AiPD: Autoinhibited Protein Database

P38919

Gene name	EIF4A3 (DDX48, KIAA0111)
Protein name	Eukaryotic initiation factor 4A-III
Names	eIF-4A-III, eIF4A-III, ATP-dependent RNA helicase DDX48, ATP-dependent RNA helicase eIF4A-3, DEAD box protein 48, Eukaryotic initiation factor 4A-like NUK-34, Eukaryotic translation initiation factor 4A isoform 3, Nuclear matrix protein 265, NMP 265, hNMP 265
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9775
EC number	3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-63 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

21 structures for P38919

Entry ID	Method	Resolution	Chain	Position	Source
2HXY	X-ray	330 A	A/B/C/D	23-411	PDB
2HYI	X-ray	230 A	C/I	1-411	PDB
2J0Q	X-ray	320 A	A/B	2-411	PDB
2J0S	X-ray	221 A	A	2-411	PDB
2J0U	X-ray	300 A	A/B	38-411	PDB
2XB2	X-ray	340 A	A/X	1-411	PDB
3EX7	X-ray	230 A	C/H	1-411	PDB
4C9B	X-ray	200 A	A	1-411	PDB
5MQF	EM	590 A	p	1-411	PDB
5XJC	EM	360 A	u	1-411	PDB
5YZG	EM	410 A	u	1-411	PDB
6ICZ	EM	300 A	u	1-411	PDB
6QDV	EM	330 A	7	22-404	PDB
6YVH	X-ray	319 A	H/J/K/L	246-411	PDB
7A5P	EM	500 A	y	1-411	PDB
7W59	EM	360 A	u	1-411	PDB
7W5A	EM	360 A	u	1-411	PDB
7W5B	EM	430 A	u	1-411	PDB
7ZNJ	EM	240 A	A/F/K/a/f/k	23-404	PDB
8C6J	EM	280 A	7	1-411	PDB
AF-P38919-F1	Predicted				AlphaFoldDB

