P38198
PR
Gene name |
STU1 (YBL034C, YBL0416) |
Protein name |
Protein STU1 |
Names |
Suppressor of tubulin 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YBL034C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P38198
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6COK | X-ray | 189 A | A | 249-567 | PDB |
| AF-P38198-F1 | Predicted | AlphaFoldDB |
31 variants for P38198
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s02-158228 | 55 | N>K | No | SGRP | |
| s02-158203 | 64 | A>T | No | SGRP | |
| s02-157791 | 201 | T>S | No | SGRP | |
| s02-157766 | 209 | N>K | No | SGRP | |
| s02-157620 | 258 | K>R | No | SGRP | |
| s02-157593 | 267 | D>V | No | SGRP | |
| s02-157334 | 353 | I>M | No | SGRP | |
| s02-157065 | 443 | I>T | No | SGRP | |
| s02-157043 | 450 | H>Q | No | SGRP | |
| s02-156688 | 569 | I>V | No | SGRP | |
| s02-156655 | 580 | A>T | No | SGRP | |
| s02-156264 | 710 | D>A | No | SGRP | |
| s02-155742 | 884 | N>T | No | SGRP | |
| s02-155594 | 933 | M>I | No | SGRP | |
| s02-155530 | 955 | I>F | No | SGRP | |
| s02-155430 | 988 | A>V | No | SGRP | |
| s02-155270 | 1041 | N>K | No | SGRP | |
| s02-155128 | 1089 | D>N | No | SGRP | |
| s02-155124 | 1090 | Q>L | No | SGRP | |
| s02-155112 | 1094 | A>G | No | SGRP | |
| s02-155112 | 1094 | A>V | No | SGRP | |
| s02-155020 | 1125 | R>G | No | SGRP | |
| s02-155013 | 1127 | L>S | No | SGRP | |
| s02-154929 | 1155 | G>E | No | SGRP | |
| s02-154845 | 1183 | I>N | No | SGRP | |
| s02-154743 | 1217 | L>P | No | SGRP | |
| s02-154622 | 1257 | K>N | No | SGRP | |
| s02-154548 | 1282 | C>Y | No | SGRP | |
| s02-154390 | 1335 | V>I | No | SGRP | |
| s02-154329 | 1355 | R>K | No | SGRP | |
| s02-153921 | 1491 | T>I | No | SGRP |
No associated diseases with P38198
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic microtubule | Any microtubule in the cytoplasm of a cell. |
| kinetochore | A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
| microtubule organizing center | An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. |
| mitotic spindle | A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. |
| mitotic spindle midzone | The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| polar microtubule | Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart. |
| spindle microtubule | Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| beta-tubulin binding | Binding to the microtubule constituent protein beta-tubulin. |
| kinetochore binding | Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached. |
| microtubule binding | Binding to a microtubule, a filament composed of tubulin monomers. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| astral microtubule depolymerization | The removal of tubulin heterodimers from one or both ends of an astral microtubule. An astral microtubule is any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. |
| attachment of spindle microtubules to kinetochore | The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| microtubule cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. |
| mitotic spindle assembly | Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9NBD7 | chb | CLIP-associating protein | Drosophila melanogaster (Fruit fly) | SS |
| Q7Z460 | CLASP1 | CLIP-associating protein 1 | Homo sapiens (Human) | SS |
| O75122 | CLASP2 | CLIP-associating protein 2 | Homo sapiens (Human) | EV |
| Q80TV8 | Clasp1 | CLIP-associating protein 1 | Mus musculus (Mouse) | SS |
