P42685
EV
Gene name |
FRK (PTK5, RAK) |
Protein name |
Tyrosine-protein kinase FRK |
Names |
FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:2444 |
EC number |
2.7.10.2: Protein-tyrosine kinases |
Protein Class |
TYROSINE-PROTEIN KINASE (PTHR24418) |
Descriptions
Tyrosine-protein kinase FRK(FYN-related kinase) plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. It is included in Src family non-receptor tyrosine kinases. Src kinase (family) share a conserved domain structure consisting of consecutive SH3, SH2, tyrosine kinase). Binding of SAP to the Fyn SH3 domain is expected to disrupt the autoinhibitory interaction of the SH3 domain, and therefore to unleash the catalytic activity of Fyn. The activation of Fyn by SAP and SLAM is critical for proper immune modulation.
Autoinhibitory domains (AIDs)
Target domain |
234-491 (Protein kinase domain) |
Relief mechanism |
Partner binding |
Assay |
Structural analysis |
Target domain |
234-491 (Protein kinase domain) |
Relief mechanism |
Partner binding |
Assay |
Structural analysis |
Target domain |
234-491 (Protein kinase domain) |
Relief mechanism |
|
Assay |
Structural analysis, Mutagenesis experiment |
Target domain |
234-491 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
Mutagenesis experiment |
Accessory elements
371-398 (Activation loop from InterPro)
Target domain |
234-491 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for P42685
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P42685-F1 | Predicted | AlphaFoldDB |
379 variants for P42685
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA3967770 rs202027495 |
2 | S>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1162191369 CA365382478 |
2 | S>R | No |
ClinGen gnomAD |
|
|
CA365382456 rs1554243381 |
5 | C>R | No |
ClinGen Ensembl |
|
|
CA145891109 rs557511096 |
5 | C>S | No |
ClinGen Ensembl |
|
|
rs764391601 CA3967768 |
6 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs1562311594 CA365382417 |
9 | W>* | No |
ClinGen Ensembl |
|
|
CA365382421 rs1487854576 |
9 | W>G | No |
ClinGen gnomAD |
|
|
CA365382413 rs1374466550 |
10 | E>K | No |
ClinGen TOPMed |
|
|
CA365382350 rs1217667865 |
14 | P>A | No |
ClinGen gnomAD |
|
|
rs1294993451 CA365382327 |
16 | L>F | No |
ClinGen Ensembl |
|
|
CA3967766 rs541669981 |
17 | P>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA145891098 rs377628003 |
21 | T>M | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs1168919049 CA365382188 |
24 | D>N | No |
ClinGen gnomAD |
|
|
CA3967763 rs773336838 |
25 | K>M | No |
ClinGen ExAC gnomAD |
|
|
CA145891038 rs1047694573 |
28 | V>L | No |
ClinGen TOPMed |
|
|
rs747664333 CA3967761 |
29 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1322439462 CA365382031 |
33 | G>R | No |
ClinGen gnomAD |
|
|
CA145891007 rs758429697 |
36 | C>F | No |
ClinGen gnomAD |
|
|
CA365381960 rs758429697 |
36 | C>S | No |
ClinGen gnomAD |
|
|
rs768389274 CA365381941 |
37 | S>C | No |
ClinGen ExAC gnomAD |
|
|
rs768389274 CA3967759 |
37 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA365381912 rs1477490893 |
39 | Q>E | No |
ClinGen gnomAD |
|
|
rs779737707 CA3967757 |
39 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA365381882 rs1188096595 |
41 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
rs369155986 CA3967755 |
42 | R>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs369155986 CA3967754 |
42 | R>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs200539604 CA3967753 |
42 | R>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs369155986 CA145891003 |
42 | R>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA365381842 rs1469888384 |
43 | H>Y | No |
ClinGen gnomAD |
|
|
CA3967752 rs753973199 |
44 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs764038139 CA3967751 |
45 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3967750 rs760776066 |
48 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA145890977 rs747443130 |
56 | R>W | No |
ClinGen Ensembl |
|
|
rs1385049797 CA365381581 |
58 | A>S | No |
ClinGen TOPMed |
|
|
rs762903671 CA3967747 |
60 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs767834932 CA3967748 |
60 | D>Y | No |
ClinGen ExAC gnomAD |
|
|
CA3967745 rs765276161 |
64 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761619321 CA3967744 |
64 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3967743 rs776602555 |
68 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3967741 rs746518625 |
70 | Q>P | No |
ClinGen ExAC gnomAD |
|
|
CA3967740 rs537441073 |
71 | V>F | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs746247007 CA365381247 |
76 | H>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746247007 CA3967738 |
76 | H>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746247007 CA365381251 |
76 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365381210 rs202087692 |
78 | G>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA3967737 rs202087692 |
78 | G>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs757790735 CA3967736 |
