P39104

PR
Gene name
PIK1
Protein name
Phosphatidylinositol 4-kinase PIK1
Names
PI4-kinase, PtdIns-4-kinase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YNL267W
EC number
2.7.1.67: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

205-301 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P39104

Entry ID Method Resolution Chain Position Source
2JU0 NMR - B 121-172 PDB
AF-P39104-F1 Predicted AlphaFoldDB

17 variants for P39104

Variant ID(s) Position Change Description Diseaes Association Provenance
s14-140971 31 E>D No SGRP
s14-141005 43 K>E No SGRP
s14-141008 44 H>Y No SGRP
s14-141054 59 A>G No SGRP
s14-141866 330 P>S No SGRP
s14-141891 338 N>S No SGRP
s14-141963 362 H>R No SGRP
s14-142023 382 S>F No SGRP
s14-142223 449 T>S No SGRP
s14-142613 579 S>P No SGRP
s14-142629 584 S>N No SGRP
s14-142630 584 S>R No SGRP
s14-142665 596 G>D No SGRP
s14-142664 596 G>S No SGRP
s14-142757 627 V>I No SGRP
s14-142860 661 S>N No SGRP
s14-142865 663 E>Q No SGRP

No associated diseases with P39104

4 regional properties for P39104

Type Name Position InterPro Accession
domain Phosphatidylinositol 3-/4-kinase, catalytic domain 770 - 1063 IPR000403
domain Phosphoinositide 3-kinase, accessory (PIK) domain 1 - 133 IPR001263
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 795 - 809 IPR018936-1
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 903 - 923 IPR018936-2

Functions

Description
EC Number 2.7.1.67 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Nucleus
  • Golgi apparatus, trans-Golgi network
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
trans-Golgi network The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

3 GO annotations of molecular function

Name Definition
1-phosphatidylinositol 4-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphatidylinositol kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate.

8 GO annotations of biological process

Name Definition
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
microlipophagy Microautophagy-mediated direct internalization of lipid droplets into a lysosome-like vacuole during nutrient depletion, such as during the transition to stationary phase or in response to nutrient limitation. Microlipophagy is mediated by the formation of sterol-enriched vacuolar microdomains at sites of engulfment. Initiation of microautophagy is defined as the point where liquid-ordered microdomains are formed at sites of engulfment, that requires S. cerevisiae Atg32p and Atg21p, as well as Niemann-Pick type C (NPC) sterol transporter proteins, Ncr1p and Npc2p. This is followed by redistribution of Atg14p from ER exit sites onto liquid-ordered vacuole membrane domains through interaction with stabilized AMP-activated protein kinase (AMPK), and together with Atg6p facilities docking and internalization of lipid droplets (LDs) at sites of invagination.
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of autophagosome assembly Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly.
positive regulation of Golgi to plasma membrane protein transport Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.
positive regulation of protein secretion Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P22543 VPS34 Phosphatidylinositol 3-kinase VPS34 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
O02810 PI4KB Phosphatidylinositol 4-kinase beta Bos taurus (Bovine) PR
Q9UBF8 PI4KB Phosphatidylinositol 4-kinase beta Homo sapiens (Human) PR
Q8BKC8 Pi4kb Phosphatidylinositol 4-kinase beta Mus musculus (Mouse) PR
O08561 Pi4kb Phosphatidylinositol 4-kinase beta Rattus norvegicus (Rat) PR
A4IID4 pi4kb Phosphatidylinositol 4-kinase beta Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q49GP3 pi4kb Phosphatidylinositol 4-kinase beta Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MHKASSSKKS FDDTIELKKN EQLLKLINSS EFTLHNCVEL LCKHSENIGI HYYLCQKLAT
70 80 90 100 110 120
FPHSELQFYI PQLVQVLVTM ETESMALEDL LLRLRAENPH FALLTFWQLQ ALLTDLSTDP
130 140 150 160 170 180
ASYGFQVARR VLNNLQTNLF NTSSGSDKNV KIHENVAPAL VLSSMIMSAI AFPQLSEVTK
190 200 210 220 230 240
PLVESQGRRQ KAFVFKLARS AMKDFTKNMT LKNTLLNKKT SRSKRVSSNR SSTPTSPIDL
250 260 270 280 290 300
IDPIKTKEDA SFRKSRHSEV KLDFDIVDDI GNQVFEERIS SSIKLPKRKP KYLDNSYVHR
310 320 330 340 350 360
TYDGKNINRD GSISNTAKAL DGNKGDYISP KGRNDENNEI GNNEDETGGE TEEDADALNS
370 380 390 400 410 420
DHFTSSMPDL HNIQPRTSSA SSASLEGTPK LNRTNSQPLS RQAFKNSKKA NSSLSQEIDL
430 440 450 460 470 480
SQLSTTSKIK MLKANYFRCE TQFAIALETI SQRLARVPTE ARLSALRAEL FLLNRDLPAE
490 500 510 520 530 540
VDIPTLLPPN KKGKLHKLVT ITANEAQVLN SAEKVPYLLL IEYLRDEFDF DPTSETNERL
550 560 570 580 590 600
LKKISGNQGG LIFDLNYMNR KENNENRNES TLTSNNTRSS VYDSNSFNNG ASRNEGLSST
610 620 630 640 650 660
SRSDSASTAH VRTEVNKEED LGDMSMVKVR NRTDDEAYRN ALVIQSAANV PILPDDSQDR
670 680 690 700 710 720
SPELNFGSNL DEVLIENGIN SKNIHSQTDA LADQMRVSAV MLAQLDKSPQ QLSESTKQIR
730 740 750 760 770 780
AQIISSMKEV QDKFGYHDLE ALHGMAGERK LENDLMTGGI DTSYLGEDWA TKKERIRKTS
790 800 810 820 830 840
EYGHFENWDL CSVIAKTGDD LRQEAFAYQM IQAMANIWVK EKVDVWVKRM KILITSANTG
850 860 870 880 890 900
LVETITNAMS VHSIKKALTK KMIEDAELDD KGGIASLNDH FLRAFGNPNG FKYRRAQDNF
910 920 930 940 950 960
ASSLAAYSVI CYLLQVKDRH NGNIMIDNEG HVSHIDFGFM LSNSPGSVGF EAAPFKLTYE
970 980 990 1000 1010 1020
YIELLGGVEG EAFKKFVELT KSSFKALRKY ADQIVSMCEI MQKDNMQPCF DAGEQTSVQL
1030 1040 1050 1060
RQRFQLDLSE KEVDDFVENF LIGKSLGSIY TRIYDQFQLI TQGIYS