134 variants for P38919

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA150727 VAR_071090 rs587777204 RCV000087740	270	D>G	Richieri Costa-Pereira syndrome RCPS [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
CA294885798 rs1041900382	2	A>E		No	ClinGen TOPMed gnomAD
CA8816285 rs11559243	4	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8816286 rs753725743	4	T>P		No	ClinGen ExAC TOPMed gnomAD
CA8816281 rs759812869	6	T>M		No	ClinGen ExAC gnomAD
rs537330257 CA8816283	6	T>P		No	ClinGen 1000Genomes ExAC gnomAD
CA8816282 rs759812869	6	T>R		No	ClinGen ExAC gnomAD
CA401346221 rs1425871135	7	M>V		No	ClinGen gnomAD
rs771230686 CA8816279	8	A>T		No	ClinGen ExAC gnomAD
CA8816278 rs749598271	8	A>V		No	ClinGen ExAC gnomAD
rs1183927840 CA401346172	9	T>A		No	ClinGen TOPMed gnomAD
CA8816276 rs199770425	9	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs199770425 CA401346159	9	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8816272 rs758092979	10	S>L		No	ClinGen ExAC gnomAD
CA401346126 rs1255525313	11	G>R		No	ClinGen gnomAD
rs778474622 CA8816270	12	S>L		No	ClinGen ExAC TOPMed gnomAD
rs750094584 CA8816271	12	S>P		No	ClinGen ExAC TOPMed gnomAD
rs374500712 CA8816269	13	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs371179642 CA8816268	16	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs752873377 CA8816265	18	L>V		No	ClinGen ExAC
rs1398046847 CA401345946	19	K>N		No	ClinGen gnomAD
rs1256304315 CA401345909	21	E>K		No	ClinGen TOPMed
TCGA novel	21	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401345850 rs146631753 CA8816263	23	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs767730035 CA8816264	23	M>V		No	ClinGen ExAC TOPMed gnomAD
CA401345818 rs1167145572	25	K>R		No	ClinGen gnomAD
rs1413518243 CA401345719	29	E>D		No	ClinGen TOPMed gnomAD
CA8816260 rs763285271	31	S>N		No	ClinGen ExAC gnomAD
CA401345629 rs1236908125	33	E>K		No	ClinGen gnomAD
rs1197412554 CA401345556	37	T>I		No	ClinGen gnomAD
rs770239554 CA8816258	38	P>A		No	ClinGen ExAC gnomAD
rs991158193 CA294885674	39	T>M		No	ClinGen TOPMed
CA401345480 rs1158658467	43	M>V		No	ClinGen TOPMed
rs1286394558 CA401345428	44	G>D		No	ClinGen gnomAD
CA294885672 rs867796526	46	R>W		No	ClinGen gnomAD
rs771577924 CA401345338	49	L>V		No	ClinGen ExAC TOPMed gnomAD
CA401345321 rs745326354	50	L>M		No	ClinGen ExAC gnomAD
rs1295427326 CA401345246	54	Y>N		No	ClinGen gnomAD
TCGA novel	57	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	61	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	62	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8816226 rs770539912	64	I>V		No	ClinGen ExAC gnomAD
rs1163812388 CA401343479	68	A>V		No	ClinGen gnomAD
rs1195385120 CA401343472	69	I>V		No	ClinGen gnomAD
CA8816197 rs750459539	88	K>Q		No	ClinGen ExAC gnomAD
rs757442778 CA8816195	94	I>V	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs777906183 CA8816173	105	R>C		No	ClinGen ExAC TOPMed gnomAD
rs777906183 CA401341321	105	R>G		No	ClinGen ExAC TOPMed gnomAD
CA294881100 rs756516726	105	R>H		No	ClinGen ExAC TOPMed gnomAD
CA8816172 rs756516726	105	R>P		No	ClinGen ExAC TOPMed gnomAD
CA401341085 rs1168579869	114	P>S		No	ClinGen TOPMed
CA8816170 rs768135698	120	V>M		No	ClinGen ExAC gnomAD
CA401340727 rs1464257374	124	K>Q		No	ClinGen TOPMed
TCGA novel	125	G>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760226009 CA8816144	125	G>R		No	ClinGen ExAC TOPMed gnomAD
rs767246848 CA8816142	130	G>S		No	ClinGen ExAC gnomAD
rs774286251 CA8816140	133	M>I		No	ClinGen ExAC gnomAD
CA401339654 rs1429810861	133	M>V		No	ClinGen gnomAD
rs367636849 CA8816139	134	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA294879867 rs367636849	134	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs749434367 CA8816138	135	V>I		No	ClinGen ExAC gnomAD
TCGA novel	138	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1022458708 CA294879845	141	I>T		No	ClinGen Ensembl
CA8816137 rs190180277	145	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8816135 rs748340572	148	E>K		No	ClinGen ExAC gnomAD
rs781432256 CA8816134	156	G>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	158	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401339045 rs1295627768	159	V>A		No	ClinGen gnomAD
rs755298107 CA8816133	159	V>I		No	ClinGen ExAC gnomAD
TCGA novel	160	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1261899180 CA401339024	161	A>T		No	ClinGen TOPMed gnomAD
CA401339012 rs1198756729	161	A>V		No	ClinGen gnomAD
rs372677327 CA8816129	163	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs777174636 CA8816128	164	P>S		No	ClinGen ExAC gnomAD
rs746409423 CA8816107	170	M>T		No	ClinGen ExAC TOPMed gnomAD
rs200525685 CA8816106	172	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1247723909 CA401338684	172	R>H		No	ClinGen gnomAD
rs755596816 CA8816105	173	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs377598321 CA294879395	182	K>E		No	ClinGen ESP
CA401338217 rs1159245310	192	M>T		No	ClinGen TOPMed
rs1598604598 CA401337806	203	D>G		No	ClinGen Ensembl
rs1173648982 CA401337813	203	D>N		No	ClinGen gnomAD
rs1598604584 CA401337701	207	Y>S		No	ClinGen Ensembl
rs764301358 CA8816072	217	I>V		No	ClinGen ExAC gnomAD
CA401337393 rs911756594	219	A>P		No	ClinGen Ensembl
CA294878714 rs911756594	219	A>T		No	ClinGen Ensembl
CA401337369 rs1598604560	220	T>P		No	ClinGen Ensembl
TCGA novel	225	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	232	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401336945 rs1598604540	234	T>P		No	ClinGen Ensembl
CA401336922 rs1279042039	235	D>Y		No	ClinGen gnomAD
rs1295310328 CA401336845	237	I>S		No	ClinGen gnomAD
CA8816065 rs201917263	237	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA8816063 rs200424645	238	R>C		No	ClinGen 1000Genomes ExAC gnomAD
rs11559244 CA401336817	238	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA294878594 rs11559244	238	R>L		No	ClinGen TOPMed gnomAD
rs113268177 CA294878593	242	K>R		No	ClinGen Ensembl
CA8816042 rs771670148	250	G>V		No	ClinGen ExAC gnomAD
CA401335534 rs1245804026	252	K>E		No	ClinGen gnomAD
CA401335327 rs1567848723	262	E>Q		No	ClinGen Ensembl
TCGA novel	268	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401335137 rs1410106098	272	Y>C		No	ClinGen gnomAD
CA401335035 rs1490903985	279	Q>H		No	ClinGen gnomAD
CA8816032 rs751807674	280	A>E		No	ClinGen ExAC gnomAD
rs751807674 CA8816033	280	A>V		No	ClinGen ExAC gnomAD
CA8816010 rs202076147	294	T>A		No	ClinGen ExAC gnomAD
rs762099502 CA8816009	294	T>K		No	ClinGen ExAC gnomAD
rs762099502 CA401334708	294	T>M		No	ClinGen ExAC gnomAD
rs764496207 CA8816007	295	E>G		No	ClinGen ExAC gnomAD
CA8816006 rs759156126	296	K>E		No	ClinGen ExAC
CA8816004 rs1555605223	297	M>K		No	ClinGen Ensembl
CA294876990 rs763058081	307	M>T		No	ClinGen Ensembl
CA8816000 rs772956229	314	K>Q		No	ClinGen ExAC gnomAD
rs2039580889 RCV001346346	316	R>W		No	ClinVar dbSNP
CA8815996 rs768473409	324	R>L		No	ClinGen ExAC TOPMed gnomAD
rs768473409 CA8815997	324	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs747890720 CA8815998	324	R>W		No	ClinGen ExAC gnomAD
rs779973276 CA8815994	325	S>L		No	ClinGen ExAC gnomAD
rs757676343 CA8815990	327	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1423240018 CA401333630	333	S>A		No	ClinGen gnomAD
rs753145766 CA401333550	336	V>F		No	ClinGen ExAC gnomAD
CA8815966 rs753145766	336	V>I		No	ClinGen ExAC gnomAD
CA8815965 rs768076226	337	W>C		No	ClinGen ExAC gnomAD
CA294875849 rs749441707	352	Y>C		No	ClinGen Ensembl
CA401332756 rs1290668885	372	G>S		No	ClinGen TOPMed
rs150484871 CA8815936	377	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA294875698 rs892982579	383	N>S		No	ClinGen TOPMed
CA401332423 rs1198325251	387	R>C		No	ClinGen TOPMed
rs1344598019 CA401332296	392	I>T		No	ClinGen gnomAD
rs891076923 CA294875650	398	T>I		No	ClinGen TOPMed gnomAD
rs867120581 CA294875649	404	P>S		No	ClinGen Ensembl
TCGA novel	405	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA294875046 rs200104923	410	L>P		No	ClinGen 1000Genomes
rs867413953 CA294875029	412	I>L		No	ClinGen Ensembl