79 | W>* | No |
ClinGen ExAC gnomAD |
|
|
CA145890938 rs148677068 |
79 | W>* | No |
ClinGen ESP |
|
|
CA365381172 rs1314599534 |
80 | W>* | No |
ClinGen TOPMed |
|
|
CA3967735 rs749797183 |
83 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs1208584760 CA365381120 |
83 | R>K | No |
ClinGen gnomAD |
|
|
CA365381053 rs1311991671 |
88 | R>I | No |
ClinGen gnomAD |
|
|
CA3967733 rs756206248 |
89 | R>* | No |
ClinGen ExAC TOPMed |
|
|
rs756206248 CA365381045 |
89 | R>G | No |
ClinGen ExAC TOPMed |
|
|
CA3967732 rs767853111 |
89 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3967731 rs767853111 |
89 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs144021686 CA3967729 |
90 | D>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs144021686 CA3967728 |
90 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA365381002 rs1299828815 |
93 | S>G | No |
ClinGen gnomAD |
|
|
CA145890900 rs1018936981 |
93 | S>T | No |
ClinGen TOPMed gnomAD |
|
|
rs776493254 CA3967726 |
94 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
CA145890877 rs1005330041 |
95 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1243402531 CA365380974 |
95 | Q>K | No |
ClinGen TOPMed |
|
|
rs1185817390 CA365380939 |
97 | Q>P | No |
ClinGen TOPMed |
|
|
rs148022890 CA3967724 |
99 | Y>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs34704018 CA3967723 VAR_041702 |
100 | I>V | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA3967721 rs771735410 |
105 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1180633174 CA365380789 |
106 | A>G | No |
ClinGen gnomAD |
|
|
rs995310265 CA145890855 |
109 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA145890851 rs79498837 |
109 | R>K | No |
ClinGen Ensembl |
|
|
CA145890844 rs957751895 |
110 | S>T | No |
ClinGen Ensembl |
|
|
rs755032467 CA3967719 |
112 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
CA3967718 rs771249183 |
112 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA365380647 rs1238898426 |
114 | E>D | No |
ClinGen gnomAD |
|
|
CA365380656 rs1407116896 |
114 | E>Q | No |
ClinGen TOPMed |
|
|
CA365380642 rs1263489856 |
115 | P>A | No |
ClinGen Ensembl |
|
|
CA3967716 rs61735630 |
115 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3967717 rs61735630 |
115 | P>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs142770112 CA3967692 |
119 | G>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs753599705 CA3967691 |
121 | I>F | No |
ClinGen ExAC gnomAD |
|
|
CA146377193 rs772793869 |
122 | G>E | No |
ClinGen Ensembl |
|
|
rs3756772 VAR_006283 CA3967689 |
122 | G>R | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA146377192 rs867784375 |
124 | S>L | No |
ClinGen Ensembl |
|
|
CA3967687 rs117605537 |
125 | D>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1454067421 CA365534894 |
125 | D>N | No |
ClinGen TOPMed |
|
|
rs759112703 CA3967686 |
129 | Q>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365534823 rs1215018592 |
131 | L>* | No |
ClinGen gnomAD |
|
|
CA3967685 rs751000439 |
133 | S>A | No |
ClinGen ExAC gnomAD |
|
|
VAR_041703 CA3967684 rs34064900 |
133 | S>L | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA3967683 rs762614101 |
134 | E>* | No |
ClinGen ExAC TOPMed |
|
|
rs1305412124 CA365534762 |
136 | K>E | No |
ClinGen TOPMed |
|
|
CA3967680 rs770246096 |
138 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs762257926 CA3967679 |
139 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1016330218 CA146377191 |
143 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA365534660 rs1210371130 |
143 | R>T | No |
ClinGen TOPMed |
|
|
CA365534628 rs1305411381 |
145 | S>G | No |
ClinGen TOPMed gnomAD |
|
|
CA365534531 rs1464110429 |
150 | G>E | No |
ClinGen gnomAD |
|
|
CA3967677 rs151309696 |
152 | F>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3967676 rs769224017 |
153 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769224017 CA365534489 |
153 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA146377190 rs772704030 |
156 | V>F | No |
ClinGen TOPMed gnomAD |
|
|
rs772704030 CA365534466 |
156 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
CA365530999 rs1554227200 |
158 | D>G | No |
ClinGen Ensembl |
|
|
CA365531008 rs1211083494 |
158 | D>H | No |
ClinGen TOPMed |
|
|
CA3967643 rs764998466 |
159 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA365530976 rs1293222319 |
160 | A>S | No |
ClinGen gnomAD |
|
|
CA146373528 rs143351471 |
161 | V>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs143351471 CA3967642 |
161 | V>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA3967640 rs764595423 |
162 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764595423 CA3967641 |
162 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365530880 rs1296809940 |
165 | Y>* | No |
ClinGen TOPMed gnomAD |
|
|
CA365530876 rs1296809940 |
165 | Y>* | No |
ClinGen TOPMed gnomAD |
|
|
CA146373527 rs978700638 |
168 | K>Q | No |
ClinGen Ensembl |
|
|
CA365530795 rs767905144 |
