P40201
PR
Gene name |
Chd1 (Chd-1) |
Protein name |
Chromodomain-helicase-DNA-binding protein 1 |
Names |
GPV, Glycoprotein 5, Carcinoembryonic antigen CGM1, Non-specific crossreacting antigen, Normal cross-reacting antigen, Cell surface antigen CD96, T cell-activated increased late expression protein, CHD-1, ATP-dependent helicase CHD1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12648 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P40201
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P40201-F1 | Predicted | AlphaFoldDB |
67 variants for P40201
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs46172621 | 21 | G>D | No | EVA | |
| rs3389384008 | 45 | S>G | No | EVA | |
| rs3407093236 | 58 | S>* | No | EVA | |
| rs3407475356 | 60 | S>I | No | EVA | |
| rs3406441812 | 60 | S>R | No | EVA | |
| rs3407274274 | 64 | S>P | No | EVA | |
| rs50761418 | 70 | R>G | No | EVA | |
| rs3389414916 | 80 | K>I | No | EVA | |
| rs3389429008 | 85 | E>Q | No | EVA | |
| rs235514386 | 132 | D>E | No | EVA | |
| rs45825784 | 200 | N>T | No | EVA | |
| rs3407357613 | 230 | S>P | No | EVA | |
| rs3389393334 | 329 | T>I | No | EVA | |
| rs3389404103 | 376 | Q>* | No | EVA | |
| rs3389428987 | 453 | K>R | No | EVA | |
| rs3389426478 | 457 | Q>R | No | EVA | |
| rs3407588687 | 513 | Q>H | No | EVA | |
| rs1132625864 | 603 | G>D | No | EVA | |
| rs1135400143 | 607 | A>S | No | EVA | |
| rs1135400143 | 607 | A>T | No | EVA | |
| rs1134189237 | 609 | I>K | No | EVA | |
| rs1134189237 | 609 | I>T | No | EVA | |
| rs3389435154 | 611 | V>F | No | EVA | |
| rs3389437503 | 651 | L>H | No | EVA | |
| rs3389437501 | 655 | L>P | No | EVA | |
| rs3389426492 | 697 | K>M | No | EVA | |
| rs3389450399 | 714 | M>T | No | EVA | |
| rs3389450412 | 846 | D>N | No | EVA | |
| rs3389444289 | 880 | F>L | No | EVA | |
| rs3389383978 | 912 | T>S | No | EVA | |
| rs3389414925 | 925 | K>I | No | EVA | |
| rs3389404164 | 953 | S>A | No | EVA | |
| rs1132484265 | 958 | F>C | No | EVA | |
| rs1133625642 | 959 | N>I | No | EVA | |
| rs1132209530 | 962 | E>G | No | EVA | |
| rs1132986176 | 995 | K>N | No | EVA | |
| rs1131907013 | 999 | T>I | No | EVA | |
| rs3389426472 | 1000 | H>Q | No | EVA | |
| rs3407588697 | 1005 | G>A | No | EVA | |
| rs3406519299 | 1005 | G>C | No | EVA | |
| rs1135342797 | 1006 | P>L | No | EVA | |
| rs1132729875 | 1006 | P>T | No | EVA | |
| rs3389435173 | 1010 | G>E | No | EVA | |
| rs3389437455 | 1058 | R>G | No | EVA | |
| rs3407502103 | 1082 | G>R | No | EVA | |
| rs3389414901 | 1106 | R>W | No | EVA | |
| rs3405648240 | 1240 | C>S | No | EVA | |
| rs3407476585 | 1241 | H>Y | No | EVA | |
| rs3389435125 | 1243 | K>M | No | EVA | |
| rs3389393338 | 1258 | N>Y | No | EVA | |
| rs3389404160 | 1294 | K>I | No | EVA | |
| rs3389441119 | 1301 | Q>E | No | EVA | |
| rs3389433401 | 1325 | G>D | No | EVA | |
| rs46250043 | 1345 | I>S | No | EVA | |
| rs237138160 | 1345 | I>V | No | EVA | |
| rs108455114 | 1381 | S>P | No | EVA | |
| rs3389429324 | 1389 | A>V | No | EVA | |
| rs3389429014 | 1400 | V>D | No | EVA | |
| rs108831472 | 1406 | S>A | No | EVA | |
| rs3389435163 | 1415 | S>N | No | EVA | |
| rs108519244 | 1523 | I>L | No | EVA | |
| rs218923794 | 1537 | H>N | No | EVA | |
| rs3412089130 | 1649 | E>D | No | EVA | |
| rs3389426423 | 1653 | H>R | No | EVA | |
