P40630
PR
Gene name |
Tfam |
Protein name |
Transcription factor A, mitochondrial |
Names |
mtTFA, Testis-specific high mobility group protein, TS-HMG |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:21780 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P40630
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P40630-F1 | Predicted | AlphaFoldDB |
14 variants for P40630
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3400155252 | 45 | M>I | No | EVA | |
| rs3400698462 | 49 | P>R | No | EVA | |
| rs3400698492 | 66 | K>I | No | EVA | |
| rs3401313159 | 70 | K>T | No | EVA | |
| rs3401569404 | 73 | D>N | No | EVA | |
| rs3389079747 | 114 | S>G | No | EVA | |
| rs3389106407 | 117 | K>N | No | EVA | |
| rs3389098224 | 129 | E>* | No | EVA | |
| rs246213942 | 135 | R>K | No | EVA | |
| rs3389102843 | 142 | L>M | No | EVA | |
| rs3389104612 | 143 | V>L | No | EVA | |
| rs228425930 | 233 | S>N | No | EVA | |
| rs3389098212 | 243 | H>L | No | EVA | |
| rs3389098238 | 243 | H>N | No | EVA |
No associated diseases with P40630
2 regional properties for P40630
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | High mobility group box domain | 48 - 118 | IPR009071-1 |
| domain | High mobility group box domain | 153 - 219 | IPR009071-2 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrial nucleoid | The region of a mitochondrion to which the DNA is confined. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA binding, bending | The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. |
| heat shock protein binding | Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. |
| mitochondrial promoter sequence-specific DNA binding | Binding to a DNA region that controls the transcription of the mitochondrial DNA. |
| mitochondrial transcription factor activity | Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
| transcription coactivator binding | Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial respiratory chain complex assembly | The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex. |
| mitochondrial transcription | The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| transcription initiation at mitochondrial promoter | A transcription initiation process that takes place at a promoter on the mitochondrial chromosome. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q32L34 | HMGB4 | High mobility group protein B4 | Bos taurus (Bovine) | PR |
| Q0II87 | TFAM | Transcription factor A, mitochondrial | Bos taurus (Bovine) | PR |
| P17480 | UBTF | Nucleolar transcription factor 1 | Homo sapiens (Human) | EV |
| Q00059 | TFAM | Transcription factor A, mitochondrial | Homo sapiens (Human) | PR |
| Q3USZ2 | Ubtfl1 | Upstream-binding factor 1-like protein 1 | Mus musculus (Mouse) | PR |
| P25976 | Ubtf | Nucleolar transcription factor 1 | Mus musculus (Mouse) | PR |
| Q5D144 | TFAM | Transcription factor A, mitochondrial | Sus scrofa (Pig) | PR |
| P25977 | Ubtf | Nucleolar transcription factor 1 | Rattus norvegicus (Rat) | PR |
| Q9T012 | HMGB13 | High mobility group B protein 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SUP7 | HMGB6 | High mobility group B protein 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALFRGMWSV | LKALGRTGVE | MCAGCGGRIP | SSISLVCIPK | CFSSMGSYPK | KPMSSYLRFS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TEQLPKFKAK | HPDAKLSELV | RKIAALWREL | PEAEKKVYEA | DFKAEWKAYK | EAVSKYKEQL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TPSQLMGMEK | EARQRRLKKK | ALVKRRELIL | LGKPKRPRSA | YNIYVSESFQ | EAKDDSAQGK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LKLVNEAWKN | LSPEEKQAYI | QLAKDDRIRY | DNEMKSWEEQ | MAEVGRSDLI | RRSVKRSGDI |
| SEH |