171 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA3967637 rs767905144 |
171 | D>Y | No |
ClinGen ExAC gnomAD |
|
|
CA365530768 rs1394243809 |
172 | E>G | No |
ClinGen TOPMed |
|
|
rs1433484332 CA365530752 |
173 | G>A | No |
ClinGen TOPMed |
|
|
rs1387866458 CA365530758 |
173 | G>R | No |
ClinGen gnomAD |
|
|
rs774236781 CA3967635 |
174 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs1475526393 CA365530744 |
174 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA365530678 rs917697615 |
177 | L>F | No |
ClinGen TOPMed |
|
|
CA146373526 rs917697615 |
177 | L>I | No |
ClinGen TOPMed |
|
|
rs190975105 CA3967632 |
178 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1474945154 CA365530658 |
178 | T>P | No |
ClinGen gnomAD |
|
|
rs190975105 CA365530646 |
178 | T>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA3967630 rs769521421 |
179 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1272690556 CA365530633 |
179 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA3967629 rs575177889 |
180 | R>* | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1305949220 CA365530604 |
181 | R>G | No |
ClinGen TOPMed |
|
|
rs780048286 CA365530593 |
181 | R>I | No |
ClinGen ExAC |
|
|
CA3967628 rs780048286 |
181 | R>K | No |
ClinGen ExAC |
|
|
rs758214793 CA3967626 |
182 | I>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365530583 rs1317801168 |
182 | I>V | No |
ClinGen gnomAD |
|
|
rs745410841 CA3967624 |
183 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs142511122 CA3967623 |
184 | S>P | No |
ClinGen ESP ExAC gnomAD |
|
|
CA365530464 rs1328982516 |
187 | N>K | No |
ClinGen TOPMed gnomAD |
|
|
CA3967620 rs753596132 |
188 | E>* | No |
ClinGen ExAC gnomAD |
|
|
CA146373525 rs969741607 |
188 | E>D | No |
ClinGen Ensembl |
|
|
CA365530459 rs753596132 |
188 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA3967619 rs562978310 |
189 | F>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA3967617 rs147589562 |
191 | S>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1177108480 CA365530370 |
192 | H>R | No |
ClinGen gnomAD |
|
|
CA365530374 rs1409164817 |
192 | H>Y | No |
ClinGen gnomAD |
|
|
rs768078513 CA3967616 |
193 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
rs751691209 CA3967614 |
194 | T>N | No |
ClinGen ExAC gnomAD |
|
|
CA365530309 rs1477201928 |
195 | K>E | No |
ClinGen gnomAD |
|
|
rs766484653 CA3967613 |
196 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA3967612 rs762996212 |
197 | S>G | No |
ClinGen ExAC |
|
|
rs1256750257 CA365530217 |
199 | G>S | No |
ClinGen gnomAD |
|
|
rs148594761 CA365530153 |
202 | V>F | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs148594761 CA3967609 |
202 | V>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA3967610 rs148594761 |
202 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1194027429 CA365529870 |
213 | V>I | No |
ClinGen Ensembl |
|
|
CA146373462 rs939660570 |
215 | A>T | No |
ClinGen TOPMed |
|
|
CA3967582 rs761901536 |
217 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs776885645 CA3967581 |
217 | F>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365529809 rs1378692061 |
218 | D>G | No |
ClinGen gnomAD |
|
|
rs1158522806 CA365529783 |
220 | S>L | No |
ClinGen gnomAD |
|
|
CA3967578 rs774495420 |
221 | Y>F | No |
ClinGen ExAC gnomAD |
|
|
rs748817352 CA3967576 |
223 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs555269385 CA365529746 |
224 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs555269385 CA3967574 |
224 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs747794545 CA3967573 |
226 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
CA3967572 rs755354945 |
229 | I>L | No |
ClinGen ExAC gnomAD |
|
|
rs755354945 CA3967571 |
229 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA3967569 rs780554453 |
230 | D>G | No |
ClinGen ExAC |
|
|
rs145089105 CA3967570 |
230 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs750533470 CA3967567 |
231 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs536661323 CA3967565 |
231 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs536661323 CA3967566 |
231 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs536661323 CA365529696 |
231 | R>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs200157990 CA3967564 |
232 | N>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3967563 rs764375270 |
234 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs376406708 CA365529676 |
235 | Q>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3967562 rs376406708 |
235 | Q>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA365529669 rs1288456033 |
236 | L>F | No |
ClinGen gnomAD |
|
|
CA3967561 rs56264603 |
239 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3967560 rs766438209 |
239 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365529643 rs1475207359 |
240 | L>W | No |
ClinGen TOPMed gnomAD |
|
|
CA3967558 rs773252538 |
245 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA3967555 rs149754042 |
