ENSVATH06639247 326 R>T No 1000Genomes
ENSVATH11604632 343 A>T No 1000Genomes
tmp_4_7606168_A_C 345 K>N No 1000Genomes
ENSVATH11604695 348 M>T No 1000Genomes
tmp_4_7606401_G_C 365 G>A No 1000Genomes
ENSVATH06639257 372 P>S No 1000Genomes
tmp_4_7606523_T_G 374 V>G No 1000Genomes
tmp_4_7606555_G_A 385 G>S No 1000Genomes
ENSVATH00497162 385 G>V No 1000Genomes
ENSVATH11604697 387 H>Q No 1000Genomes
ENSVATH11604698 388 A>S No 1000Genomes
tmp_4_7606601_G_A 400 S>N No 1000Genomes
tmp_4_7606703_G_T 408 G>V No 1000Genomes
ENSVATH11604745 417 M>T No 1000Genomes
ENSVATH02808907 427 D>E No 1000Genomes
tmp_4_7606783_G_A 435 A>T No 1000Genomes

No associated diseases with P43294

7 regional properties for P43294

Type Name Position InterPro Accession
repeat Leucine-rich repeat 48 - 69 IPR001611
repeat WD40 repeat 377 - 434 IPR001680-1
repeat WD40 repeat 437 - 487 IPR001680-2
repeat WD40 repeat 490 - 531 IPR001680-3
repeat WD40 repeat 541 - 580 IPR001680-4
conserved_site WD40 repeat, conserved site 517 - 531 IPR019775
repeat Leucine rich repeat 4 48 - 82 IPR025875

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.

26 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UQ07 MOK MAPK/MAK/MRK overlapping kinase Homo sapiens (Human) PR
P20794 MAK Serine/threonine-protein kinase MAK Homo sapiens (Human) PR
Q9WVS4 Mok MAPK/MAK/MRK overlapping kinase Mus musculus (Mouse) PR
Q04859 Mak Serine/threonine-protein kinase MAK Mus musculus (Mouse) PR
Q9JKV2 Cilk1 Serine/threonine-protein kinase ICK Mus musculus (Mouse) PR
P20793 Mak Serine/threonine-protein kinase MAK Rattus norvegicus (Rat) PR
Q9LQQ9 MPK13 Mitogen-activated protein kinase 13 Arabidopsis thaliana (Mouse-ear cress) SS
Q39025 MPK5 Mitogen-activated protein kinase 5 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GYQ5 MPK12 Mitogen-activated protein kinase 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LMM5 MPK11 Mitogen-activated protein kinase 11 Arabidopsis thaliana (Mouse-ear cress) SS
Q39024 MPK4 Mitogen-activated protein kinase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q84M93 MPK17 Mitogen-activated protein kinase 17 Arabidopsis thaliana (Mouse-ear cress) SS
Q9C9U4 MPK15 Mitogen-activated protein kinase 15 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LV37 MPK9 Mitogen-activated protein kinase 9 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LM33 MPK8 Mitogen-activated protein kinase 8 Arabidopsis thaliana (Mouse-ear cress) SS
Q8W4J2 MPK16 Mitogen-activated protein kinase 16 Arabidopsis thaliana (Mouse-ear cress) SS
Q9C5C0 MPK18 Mitogen-activated protein kinase 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LUC3 MPK19 Mitogen-activated protein kinase 19 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SJG9 MPK20 Mitogen-activated protein kinase 20 Arabidopsis thaliana (Mouse-ear cress) SS
O23236 MPK14 Mitogen-activated protein kinase 14 Arabidopsis thaliana (Mouse-ear cress) SS
Q39027 MPK7 Mitogen-activated protein kinase 7 Arabidopsis thaliana (Mouse-ear cress) SS
Q39021 MPK1 Mitogen-activated protein kinase 1 Arabidopsis thaliana (Mouse-ear cress) SS
Q39022 MPK2 Mitogen-activated protein kinase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q39023 MPK3 Mitogen-activated protein kinase 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M1Z5 MPK10 Mitogen-activated protein kinase 10 Arabidopsis thaliana (Mouse-ear cress) SS
Q39026 MPK6 Mitogen-activated protein kinase 6 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MMVFVVFVMC RYKILEELGD GTCGSVYKAV NLETYEVVAV KKMKRKFYYW EECVNLREVK
70 80 90 100 110 120
ALRKLNHPHI IKLKEIVREH NELFFIFECM DHNLYHIMKE RERPFSEGEI RSFMSQMLQG
130 140 150 160 170 180
LAHMHKNGYF HRDLKPENLL VTNNILKIAD FGLAREVASM PPYTEYVSTR WYRAPEVLLQ
190 200 210 220 230 240
SSLYTPAVDM WAVGAILAEL YALTPLFPGE SEIDQLYKIC CVLGKPDWTT FPEAKSISRI
250 260 270 280 290 300
MSISHTEFPQ TRIADLLPNA APEAIDLINR LCSWDPLKRP TADEALNHPF FSMATQASYP
310 320 330 340 350 360
IHDLELRLDN MAALPNLELN LWDFNREPEE CFLGLTLAVK PSAPKLEMLR NVSQDMSENF
370 380 390 400 410 420
LFCPGVNNDR EPSVFWSLLS PDENGLHAPV ESSPLSLSFS PMQQHTVGPP QSSGFTMTSS
430 440
MQPNMLDRPW MAVSAPFQQS HYL