P42680

SS
Gene name
TEC (PSCTK4)
Protein name
Tyrosine-protein kinase Tec
Names
EC 2.7.10.2
Species
Homo sapiens (Human)
KEGG Pathway
hsa:7006
EC number
2.7.10.2: Protein-tyrosine kinases
Protein Class

Descriptions

Bruton’s tyrosine kinase (BTK) is a non-receptor tyrosine kinase belonging to the TEC family, and is expressed primarily in B cells and myeloid cells, where it functions downstream of receptors including the B-cell receptor, Fc receptors, and toll-like receptors. BTK is autoinhibited by its SH3 and SH2 domains, forming a compact autoinhibitory conformation on the distal surface of the kinase domain. Additionally, there exists another autoinhibitory interface on the activation loop face of the kinase domain, which is occupied by the Pleckstrin homology and Tec homology (PHTH) domain. B-cell receptor engagement lead to BTK activation (via phosphorylation on Y551 in the activation loop), which results in the direct phosphorylation and activation of phospholipase C gamma 2 triggering calcium flux and subsequent regulation of gene transcription.

Autoinhibitory domains (AIDs)

179-346 (SH3 and SH2 domain) SS

Target domain

365-620 (Protein kinase domain)

Relief mechanism

PTM

Assay

5-149 (Pleckstrin homology and Tec homology domain) SS

Target domain

365-620 (Protein kinase domain)

Relief mechanism

PTM

Assay

351-355 (SH2-kinase linker) SS

Target domain

370-623 (Kinase domain)

Relief mechanism

Assay

Accessory elements

506-530 (Activation loop from InterPro)

Target domain

370-623 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

2 structures for P42680

Entry ID Method Resolution Chain Position Source
2LUL NMR - A 1-154 PDB
AF-P42680-F1 Predicted AlphaFoldDB