247 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1259271396 CA365529592 |
248 | V>I | No |
ClinGen gnomAD |
|
|
rs1044344981 CA146373458 |
249 | W>R | No |
ClinGen TOPMed gnomAD |
|
|
rs865935963 CA146373457 |
253 | W>* | No |
ClinGen gnomAD |
|
|
rs780358184 CA365529546 |
254 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365529531 rs1424151026 |
257 | T>A | No |
ClinGen TOPMed |
|
|
CA365529524 rs1234928702 |
258 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
CA365529522 rs1324424101 |
258 | P>L | No |
ClinGen gnomAD |
|
|
CA365529523 rs1234928702 |
258 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA365529525 rs1234928702 |
258 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1391653045 CA365529447 |
268 | S>A | No |
ClinGen gnomAD |
|
|
rs1391653045 CA365529449 |
268 | S>T | No |
ClinGen gnomAD |
|
|
CA3967530 rs200172011 |
269 | M>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA3967528 rs749347146 |
269 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs200172011 CA3967529 |
269 | M>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA3967527 rs777865782 |
270 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs756227805 CA3967526 |
270 | D>V | No |
ClinGen ExAC gnomAD |
|
|
rs753016460 CA3967525 |
271 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs146859190 CA3967523 |
272 | N>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs750164707 CA3967522 |
273 | D>V | No |
ClinGen ExAC gnomAD |
|
|
CA3967521 rs765111675 |
274 | F>C | No |
ClinGen ExAC gnomAD |
|
|
rs1233770824 CA365529376 |
279 | Q>P | No |
ClinGen gnomAD |
|
|
CA3967519 rs753688717 |
280 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA3967520 rs748333424 |
280 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA146372672 rs1048507606 |
286 | H>R | No |
ClinGen Ensembl |
|
|
CA3967516 rs369393469 |
286 | H>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs775194998 CA365529319 |
287 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365529320 rs775194998 |
287 | P>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3967514 rs775194998 |
287 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs771649351 CA3967513 |
288 | K>N | No |
ClinGen ExAC gnomAD |
|
|
CA3967511 rs774725821 |
290 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1582644652 CA365529289 |
292 | L>F | No |
ClinGen Ensembl |
|
|
rs1173872484 CA365529267 |
295 | V>A | No |
ClinGen gnomAD |
|
|
rs1159794163 CA365529253 |
297 | T>S | No |
ClinGen TOPMed |
|
|
CA3967506 rs770056660 |
301 | P>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3967505 rs748232767 |
302 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365529211 rs1486143675 |
303 | Y>* | No |
ClinGen gnomAD |
|
|
rs1209880938 CA365529212 |
303 | Y>F | No |
ClinGen gnomAD |
|
|
rs781568745 CA3967504 |
304 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365529197 rs1315906635 |
305 | I>M | No |
ClinGen gnomAD |
|
|
rs755204307 CA365529192 |
306 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA3967503 rs755204307 |
306 | T>K | No |
ClinGen ExAC gnomAD |
|
|
rs756980777 CA3967500 |
309 | M>L | No |
ClinGen ExAC gnomAD |
|
|
rs1554225404 CA3967498 |
310 | R>K | No |
ClinGen Ensembl |
|
|
rs1241728414 CA365529156 |
311 | H>Q | No |
ClinGen gnomAD |
|
|
CA365529158 rs1332777980 |
311 | H>R | No |
ClinGen TOPMed |
|
|
rs753874882 CA3967497 |
312 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA3967496 rs764018284 |
313 | S>I | No |
ClinGen ExAC gnomAD |
|
|
rs1415760772 CA365529144 |
313 | S>R | No |
ClinGen gnomAD |
|
|
CA146372671 rs890575644 |
314 | L>P | No |
ClinGen TOPMed |
|
|
rs1229161049 CA365529138 |
315 | Q>K | No |
ClinGen TOPMed |
|
|
rs1582644456 CA365529111 |
318 | L>H | No |
ClinGen Ensembl |
|
|
rs368142898 CA146372670 |
320 | N>H | No |
ClinGen Ensembl |
|
|
CA3967470 rs139630641 |
320 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA146371365 rs995659340 |
322 | T>N | No |
ClinGen TOPMed |
|
|
rs1224283568 CA365532622 |
324 | S>* | No |
ClinGen TOPMed gnomAD |
|
|
rs765942689 CA3967469 |
324 | S>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1562248228 CA365532599 |
326 | I>T | No |
ClinGen Ensembl |
|
|
CA3967468 rs763378072 |
327 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365532534 rs1297809422 |
332 | V>I | No |
ClinGen gnomAD |
|
|
rs773653298 CA3967467 |
333 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs1351180477 CA365532514 |
334 | M>V | No |
ClinGen TOPMed |
|
|
CA365532504 rs1368063853 |
335 | A>S | No |
ClinGen gnomAD |
|
|
rs765878107 CA3967466 |
335 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1582628969 CA365532488 |
336 | A>G | No |
ClinGen Ensembl |
|
|
rs777256878 CA3967464 |
337 | Q>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1582628924 CA365532468 |
338 | V>G | No |
ClinGen Ensembl |
|
|
rs747059057 CA3967462 |
338 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs1582628909 CA365532459 |
339 | A>G | No |
ClinGen Ensembl |
|
|