No associated diseases with P38919

7 regional properties for P38919

Type	Name	Position	InterPro Accession
repeat	Leucine-rich repeat	48 - 69	IPR001611
repeat	WD40 repeat	377 - 434	IPR001680-1
repeat	WD40 repeat	437 - 487	IPR001680-2
repeat	WD40 repeat	490 - 531	IPR001680-3
repeat	WD40 repeat	541 - 580	IPR001680-4
conserved_site	WD40 repeat, conserved site	517 - 531	IPR019775
repeat	Leucine rich repeat 4	48 - 82	IPR025875

Functions

		Description
EC Number	3.6.4.13	Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization	Nucleus Nucleus speckle Cytoplasm	Nucleocytoplasmic shuttling protein Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA Detected in dendritic layer as well as the nuclear and cytoplasmic (somatic) compartments of neurons Colocalizes with STAU1 and FMR1 in dendrites (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

14 GO annotations of cellular component

Name	Definition
catalytic step 2 spliceosome	A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
exon-exon junction complex	A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
postsynaptic cytosol	The region of the cytosol consisting of all cytosol that is part of the postsynapse.
U2-type catalytic step 1 spliceosome	A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs.

10 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
poly(A) binding	Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
ribonucleoprotein complex binding	Binding to a complex of RNA and protein.
RNA binding	Binding to an RNA molecule or a portion thereof.
RNA helicase activity	Unwinding of an RNA helix, driven by ATP hydrolysis.
RNA stem-loop binding	Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.
selenocysteine insertion sequence binding	Binding to a selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation.
translation regulator activity	Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.