547 variants for P42680

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1723556805 5 T>S No TOPMed
rs1304801555 6 I>V No TOPMed
gnomAD
rs1388197653 8 E>K No gnomAD
TCGA novel 9 E>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1560418245 9 E>V No Ensembl
rs1560418242 10 I>T No Ensembl
rs1457600081 11 L>P No gnomAD
rs1395393224 14 R>K No Ensembl
rs1723555539 14 R>W No TOPMed
rs1304356128 15 S>* No TOPMed
gnomAD
rs1345607054 16 Q>P No TOPMed
gnomAD
rs759676495 17 Q>P No ExAC
TOPMed
gnomAD
rs1283283542 18 K>E No TOPMed
gnomAD
rs776737918 18 K>N No ExAC
gnomAD
COSM1055801
rs766554666
 19 K>N Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
gnomAD
rs760902506 20 K>N No ExAC
gnomAD
rs1723553613 20 K>T No Ensembl
rs773480124
COSM1267597
 21 T>A oesophagus [Cosmic] No cosmic curated
ExAC
TOPMed
gnomAD
rs1723553284
COSM1267596
 21 T>I oesophagus [Cosmic] No cosmic curated
TOPMed
rs772497479
COSM3917872
 22 S>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ExAC
NCI-TCGA
TOPMed
gnomAD
rs1322388850 25 N>S No gnomAD
rs769256758 26 Y>C No ExAC
gnomAD
rs1723552288 27 K>E No Ensembl
rs748798649 27 K>R No ExAC
gnomAD
TCGA novel 28 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
COSM1055799 28 E>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs779567477 29 R>G No ExAC
TOPMed
gnomAD
rs1435506923 29 R>K No TOPMed
gnomAD
rs1390649123 30 L>F No TOPMed
gnomAD
rs1291703382 31 F>S No gnomAD
rs1382362335 33 L>F No gnomAD
rs1457297072 34 T>A No gnomAD
rs148824532 34 T>K No ESP
ExAC
TOPMed
gnomAD
rs148824532 34 T>R No ESP
ExAC
TOPMed
gnomAD
rs1328574336 36 S>T No Ensembl
rs745461310 37 M>I No ExAC
TOPMed
gnomAD
rs1166244762 37 M>V No gnomAD
rs145490815 39 T>A No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs759435324 40 Y>C No ExAC
TOPMed
gnomAD
rs759435324 40 Y>S No ExAC
TOPMed
gnomAD
rs143319990 41 Y>F No ESP
ExAC
TOPMed
gnomAD
rs1723548915 42 E>G No TOPMed
gnomAD
rs767837039 44 R>* No ExAC
TOPMed
gnomAD
VAR_041850
rs35374286
 44 R>Q No UniProt
ExAC
TOPMed
dbSNP
gnomAD
rs1723548067 45 A>T No TOPMed
rs1293641263 48 K>N No TOPMed
gnomAD
rs1171685686 52 G>A No gnomAD
rs2109555637 52 G>R No Ensembl
rs1320770850 54 I>S No TOPMed
gnomAD
rs1320770850 54 I>T No TOPMed
gnomAD
TCGA novel 55 D>E Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs767902369 55 D>G No ExAC
TOPMed
gnomAD
rs767902369 55 D>V No ExAC
TOPMed
gnomAD
rs1055939759 59 I>V No TOPMed
gnomAD
rs1242089632 60 K>Q No TOPMed
gnomAD
rs762078095 60 K>R No ExAC
gnomAD
rs1253211646 61 C>G No gnomAD
rs1445679604 65 V>M No TOPMed
gnomAD
rs1006089815 68 D>G No TOPMed
gnomAD
rs1006089815 68 D>V No TOPMed
gnomAD
rs1201307682 69 D>G No TOPMed
gnomAD
rs1560391037 70 G>A No gnomAD
rs763388390 72 I>T No ExAC
TOPMed
gnomAD
rs1487535249 73 P>A No TOPMed
COSM6167515 73 P>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1721314034 74 C>F No TOPMed
rs776126020 74 C>R No ExAC
gnomAD
TCGA novel 76 N>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1288931917 79 P>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
gnomAD
rs1721107856 82 V>I No Ensembl
rs1721107577 83 V>I No TOPMed
rs1721107461 84 H>R No TOPMed
rs1180964661
COSM1637104
 85 D>E bone [Cosmic] No cosmic curated
TOPMed
rs1721107182 85 D>G No gnomAD
rs1341844116 85 D>N No gnomAD
rs75574368 86 A>D No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs75574368 86 A>V No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs776146242 91 I>V No ExAC
gnomAD
rs1721106096 93 A>E No TOPMed
COSM3974927 93 A>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1465973033 94 P>A No TOPMed
gnomAD
rs1465973033 94 P>S No TOPMed
gnomAD
COSM1429925 95 S>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs894500072 98 S>N No TOPMed
gnomAD
TCGA novel 100 D>E Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
COSM4901424 100 D>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1721105319 100 D>N No TOPMed
rs760332965 101 L>R No ExAC
TOPMed
gnomAD
rs1721105036 102 W>* No TOPMed
gnomAD
rs1721104907 102 W>* No TOPMed
gnomAD
rs940793291 104 K>Q No TOPMed
gnomAD
TCGA novel 108 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1188210081 108 E>G No gnomAD
COSM4124960 109 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1721051550 109 E>G No TOPMed
TCGA novel 110 I>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1483141979 110 I>V No TOPMed
COSM1055797 111 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs772564593 112 N>I No ExAC
TOPMed
gnomAD
rs767223534 112 N>K No ExAC
gnomAD
rs774201318 117 M>I No ExAC
TOPMed
gnomAD
rs1342382369 117 M>T No gnomAD
TCGA novel 118 I>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs911548228 122 P>S No Ensembl
rs200376782 126 T>I No 1000Genomes
ExAC
TOPMed
gnomAD
rs200376782 126 T>K No 1000Genomes
ExAC
TOPMed
gnomAD
rs1203145607 127 D>E No gnomAD
rs1275956051 129 S>R No gnomAD
rs1577718756 129 S>T No Ensembl
rs1407361042 131 Q>K No gnomAD
rs139186461 131 Q>L No ESP
ExAC
