AiPD: Autoinhibited Protein Database

Gene name	YEN1 (YER041W)
Protein name	Holliday junction resolvase YEN1
Names
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YER041W
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

37-188 (Predicted disordered autoinhibitory region) PR

37-188 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P40028-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s05-232793	112	E>K	No	SGRP
s05-232868	137	T>S	No	SGRP
s05-232887	143	E>G	No	SGRP
s05-232890	144	Y>C	No	SGRP
s05-233355	299	N>S	No	SGRP
s05-233445	329	T>K	No	SGRP
s05-233469	337	R>Q	No	SGRP
s05-233642	395	V>I	No	SGRP
s05-233661	401	I>T	No	SGRP
s05-233679	407	G>E	No	SGRP
s05-233687	410	R>G	No	SGRP
s05-233816	453	D>N	No	SGRP
s05-234224	589	G>R	No	SGRP
s05-234263	602	V>L	No	SGRP
s05-234318	620	P>L	No	SGRP
s05-234339	627	T>I	No	SGRP
s05-234354	632	S>N	No	SGRP
s05-234407	650	S>G	No	SGRP
s05-234419	654	S>G	No	SGRP
s05-234440	661	R>G	No	SGRP
s05-234488	677	E>K	No	SGRP
s05-234519	687	T>S	No	SGRP
s05-234528	690	E>A	No	SGRP
s05-234535	692	N>K	No	SGRP
s05-234536	693	P>S	No	SGRP
s05-234543	695	E>A	No	SGRP
s05-234570	704	I>T	No	SGRP
s05-234578	707	N>D	No	SGRP
s05-234588	710	L>P	No	SGRP
s05-234653	732	V>I	No	SGRP
s05-234668	737	V>F	No	SGRP

Type	Name	Position	InterPro Accession
domain	XPG, N-terminal	1 - 134	IPR006085
domain	XPG-I domain	181 - 288	IPR006086
domain	Yen1, H3TH domain	286 - 388	IPR037316

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	Predominantly nuclear in G1-arrested cells, but cytoplasmically localized after release from G1 arrest
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
5'-3' exonuclease activity	Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.
5'-flap endonuclease activity	Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.
crossover junction endodeoxyribonuclease activity	Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).
four-way junction DNA binding	Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.
magnesium ion binding	Binding to a magnesium (Mg) ion.
protein homodimerization activity	Binding to an identical protein to form a homodimer.

Name	Definition
cellular response to DNA damage stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
DNA repair	The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
replication fork processing	The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q12086	DIN7	DNA damage-inducible protein DIN7	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR