P38735

PR
Gene name
VMR1 (YHL035C)
Protein name
ABC transporter ATP-binding protein/permease VMR1
Names
Vacuolar multidrug resistance protein 1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YHL035C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

875-988 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P38735

Entry ID Method Resolution Chain Position Source
AF-P38735-F1 Predicted AlphaFoldDB

78 variants for P38735

Variant ID(s) Position Change Description Diseaes Association Provenance
s08-32750 2 G>E No SGRP
s08-32706 17 V>I No SGRP
s08-32625 44 F>I No SGRP
s08-32624 44 F>S No SGRP
s08-32612 48 R>H No SGRP
s08-32576 60 C>S No SGRP
s08-32456 100 G>E No SGRP
s08-32436 107 H>Y No SGRP
s08-32406 117 Q>K No SGRP
s08-32371 128 F>L No SGRP
s08-32369 129 S>N No SGRP
s08-32115 214 I>L No SGRP
s08-32086 223 D>E No SGRP
s08-32087 223 D>G No SGRP
s08-32027 243 P>L No SGRP
s08-31997 253 N>S No SGRP
s08-31955 267 S>L No SGRP
s08-31946 270 H>R No SGRP
s08-31901 285 N>S No SGRP
s08-31740 339 L>F No SGRP
s08-31735 340 I>M No SGRP
s08-31695 354 L>V No SGRP
s08-31643 371 R>H No SGRP
s08-31598 386 M>T No SGRP
s08-31581 392 T>A No SGRP
s08-31338 473 V>I No SGRP
s08-31302 485 N>H No SGRP
s08-31259 499 L>* No SGRP
s08-31194 521 K>Q No SGRP
s08-31173 528 S>A No SGRP
s08-31067 563 S>F No SGRP
s08-31047 570 V>M No SGRP
s08-30977 593 C>Y No SGRP
s08-30930 609 T>A No SGRP
s08-30869 629 F>Y No SGRP
s08-30813 648 D>N No SGRP
s08-30750 669 A>S No SGRP
s08-30657 700 I>V No SGRP
s08-30653 701 L>S No SGRP
s08-30630 709 S>G No SGRP
s08-30594 721 L>V No SGRP
s08-30590 722 I>N No SGRP
s08-30587 723 S>N No SGRP
s08-30554 734 K>R No SGRP
s08-30398 786 L>P No SGRP
s08-30384 791 E>K No SGRP
s08-30309 816 I>V No SGRP
s08-30236 840 S>L No SGRP
s08-30149 869 S>L No SGRP
s08-30117 880 V>M No SGRP
s08-30104 884 G>D No SGRP
s08-30101 885 K>R No SGRP
s08-30043 904 K>N No SGRP
s08-30033 908 L>F No SGRP
s08-29906 950 G>D No SGRP
s08-29879 959 S>* No SGRP
s08-29861 965 P>L No SGRP
s08-29807 983 A>V No SGRP
s08-29740 1005 W>* No SGRP
s08-29692 1021 D>E No SGRP
s08-29690 1022 T>M No SGRP
s08-29669 1029 T>I No SGRP
s08-29665 1030 D>E No SGRP
s08-29589 1056 G>S No SGRP
s08-29451 1102 F>L No SGRP
s08-29270 1162 A>V No SGRP
s08-29198 1186 V>A No SGRP
s08-29139 1206 N>D No SGRP
s08-28808 1316 S>L No SGRP
s08-28795 1320 D>E No SGRP
s08-28475 1427 K>R No SGRP
s08-28466 1430 F>S No SGRP
s08-28360 1465 H>Q No SGRP
s08-28283 1491 R>L No SGRP
s08-28184 1524 S>N No SGRP
s08-28071 1562 D>N No SGRP
s08-28028 1576 G>D No SGRP
s08-27986 1590 M>R No SGRP

No associated diseases with P38735

2 regional properties for P38735

Type Name Position InterPro Accession
domain Homeobox domain 6 - 70 IPR001356
conserved_site Homeobox, conserved site 41 - 64 IPR017970

Functions

Description
EC Number
Subcellular Localization
  • Vacuole membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
fungal-type vacuole membrane The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
ABC-type xenobiotic transporter activity Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.