TOPMed
gnomAD
rs139186461 131 Q>R No ESP
ExAC
TOPMed
gnomAD
rs1307457350 133 C>Y No gnomAD
COSM258159 137 E>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1410542142 138 K>N No TOPMed
gnomAD
rs769826531 141 P>A No ExAC
gnomAD
rs768480313 142 G>R No TOPMed
gnomAD
COSM734279 143 C>F Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs758673994 147 N>K No ExAC
TOPMed
gnomAD
rs1172955840 147 N>S No gnomAD
TCGA novel 147 N>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1721047295 149 F>L No TOPMed
TCGA novel 149 F>L Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1721047063 151 S>I No TOPMed
rs2271173 151 S>R No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1179621689 152 S>N No gnomAD
rs1720973261 153 I>M No TOPMed
gnomAD
rs1271019174 153 I>V No TOPMed
gnomAD
rs1720973136 154 R>G No TOPMed
rs1039903900 154 R>K No TOPMed
gnomAD
rs370571771 156 A>P No ESP
ExAC
TOPMed
gnomAD
rs370571771 156 A>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs1720972502 157 L>V No TOPMed
rs1474142023 158 P>A No TOPMed
gnomAD
rs780358141 158 P>L No ExAC
gnomAD
rs1474142023 158 P>T No TOPMed
gnomAD
COSM481317 164 K>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs756617928 165 K>E No ExAC
gnomAD
rs1420726452 165 K>N No TOPMed
gnomAD
rs534338993
COSM1429923
 166 R>* Variant assessed as Somatic; HIGH impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
1000Genomes
ExAC
NCI-TCGA
gnomAD
rs199797945 166 R>Q No ESP
ExAC
TOPMed
gnomAD
rs781592886 168 P>L No ExAC
gnomAD
rs1161019348
TCGA novel
 168 P>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
rs1161019348 168 P>T No TOPMed
COSM734280 169 P>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
TCGA novel 170 P>H Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1389205450 170 P>R No gnomAD
rs1414796827 171 P>S No TOPMed
gnomAD
rs1577716532 172 I>T No Ensembl
rs751140099 172 I>V No ExAC
gnomAD
rs777374319 173 P>L No ExAC
rs1265850213 174 L>I No gnomAD
rs1488841792 175 E>K No gnomAD
rs1203118250 176 E>G No gnomAD
rs1271070833 176 E>K No gnomAD
COSM1429921 177 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs141394616 177 E>D No ESP
ExAC
gnomAD
rs752337530 179 N>D No ExAC
TOPMed
gnomAD
rs764967387 180 S>N No ExAC
gnomAD
rs1720937735 181 E>G No TOPMed
COSM1694356 181 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs574810323 183 I>M No ExAC
TOPMed
gnomAD
rs1285467499 184 V>A No gnomAD
rs539573453
COSM1429920
 184 V>I Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
rs2109542316 185 V>I No Ensembl
rs2109542304 186 A>P No Ensembl
rs1720936352 187 M>I No TOPMed
gnomAD
rs1346070481 187 M>T No gnomAD
rs897275754 187 M>V No TOPMed
gnomAD
rs760611263 189 D>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
gnomAD
TCGA novel 189 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1720935830 191 Q>H No Ensembl
rs1720935969 191 Q>L No Ensembl
rs1407485278 192 A>S No TOPMed
gnomAD
rs1407485278 192 A>T No TOPMed
gnomAD
rs2109542251 193 A>S No Ensembl
rs1298434457 194 E>A No gnomAD
rs2109542243 194 E>K No Ensembl
rs768664754 195 G>E No ExAC
TOPMed
gnomAD
rs768664754
COSM359910
 195 G>V lung [Cosmic] No cosmic curated
ExAC
TOPMed
gnomAD
rs1376345712 196 H>R No TOPMed
gnomAD
rs1239721322 198 L>V No TOPMed
gnomAD
rs763008568 199 R>S No ExAC
TOPMed
gnomAD
rs1432122009 200 L>* No gnomAD
COSM1310099 201 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs370906002 202 R>K No ESP
ExAC
TOPMed
gnomAD
rs746270033 202 R>S No ExAC
gnomAD
rs1720932409 203 G>D No TOPMed
gnomAD
rs941365394 204 Q>E No TOPMed
gnomAD
rs771376138 206 Y>* No ExAC
gnomAD
rs1482405725 206 Y>C No gnomAD
rs1197835955 206 Y>D No TOPMed
gnomAD
TCGA novel 206 Y>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1720930800 207 L>F No Ensembl
rs1003501745 208 I>T No TOPMed
gnomAD
COSM1055795 210 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs777431361 210 E>K No ExAC
gnomAD
COSM1055793
rs905849900
 211 K>N Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
Ensembl
NCI-TCGA
rs1226010019 213 D>E No gnomAD
TCGA novel 213 D>Y Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs2109542108 214 V>A No Ensembl
rs2109542115 214 V>I No Ensembl
rs1335722528 215 H>P No gnomAD
rs1309211010 215 H>Q No TOPMed
gnomAD
COSM6167516 216 W>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs566875728 216 W>S No 1000Genomes
ExAC
TOPMed
gnomAD
rs747656157 217 W>C No ExAC
gnomAD
rs1023856881 218 R>G No TOPMed
gnomAD
rs1399616619 218 R>K No TOPMed
gnomAD
rs1399616619 218 R>T No TOPMed
gnomAD
rs1560385830 221 D>G No Ensembl
rs1302593702 221 D>N No TOPMed
gnomAD
rs2109542062 224 G>V No Ensembl
rs779559749 226 E>K No ExAC
TOPMed
gnomAD
rs1341640879 227 G>V No Ensembl
rs1272263155 231 S>N No TOPMed
gnomAD
COSM288307
rs750190240
 234 V>I Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
rs191626703 235 T>M No 1000Genomes
ExAC
TOPMed
gnomAD
rs1289506269 237 K>N No TOPMed
gnomAD
