P41164
SS
Gene name |
Etv1 (Er81, Etsrp81) |
Protein name |
ETS translocation variant 1 |
Names |
Ets-related protein 81 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14009 |
EC number |
|
Protein Class |
|
Descriptions
ETS translocation variant 4 is a transcriptional activator that plays a vital role in keratinocyte differentiation. Inhibitory segments that hinders DNA binding sites in regions N- and C-terminal of the ETS domain. Acetylation of selected lysines within the N-terminal inhibitory domain activates DNA binding.
Autoinhibitory domains (AIDs)
Target domain |
331-424 (ETS domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for P41164
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P41164-F1 | Predicted | AlphaFoldDB |
14 variants for P41164
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389232558 | 94 | S>G | No | EVA | |
| rs3403183265 | 109 | F>L | No | EVA | |
| rs3389235360 | 123 | A>V | No | EVA | |
| rs3389239674 | 142 | S>I | No | EVA | |
| rs3389211690 | 145 | V>M | No | EVA | |
| rs3389244538 | 146 | S>F | No | EVA | |
| rs3389211724 | 162 | D>H | No | EVA | |
| rs3389230179 | 213 | R>S | No | EVA | |
| rs3389168658 | 264 | A>V | No | EVA | |
| rs3389244567 | 301 | F>I | No | EVA | |
| rs3389251556 | 324 | R>W | No | EVA | |
| rs3389239689 | 334 | S>C | No | EVA | |
| rs3389236071 | 337 | L>P | No | EVA | |
| rs3389240482 | 451 | S>Y | No | EVA |
No associated diseases with P41164
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| mechanosensory behavior | Behavior that is dependent upon the sensation of a mechanical stimulus. |
| muscle organ development | The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
39 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A1A4L6 | ETS2 | Protein C-ets-2 | Bos taurus (Bovine) | SS |
| Q2KIC2 | ETV1 | ETS translocation variant 1 | Bos taurus (Bovine) | SS |
| P15062 | ETS1 | Transforming protein p68/c-ets-1 | Gallus gallus (Chicken) | SS |
| P10157 | ETS2 | Protein C-ets-2 | Gallus gallus (Chicken) | SS |
| Q90837 | ERG | Transcriptional regulator Erg | Gallus gallus (Chicken) | SS |
| A2T762 | ETV3 | ETS translocation variant 3 | Pan troglodytes (Chimpanzee) | PR |
| Q04688 | Ets97D | DNA-binding protein Ets97D | Drosophila melanogaster (Fruit fly) | PR |
| P50548 | ERF | ETS domain-containing transcription factor ERF | Homo sapiens (Human) | PR |
| P41970 | ELK3 | ETS domain-containing protein Elk-3 | Homo sapiens (Human) | SS |
| P41161 | ETV5 | ETS translocation variant 5 | Homo sapiens (Human) | SS |
| P43268 | ETV4 | ETS translocation variant 4 | Homo sapiens (Human) | EV |
| Q06546 | GABPA | GA-binding protein alpha chain | Homo sapiens (Human) | SS |
| P28324 | ELK4 | ETS domain-containing protein Elk-4 | Homo sapiens (Human) | EV |
| P15036 | ETS2 | Protein C-ets-2 | Homo sapiens (Human) | EV |
| P41162 | ETV3 | ETS translocation variant 3 | Homo sapiens (Human) | PR |
| P14921 | ETS1 | Protein C-ets-1 | Homo sapiens (Human) | EV |
| P11308 | ERG | Transcriptional regulator ERG | Homo sapiens (Human) | EV |
| P19419 | ELK1 | ETS domain-containing protein Elk-1 | Homo sapiens (Human) | EV |
| P50549 | ETV1 | ETS translocation variant 1 | Homo sapiens (Human) | EV |
| P15037 | Ets2 | Protein C-ets-2 | Mus musculus (Mouse) | SS |
| P41158 | Elk4 | ETS domain-containing protein Elk-4 | Mus musculus (Mouse) | PR |
| P41969 | Elk1 | ETS domain-containing protein Elk-1 | Mus musculus (Mouse) | PR |
| P41971 | Elk3 | ETS domain-containing protein Elk-3 | Mus musculus (Mouse) | EV |
| Q00422 | Gabpa | GA-binding protein alpha chain | Mus musculus (Mouse) | EV |
| Q9CXC9 | Etv5 | ETS translocation variant 5 | Mus musculus (Mouse) | SS |
| P97360 | Etv6 | Transcription factor ETV6 | Mus musculus (Mouse) | EV |
| Q8VDK3 | Elf5 | ETS-related transcription factor Elf-5 | Mus musculus (Mouse) | SS |
| Q60775 | Elf1 | ETS-related transcription factor Elf-1 | Mus musculus (Mouse) | PR |
| Q9Z2U4 | Elf4 | ETS-related transcription factor Elf-4 | Mus musculus (Mouse) | PR |
| Q9JHC9 | Elf2 | ETS-related transcription factor Elf-2 | Mus musculus (Mouse) | PR |
| Q9WTP3 | Spdef | SAM pointed domain-containing Ets transcription factor | Mus musculus (Mouse) | PR |
| P70459 | Erf | ETS domain-containing transcription factor ERF | Mus musculus (Mouse) | PR |
| P81270 | Erg | Transcriptional regulator ERG | Mus musculus (Mouse) | SS |
| P28322 | Etv4 | ETS translocation variant 4 | Mus musculus (Mouse) | SS |
| P27577 | Ets1 | Protein C-ets-1 | Mus musculus (Mouse) | EV |
| P41156 | Ets1 | Protein C-ets-1 | Rattus norvegicus (Rat) | SS |
| A4GTP4 | Elk1 | ETS domain-containing protein Elk-1 | Rattus norvegicus (Rat) | PR |
| Q9PUQ1 | etv4 | ETS translocation variant 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| A3FEM2 | fev | Protein FEV | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDGFYDQQVP | YVVTNSQRGR | NCTEKPTNVR | KRKFINRDLA | HDSEELFQDL | SQLQETWLAE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AQVPDNDEQF | VPDYQAESLA | FHGLPLKIKK | EPHSPCSELG | SACSQEQPFK | FSYGEKCLYN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VSAYDQKPQV | GMRPSNPPTP | SSTPVSPLHH | ASPNTAHTPK | PDRAFPAHLP | PSQSIPDSTY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PMDHRFRRQL | SEPCNSFPPL | PTMPREGRPM | YQRQMSEPNI | PFPPQGFKQE | YHDPVYEHTT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MVGGAASQSF | PPPLMIKQEP | RDFAYDSEVP | SCHSIYMRQE | GFLAHPSRTE | GCMFEKGPRQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FYDDTCVVPE | KFDGDIKQEP | GMYREGPTYQ | RRGSLQLWQF | LVALLDDPSN | SHFIAWTGRG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MEFKLIEPEE | VARRWGIQKN | RPAMNYDKLS | RSLRYYYEKG | IMQKVAGERY | VYKFVCDPEA |
| 430 | 440 | 450 | 460 | 470 | |
| LFSMAFPDNQ | RPLLKTDMER | HINEEDTVPL | SHFDESMTYM | PEGGCCNPHP | YNEGYVY |