P38929
PR
Gene name |
PMC1 (YGL006W) |
Protein name |
Calcium-transporting ATPase 2 |
Names |
Vacuolar Ca(2+)-ATPase |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGL006W |
EC number |
7.2.2.10: Linked to the hydrolysis of a nucleoside triphosphate |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P38929
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38929-F1 | Predicted | AlphaFoldDB |
10 variants for P38929
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-486007 | 28 | V>A | No | SGRP | |
| s07-486133 | 70 | K>R | No | SGRP | |
| s07-487309 | 462 | P>L | No | SGRP | |
| s07-487333 | 470 | S>N | No | SGRP | |
| s07-487344 | 474 | P>T | No | SGRP | |
| s07-487941 | 673 | E>K | No | SGRP | |
| s07-488016 | 698 | E>K | No | SGRP | |
| s07-488076 | 718 | L>I | No | SGRP | |
| s07-489046 | 1041 | G>D | No | SGRP | |
| s07-489427 | 1168 | E>G | No | SGRP |
No associated diseases with P38929
4 regional properties for P38929
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cation-transporting P-type ATPase, N-terminal | 53 - 132 | IPR004014 |
| domain | Cation-transporting P-type ATPase, C-terminal | 926 - 1118 | IPR006068 |
| ptm | P-type ATPase, phosphorylation site | 445 - 451 | IPR018303 |
| domain | P-type ATPase, haloacid dehalogenase domain | 425 - 892 | IPR044492 |
Functions
| Description | ||
|---|---|---|
| EC Number | 7.2.2.10 | Linked to the hydrolysis of a nucleoside triphosphate |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| fungal-type vacuole membrane | The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATPase-coupled cation transmembrane transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). |
| metal ion binding | Binding to a metal ion. |
| P-type calcium transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion transport | The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| cellular calcium ion homeostasis | Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
31 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| D3K0R6 | ATP2B4 | Plasma membrane calcium-transporting ATPase 4 | Bos taurus (Bovine) | SS |
| Q01814 | ATP2B2 | Plasma membrane calcium-transporting ATPase 2 | Homo sapiens (Human) | SS |
| P23634 | ATP2B4 | Plasma membrane calcium-transporting ATPase 4 | Homo sapiens (Human) | EV |
| P20020 | ATP2B1 | Plasma membrane calcium-transporting ATPase 1 | Homo sapiens (Human) | SS |
| Q16720 | ATP2B3 | Plasma membrane calcium-transporting ATPase 3 | Homo sapiens (Human) | EV |
| Q9R0K7 | Atp2b2 | Plasma membrane calcium-transporting ATPase 2 | Mus musculus (Mouse) | SS |
| Q6Q477 | Atp2b4 | Plasma membrane calcium-transporting ATPase 4 | Mus musculus (Mouse) | SS |
| G5E829 | Atp2b1 | Plasma membrane calcium-transporting ATPase 1 | Mus musculus (Mouse) | SS |
| P23220 | ATP2B1 | Plasma membrane calcium-transporting ATPase 1 | Sus scrofa (Pig) | SS |
| P11506 | Atp2b2 | Plasma membrane calcium-transporting ATPase 2 | Rattus norvegicus (Rat) | SS |
| Q64542 | Atp2b4 | Plasma membrane calcium-transporting ATPase 4 | Rattus norvegicus (Rat) | SS |
| P11505 | Atp2b1 | Plasma membrane calcium-transporting ATPase 1 | Rattus norvegicus (Rat) | SS |
| Q64568 | Atp2b3 | Plasma membrane calcium-transporting ATPase 3 | Rattus norvegicus (Rat) | SS |
| Q8RUN1 | ACA1 | Calcium-transporting ATPase 1, plasma membrane-type | Oryza sativa subsp japonica (Rice) | SS |
| Q2QY12 | ACA9 | Probable calcium-transporting ATPase 9, plasma membrane-type | Oryza sativa subsp japonica (Rice) | SS |
| Q6ATV4 | ACA3 | Calcium-transporting ATPase 3, plasma membrane-type | Oryza sativa subsp japonica (Rice) | SS |
| Q2QMX9 | ACA10 | Calcium-transporting ATPase 10, plasma membrane-type | Oryza sativa subsp japonica (Rice) | SS |
| Q7XEK4 | ACA7 | Calcium-transporting ATPase 7, plasma membrane-type | Oryza sativa subsp japonica (Rice) | EV |