COSM1055791 238 K>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs757140518 239 S>P No ExAC
gnomAD
rs752755232 240 N>D No ExAC
gnomAD
rs973959312 240 N>S No TOPMed
gnomAD
rs1242626865 241 N>H No gnomAD
rs1195314878 243 D>N No TOPMed
gnomAD
rs1195314878 243 D>Y No TOPMed
gnomAD
TCGA novel 245 Y>= Variant assessed as Somatic; LOW impact. [NCI-TCGA] No NCI-TCGA
rs1387746424 246 E>K No TOPMed
rs1476975842 247 W>* No gnomAD
rs1428541566 249 C>F No gnomAD
rs1039698473 252 M>I No TOPMed
rs1720418920 252 M>V No TOPMed
rs1490707890 253 N>K No gnomAD
rs779798762 253 N>S No ExAC
TOPMed
gnomAD
rs138464079 255 S>N No ESP
ExAC
gnomAD
rs745689320 256 K>R No ExAC
gnomAD
rs1438063005 257 A>E No gnomAD
COSM6100376 258 E>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1323393088 260 L>V No gnomAD
rs147079314 262 R>C No ESP
ExAC
TOPMed
gnomAD
rs137884397 262 R>H No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs137884397 262 R>L No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs200509274 263 S>G No 1000Genomes
ExAC
TOPMed
gnomAD
TCGA novel 264 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
COSM3825928
rs761984494
 269 G>D Variant assessed as Somatic; MODERATE impact. breast [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
Ensembl
NCI-TCGA
rs764686962 271 M>V No ExAC
gnomAD
rs1035732920 272 V>I No Ensembl
COSM587369 274 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1409664773 275 S>F No TOPMed
gnomAD
rs1409664773 275 S>Y No TOPMed
gnomAD
rs2109516794 276 S>C No Ensembl
COSM3825927 277 Q>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1443645002 278 P>S No TOPMed
gnomAD
rs1443645002 278 P>T No TOPMed
gnomAD
rs750310314 282 T>I No ExAC
gnomAD
rs1213280873 282 T>P No gnomAD
rs867297832 284 S>Y No Ensembl
rs2109516741 285 L>F No Ensembl
rs1720130529 287 T>A No TOPMed
rs1463895029 287 T>I No gnomAD
rs1260702660 288 K>R No gnomAD
rs759030525 290 G>E No ExAC
gnomAD
rs764277354 291 G>E No gnomAD
rs1322673151 292 E>D No TOPMed
gnomAD
rs1332172366 292 E>G No TOPMed
rs776093286 293 G>A No ExAC
gnomAD
rs776093286 293 G>D No ExAC
gnomAD
rs776093286 293 G>V No ExAC
gnomAD
COSM3428540 294 S>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs61729380 294 S>L No ExAC
TOPMed
gnomAD
rs773063384 295 S>L No ExAC
TOPMed
gnomAD
rs2109515036 296 G>D No Ensembl
rs747952759 296 G>S No ExAC
gnomAD
rs527854494 298 R>K No 1000Genomes
ExAC
TOPMed
gnomAD
rs1720074778 300 Y>* No gnomAD
rs1316209550 300 Y>C No TOPMed
rs768694592 301 H>Q No ExAC
rs541078451 306 T>I No 1000Genomes
ExAC
gnomAD
rs541078451 306 T>R No 1000Genomes
ExAC
gnomAD
rs757509359 307 T>A No ExAC
gnomAD
rs757509359 307 T>S No ExAC
gnomAD
rs1490545987 308 S>C No gnomAD
rs1490545987 308 S>Y No gnomAD
rs561711226 311 K>N No 1000Genomes
ExAC
gnomAD
rs543420319 318 H>P No 1000Genomes
ExAC
gnomAD
rs543420319 318 H>R No 1000Genomes
ExAC
gnomAD
rs1560376063 322 S>P No Ensembl
rs1720071958 323 I>V No TOPMed
rs1309161559
COSM1310098
 325 E>D urinary_tract [Cosmic] No cosmic curated
gnomAD
rs765779795 325 E>K No ExAC
gnomAD
rs576422071 326 I>V No 1000Genomes
ExAC
gnomAD
rs1345656048 327 I>T No TOPMed
gnomAD
COSM285650 327 I>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
COSM6100377
rs746395396
COSM587370
 328 E>D lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] No cosmic curated
NCI-TCGA Cosmic
ExAC
NCI-TCGA
gnomAD
rs1720069933 329 Y>H No Ensembl
rs1169580855 331 K>N No TOPMed
rs1720069315 334 A>V No Ensembl
rs1344147450 336 G>E Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
rs1408957123 340 R>G No TOPMed
rs747111814 341 L>V No ExAC
gnomAD
rs777892454 342 R>Q No ExAC
TOPMed
gnomAD
rs1453194718 342 R>W No gnomAD
rs748532219 343 Y>N No ExAC
TOPMed
gnomAD
rs779206975 344 P>A No ExAC
TOPMed
gnomAD
rs1240965997 344 P>R No gnomAD
rs754284170 345 V>I No ExAC
gnomAD
rs780597024 346 S>R No ExAC
gnomAD
rs1265035864 347 V>A No TOPMed
gnomAD
rs1265035864 347 V>E No TOPMed
gnomAD
rs1202827426 351 N>D No gnomAD
COSM3917870 351 N>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs151151021 351 N>S No ESP
ExAC
TOPMed
gnomAD
rs1560374359 352 A>T No Ensembl
rs761515779 353 P>L No ExAC
gnomAD
rs767097402 353 P>S No ExAC
TOPMed
gnomAD
rs763921020 357 G>E No ExAC
gnomAD
TCGA novel 359 S>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1168086018
COSM1055789
 361 E>D Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
gnomAD
TCGA novel 361 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1719873859 363 W>* No TOPMed
gnomAD
rs1719873984 363 W>R No gnomAD
rs1719873721 364 E>K No Ensembl
rs144659420 367 P>A No ESP
ExAC
TCGA novel 367 P>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs765113539 370 L>R No ExAC
rs565655073 370 L>V No Ensembl
rs946733895 374 R>S No gnomAD
rs201608922 376 L>S No ExAC
gnomAD
rs868276572 377 G>R No Ensembl
rs140868704 378 S>G No ESP
ExAC
TOPMed
gnomAD
rs767529253 378 S>N No ExAC
TOPMed
gnomAD
rs761869739 380 L>P No ExAC
gnomAD