| rs3389426503 | 1653 | H>Y | No | EVA | |
| rs3389437488 | 1657 | R>G | No | EVA | |
| rs3389435122 | 1659 | Y>F | No | EVA |
No associated diseases with P40201
11 regional properties for P40201
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SNF2, N-terminal | 497 - 762 | IPR000330 |
| domain | Chromo/chromo shadow domain | 268 - 362 | IPR000953-1 |
| domain | Chromo/chromo shadow domain | 385 - 450 | IPR000953-2 |
| domain | Helicase, C-terminal | 790 - 941 | IPR001650 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 475 - 672 | IPR014001 |
| conserved_site | Chromo domain, conserved site | 316 - 336 | IPR023779-1 |
| conserved_site | Chromo domain, conserved site | 407 - 427 | IPR023779-2 |
| domain | Chromo domain | 272 - 352 | IPR023780-1 |
| domain | Chromo domain | 387 - 441 | IPR023780-2 |
| domain | Chromodomain-helicase-DNA-binding protein 1-like, C-terminal domain | 1396 - 1500 | IPR025260 |
| domain | CDH1/2, SANT-Helical linker 1 | 1122 - 1208 | IPR040793 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear chromosome | A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATP-dependent chromatin remodeler activity | An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. |
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
| helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| methylated histone binding | Binding to a histone in which a residue has been modified by methylation. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| nucleosome organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes. |
| positive regulation by host of viral transcription | Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q32KP7 | Uncharacterized protein C17orf64 homolog | Bos taurus (Bovine) | PR | |
| Q24368 | Iswi | Chromatin-remodeling complex ATPase chain Iswi | Drosophila melanogaster (Fruit fly) | SS |
| Q86WR6 | C17orf64 | Uncharacterized protein C17orf64 | Homo sapiens (Human) | PR |
| P28370 | SMARCA1 | Probable global transcription activator SNF2L1 | Homo sapiens (Human) | SS |
| O60264 | SMARCA5 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 | Homo sapiens (Human) | EV |
| O14646 | CHD1 | Chromodomain-helicase-DNA-binding protein 1 | Homo sapiens (Human) | PR |
| Q6PGB8 | Smarca1 | Probable global transcription activator SNF2L1 | Mus musculus (Mouse) | SS |
| A2A8L1 | Chd5 | Chromodomain-helicase-DNA-binding protein 5 | Mus musculus (Mouse) | PR |
| Q91ZW3 | Smarca5 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 | Mus musculus (Mouse) | SS |
| Q6PDQ2 | Chd4 | Chromodomain-helicase-DNA-binding protein 4 | Mus musculus (Mouse) | PR |
| P41877 | isw-1 | Chromatin-remodeling complex ATPase chain isw-1 | Caenorhabditis elegans | SS |
| Q22516 | chd-3 | Chromodomain-helicase-DNA-binding protein 3 homolog | Caenorhabditis elegans | PR |