rs1452674346 CA365532455 |
340 | S>P | No |
ClinGen gnomAD |
|
|
rs1461275924 CA365532431 |
342 | M>I | No |
ClinGen TOPMed |
|
|
CA3967460 rs199982973 |
344 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365532388 rs1582628808 |
347 | S>A | No |
ClinGen Ensembl |
|
|
CA3967458 rs190064484 |
348 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs141736614 CA3967459 |
348 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA365532377 rs1582628772 |
349 | N>D | No |
ClinGen Ensembl |
|
|
CA3967457 rs566584137 |
350 | Y>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA3967456 rs201586564 |
352 | H>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs368409399 CA3967455 |
352 | H>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA365532348 rs201586564 |
352 | H>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA146371363 rs1009449848 |
353 | R>G | No |
ClinGen gnomAD |
|
|
rs1455539304 CA365532322 |
354 | D>E | No |
ClinGen TOPMed |
|
|
rs1420275736 CA365532314 |
356 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1420275736 CA365532312 |
356 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1401498889 CA365532306 |
357 | A>T | No |
ClinGen TOPMed |
|
|
rs1562248050 CA365532293 |
358 | R>K | No |
ClinGen Ensembl |
|
|
rs1345271638 CA365532280 |
359 | N>S | No |
ClinGen gnomAD |
|
|
rs754582583 CA3967454 |
360 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs146191498 CA3967451 |
362 | V>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA146371362 rs1029041198 |
362 | V>I | No |
ClinGen Ensembl |
|
|
rs200726682 CA146371361 |
365 | H>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs200726682 CA3967449 |
365 | H>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs750070578 CA3967450 |
365 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs762255641 CA3967448 |
366 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs1174394679 CA365532211 |
367 | I>F | No |
ClinGen gnomAD |
|
|
CA3967446 rs777345077 |
369 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs1307436084 CA365532183 |
370 | V>I | No |
ClinGen TOPMed |
|
|
rs1209166805 CA365532131 |
375 | L>R | No |
ClinGen gnomAD |
|
|
rs1279132273 CA365532121 |
376 | A>V | No |
ClinGen gnomAD |
|
|
CA3967440 rs774532729 |
377 | R>T | No |
ClinGen ExAC gnomAD |
|
|
rs1304806124 CA365532104 |
378 | V>G | No |
ClinGen gnomAD |
|
|
rs769630616 CA146371360 |
379 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3967439 rs769630616 |
379 | F>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747931398 CA3967438 |
380 | K>T | No |
ClinGen ExAC gnomAD |
|
|
CA365532041 rs1470196516 |
381 | V>I | No |
ClinGen TOPMed |
|
|
rs1370847162 CA365531948 |
389 | S>F | No |
ClinGen TOPMed |
|
|
CA365531942 rs1360123687 |
390 | R>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1288402106 CA365531937 |
391 | H>N | No |
ClinGen gnomAD |
|
|
rs143648469 CA3967413 |
391 | H>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs185354663 CA3967411 |
392 | E>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs149341971 CA365531912 |
393 | I>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs149341971 CA3967410 |
393 | I>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1461263596 CA365531893 |
394 | K>N | No |
ClinGen gnomAD |
|
|
rs1461263596 CA365531897 |
394 | K>N | No |
ClinGen gnomAD |
|
|
CA3967409 rs138957087 |
396 | P>L | No |
ClinGen 1000Genomes ESP ExAC gnomAD |
|
|
CA365531881 rs1582627018 |
396 | P>T | No |
ClinGen Ensembl |
|
|
rs1479838440 CA365531871 |
397 | V>A | No |
ClinGen TOPMed |
|
|
rs150259692 CA365531873 |
397 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs150259692 CA3967406 |
397 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1582626973 CA365531864 |
398 | K>R | No |
ClinGen Ensembl |
|
|
rs376090182 CA3967404 |
401 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3967401 rs374511452 |
403 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA365531786 rs1265874833 |
404 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1306029667 CA365531768 |
406 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
rs377733382 CA3967399 |
406 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA146371265 rs146969929 |
407 | S>G | No |
ClinGen ESP TOPMed |
|
|
rs947651624 CA146371264 |
407 | S>N | No |
ClinGen Ensembl |
|
|
CA3967397 rs766611219 |
409 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA3967396 rs763121310 |
410 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs773462469 CA365531678 |
413 | K>* | No |
ClinGen ExAC gnomAD |
|
|
rs773462469 CA3967395 |
413 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs763853996 CA3967394 |
414 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA365531651 rs1167496191 |
415 | D>G | No |
ClinGen gnomAD |
|
|
CA365531656 rs1371017094 |
415 | D>N | No |
ClinGen gnomAD |
|
|
CA3967391 rs772080212 |
416 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA3967392 rs772080212 |
416 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA146371262 rs370495146 |