| Q7X8B5 | ACA5 | Calcium-transporting ATPase 5, plasma membrane-type | Oryza sativa subsp japonica (Rice) | SS |
| Q65X71 | ACA6 | Probable calcium-transporting ATPase 6, plasma membrane-type | Oryza sativa subsp japonica (Rice) | SS |
| Q2RAS0 | ACA8 | Probable calcium-transporting ATPase 8, plasma membrane-type | Oryza sativa subsp japonica (Rice) | SS |
| O22218 | ACA4 | Calcium-transporting ATPase 4, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M2L4 | ACA11 | Putative calcium-transporting ATPase 11, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64806 | ACA7 | Putative calcium-transporting ATPase 7, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81108 | ACA2 | Calcium-transporting ATPase 2, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | EV |
| Q9LY77 | ACA12 | Calcium-transporting ATPase 12, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LIK7 | ACA13 | Putative calcium-transporting ATPase 13, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LU41 | ACA9 | Calcium-transporting ATPase 9, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LF79 | ACA8 | Calcium-transporting ATPase 8, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | EV |
| Q9SZR1 | ACA10 | Calcium-transporting ATPase 10, plasma membrane-type | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q37145 | ACA1 | Calcium-transporting ATPase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRQDENSAL | LANNENNKPS | YTGNENGVYD | NFKLSKSQLS | DLHNPKSIRS | FVRLFGYESN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SLFKYLKTDK | NAGISLPEIS | NYRKTNRYKN | YGDNSLPERI | PKSFLQLVWA | AFNDKTMQLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TVAAVVSFVL | GLYELWMQPP | QYDPEGNKIK | QVDWIEGVAI | MIAVFVVVLV | SAANDYQKEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QFAKLNKKKE | NRKIIVIRND | QEILISIHHV | LVGDVISLQT | GDVVPADCVM | ISGKCEADES |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SITGESNTIQ | KFPVDNSLRD | FKKFNSIDSH | NHSKPLDIGD | VNEDGNKIAD | CMLISGSRIL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SGLGRGVITS | VGINSVYGQT | MTSLNAEPES | TPLQLHLSQL | ADNISVYGCV | SAIILFLVLF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TRYLFYIIPE | DGRFHDLDPA | QKGSKFMNIF | ITSITVIVVA | VPEGLPLAVT | LALAFATTRM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TKDGNLVRVL | RSCETMGSAT | AVCSDKTGTL | TENVMTVVRG | FPGNSKFDDS | KSLPVSEQRK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LNSKKVFEEN | CSSSLRNDLL | ANIVLNSTAF | ENRDYKKNDK | NTNGSKNMSK | NLSFLDKCKS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RLSFFKKGNR | EDDEDQLFKN | VNKGRQEPFI | GSKTETALLS | LARLSLGLQP | GELQYLRDQP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| MEKFNIEKVV | QTIPFESSRK | WAGLVVKYKE | GKNKKPFYRF | FIKGAAEIVS | KNCSYKRNSD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DTLEEINEDN | KKETDDEIKN | LASDALRAIS | VAHKDFCECD | SWPPEQLRDK | DSPNIAALDL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LFNSQKGLIL | DGLLGIQDPL | RAGVRESVQQ | CQRAGVTVRM | VTGDNILTAK | AIARNCAILS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TDISSEAYSA | MEGTEFRKLT | KNERIRILPN | LRVLARSSPE | DKRLLVETLK | GMGDVVAVTG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DGTNDAPALK | LADVGFSMGI | SGTEVAREAS | DIILMTDDFS | AIVNAIKWGR | CVSVSIKKFI |
| 910 | 920 | 930 | 940 | 950 | 960 |
| QFQLIVNITA | VILTFVSSVA | SSDETSVLTA | VQLLWINLIM | DTLAALALAT | DKPDPNIMDR |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KPRGRSTSLI | SVSTWKMILS | QATLQLIVTF | ILHFYGPELF | FKKHEDEITS | HQQQQLNAMT |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| FNTFVWLQFF | TMLVSRKLDE | GDGISNWRGR | ISAANLNFFQ | DLGRNYYFLT | IMAIIGSCQV |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LIMFFGGAPF | SIARQTKSMW | ITAVLCGMLS | LIMGVLVRIC | PDEVAVKVFP | AAFVQRFKYV |
| 1150 | 1160 | 1170 | |||
| FGLEFLRKNH | TGKHDDEEAL | LEESDSPEST | AFY |