P41156

SS
Gene name
Ets1 (Ets-1)
Protein name
Protein C-ets-1
Names
p54
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:24356
EC number
Protein Class

Descriptions

Ets1 is a transcription factor directly controlling the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. Truncation of either the N-terminal inhibitory region (residues 280-330) or the C-terminal inhibitory region (residues 416-440) increases the DNA binding affinity of Ets-1 by 10- to 20-fold, indicating that the two inhibitory regions act in concert to impair DNA binding

Autoinhibitory domains (AIDs)

304-310 (Alpha-helix HI-1 in N-terminal inhibitory region) SS

Target domain

331-415 (ETS domain)

Relief mechanism

Partner binding

Assay

416-441 (C-terminal inhibitory region) SS

Target domain

331-415 (ETS domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P41156

Entry ID Method Resolution Chain Position Source
AF-P41156-F1 Predicted AlphaFoldDB

No variants for P41156

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P41156

No associated diseases with P41156

9 regional properties for P41156

Type Name Position InterPro Accession
domain Zinc finger, TAZ-type 346 - 432 IPR000197-1
domain Zinc finger, TAZ-type 1766 - 1847 IPR000197-2
domain Zinc finger, ZZ-type 1702 - 1751 IPR000433
domain Bromodomain 1085 - 1195 IPR001487
domain Coactivator CBP, KIX domain 586 - 666 IPR003101
domain CREB-binding protein/p300, atypical RING domain 1193 - 1279 IPR010303
domain Nuclear receptor coactivator, CREB-bp-like, interlocking 2016 - 2114 IPR014744
conserved_site Bromodomain, conserved site 1109 - 1168 IPR018359
domain CBP/p300-type histone acetyltransferase domain 1324 - 1701 IPR031162

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

15 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor binding Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
histone acetyltransferase binding Binding to an histone acetyltransferase.
identical protein binding Binding to an identical protein or proteins.
nuclear receptor coactivator activity A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.
nucleic acid binding Binding to a nucleic acid.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II-specific DNA-binding transcription factor binding Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
transcription corepressor binding Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.

33 GO annotations of biological process

Name Definition
angiogenesis involved in wound healing Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury.
cell differentiation The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cell motility Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
cellular response to hydrogen peroxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
estrous cycle A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.
female pregnancy The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
hypothalamus development The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state.
immune system process Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
negative regulation of inflammatory response Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
pituitary gland development The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands.
PML body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia).
positive regulation of angiogenesis Any process that activates or increases angiogenesis.
positive regulation of blood vessel endothelial cell migration Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of endothelial cell migration Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
positive regulation of erythrocyte differentiation Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of inflammatory response Any process that activates or increases the frequency, rate or extent of the inflammatory response.
positive regulation of leukocyte adhesion to vascular endothelial cell Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell.
positive regulation of miRNA transcription Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of angiogenesis Any process that modulates the frequency, rate or extent of angiogenesis.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of extracellular matrix disassembly Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to estradiol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
response to hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
response to interleukin-1 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
response to laminar fluid shear stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls.
response to mechanical stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
response to salt Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus.

34 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A1A4L6 ETS2 Protein C-ets-2 Bos taurus (Bovine) SS
Q2KIC2 ETV1 ETS translocation variant 1 Bos taurus (Bovine) SS
P10157 ETS2 Protein C-ets-2 Gallus gallus (Chicken) SS
Q90837 ERG Transcriptional regulator Erg Gallus gallus (Chicken) SS
P13474 ETS1 Transforming protein p54/c-ets-1 Gallus gallus (Chicken) SS
P15062 ETS1 Transforming protein p68/c-ets-1 Gallus gallus (Chicken) SS
A2T762 ETV3 ETS translocation variant 3 Pan troglodytes (Chimpanzee) PR
Q04688 Ets97D DNA-binding protein Ets97D Drosophila melanogaster (Fruit fly) PR
P50548 ERF ETS domain-containing transcription factor ERF Homo sapiens (Human) PR
P41970 ELK3 ETS domain-containing protein Elk-3 Homo sapiens (Human) SS
P41161 ETV5 ETS translocation variant 5 Homo sapiens (Human) SS
P43268 ETV4 ETS translocation variant 4 Homo sapiens (Human) EV
Q06546 GABPA GA-binding protein alpha chain Homo sapiens (Human) SS
P28324 ELK4 ETS domain-containing protein Elk-4 Homo sapiens (Human) EV
P15036 ETS2 Protein C-ets-2 Homo sapiens (Human) EV
P41162 ETV3 ETS translocation variant 3 Homo sapiens (Human) PR
P50549 ETV1 ETS translocation variant 1 Homo sapiens (Human) EV
P11308 ERG Transcriptional regulator ERG Homo sapiens (Human) EV
P19419 ELK1 ETS domain-containing protein Elk-1 Homo sapiens (Human) EV
P14921 ETS1 Protein C-ets-1 Homo sapiens (Human) EV
P41971 Elk3 ETS domain-containing protein Elk-3 Mus musculus (Mouse) EV
Q00422 Gabpa GA-binding protein alpha chain Mus musculus (Mouse) EV
P41969 Elk1 ETS domain-containing protein Elk-1 Mus musculus (Mouse) PR
P28322 Etv4 ETS translocation variant 4 Mus musculus (Mouse) SS
P15037 Ets2 Protein C-ets-2 Mus musculus (Mouse) SS
P70459 Erf ETS domain-containing transcription factor ERF Mus musculus (Mouse) PR
Q9CXC9 Etv5 ETS translocation variant 5 Mus musculus (Mouse) SS
P41158 Elk4 ETS domain-containing protein Elk-4 Mus musculus (Mouse) PR
P41164 Etv1 ETS translocation variant 1 Mus musculus (Mouse) SS
P81270 Erg Transcriptional regulator ERG Mus musculus (Mouse) SS
P27577 Ets1 Protein C-ets-1 Mus musculus (Mouse) EV
A4GTP4 Elk1 ETS domain-containing protein Elk-1 Rattus norvegicus (Rat) PR
Q9PUQ1 etv4 ETS translocation variant 4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
A3FEM2 fev Protein FEV Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK ATFSGFTKEQ
70 80 90 100 110 120
QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM NGAALCALGK ECFLELAPDF
130 140 150 160 170 180
VGDILWEHLE ILQKEDVKPY QVNGVNPTYP ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF
190 200 210 220 230 240
ITESYQTLHP ISSEELLSLK YENDYPSVIL RDPLQTDTLQ TDYFAIKQEV LTPDNMCMGR
250 260 270 280 290 300
ASRGKLGGQD SFESIESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDSED YPAALPNHKP
310 320 330 340 350 360
KGTFKDYVRD RADLNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC QSFISWTGDG
370 380 390 400 410 420
WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKN IIHKTAGKRY VYRFVCDLQS
430 440
LLGYTPEELH AMLDVKPDAD E