417 | W>* | No |
ClinGen Ensembl |
|
|
rs141208044 CA3967390 |
418 | S>* | No |
ClinGen ESP ExAC gnomAD |
|
|
CA3967385 rs777464965 |
427 | I>T | No |
ClinGen ExAC |
|
|
CA365531527 rs1229491183 |
427 | I>V | No |
ClinGen gnomAD |
|
|
rs913414438 CA146371261 |
430 | G>D | No |
ClinGen TOPMed |
|
|
CA365531486 rs1301397524 |
431 | K>R | No |
ClinGen gnomAD |
|
|
CA3967355 rs780534370 |
436 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1332202061 CA365531435 |
436 | G>S | No |
ClinGen gnomAD |
|
|
rs780534370 CA365531072 |
436 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1411119447 CA365531046 |
438 | T>K | No |
ClinGen gnomAD |
|
|
rs1182664550 CA365531031 |
439 | G>C | No |
ClinGen gnomAD |
|
|
rs765403881 CA3967352 |
444 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA3967353 rs750461325 |
444 | Q>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs954561645 CA146371217 |
445 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
CA3967351 rs757464320 |
445 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA365530881 rs1327248647 |
447 | A>S | No |
ClinGen TOPMed |
|
|
rs754085532 CA3967350 |
448 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA3967349 rs767472515 |
448 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs759388740 CA3967348 |
449 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA3967347 rs751610314 |
450 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA146371216 rs12209851 |
451 | R>K | No |
ClinGen Ensembl |
|
|
CA3967346 rs766270865 |
453 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365530727 rs1340670152 |
456 | S>F | No |
ClinGen TOPMed gnomAD |
|
|
rs1335679259 CA365530722 |
457 | N>S | No |
ClinGen gnomAD |
|
|
rs1562246652 CA365530724 |
457 | N>Y | No |
ClinGen Ensembl |
|
|
rs772727266 CA3967344 |
458 | C>G | No |
ClinGen ExAC gnomAD |
|
|
CA3967343 rs769360767 |
458 | C>S | No |
ClinGen ExAC gnomAD |
|
|
CA146371215 rs1030157839 |
460 | Q>* | No |
ClinGen Ensembl |
|
|
rs761567620 CA3967342 |
460 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1162425669 CA365530603 |
465 | I>V | No |
ClinGen gnomAD |
|
|
CA3967339 rs151160060 |
466 | M>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3967340 rs151160060 |
466 | M>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1473269764 CA365530589 |
466 | M>V | No |
ClinGen gnomAD |
|
|
CA3967338 rs780554612 |
468 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1407465093 CA365530460 |
473 | E>G | No |
ClinGen gnomAD |
|
|
rs371033823 CA3967336 |
473 | E>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA146371214 rs972651315 |
474 | P>S | No |
ClinGen TOPMed |
|
|
rs745969108 CA3967335 |
476 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs779092947 CA3967334 |
477 | R>* | No |
ClinGen ExAC gnomAD |
|
|
CA3967333 rs199509116 |
477 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs199509116 CA146371213 |
477 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3967332 rs142072444 |
479 | T>I | No |
ClinGen ESP ExAC TOPMed |
|
|
rs1016687478 CA146371212 |
481 | E>Q | No |
ClinGen TOPMed |
|
|
CA3967330 rs150528750 |
481 | E>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1224621956 CA365530326 |
482 | T>R | No |
ClinGen gnomAD |
|
|
CA3967329 rs751339995 |
483 | L>Q | No |
ClinGen ExAC gnomAD |
|
|
CA3967327 rs762906692 |
484 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs141525046 CA3967326 |
484 | R>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs141525046 CA365530308 |
484 | R>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs762906692 CA365530315 |
484 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA365530236 rs372823762 |
488 | E>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1405689245 CA365530223 |
489 | D>V | No |
ClinGen gnomAD |
|
|
CA146371210 rs892044220 |
490 | Y>C | No |
ClinGen gnomAD |
|
|
CA365530211 rs1416269108 |
490 | Y>D | No |
ClinGen gnomAD |
|
|
rs1003526937 CA146371209 |
493 | T>I | No |
ClinGen TOPMed |
|
|
rs1246276760 CA365530103 |
496 | S>P | No |
ClinGen TOPMed gnomAD |
|
|
rs1185496710 CA365530078 |
497 | Y>N | No |
ClinGen gnomAD |
|
|
rs1190561956 CA365530046 |
499 | D>H | No |
ClinGen gnomAD |
|
|
rs563923955 CA3967322 |
501 | N>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA365529975 rs1332767083 |
502 | N>K | No |
ClinGen TOPMed |
|
|
CA3967321 rs761052080 |
504 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA3967320 rs775887093 |
505 | R>* | No |
ClinGen ExAC gnomAD |
|
|
rs1461759452 CA365529940 |
505 | R>K | No |
ClinGen gnomAD |
No associated diseases with P42685
7 regional properties for P42685
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 234 - 491 | IPR000719 |
| domain | SH2 domain | 114 - 208 | IPR000980 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 234 - 486 | IPR001245 |
| domain | SH3 domain | 42 - 110 | IPR001452 |
| active_site | Tyrosine-protein kinase, active site | 350 - 362 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 240 - 262 | IPR017441 |