TCGA novel 381 F>L Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1271268431 383 V>A No gnomAD
rs1719870743 383 V>M No gnomAD
rs749636109 385 R>K No ExAC
gnomAD
COSM481315 385 R>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1280697465 386 L>P No gnomAD
rs199646567 389 W>R No ExAC
TOPMed
gnomAD
rs1254880258 390 R>* No gnomAD
rs746326176 390 R>Q No ExAC
TOPMed
gnomAD
rs1719868798 391 A>T No gnomAD
rs1312156368 392 Q>K No TOPMed
rs756890387 395 V>A No ExAC
TOPMed
gnomAD
rs1353010758 395 V>L No gnomAD
rs752469056 396 A>S No ExAC
TOPMed
gnomAD
COSM1228858
rs752469056
 396 A>T Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
COSM3825926 397 I>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs765018274 398 K>R No ExAC
TOPMed
gnomAD
rs1484539226
COSM587371
COSM6100378
 401 R>L lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] No cosmic curated
NCI-TCGA Cosmic
NCI-TCGA
gnomAD
rs1484539226 401 R>Q No gnomAD
rs754887835 401 R>W Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs1719865994 402 E>G No Ensembl
COSM734281 403 G>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1199548264 404 A>S No gnomAD
rs1719865272 405 M>I No TOPMed
rs1719865414 405 M>T No Ensembl
rs1230873045 405 M>V No gnomAD
rs961818658 406 C>* No TOPMed
gnomAD
rs961818658 406 C>W No TOPMed
gnomAD
COSM1429918
rs1719864805
 407 E>K large_intestine [Cosmic] No cosmic curated
TOPMed
rs1438827121 408 E>* No gnomAD
rs868616029 411 I>K No Ensembl
rs868616029 411 I>T No Ensembl
rs1260541310 414 A>T No gnomAD
rs774365822 415 K>E No ExAC
TOPMed
gnomAD
rs764331227 416 V>M No ExAC
gnomAD
rs41307144 418 M>R No TOPMed
rs41307144 418 M>T No TOPMed
rs762925756 419 K>T No ExAC
gnomAD
rs369398035 423 P>L No ESP
ExAC
TOPMed
gnomAD
rs369398035 423 P>R No ESP
ExAC
TOPMed
gnomAD
rs145617527 426 V>M No ESP
gnomAD
rs1719855761 428 L>F No Ensembl
rs999385114 429 Y>S No Ensembl
rs777091415 431 V>A No ExAC
gnomAD
rs777091415 431 V>E No ExAC
gnomAD
rs1186478879 433 T>S No TOPMed
gnomAD
rs555121105 433 T>S No ExAC
TOPMed
gnomAD
rs773014819 434 Q>* No Ensembl
COSM3604277 437 P>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs772865397 437 P>R No ExAC
gnomAD
rs1241549571 438 I>T No gnomAD
rs61744269 442 T>I No Ensembl
rs1164902930 445 M>V No gnomAD
rs149757303 446 E>A No ESP
ExAC
TOPMed
gnomAD
rs1719853568 446 E>K No TOPMed
rs1163619725 447 R>K No Ensembl
rs1560373439 448 G>V No Ensembl
rs559961259 450 L>F No 1000Genomes
rs1719852671 453 F>S No gnomAD
COSM3604275 454 L>F Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs768171223
COSM247775
 455 R>* prostate [Cosmic] No cosmic curated
ExAC
TOPMed
gnomAD
rs372216578 455 R>Q No ESP
ExAC
TOPMed
gnomAD
rs75184130 457 R>G No Ensembl
rs374511784 458 Q>H No ESP
ExAC
TOPMed
gnomAD
rs1719851613 459 G>D No Ensembl
rs750417190 460 H>D No ExAC
gnomAD
rs1719851361 462 S>R No Ensembl
rs780984861 465 V>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs780984861 465 V>L No ExAC
TOPMed
gnomAD
rs752693893 468 S>G No ExAC
gnomAD
COSM4124958 468 S>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1560373331 469 M>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No Ensembl
NCI-TCGA
rs765514796 470 C>R No ExAC
TOPMed
gnomAD
rs1680429350 473 V>M No TOPMed
rs1427207673 474 C>Y No gnomAD
rs759796647 475 E>G No ExAC
TOPMed
gnomAD
rs1194437456 476 G>E No TOPMed
gnomAD
rs1194437456 476 G>V No TOPMed
gnomAD
rs1719849351 477 M>I No gnomAD
COSM6167517 478 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs754263100 478 E>K No ExAC
TOPMed
gnomAD
rs761110899 479 Y>S No ExAC
TOPMed
gnomAD
rs773925325 480 L>V No ExAC
TOPMed
gnomAD
rs139680290 481 E>K No ESP
ExAC
TOPMed
gnomAD
rs910063103 483 N>D No Ensembl
rs761436897 483 N>T No ExAC
gnomAD
COSM6167518 484 S>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1223527921 484 S>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
gnomAD
rs773686592 484 S>R No ExAC
gnomAD
rs1332465750 497 V>A No TOPMed
gnomAD
rs1719658017 498 S>N No gnomAD
rs763650133
COSM1429917
 500 A>V Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
gnomAD
rs1719657050 501 G>R No TOPMed
rs775160457 502 V>I No ExAC
gnomAD
rs769412539 505 V>I No ExAC
TOPMed
gnomAD
rs150324512
COSM109828
 509 G>E skin [Cosmic] No cosmic curated
Ensembl
rs1256817357 509 G>R No TOPMed
COSM4895307 510 M>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1237293687 510 M>K No TOPMed
gnomAD
rs1237293687 510 M>T No TOPMed
gnomAD
rs145358315 514 V>I No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1012041959 517 D>N No TOPMed
gnomAD
rs1012041959 517 D>Y No TOPMed
gnomAD
rs896582721 520 T>I No Ensembl
rs1283975092 520 T>P No gnomAD
rs1246113513 521 S>G No gnomAD
COSM447908 522 S>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs369215066 524 G>C No ESP
ExAC
TOPMed
gnomAD
rs1381762842 526 K>E No TOPMed
gnomAD
rs1381762842 526 K>Q No TOPMed
gnomAD
rs1422989284 527 F>L No gnomAD
rs1300343530 527 F>L No TOPMed
gnomAD
rs1363412879 529 V>G No gnomAD