17 GO annotations of biological process

Name	Definition
associative learning	Learning by associating a stimulus (the cause) with a particular outcome (the effect).
cellular response to brain-derived neurotrophic factor stimulus	A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus.
cellular response to selenite ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus.
embryonic cranial skeleton morphogenesis	The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase.
exploration behavior	The specific behavior of an organism in response to a novel environment or stimulus.
mRNA export from nucleus	The directed movement of mRNA from the nucleus to the cytoplasm.
mRNA splicing, via spliceosome	The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
negative regulation of excitatory postsynaptic potential	Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
negative regulation of selenocysteine incorporation	Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine incorporation.
negative regulation of selenocysteine insertion sequence binding	Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine insertion sequence binding.
negative regulation of translation	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
positive regulation of translation	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay.
regulation of translation at postsynapse, modulating synaptic transmission	Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.
response to organic cyclic compound	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

22 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q12099	FAL1	ATP-dependent RNA helicase FAL1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q2NL22	EIF4A3	Eukaryotic initiation factor 4A-III	Bos taurus (Bovine)	PR
Q5ZM36	EIF4A3	Eukaryotic initiation factor 4A-III	Gallus gallus (Chicken)	PR
Q9VHS8	CG7483	Eukaryotic initiation factor 4A-III	Drosophila melanogaster (Fruit fly)	PR
Q9NQI0	DDX4	Probable ATP-dependent RNA helicase DDX4	Homo sapiens (Human)	SS
O15523	DDX3Y	ATP-dependent RNA helicase DDX3Y	Homo sapiens (Human)	SS
O00571	DDX3X	ATP-dependent RNA helicase DDX3X	Homo sapiens (Human)	EV
Q9UHL0	DDX25	ATP-dependent RNA helicase DDX25	Homo sapiens (Human)	PR
Q9UMR2	DDX19B	ATP-dependent RNA helicase DDX19B	Homo sapiens (Human)	PR
Q9NUU7	DDX19A	ATP-dependent RNA helicase DDX19A	Homo sapiens (Human)	PR
P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	Homo sapiens (Human)	PR
O00148	DDX39A	ATP-dependent RNA helicase DDX39A	Homo sapiens (Human)	PR
Q13838	DDX39B	Spliceosome RNA helicase DDX39B	Homo sapiens (Human)	PR
Q9UJV9	DDX41	Probable ATP-dependent RNA helicase DDX41	Homo sapiens (Human)	PR
Q91VC3	Eif4a3	Eukaryotic initiation factor 4A-III	Mus musculus (Mouse)	PR
A6M931	EIF4A3	Eukaryotic initiation factor 4A-III	Sus scrofa (Pig)	PR
Q3B8Q2	Eif4a3	Eukaryotic initiation factor 4A-III	Rattus norvegicus (Rat)	PR
Q10I26	EIF4A3B	Eukaryotic initiation factor 4A-III homolog B	Oryza sativa subsp japonica (Rice)	PR
Q5VNM3	EIF4A3A	Eukaryotic initiation factor 4A-III homolog A	Oryza sativa subsp japonica (Rice)	PR
Q94A52	EIF4A3	Eukaryotic initiation factor 4A-III homolog	Arabidopsis thaliana (Mouse-ear cress)	PR
B7ZTW1	eif4a3	Eukaryotic initiation factor 4A-III	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q7ZVA6	eif4a3	Eukaryotic initiation factor 4A-III	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MATTATMATS	GSARKRLLKE	EDMTKVEFET	SEEVDVTPTF	DTMGLREDLL	RGIYAYGFEK
70	80	90	100	110	120
PSAIQQRAIK	QIIKGRDVIA	QSQSGTGKTA	TFSISVLQCL	DIQVRETQAL	ILAPTRELAV
130	140	150	160	170	180
QIQKGLLALG	DYMNVQCHAC	IGGTNVGEDI	RKLDYGQHVV	AGTPGRVFDM	IRRRSLRTRA
190	200	210	220	230	240
IKMLVLDEAD	EMLNKGFKEQ	IYDVYRYLPP	ATQVVLISAT	LPHEILEMTN	KFMTDPIRIL
250	260	270	280	290	300
VKRDELTLEG	IKQFFVAVER	EEWKFDTLCD	LYDTLTITQA	VIFCNTKRKV	DWLTEKMREA
310	320	330	340	350	360
NFTVSSMHGD	MPQKERESIM	KEFRSGASRV	LISTDVWARG	LDVPQVSLII	NYDLPNNREL
370	380	390	400	410
YIHRIGRSGR	YGRKGVAINF	VKNDDIRILR	DIEQYYSTQI	DEMPMNVADL	I