| domain | Tyrosine-protein kinase Frk, SH2 domain | 112 - 207 | IPR035805 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.2 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | PTHR24418 | TYROSINE-PROTEIN KINASE |
| PANTHER Subfamily | PTHR24418:SF465 | TYROSINE-PROTEIN KINASE FRK |
| PANTHER Protein Class | non-receptor tyrosine protein kinase | |
| PANTHER Pathway Category |
Axon guidance mediated by semaphorins Fyn Parkinson disease Src kinase Cadherin signaling pathway Fyn Integrin signalling pathway Src B cell activation Blk Parkinson disease Fyn kinase |
|
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| azurophil granule lumen | The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| extrinsic component of cytoplasmic side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. |
| intracellular anatomical structure | A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| specific granule lumen | The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| non-membrane spanning protein tyrosine kinase activity | Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. |
| protein serine/threonine/tyrosine kinase activity | Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| protein tyrosine kinase activity | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| negative regulation of cell population proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
90 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A0JNB0 | FYN | Tyrosine-protein kinase Fyn | Bos taurus (Bovine) | SS |
| Q0VBZ0 | CSK | Tyrosine-protein kinase CSK | Bos taurus (Bovine) | SS |
| Q3ZC95 | BTK | Tyrosine-protein kinase | Bos taurus (Bovine) | EV SS |
| P42683 | LCK | Proto-oncogene tyrosine-protein kinase LCK | Gallus gallus (Chicken) | SS |
| P41239 | CSK | Tyrosine-protein kinase CSK | Gallus gallus (Chicken) | SS |
| P00523 | SRC | Proto-oncogene tyrosine-protein kinase Src | Gallus gallus (Chicken) | EV |
| Q02977 | YRK | Proto-oncogene tyrosine-protein kinase Yrk | Gallus gallus (Chicken) | SS |
| Q8JH64 | BTK | Tyrosine-protein kinase BTK | Gallus gallus (Chicken) | SS |
| P09324 | YES1 | Tyrosine-protein kinase Yes | Gallus gallus (Chicken) | SS |
| Q05876 | FYN | Tyrosine-protein kinase Fyn | Gallus gallus (Chicken) | SS |
| Q75R65 | JAK2 | Tyrosine-protein kinase JAK2 | Gallus gallus (Chicken) | SS |
| Q24592 | hop | Tyrosine-protein kinase hopscotch | Drosophila melanogaster (Fruit fly) | PR |
| P08630 | Btk | Tyrosine-protein kinase Btk | Drosophila melanogaster (Fruit fly) | SS |
| P00528 | Src64B | Tyrosine-protein kinase Src64B | Drosophila melanogaster (Fruit fly) | SS |
| Q9V9J3 | Src42A | Tyrosine-protein kinase Src42A | Drosophila melanogaster (Fruit fly) | SS |
| P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Homo sapiens (Human) | SS |
| O60674 | JAK2 | Tyrosine-protein kinase JAK2 | Homo sapiens (Human) | EV |
| P52333 | JAK3 | Tyrosine-protein kinase JAK3 | Homo sapiens (Human) | SS |
| P29597 | TYK2 | Non-receptor tyrosine-protein kinase TYK2 | Homo sapiens (Human) | EV |
| P43405 | SYK | Tyrosine-protein kinase SYK | Homo sapiens (Human) | EV |
| P43403 | ZAP70 | Tyrosine-protein kinase ZAP-70 | Homo sapiens (Human) | EV |
| Q13882 | PTK6 | Protein-tyrosine kinase 6 | Homo sapiens (Human) | EV |
| P09769 | FGR | Tyrosine-protein kinase Fgr | Homo sapiens (Human) | SS |
| P07948 | LYN | Tyrosine-protein kinase Lyn | Homo sapiens (Human) | SS |
| P06241 | FYN | Tyrosine-protein kinase Fyn | Homo sapiens (Human) | SS |
| P12931 | SRC | Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (Human) | EV |
| P06239 | LCK | Tyrosine-protein kinase Lck | Homo sapiens (Human) | EV |
| P51451 | BLK | Tyrosine-protein kinase Blk | Homo sapiens (Human) | SS |
| P08631 | HCK | Tyrosine-protein kinase HCK | Homo sapiens (Human) | EV |
| P07947 | YES1 | Tyrosine-protein kinase Yes | Homo sapiens (Human) | SS |
| Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Homo sapiens (Human) | EV |
| Q06187 | BTK | Tyrosine-protein kinase BTK | Homo sapiens (Human) | EV |
| P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Homo sapiens (Human) | SS |
| P42680 | TEC | Tyrosine-protein kinase Tec | Homo sapiens (Human) | SS |
| P42679 | MATK | Megakaryocyte-associated tyrosine-protein kinase | Homo sapiens (Human) | SS |
| P41240 | CSK | Tyrosine-protein kinase CSK | Homo sapiens (Human) | SS |
| Q14289 | PTK2B | Protein-tyrosine kinase 2-beta | Homo sapiens (Human) | PR |
| Q05397 | PTK2 | Focal adhesion kinase 1 | Homo sapiens (Human) | EV |
| Q13470 | TNK1 | Non-receptor tyrosine-protein kinase TNK1 | Homo sapiens (Human) | PR |
| Q07912 | TNK2 | Activated CDC42 kinase 1 | Homo sapiens (Human) | EV |
| P16591 | FER | Tyrosine-protein kinase Fer | Homo sapiens (Human) | PR |
| Q6J9G0 | STYK1 | Tyrosine-protein kinase STYK1 | Homo sapiens (Human) | PR |
| P42684 | ABL2 | Tyrosine-protein kinase ABL2 | Homo sapiens (Human) | SS |