COSM3917869 530 K>R Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs746818910 532 C>Y No ExAC
TOPMed
gnomAD
rs139947477 534 P>L No ESP
ExAC
TOPMed
gnomAD
rs1479230692 536 V>M No Ensembl
rs200292050 539 Y>F No TOPMed
gnomAD
rs200292050 539 Y>S No TOPMed
gnomAD
TCGA novel 540 S>T Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs376411203 541 R>C No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs746133746 541 R>H No ExAC
TOPMed
gnomAD
rs746133746 541 R>L No ExAC
TOPMed
gnomAD
rs746133746 541 R>P No ExAC
TOPMed
gnomAD
rs751891388 544 S>G No Ensembl
COSM2149549
rs1210858990
 544 S>N Variant assessed as Somatic; MODERATE impact. central_nervous_system [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
TOPMed
gnomAD
rs757601498 546 S>* No ExAC
gnomAD
COSM1310097 546 S>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1719545755 547 D>E No gnomAD
rs1719545405 548 V>G No Ensembl
rs1250190269 548 V>I No gnomAD
rs113970135 549 W>R No Ensembl
rs147484158 552 G>A No ESP
TOPMed
rs147484158 552 G>D No ESP
TOPMed
rs1363722534 553 V>A No Ensembl
rs1719540036 553 V>F No gnomAD
rs1268288282 554 L>S No gnomAD
rs769831718 555 M>I No ExAC
TOPMed
gnomAD
rs532438469 555 M>L No gnomAD
rs1211914902 555 M>T No gnomAD
rs532438469 555 M>V No gnomAD
rs781315048 556 W>G No ExAC
gnomAD
rs781315048 556 W>R No ExAC
gnomAD
rs1719538882 558 V>L No Ensembl
COSM1228854
rs185446950
 560 T>M large_intestine [Cosmic] No cosmic curated
1000Genomes
ExAC
TOPMed
gnomAD
COSM1540311
COSM6167519
rs1719538623
 560 T>S lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] No cosmic curated
NCI-TCGA Cosmic
TOPMed
rs1023904247 561 E>K No TOPMed
gnomAD
TCGA novel 562 G>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
VAR_041851 563 R>K a lung adenocarcinoma sample; somatic mutation [UniProt] No UniProt
COSM3775874 563 R>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1014141563 564 M>I No TOPMed
rs940417359 565 P>R No Ensembl
rs1719537610 566 F>S No TOPMed
rs1719536985 570 T>N No Ensembl
rs1401001159 571 N>S No TOPMed
gnomAD
rs758922575 574 V>A No ExAC
gnomAD
rs907574224 575 V>I No TOPMed
gnomAD
rs1719536157 576 T>S No TOPMed
rs1424013141 577 M>T No gnomAD
rs1719536030 577 M>V No Ensembl
rs1719535762 578 V>A No TOPMed
rs1478808162 579 T>I No TOPMed
gnomAD
rs779390935 580 R>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No ExAC
NCI-TCGA
gnomAD
rs182366408 580 R>L No 1000Genomes
ExAC
TOPMed
gnomAD
rs182366408 580 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No 1000Genomes
ExAC
NCI-TCGA
TOPMed
gnomAD
rs753368684 582 H>Y No ExAC
gnomAD
rs765971294
COSM1055787
 583 R>Q Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
gnomAD
rs760335372 584 L>P No ExAC
TOPMed
gnomAD
rs1719533187 585 Y>C No TOPMed
rs952056934 586 Q>R No TOPMed
gnomAD
rs761626081 587 P>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
gnomAD
rs761626081 587 P>Q No ExAC
gnomAD
COSM6167520
COSM1540312
rs1306776603
 588 K>N lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] No cosmic curated
NCI-TCGA Cosmic
NCI-TCGA
TOPMed
gnomAD
rs148361115 589 L>V No ESP
TOPMed
gnomAD
rs1719531964 589 L>W No Ensembl
rs1377544625 590 A>T No gnomAD
rs761695684 590 A>V No ExAC
TOPMed
gnomAD
rs149649815 591 S>A No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs759553648 592 N>D No ExAC
gnomAD
TCGA novel 592 N>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1415775291 592 N>S No gnomAD
rs776729923 593 Y>C No ExAC
TOPMed
gnomAD
rs771059101 594 V>G No ExAC
TOPMed
gnomAD
rs1158386165 594 V>M No gnomAD
rs960602007 595 Y>C No Ensembl
rs747172604 596 E>K No ExAC
TOPMed
gnomAD
rs1719529551 598 M>I No TOPMed
rs1719529413 599 L>P No Ensembl
rs1212392632 602 W>* No gnomAD
rs1445462271 604 E>D No TOPMed
gnomAD
rs1719475672 606 P>L No TOPMed
rs766542747 606 P>S No ExAC
gnomAD
rs760741758 607 E>G No ExAC
TOPMed
rs748536244 610 P>A No ExAC
TOPMed
gnomAD
rs748536244 610 P>T No ExAC
TOPMed
gnomAD
COSM3365652
rs1560368654
 611 S>Y kidney Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
gnomAD
rs552094470 612 F>L No 1000Genomes
ExAC
TOPMed
gnomAD
rs1464522425 613 E>G No gnomAD
rs1027163742 613 E>K No TOPMed
gnomAD
rs138487528 617 R>C No ESP
ExAC
TOPMed
gnomAD
rs533445085
COSM1228856
 617 R>H large_intestine [Cosmic] No cosmic curated
1000Genomes
ExAC
TOPMed
gnomAD
rs375268361 618 T>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ESP
NCI-TCGA
rs1269931727 618 T>I No gnomAD
rs1247084546 619 I>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
rs1488069401 619 I>V No gnomAD
rs781013041 620 D>H No ExAC
gnomAD
TCGA novel 621 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1324007287 623 V>I No TOPMed
gnomAD
rs1324007287 623 V>L No TOPMed
gnomAD
rs1316027340 625 C>S No gnomAD
rs756926914 625 C>Y No ExAC
gnomAD
rs763889694 627 E>D No ExAC
TOPMed
gnomAD
rs373626137 627 E>G No ESP
ExAC
TOPMed
gnomAD
TCGA novel 629 F>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1003226298 632 R>Q No Ensembl

