P41808

PR
Gene name
SMK1 (YPR054W, YP9499.10)
Protein name
Sporulation-specific mitogen-activated protein kinase SMK1
Names
MAP kinase SMK1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPR054W
EC number
2.7.11.24: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P41808

Entry ID Method Resolution Chain Position Source
AF-P41808-F1 Predicted AlphaFoldDB

7 variants for P41808

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-666283 3 C>R No SGRP
s16-666319 15 A>T No SGRP
s16-666334 20 A>T No SGRP
s16-666869 198 C>S No SGRP
s16-667034 253 R>H No SGRP
s16-667246 324 H>Y No SGRP
s16-667372 366 S>P No SGRP

No associated diseases with P41808

3 regional properties for P41808

Type Name Position InterPro Accession
domain Protein kinase domain 38 - 337 IPR000719
active_site Serine/threonine-protein kinase, active site 162 - 174 IPR008271
binding_site Protein kinase, ATP binding site 44 - 70 IPR017441

Functions

Description
EC Number 2.7.11.24 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase activity Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

5 GO annotations of biological process

Name Definition
ascospore wall assembly The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of sporulation resulting in formation of a cellular spore Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of cell shape Any process that modulates the surface configuration of a cell.

36 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P14681 KSS1 Mitogen-activated protein kinase KSS1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
P16892 FUS3 Mitogen-activated protein kinase FUS3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
Q00772 SLT2 Mitogen-activated protein kinase SLT2/MPK1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P32485 HOG1 Mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
A5PKJ4 MAPK7 Mitogen-activated protein kinase 7 Bos taurus (Bovine) SS
Q9UBE8 NLK Serine/threonine-protein kinase NLK Homo sapiens (Human) SS
Q13164 MAPK7 Mitogen-activated protein kinase 7 Homo sapiens (Human) SS
Q9WVS8 Mapk7 Mitogen-activated protein kinase 7 Mus musculus (Mouse) SS
P0C865 Mapk7 Mitogen-activated protein kinase 7 Rattus norvegicus (Rat) SS
Q5VN19 MPK11 Mitogen-activated protein kinase 11 Oryza sativa subsp. japonica (Rice) SS
Q5ZCI1 MPK10 Mitogen-activated protein kinase 10 Oryza sativa subsp. japonica (Rice) SS
Q75KK8 MPK14 Mitogen-activated protein kinase 14 Oryza sativa subsp. japonica (Rice) SS
Q53N72 MPK15 Mitogen-activated protein kinase 15 Oryza sativa subsp. japonica (Rice) SS
Q6L5F7 MPK17 Mitogen-activated protein kinase 17 Oryza sativa subsp. japonica (Rice) SS
Q5VP69 MPK16 Mitogen-activated protein kinase 16 Oryza sativa subsp. japonica (Rice) SS
Q5Z9J0 MPK12 Mitogen-activated protein kinase 12 Oryza sativa subsp. japonica (Rice) SS
Q6Z437 MPK3 Mitogen-activated protein kinase 3 Oryza sativa subsp. japonica (Rice) SS
Q5Z859 MPK4 Mitogen-activated protein kinase 4 Oryza sativa subsp. japonica (Rice) SS
Q6L5D4 MPK9 Mitogen-activated protein kinase 9 Oryza sativa subsp japonica (Rice) PR
Q67C40 MPK7 Mitogen-activated protein kinase 7 Oryza sativa subsp. japonica (Rice) SS
Q5SN53 MPK8 Mitogen-activated protein kinase 8 Oryza sativa subsp. japonica (Rice) SS
Q0E459 MPK13 Mitogen-activated protein kinase 13 Oryza sativa subsp. japonica (Rice) SS
O44514 pmk-3 Mitogen-activated protein kinase pmk-3 Caenorhabditis elegans PR
G5EBT1 sma-5 Mitogen-activated protein kinase sma-5 Caenorhabditis elegans SS
Q9C5C0 MPK18 Mitogen-activated protein kinase 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LUC3 MPK19 Mitogen-activated protein kinase 19 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SJG9 MPK20 Mitogen-activated protein kinase 20 Arabidopsis thaliana (Mouse-ear cress) SS
Q8W4J2 MPK16 Mitogen-activated protein kinase 16 Arabidopsis thaliana (Mouse-ear cress) SS
Q9C9U4 MPK15 Mitogen-activated protein kinase 15 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LM33 MPK8 Mitogen-activated protein kinase 8 Arabidopsis thaliana (Mouse-ear cress) SS
Q84M93 MPK17 Mitogen-activated protein kinase 17 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LV37 MPK9 Mitogen-activated protein kinase 9 Arabidopsis thaliana (Mouse-ear cress) SS
O23236 MPK14 Mitogen-activated protein kinase 14 Arabidopsis thaliana (Mouse-ear cress) SS
Q39027 MPK7 Mitogen-activated protein kinase 7 Arabidopsis thaliana (Mouse-ear cress) SS
Q39022 MPK2 Mitogen-activated protein kinase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q39021 MPK1 Mitogen-activated protein kinase 1 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MNCTLTDNTR AINVASNLGA PQQRTIFAKE RISIPGYYEI IQFLGKGAYG TVCSVKFKGR
70 80 90 100 110 120
SPAARIAVKK ISNIFNKEIL LKRAIRELKF MNFFKGHKNI VNLIDLEIVT SSPYDGLYCY
130 140 150 160 170 180
QELIDYDLAK VIHSSVQLSE FHIKYFLYQI LCGLKYIHSA DVIHRDLKPG NILCTLNGCL
190 200 210 220 230 240
KICDFGLARG IHAGFFKCHS TVQPHITNYV ATRWYRAPEL LLSNQPYSKS VDIWAVGCIL
250 260 270 280 290 300
AEFYARKPVF MGRDSMHQIF EIIKVLGTPD KDILIKFGTI KAWNLGKNSN NPVYKKIPWS
310 320 330 340 350 360
NIFPFASHEA INLIESLLHW DSTHRLNVEQ AISHPFLNEV RKPDDEPVCL QGPFDFTYES
370 380
ELNSMSKLRD YLVEEVKNFK TDLSSSSL