P41158
PR
Gene name |
Elk4 (Sap1) |
Protein name |
ETS domain-containing protein Elk-4 |
Names |
Serum response factor accessory protein 1, SAP-1, SRF accessory protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13714 |
EC number |
|
Protein Class |
|
Descriptions
(Annotation based on sequence homology with P19419)
ELK1 belongs to a subfamily of ETS domain transcription factors. Its characteristic property is the ability to form a ternary nucleoprotein complex with the serum response factor (SRF) over the serum response element (SRE) of the c-fos promoter. The R motif is a repressor domain that dampens the activity of the C-terminal activation domain through recruitment of histone deacetylase complexes.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P41158
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P41158-F1 | Predicted | AlphaFoldDB |
19 variants for P41158
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388497042 | 8 | W>* | No | EVA | |
| rs3388497042 | 8 | W>C | No | EVA | |
| rs3388499441 | 31 | G>R | No | EVA | |
| rs3388496816 | 49 | K>M | No | EVA | |
| rs3388496978 | 52 | P>H | No | EVA | |
| rs3388497744 | 71 | I>F | No | EVA | |
| rs3388497005 | 73 | K>* | No | EVA | |
| rs3388498972 | 196 | K>R | No | EVA | |
| rs37791246 | 203 | A>T | No | EVA | |
| rs3388500314 | 234 | L>M | No | EVA | |
| rs3388497703 | 297 | L>P | No | EVA | |
| rs3388498628 | 306 | L>V | No | EVA | |
| rs3388498504 | 310 | D>E | No | EVA | |
| rs36921307 | 313 | N>S | No | EVA | |
| rs3390641691 | 340 | L>W | No | EVA | |
| rs3388497072 | 390 | L>P | No | EVA | |
| rs3388500086 | 391 | Q>H | No | EVA | |
| rs3388494719 | 396 | L>R | No | EVA | |
| rs222535563 | 411 | L>M | No | EVA |
No associated diseases with P41158
9 regional properties for P41158
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ABC transporter-like, ATP-binding domain | 499 - 722 | IPR003439-1 |
| domain | ABC transporter-like, ATP-binding domain | 1119 - 1352 | IPR003439-2 |
| domain | AAA+ ATPase domain | 526 - 699 | IPR003593-1 |
| domain | AAA+ ATPase domain | 1145 - 1329 | IPR003593-2 |
| domain | ABC transporter type 1, transmembrane domain | 171 - 438 | IPR011527-1 |
| domain | ABC transporter type 1, transmembrane domain | 794 - 1079 | IPR011527-2 |
| conserved_site | ABC transporter-like, conserved site | 624 - 638 | IPR017871-1 |
| conserved_site | ABC transporter-like, conserved site | 1255 - 1269 | IPR017871-2 |
| domain | ABC transporter C family, six-transmembrane helical domain 1 | 171 - 458 | IPR044746 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| sequence-specific double-stranded DNA binding | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| histone H3 deacetylation | The modification of histone H3 by the removal of one or more acetyl groups. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
39 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A1A4L6 | ETS2 | Protein C-ets-2 | Bos taurus (Bovine) | SS |
| Q2KIC2 | ETV1 | ETS translocation variant 1 | Bos taurus (Bovine) | SS |
| P15062 | ETS1 | Transforming protein p68/c-ets-1 | Gallus gallus (Chicken) | SS |
| P10157 | ETS2 | Protein C-ets-2 | Gallus gallus (Chicken) | SS |
| Q90837 | ERG | Transcriptional regulator Erg | Gallus gallus (Chicken) | SS |
| A2T762 | ETV3 | ETS translocation variant 3 | Pan troglodytes (Chimpanzee) | PR |
| Q04688 | Ets97D | DNA-binding protein Ets97D | Drosophila melanogaster (Fruit fly) | PR |