No associated diseases with P42680

10 regional properties for P42680

Type Name Position InterPro Accession
domain Protein kinase domain 370 - 623 IPR000719
domain SH2 domain 245 - 345 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 370 - 618 IPR001245
domain SH3 domain 179 - 239 IPR001452
conserved_site Zinc finger, Btk motif 102 - 149 IPR001562
domain Pleckstrin homology domain 4 - 113 IPR001849
active_site Tyrosine-protein kinase, active site 485 - 497 IPR008266
binding_site Protein kinase, ATP binding site 376 - 398 IPR017441
domain Tyrosine-protein kinase, catalytic domain 370 - 619 IPR020635
domain Tyrosine-protein kinase Tec, SH3 domain 182 - 237 IPR035572

Functions

Description
EC Number 2.7.10.2 Protein-tyrosine kinases
Subcellular Localization
  • Cytoplasm
  • Cell membrane; Peripheral membrane protein
  • Cytoplasm, cytoskeleton
  • Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain
  • Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation
  • In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
non-membrane spanning protein tyrosine kinase activity Catalysis of the reaction
phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.
protein self-association Binding to a domain within the same polypeptide.

8 GO annotations of biological process

Name Definition
adaptive immune response An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
B cell receptor signaling pathway The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
integrin-mediated signaling pathway The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of platelet activation Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
T cell receptor signaling pathway The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
tissue regeneration The regrowth of lost or destroyed tissues.