| Q8BRT1 | Clasp2 | CLIP-associating protein 2 | Mus musculus (Mouse) | SS |
| Q99JD4 | Clasp2 | CLIP-associating protein 2 | Rattus norvegicus (Rat) | SS |
| Q6NYW6 | clasp2 | CLIP-associating protein 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSFNNETNN | NSNTNTHPDD | SFPLYTVFKD | ESVPIEEKMA | LLTRFKGHVK | KELVNESSIQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AYFAALLFIS | GHYAYRSYPR | LIFLSHSSLC | YLIKRVAMQS | PVQFNDTLVE | QLLNHLIFEL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PNEKKFWLAS | IKAIEAIYLV | NPSKIQAILA | NFLRRPSENQ | NGDYLNRIKS | TLLTIDELIQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| INEKNNSNHL | QLLRFFMLSF | TNLLNNNLNE | HANDDNNNVI | IELIFDIMYK | YLKMDDENSQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DLIDGFINDL | EVEKFKQKFI | SLAKSQDQHG | SQEDKSTLFD | EEYEFQLLLA | EAKLPQLSNN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LSSKDPAMKK | NYESLNQLQQ | DLENLLAPFQ | SVKETEQNWK | LRQSNIIELD | NIISGNIPKD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NPEEFVTVIK | EVQLIELISR | ATSSLRTTLS | LTALLFLKRL | IHILNDQLPL | SILDQIFVIF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KNLLSSTKKI | SSQTAFHCLI | TLIIDINHFH | NKLFQLSFLL | INEKTVTPRF | CSAILLRSFL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IKFNDSNLSL | NNSNTTSPTS | KLENNIIYIE | EWLKKGISDS | QTTVREAMRL | TFWYFYKCYP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TNAKRLLSSS | FSPQLKKATE | LAIPAHLNIN | YQVSRVSSTA | SASSATSRLY | SHSSNNSSRK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TSLLEQKRNY | PSYAQPTQSS | STSLLNAPAV | TAGGSVIASK | LSNKLKTNLR | STSEYSSKEN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EKRARHHDSM | NSVSNSNTKD | NNNVTKRKVS | APPSSTAATK | VSENYTNFDD | FPSNQIDLTD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ELSNSYSNPL | IKKYMDKNDV | SMSSSPISLK | GSNKLGEYET | LYKKFNDASF | PAQIKDALQY |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LQKELLLTSQ | QSSSAPKFEF | PMIMKKLRQI | MIKSPNDFKP | FLSIEKFTNG | VPLNYLIELY |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SINSFDYAEI | LKNRMNPEKP | YELTNLIITI | ADLFNFLNAN | NCPNDFKLYY | MKYKTTFFNY |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NFKLLLEIFR | NLNIKHDNTL | RSGTNDLMPK | ISMILFQIYG | KEFDYTCYFN | LIFEIYKFDN |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| NRFNKLLADF | DIVSTKMKIC | HELEKKDANF | KVEDIISRES | SVSFTPIDNK | KSEGDEESDD |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| AVDENDVKKC | MEMTMINPFK | NLETDKTLEL | KNNVGKRTSS | TDSVVIHDDN | DKDKKLSEMT |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| KIVSVYQLDQ | PNPAKEEDDI | DMENSQKSDL | NLSEIFQNSG | ENTERKLKDD | NEPTVKFSTD |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| PPKIINEPEK | LIGNGNENEK | PDLETMSPIK | INGDENMGQK | QRITVKRERD | VALTEQDINS |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| KKMKLVNNKK | SEKMHLLIMD | NFPRDSLTVY | EISHLLMVDS | NGNTLMDFDV | YFNHMSKAIN |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| RIKSGSFTMK | HINYLIEPLI | TCFQNQKMTD | WLTNENGFDE | LLDVAIMLLK | STDDTPSIPS |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| KISSKSIILV | HCLLVWKKFL | NTLSENADDD | GVSVRMCFEE | VWEQILLMLN | KFSDYGNEIY |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| KLAQEFRDSL | MLSHFFKKHS | ATRILSMLVT | EIQPDTAGVK | ETFLIETLWK | MLQSPTICQQ |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| FKKSNISEII | QTMSYFIMGT | DNTSWNFTSA | VVLARCLRVL | QTTPDYTEQE | TERLFDCLPK |
| 1510 | |||||
| NVFKMIMFIA | SNE |