| P00519 | ABL1 | Tyrosine-protein kinase ABL1 | Homo sapiens (Human) | EV |
| Q9R117 | Tyk2 | Non-receptor tyrosine-protein kinase TYK2 | Mus musculus (Mouse) | SS |
| P08103 | Hck | Tyrosine-protein kinase HCK | Mus musculus (Mouse) | SS |
| P16277 | Blk | Tyrosine-protein kinase Blk | Mus musculus (Mouse) | SS |
| Q62270 | Srms | Tyrosine-protein kinase Srms | Mus musculus (Mouse) | SS |
| Q64434 | Ptk6 | Protein-tyrosine kinase 6 | Mus musculus (Mouse) | SS |
| P05480 | Src | Proto-oncogene tyrosine-protein kinase Src | Mus musculus (Mouse) | EV |
| P14234 | Fgr | Tyrosine-protein kinase Fgr | Mus musculus (Mouse) | SS |
| P35991 | Btk | Tyrosine-protein kinase BTK | Mus musculus (Mouse) | EV |
| P41241 | Csk | Tyrosine-protein kinase CSK | Mus musculus (Mouse) | EV |
| P25911 | Lyn | Tyrosine-protein kinase Lyn | Mus musculus (Mouse) | EV |
| Q62137 | Jak3 | Tyrosine-protein kinase JAK3 | Mus musculus (Mouse) | SS |
| Q62120 | Jak2 | Tyrosine-protein kinase JAK2 | Mus musculus (Mouse) | EV |
| P06240 | Lck | Proto-oncogene tyrosine-protein kinase LCK | Mus musculus (Mouse) | SS |
| P24604 | Tec | Tyrosine-protein kinase Tec | Mus musculus (Mouse) | SS |
| Q04736 | Yes1 | Tyrosine-protein kinase Yes | Mus musculus (Mouse) | SS |
| P39688 | Fyn | Tyrosine-protein kinase Fyn | Mus musculus (Mouse) | SS |
| P52332 | Jak1 | Tyrosine-protein kinase JAK1 | Mus musculus (Mouse) | SS |
| Q03526 | Itk | Tyrosine-protein kinase ITK/TSK | Mus musculus (Mouse) | SS |
| P41242 | Matk | Megakaryocyte-associated tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q922K9 | Frk | Tyrosine-protein kinase FRK | Mus musculus (Mouse) | SS |
| A1Y2K1 | FYN | Tyrosine-protein kinase Fyn | Sus scrofa (Pig) | SS |
| O19064 | JAK2 | Tyrosine-protein kinase JAK2 | Sus scrofa (Pig) | SS |
| Q62844 | Fyn | Tyrosine-protein kinase Fyn | Rattus norvegicus (Rat) | SS |
| Q07014 | Lyn | Tyrosine-protein kinase Lyn | Rattus norvegicus (Rat) | SS |
| P50545 | Hck | Tyrosine-protein kinase HCK | Rattus norvegicus (Rat) | SS |
| Q9WUD9 | Src | Proto-oncogene tyrosine-protein kinase Src | Rattus norvegicus (Rat) | SS |
| Q01621 | Lck | Proto-oncogene tyrosine-protein kinase LCK | Rattus norvegicus (Rat) | SS |
| Q6P6U0 | Fgr | Tyrosine-protein kinase Fgr | Rattus norvegicus (Rat) | SS |
| Q62689 | Jak2 | Tyrosine-protein kinase JAK2 | Rattus norvegicus (Rat) | SS |
| Q63272 | Jak3 | Tyrosine-protein kinase JAK3 | Rattus norvegicus (Rat) | SS |
| P32577 | Csk | Tyrosine-protein kinase CSK | Rattus norvegicus (Rat) | SS |
| P41243 | Matk | Megakaryocyte-associated tyrosine-protein kinase | Rattus norvegicus (Rat) | SS |
| F1LM93 | Yes1 | Tyrosine-protein kinase Yes | Rattus norvegicus (Rat) | SS |
| Q62662 | Frk | Tyrosine-protein kinase FRK | Rattus norvegicus (Rat) | SS |
| G5ECJ6 | csk-1 | Tyrosine-protein kinase csk-1 | Caenorhabditis elegans | SS |
| O45539 | src-2 | Tyrosine protein-kinase src-2 | Caenorhabditis elegans | SS |
| G5EE56 | src-1 | Tyrosine protein-kinase src-1 | Caenorhabditis elegans | SS |
| F4JTP5 | STY46 | Serine/threonine-protein kinase STY46 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22558 | STY8 | Serine/threonine-protein kinase STY8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q2MHE4 | HT1 | Serine/threonine/tyrosine-protein kinase HT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWL6 | STY17 | Serine/threonine-protein kinase STY17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A1A5H8 | yes1 | Tyrosine-protein kinase yes | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| F1RDG9 | fynb | Tyrosine-protein kinase fynb | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O12990 | jak1 | Tyrosine-protein kinase JAK1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q1JPZ3 | src | Proto-oncogene tyrosine-protein kinase Src | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6EWH2 | fyna | Tyrosine-protein kinase fyna | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNICQRLWE | YLEPYLPCLS | TEADKSTVIE | NPGALCSPQS | QRHGHYFVAL | FDYQARTAED |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LSFRAGDKLQ | VLDTLHEGWW | FARHLEKRRD | GSSQQLQGYI | PSNYVAEDRS | LQAEPWFFGA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IGRSDAEKQL | LYSENKTGSF | LIRESESQKG | EFSLSVLDGA | VVKHYRIKRL | DEGGFFLTRR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RIFSTLNEFV | SHYTKTSDGL | CVKLGKPCLK | IQVPAPFDLS | YKTVDQWEID | RNSIQLLKRL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GSGQFGEVWE | GLWNNTTPVA | VKTLKPGSMD | PNDFLREAQI | MKNLRHPKLI | QLYAVCTLED |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PIYIITELMR | HGSLQEYLQN | DTGSKIHLTQ | QVDMAAQVAS | GMAYLESRNY | IHRDLAARNV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LVGEHNIYKV | ADFGLARVFK | VDNEDIYESR | HEIKLPVKWT | APEAIRSNKF | SIKSDVWSFG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ILLYEIITYG | KMPYSGMTGA | QVIQMLAQNY | RLPQPSNCPQ | QFYNIMLECW | NAEPKERPTF |
| 490 | 500 | ||||
| ETLRWKLEDY | FETDSSYSDA | NNFIR |