| Q9XFH4 | DDM1 | ATP-dependent DNA helicase DDM1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNGHSDEESV | RNGSGESSQS | GDDCGSASGS | GSGSSSGSSS | DGSSSQSGSS | DSDSGSDSGS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QSESESDTSR | ENKVQAKPPK | VDGAEFWKSS | PSILAVQRSA | MLRKQPQQAQ | QQRPASSNSG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SEEDSSSSED | SDDSSSGAKR | KKHNDEDWQM | SGSGSPSQSG | SDSESEEERD | KSSCDGTESD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YEPKNKVRSR | KPQNRSKSKN | GKKILGQKKR | QIDSSEDEDD | EDYDNDKRSS | RRQATVNVSY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KEDEEMKTDS | DDLLEVCGED | VPQPEDEEFE | TIERVMDCRV | GRKGATGATT | TIYAVEADGD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PNAGFERNKE | PGDIQYLIKW | KGWSHIHNTW | ETEETLKQQN | VRGMKKLDNY | KKKDQETKRW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LKNASPEDVE | YYNCQQELTD | DLHKQYQIVE | RIIAHSNQKS | AAGLPDYYCK | WQGLPYSECS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| WEDGALISKK | FQTCIDEYFS | RNQSKTTPFK | DCKVLKQRPR | FVALKKQPSY | IGGHEGLELR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DYQLNGLNWL | AHSWCKGNSC | ILADEMGLGK | TIQTISFLNY | LFHEHQLYGP | FLLVVPLSTL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TSWQREIQTW | ASQMNAVVYL | GDINSRNMIR | THEWMHPQTK | RLKFNILLTT | YEILLKDKAF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LGGLNWAFIG | VDEAHRLKND | DSLLYKTLID | FKSNHRLLIT | GTPLQNSLKE | LWSLLHFIMP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EKFSSWEDFE | EEHGKGREYG | YASLHKELEP | FLLRRVKKDV | EKSLPAKVEQ | ILRMEMSALQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KQYYKWILTR | NYKALSKGSK | GSTSGFLNIM | MELKKCCNHC | YLIKPPDNNE | FYNKQEALQH |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LIRSSGKLIL | LDKLLIRLRE | RGNRVLIFSQ | MVRMLDILAE | YLKYRQFPFQ | RLDGSIKGEL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| RKQALDHFNA | EGSEDFCFLL | STRAGGLGIN | LASADTVVIF | DSDWNPQNDL | QAQARAHRIG |
| 910 | 920 | 930 | 940 | 950 | 960 |
| QKKQVNIYRL | VTKGSVEEDI | LERAKKKMVL | DHLVIQRMDT | TGKTVLHTGS | APSSSTPFNK |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| EELSAILKFG | AEELFKEPEG | EEQEPQEMDI | DEILKRAETH | ENEPGPLSVG | DELLSQFKVA |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| NFSNMDEDDI | ELEPERNSKN | WEEIIPEEQR | RRLEEEERQK | ELEEIYMLPR | MRNCAKQISF |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| NGSEGRRSRS | RRYSGSDSDS | ISERKRPKKR | GRPRTIPREN | IKGFSDAEIR | RFIKSYKKFG |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| GPLERLDAIA | RDAELVDKSE | TDLRRLGELV | HNGCVKALKD | SSSGTERAGG | RLGKVKGPTF |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| RISGVQVNAK | LVIAHEDELI | PLHKSIPSDP | EERKQYTIPC | HTKAAHFDID | WGKEDDSNLL |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| IGIYEYGYGS | WEMIKMDPDL | SLTHKILPDD | PDKKPQAKQL | QTRADYLIKL | LSRDLAKREA |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| QRLCGAGGSK | RRKTRAKKSK | AMKSIKVKEE | IKSDSSPLPS | EKSDEDDDKL | NDSKPESKDR |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| SKKSVVSDAP | VHITASGEPV | PIAEESEELD | QKTFSICKER | MRPVKAALKQ | LDRPEKGLSE |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| REQLEHTRQC | LIKIGDHITE | CLKEYSNPEQ | IKQWRKNLWI | FVSKFTEFDA | RKLHKLYKHA |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| IKKRQESQQN | SDQNSNVATT | HVIRNPDMER | LKENTNHDDS | SRDSYSSDRH | LSQYHDHHKD |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| RHQGDSYKKS | DSRKRPYSSF | SNGKDHREWD | HYRQDSRYYS | DREKHRKLDD | HRSREHRPSL |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| EGGLKDRCHS | DHRSHSDHRM | HSDHRSSSEH | THHKSSRDYR | YLSDWQLDHR | AASSGPRSPL |
| 1690 | 1700 | 1710 | |||
| DQRSPYGSRS | PFEHSAEHRS | TPEHTWSSRK | T |