86 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A0JNB0 FYN Tyrosine-protein kinase Fyn Bos taurus (Bovine) SS
Q0VBZ0 CSK Tyrosine-protein kinase CSK Bos taurus (Bovine) SS
Q3ZC95 BTK Tyrosine-protein kinase Bos taurus (Bovine) EV SS
P42683 LCK Proto-oncogene tyrosine-protein kinase LCK Gallus gallus (Chicken) SS
P41239 CSK Tyrosine-protein kinase CSK Gallus gallus (Chicken) SS
P00523 SRC Proto-oncogene tyrosine-protein kinase Src Gallus gallus (Chicken) EV
Q02977 YRK Proto-oncogene tyrosine-protein kinase Yrk Gallus gallus (Chicken) SS
Q8JH64 BTK Tyrosine-protein kinase BTK Gallus gallus (Chicken) SS
P09324 YES1 Tyrosine-protein kinase Yes Gallus gallus (Chicken) SS
Q05876 FYN Tyrosine-protein kinase Fyn Gallus gallus (Chicken) SS
Q75R65 JAK2 Tyrosine-protein kinase JAK2 Gallus gallus (Chicken) SS
Q24592 hop Tyrosine-protein kinase hopscotch Drosophila melanogaster (Fruit fly) PR
Q9V9J3 Src42A Tyrosine-protein kinase Src42A Drosophila melanogaster (Fruit fly) SS
P00528 Src64B Tyrosine-protein kinase Src64B Drosophila melanogaster (Fruit fly) SS
P08630 Btk Tyrosine-protein kinase Btk Drosophila melanogaster (Fruit fly) SS
P23458 JAK1 Tyrosine-protein kinase JAK1 Homo sapiens (Human) SS
O60674 JAK2 Tyrosine-protein kinase JAK2 Homo sapiens (Human) EV
P52333 JAK3 Tyrosine-protein kinase JAK3 Homo sapiens (Human) SS
P29597 TYK2 Non-receptor tyrosine-protein kinase TYK2 Homo sapiens (Human) EV
P07947 YES1 Tyrosine-protein kinase Yes Homo sapiens (Human) SS
P09769 FGR Tyrosine-protein kinase Fgr Homo sapiens (Human) SS
P41240 CSK Tyrosine-protein kinase CSK Homo sapiens (Human) SS
P51451 BLK Tyrosine-protein kinase Blk Homo sapiens (Human) SS
P51813 BMX Cytoplasmic tyrosine-protein kinase BMX Homo sapiens (Human) SS
Q08881 ITK Tyrosine-protein kinase ITK/TSK Homo sapiens (Human) EV
P43405 SYK Tyrosine-protein kinase SYK Homo sapiens (Human) EV
P43403 ZAP70 Tyrosine-protein kinase ZAP-70 Homo sapiens (Human) EV
Q13882 PTK6 Protein-tyrosine kinase 6 Homo sapiens (Human) EV
P07948 LYN Tyrosine-protein kinase Lyn Homo sapiens (Human) SS
P06241 FYN Tyrosine-protein kinase Fyn Homo sapiens (Human) SS
P12931 SRC Proto-oncogene tyrosine-protein kinase Src Homo sapiens (Human) EV
P06239 LCK Tyrosine-protein kinase Lck Homo sapiens (Human) EV
P08631 HCK Tyrosine-protein kinase HCK Homo sapiens (Human) EV
P42685 FRK Tyrosine-protein kinase FRK Homo sapiens (Human) EV
Q06187 BTK Tyrosine-protein kinase BTK Homo sapiens (Human) EV
P42679 MATK Megakaryocyte-associated tyrosine-protein kinase Homo sapiens (Human) SS
Q14289 PTK2B Protein-tyrosine kinase 2-beta Homo sapiens (Human) PR
Q05397 PTK2 Focal adhesion kinase 1 Homo sapiens (Human) EV
Q13470 TNK1 Non-receptor tyrosine-protein kinase TNK1 Homo sapiens (Human) PR
Q07912 TNK2 Activated CDC42 kinase 1 Homo sapiens (Human) EV
P16591 FER Tyrosine-protein kinase Fer Homo sapiens (Human) PR
Q6J9G0 STYK1 Tyrosine-protein kinase STYK1 Homo sapiens (Human) PR
P42684 ABL2 Tyrosine-protein kinase ABL2 Homo sapiens (Human) SS
P00519 ABL1 Tyrosine-protein kinase ABL1 Homo sapiens (Human) EV
Q9R117 Tyk2 Non-receptor tyrosine-protein kinase TYK2 Mus musculus (Mouse) SS
P08103 Hck Tyrosine-protein kinase HCK Mus musculus (Mouse) SS
P16277 Blk Tyrosine-protein kinase Blk Mus musculus (Mouse) SS
Q62270 Srms Tyrosine-protein kinase Srms Mus musculus (Mouse) SS
Q64434 Ptk6 Protein-tyrosine kinase 6 Mus musculus (Mouse) SS
P05480 Src Proto-oncogene tyrosine-protein kinase Src Mus musculus (Mouse) EV
P14234 Fgr Tyrosine-protein kinase Fgr Mus musculus (Mouse) SS
P35991 Btk Tyrosine-protein kinase BTK Mus musculus (Mouse) EV
P41241 Csk Tyrosine-protein kinase CSK Mus musculus (Mouse) EV
P25911 Lyn Tyrosine-protein kinase Lyn Mus musculus (Mouse) EV
Q62137 Jak3 Tyrosine-protein kinase JAK3 Mus musculus (Mouse) SS
Q62120 Jak2 Tyrosine-protein kinase JAK2 Mus musculus (Mouse) EV
P06240 Lck Proto-oncogene tyrosine-protein kinase LCK Mus musculus (Mouse) SS
Q04736 Yes1 Tyrosine-protein kinase Yes Mus musculus (Mouse) SS
P39688 Fyn Tyrosine-protein kinase Fyn Mus musculus (Mouse) SS
P52332 Jak1 Tyrosine-protein kinase JAK1 Mus musculus (Mouse) SS
Q03526 Itk Tyrosine-protein kinase ITK/TSK Mus musculus (Mouse) SS
P41242 Matk Megakaryocyte-associated tyrosine-protein kinase Mus musculus (Mouse) SS
Q922K9 Frk Tyrosine-protein kinase FRK Mus musculus (Mouse) SS
P24604 Tec Tyrosine-protein kinase Tec Mus musculus (Mouse) SS
A1Y2K1 FYN Tyrosine-protein kinase Fyn Sus scrofa (Pig) SS
O19064 JAK2 Tyrosine-protein kinase JAK2 Sus scrofa (Pig) SS
Q62662 Frk Tyrosine-protein kinase FRK Rattus norvegicus (Rat) SS
Q62844 Fyn Tyrosine-protein kinase Fyn Rattus norvegicus (Rat) SS
Q07014 Lyn Tyrosine-protein kinase Lyn Rattus norvegicus (Rat) SS
P50545 Hck Tyrosine-protein kinase HCK Rattus norvegicus (Rat) SS
Q9WUD9 Src Proto-oncogene tyrosine-protein kinase Src Rattus norvegicus (Rat) SS
Q01621 Lck Proto-oncogene tyrosine-protein kinase LCK Rattus norvegicus (Rat) SS
Q6P6U0 Fgr Tyrosine-protein kinase Fgr Rattus norvegicus (Rat) SS
Q62689 Jak2 Tyrosine-protein kinase JAK2 Rattus norvegicus (Rat) SS
Q63272 Jak3 Tyrosine-protein kinase JAK3 Rattus norvegicus (Rat) SS
P32577 Csk Tyrosine-protein kinase CSK Rattus norvegicus (Rat) SS
P41243 Matk Megakaryocyte-associated tyrosine-protein kinase Rattus norvegicus (Rat) SS
F1LM93 Yes1 Tyrosine-protein kinase Yes Rattus norvegicus (Rat) SS
O45539 src-2 Tyrosine protein-kinase src-2 Caenorhabditis elegans SS
G5ECJ6 csk-1 Tyrosine-protein kinase csk-1 Caenorhabditis elegans SS
G5EE56 src-1 Tyrosine protein-kinase src-1 Caenorhabditis elegans SS
A1A5H8 yes1 Tyrosine-protein kinase yes Danio rerio (Zebrafish) (Brachydanio rerio) SS
F1RDG9 fynb Tyrosine-protein kinase fynb Danio rerio (Zebrafish) (Brachydanio rerio) SS
O12990 jak1 Tyrosine-protein kinase JAK1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q1JPZ3 src Proto-oncogene tyrosine-protein kinase Src Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q6EWH2 fyna Tyrosine-protein kinase fyna Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MNFNTILEEI LIKRSQQKKK TSPLNYKERL FVLTKSMLTY YEGRAEKKYR KGFIDVSKIK
70 80 90 100 110 120
CVEIVKNDDG VIPCQNKYPF QVVHDANTLY IFAPSPQSRD LWVKKLKEEI KNNNNIMIKY
130 140 150 160 170 180
HPKFWTDGSY QCCRQTEKLA PGCEKYNLFE SSIRKALPPA PETKKRRPPP PIPLEEEDNS
190 200 210 220 230 240
EEIVVAMYDF QAAEGHDLRL ERGQEYLILE KNDVHWWRAR DKYGNEGYIP SNYVTGKKSN
250 260 270 280 290 300
NLDQYEWYCR NMNRSKAEQL LRSEDKEGGF MVRDSSQPGL YTVSLYTKFG GEGSSGFRHY
310 320 330 340 350 360
HIKETTTSPK KYYLAEKHAF GSIPEIIEYH KHNAAGLVTR LRYPVSVKGK NAPTTAGFSY
370 380 390 400 410 420
EKWEINPSEL TFMRELGSGL FGVVRLGKWR AQYKVAIKAI REGAMCEEDF IEEAKVMMKL
430 440 450 460 470 480
THPKLVQLYG VCTQQKPIYI VTEFMERGCL LNFLRQRQGH FSRDVLLSMC QDVCEGMEYL
490 500 510 520 530 540
ERNSFIHRDL AARNCLVSEA GVVKVSDFGM ARYVLDDQYT SSSGAKFPVK WCPPEVFNYS
550 560 570 580 590 600
RFSSKSDVWS FGVLMWEVFT EGRMPFEKYT NYEVVTMVTR GHRLYQPKLA SNYVYEVMLR
610 620 630
CWQEKPEGRP SFEDLLRTID ELVECEETFG R