| P50548 | ERF | ETS domain-containing transcription factor ERF | Homo sapiens (Human) | PR |
| P41161 | ETV5 | ETS translocation variant 5 | Homo sapiens (Human) | SS |
| P43268 | ETV4 | ETS translocation variant 4 | Homo sapiens (Human) | EV |
| Q06546 | GABPA | GA-binding protein alpha chain | Homo sapiens (Human) | SS |
| P15036 | ETS2 | Protein C-ets-2 | Homo sapiens (Human) | EV |
| P41162 | ETV3 | ETS translocation variant 3 | Homo sapiens (Human) | PR |
| P14921 | ETS1 | Protein C-ets-1 | Homo sapiens (Human) | EV |
| P50549 | ETV1 | ETS translocation variant 1 | Homo sapiens (Human) | EV |
| P11308 | ERG | Transcriptional regulator ERG | Homo sapiens (Human) | EV |
| P19419 | ELK1 | ETS domain-containing protein Elk-1 | Homo sapiens (Human) | EV |
| P41970 | ELK3 | ETS domain-containing protein Elk-3 | Homo sapiens (Human) | SS |
| P28324 | ELK4 | ETS domain-containing protein Elk-4 | Homo sapiens (Human) | EV |
| P15037 | Ets2 | Protein C-ets-2 | Mus musculus (Mouse) | SS |
| P41164 | Etv1 | ETS translocation variant 1 | Mus musculus (Mouse) | SS |
| P41969 | Elk1 | ETS domain-containing protein Elk-1 | Mus musculus (Mouse) | PR |
| P41971 | Elk3 | ETS domain-containing protein Elk-3 | Mus musculus (Mouse) | EV |
| Q00422 | Gabpa | GA-binding protein alpha chain | Mus musculus (Mouse) | EV |
| Q9CXC9 | Etv5 | ETS translocation variant 5 | Mus musculus (Mouse) | SS |
| P97360 | Etv6 | Transcription factor ETV6 | Mus musculus (Mouse) | EV |
| Q8VDK3 | Elf5 | ETS-related transcription factor Elf-5 | Mus musculus (Mouse) | SS |
| Q60775 | Elf1 | ETS-related transcription factor Elf-1 | Mus musculus (Mouse) | PR |
| Q9Z2U4 | Elf4 | ETS-related transcription factor Elf-4 | Mus musculus (Mouse) | PR |
| Q9JHC9 | Elf2 | ETS-related transcription factor Elf-2 | Mus musculus (Mouse) | PR |
| Q9WTP3 | Spdef | SAM pointed domain-containing Ets transcription factor | Mus musculus (Mouse) | PR |
| P70459 | Erf | ETS domain-containing transcription factor ERF | Mus musculus (Mouse) | PR |
| P81270 | Erg | Transcriptional regulator ERG | Mus musculus (Mouse) | SS |
| P28322 | Etv4 | ETS translocation variant 4 | Mus musculus (Mouse) | SS |
| P27577 | Ets1 | Protein C-ets-1 | Mus musculus (Mouse) | EV |
| P41156 | Ets1 | Protein C-ets-1 | Rattus norvegicus (Rat) | SS |
| A4GTP4 | Elk1 | ETS domain-containing protein Elk-1 | Rattus norvegicus (Rat) | PR |
| Q9PUQ1 | etv4 | ETS translocation variant 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| A3FEM2 | fev | Protein FEV | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDSAITLWQF | LLQLLQEPQN | EHMICWTSNN | GEFKLLQAEE | VARLWGIRKN | KPNMNYDKLS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RALRYYYVKN | IIKKVNGQKF | VYKFVSYPEI | LKMDPLTVGR | IEGDCEALNS | IETSSSKDVE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YGGKERPPQP | GAKTSSRNDY | IHSGLYSSFT | LNSLNTSNKK | LFKSIKIENP | AEKLAEKKAQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EPTPSVIKFV | TTPAKKPPIE | PVAAAFATSP | SLSPSSEETI | QALETLVSPT | LPSLETPASI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SILATTFNPT | PPVPSTPLPL | KEPPRTPSPP | LSSNPDIDTD | IESVASQPME | LPENLSLEPK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NEDSALPEKD | KTNNSSRSKK | PKGLELTPAL | VVTGSDPSPL | GILSPSLPTA | SLTPALFSQT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PILLTPSPLL | SSIHFWSTLS | PFAPLSPARL | QGANTLFQFP | SVLNSHGPFT | LSGLDGPSTP |
| GPFSPDLQKT |