P38408
PR
Gene name |
GNA14 |
Protein name |
Guanine nucleotide-binding protein subunit alpha-14 |
Names |
G alpha-14, G-protein subunit alpha-14, G-protein subunit GL1 alpha |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:281789 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P38408
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38408-F1 | Predicted | AlphaFoldDB |
38 variants for P38408
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs468078628 | 11 | E>V | No | EVA | |
| rs445367088 | 13 | E>G | No | EVA | |
| rs482460439 | 13 | E>Q | No | EVA | |
| rs444252429 | 16 | R>L | No | EVA | |
| rs452158897 | 18 | S>T | No | EVA | |
| rs473108378 | 21 | I>N | No | EVA | |
| rs436026295 | 22 | E>K | No | EVA | |
| rs457631836 | 31 | D>A | No | EVA | |
| rs465579838 | 34 | R>H | No | EVA | |
| rs480028456 | 38 | L>V | No | EVA | |
| rs449366466 | 40 | L>V | No | EVA | |
| rs465893362 | 76 | Y>S | No | EVA | |
| rs448909486 | 77 | Q>K | No | EVA | |
| rs479264908 | 107 | Q>E | No | EVA | |
| rs442164083 | 110 | R>S | No | EVA | |
| rs434659615 | 121 | S>Y | No | EVA | |
| rs455534626 | 140 | C>G | No | EVA | |
| rs469926054 | 143 | R>P | No | EVA | |
| rs477836976 | 146 | E>G | No | EVA | |
| rs447227167 | 147 | Y>D | No | EVA | |
| rs469244249 | 155 | Y>N | No | EVA | |
| rs464160446 | 163 | I>M | No | EVA | |
| rs384431727 | 186 | I>T | No | EVA | |
| rs443052290 | 200 | V>E | No | EVA | |
| rs443052290 | 200 | V>G | No | EVA | |
| rs457478997 | 211 | K>E | No | EVA | |
| rs471855153 | 213 | I>T | No | EVA | |
| rs434765124 | 218 | S>R | No | EVA | |
| rs453130366 | 220 | T>P | No | EVA | |
| rs467412992 | 224 | F>L | No | EVA | |
| rs481748690 | 232 | D>G | No | EVA | |
| rs460099512 | 241 | E>G | No | EVA | |
| rs444861921 | 241 | E>K | No | EVA | |
| rs469228355 | 289 | P>L | No | EVA | |
| rs477234587 | 293 | G>R | No | EVA | |
| rs445965630 | 308 | L>V | No | EVA | |
| rs452676706 | 330 | T>P | No | EVA | |
| rs478810858 | 350 | R>T | No | EVA |
No associated diseases with P38408
No regional properties for P38408
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P38408 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| heterotrimeric G-protein complex | Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled receptor binding | Binding to a G protein-coupled receptor. |
| G-protein beta/gamma-subunit complex binding | Binding to a complex of G-protein beta/gamma subunits. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| metal ion binding | Binding to a metal ion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| action potential | A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP). |
| phospholipase C-activating dopamine receptor signaling pathway | A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P63097 | GNAI1 | Guanine nucleotide-binding protein G | Bos taurus (Bovine) | SS |
| P0C7Q4 | GNAT3 | Guanine nucleotide-binding protein G | Bos taurus (Bovine) | SS |
| P04696 | GNAT2 | Guanine nucleotide-binding protein G | Bos taurus (Bovine) | SS |
| P04695 | GNAT1 | Guanine nucleotide-binding protein G | Bos taurus (Bovine) | SS |
| P08239 | GNAO1 | Guanine nucleotide-binding protein G | Bos taurus (Bovine) | SS |
| P04896 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Bos taurus (Bovine) | PR |
| P23625 | Galphaq | G protein alpha q subunit | Drosophila melanogaster (Fruit fly) | PR |
| P29992 | GNA11 | Guanine nucleotide-binding protein subunit alpha-11 | Homo sapiens (Human) | SS |
| P30679 | GNA15 | Guanine nucleotide-binding protein subunit alpha-15 | Homo sapiens (Human) | SS |
| P50148 | GNAQ | Guanine nucleotide-binding protein G | Homo sapiens (Human) | SS |
| O95837 | GNA14 | Guanine nucleotide-binding protein subunit alpha-14 | Homo sapiens (Human) | SS |
| P21279 | Gnaq | Guanine nucleotide-binding protein G(q) subunit alpha | Mus musculus (Mouse) | PR |
| P30678 | Gna15 | Guanine nucleotide-binding protein subunit alpha-15 | Mus musculus (Mouse) | PR |
| Q2PKF4 | GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha | Sus scrofa (Pig) | PR |
| P93564 | GPA1 | Guanine nucleotide-binding protein alpha-1 subunit | Solanum tuberosum (Potato) | SS |
| O88302 | Gna15 | Guanine nucleotide-binding protein subunit alpha-15 | Rattus norvegicus (Rat) | SS |
| Q9JID2 | Gna11 | Guanine nucleotide-binding protein subunit alpha-11 | Rattus norvegicus (Rat) | SS |
| P82471 | Gnaq | Guanine nucleotide-binding protein G | Rattus norvegicus (Rat) | SS |
| Q0DJ33 | GPA1 | Guanine nucleotide-binding protein alpha-1 subunit | Oryza sativa subsp. japonica (Rice) | SS |
| P49084 | GPA1 | Guanine nucleotide-binding protein alpha-1 subunit | Glycine max (Soybean) (Glycine hispida) | SS |
| P93163 | GPA2 | Guanine nucleotide-binding protein alpha-2 subunit | Glycine max (Soybean) (Glycine hispida) | SS |
| O80462 | XLG1 | Extra-large guanine nucleotide-binding protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P18064 | GPA1 | Guanine nucleotide-binding protein alpha-1 subunit | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P26981 | GPA1 | Guanine nucleotide-binding protein alpha-1 subunit | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGCCCLSAE | EKESQRISAE | IERQLRRDKK | DARRELKLLL | LGTGESGKST | FIKQMRIIHG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SGYSDEDRKG | FTKLVYQNIF | TAMQAMIRAM | DTLKIQYVCE | QNKENAQLIR | EVEVDKVSTL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SRDQVEAIKQ | LWQDPGIQEC | YDRRREYQLS | DSAKYYLTDI | DRIAMPAFVP | TQQDVLRVRV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PTTGIIEYPF | DLENIIFRMV | DVGGQRSERR | KWIHCFESVT | SIIFLVALSE | YDQVLAECDN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ENRMEESKAL | FKTIITYPWF | LNSSVILFLN | KKDLLEEKIM | YSHLISYFPE | YTGPKQDVKA |
| 310 | 320 | 330 | 340 | 350 | |
| ARDFILKLYQ | DQNPDKEKVI | YSHFTCATDT | ENIRFVFAAV | KDTILQLNLR | EFNLV |