P39009

PR
Gene name
DUN1 (YDL101C, D2370)
Protein name
DNA damage response protein kinase DUN1
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDL101C
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-59 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

364-386 (Activation loop from InterPro)

Target domain

200-480 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

3 structures for P39009

Entry ID Method Resolution Chain Position Source
2JQJ NMR - A 19-159 PDB
2JQL NMR - A 19-159 PDB
AF-P39009-F1 Predicted AlphaFoldDB

6 variants for P39009

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-281643 69 S>N No SGRP
s04-281405 148 D>E No SGRP
s04-281392 153 S>G No SGRP
s04-281314 179 A>S No SGRP
s04-281307 181 T>M No SGRP
s04-280962 296 R>K No SGRP

No associated diseases with P39009

4 regional properties for P39009

Type Name Position InterPro Accession
domain Forkhead-associated (FHA) domain 55 - 128 IPR000253
domain Protein kinase domain 200 - 480 IPR000719
active_site Serine/threonine-protein kinase, active site 324 - 336 IPR008271
binding_site Protein kinase, ATP binding site 206 - 229 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

4 GO annotations of biological process

Name Definition
DNA damage checkpoint signaling A signal transduction process that contributes to a DNA damage checkpoint.
meiotic recombination checkpoint signaling A signaling process that contributes to a meiotic recombination checkpoint, that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes.
protein phosphorylation The process of introducing a phosphate group on to a protein.
replication fork protection Any process that prevents the collapse of stalled replication forks.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0VD22 STK33 Serine/threonine-protein kinase 33 Bos taurus (Bovine) PR
Q9BYT3 STK33 Serine/threonine-protein kinase 33 Homo sapiens (Human) PR
O96017 CHEK2 Serine/threonine-protein kinase Chk2 Homo sapiens (Human) EV
Q924X7 Stk33 Serine/threonine-protein kinase 33 Mus musculus (Mouse) PR
Q95QC4 zyg-8 Serine/threonine-protein kinase zyg-8 Caenorhabditis elegans PR
10 20 30 40 50 60
MSLSTKREHS GDVTDSSFKR QQRSNKPSSE YTCLGHLVNL IPGKEQKVEI TNRNVTTIGR
70 80 90 100 110 120
SRSCDVILSE PDISTFHAEF HLLQMDVDNF QRNLINVIDK SRNGTFINGN RLVKKDYILK
130 140 150 160 170 180
NGDRIVFGKS CSFLFKYASS SSTDIENDDE KVSSESRSYK NDDEVFKKPQ ISATSSQNAT
190 200 210 220 230 240
TSAAIRKLNK TRPVSFFDKY LLGKELGAGH YALVKEAKNK KTGQQVAVKI FHAQQNDDQK
250 260 270 280 290 300
KNKQFREETN ILMRVQHPNI VNLLDSFVEP ISKSQIQKYL VLEKIDDGEL FERIVRKTCL
310 320 330 340 350 360
RQDESKALFK QLLTGLKYLH EQNIIHRDIK PENILLNITR RENPSQVQLG PWDEDEIDIQ
370 380 390 400 410 420
VKIADFGLAK FTGEMQFTNT LCGTPSYVAP EVLTKKGYTS KVDLWSAGVI LYVCLCGFPP
430 440 450 460 470 480
FSDQLGPPSL KEQILQAKYA FYSPYWDKID DSVLHLISNL LVLNPDERYN IDEALNHPWF
490 500 510
NDIQQQSSVS LELQRLQITD NKIPKTYSEL SCL