3 GO annotations of biological process

Name Definition
response to metal ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
xenobiotic detoxification by transmembrane export across the plasma membrane A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P14772 BPT1 Bile pigment transporter 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P0CE68 NFT1 ABC transporter NFT1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q96J66 ABCC11 ATP-binding cassette sub-family C member 11 Homo sapiens (Human) PR
Q80WJ6 Abcc12 ATP-binding cassette sub-family C member 12 Mus musculus (Mouse) PR
Q6Y306 Abcc12 ATP-binding cassette sub-family C member 12 Rattus norvegicus (Rat) PR
Q9C8H0 ABCC12 ABC transporter C family member 12 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8G9 ABCC1 ABC transporter C family member 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VZZ4 ABCC6 ABC transporter C family member 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M1C7 ABCC9 ABC transporter C family member 9 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGTDPLIIRN NGSFWEVDDF TRLGRTQLLS YYLPLAIIAS IGIFALCRSG LSRYVRSAEC
70 80 90 100 110 120
DLVNEYLFGA QEERKEDNSI ERLLRNSNTQ ANYVNVKKQG RILKLRHFDI TTIDVKQIDA
130 140 150 160 170 180
KNHGGLTFSR PSTSDHLRKS SEIVLMSLQI IGLSFLRVTK INIELTNRDV TTLLLFWLIL
190 200 210 220 230 240
LSLSILRVYK RSTNLWAICF TAHTTIWIST WIPIRSVYIG NIDDVPSQIF YIFEFVITST
250 260 270 280 290 300
LQPIKLTSPI KDNSSIIYVR DDHTSPSREH ISSILSCITW SWITNFIWEA QKNTIKLKDI
310 320 330 340 350 360
WGLSMEDYSI FILKGFTRRN KHINNLTLAL FESFKTYLLI GMLWVLVNSI VNLLPTILMK
370 380 390 400 410 420
RFLEIVDNPN RSSSCMNLAW LYIIGMFICR LTLAICNSQG QFVSDKICLR IRAILIGEIY
430 440 450 460 470 480
AKGLRRRLFT SPKTSSDSDS ISANLGTIIN LISIDSFKVS ELANYLYVTV QAVIMIIVVV
490 500 510 520 530 540
GLLFNFLGVS AFAGISIILV MFPLNFLLAN LLGKFQKQTL KCTDQRISKL NECLQNIRIV
550 560 570 580 590 600
KYFAWERNII NEIKSIRQKE LRSLLKKSLV WSVTSFLWFV TPTLVTGVTF AICTFVQHED
610 620 630 640 650 660
LNAPLAFTTL SLFTLLKTPL DQLSNMLSFI NQSKVSLKRI SDFLRMDDTE KYNQLTISPD
670 680 690 700 710 720
KNKIEFKNAT LTWNENDSDM NAFKLCGLNI KFQIGKLNLI LGSTGSGKSA LLLGLLGELN
730 740 750 760 770 780
LISGSIIVPS LEPKHDLIPD CEGLTNSFAY CSQSAWLLND TVKNNIIFDN FYNEDRYNKV
790 800 810 820 830 840
IDACGLKRDL EILPAGDLTE IGEKGITLSG GQKQRISLAR AVYSSAKHVL LDDCLSAVDS
850 860 870 880 890 900
HTAVWIYENC ITGPLMKNRT CILVTHNVSL TLRNAHFAIV LENGKVKNQG TITELQSKGL
910 920 930 940 950 960
FKEKYVQLSS RDSINEKNAN RLKAPRKNDS QKIEPVTENI NFDANFVNDG QLIEEEEKSN
970 980 990 1000 1010 1020
GAISPDVYKW YLKFFGGFKA LTALFALYIT AQILFISQSW WIRHWVNDTN VRINAPGFAM
1030 1040 1050 1060 1070 1080
DTLPLKGMTD SSKNKHNAFY YLTVYFLIGI IQAMLGGFKT MMTFLSGMRA SRKIFNNLLD
1090 1100 1110 1120 1130 1140
LVLHAQIRFF DVTPVGRIMN RFSKDIEGVD QELIPYLEVT IFCLIQCASI IFLITVITPR
1150 1160 1170 1180 1190 1200
FLTVAVIVFV LYFFVGKWYL TASRELKRLD SITKSPIFQH FSETLVGVCT IRAFGDERRF
1210 1220 1230 1240 1250 1260
ILENMNKIDQ NNRAFFYLSV TVKWFSFRVD MIGAFIVLAS GSFILLNIAN IDSGLAGISL
1270 1280 1290 1300 1310 1320
TYAILFTDGA LWLVRLYSTF EMNMNSVERL KEYSSIEQEN YLGHDEGRIL LLNEPSWPKD
1330 1340 1350 1360 1370 1380
GEIEIENLSL RYAPNLPPVI RNVSFKVDPQ SKIGIVGRTG AGKSTIITAL FRLLEPITGC
1390 1400 1410 1420 1430 1440
IKIDGQDISK IDLVTLRRSI TIIPQDPILF AGTIKSNVDP YDEYDEKKIF KALSQVNLIS
1450 1460 1470 1480 1490 1500
SHEFEEVLNS EERFNSTHNK FLNLHTEIAE GGLNLSQGER QLLFIARSLL REPKIILLDE
1510 1520 1530 1540 1550 1560
ATSSIDYDSD HLIQGIIRSE FNKSTILTIA HRLRSVIDYD RIIVMDAGEV KEYDRPSELL
1570 1580 1590
KDERGIFYSM CRDSGGLELL KQIAKQSSKM MK