P38144

PR
Gene name
ISW1 (YBR245C, YBR1633)
Protein name
ISWI chromatin-remodeling complex ATPase ISW1
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YBR245C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

47-203 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for P38144

Entry ID Method Resolution Chain Position Source
2Y9Y X-ray 325 A A 763-1129 PDB
2Y9Z X-ray 360 A A 763-1129 PDB
6IRO EM 340 A L 69-1129 PDB
6JYL EM 337 A K 69-1129 PDB
6K1P EM 387 A K 69-1129 PDB
7X3T EM 540 A V 68-1129 PDB
7X3W EM 310 A K 68-1129 PDB
7X3X EM 320 A V 68-1129 PDB
AF-P38144-F1 Predicted AlphaFoldDB

17 variants for P38144

Variant ID(s) Position Change Description Diseaes Association Provenance
s02-711450 29 N>D No SGRP
s02-711434 34 D>G No SGRP
s02-711411 42 L>F No SGRP
s02-711390 49 K>E No SGRP
s02-711177 120 K>E No SGRP
s02-711090 149 G>S No SGRP
s02-710802 245 P>S No SGRP
s02-709988 516 E>G No SGRP
s02-709870 555 E>D No SGRP
s02-709568 656 T>N No SGRP
s02-709266 757 D>N No SGRP
s02-709256 760 S>T No SGRP
s02-709023 838 V>I No SGRP
s02-708947 863 N>S No SGRP
s02-708791 915 A>V No SGRP
s02-708450 1029 E>Q No SGRP
s02-708197 1113 G>E No SGRP

No associated diseases with P38144

9 regional properties for P38144

Type Name Position InterPro Accession
domain SNF2, N-terminal 199 - 481 IPR000330
domain SANT/Myb domain 883 - 933 IPR001005-1
domain SANT/Myb domain 988 - 1052 IPR001005-2
domain Helicase, C-terminal 503 - 657 IPR001650
domain Helicase superfamily 1/2, ATP-binding domain 192 - 384 IPR014001
domain ISWI, HAND domain 776 - 883 IPR015194
domain SLIDE domain 941 - 1057 IPR015195
domain SANT domain 882 - 935 IPR017884
domain Isw1/2, N-terminal 193 - 414 IPR044754

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
Isw1 complex A protein complex that contains an Isw1 subunit from the ISWI-family of ATPases and acts to modify chromatin structure.
Isw1a complex An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc3p.
Isw1b complex An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc2p and Ioc4p.
nucleolar chromatin The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

8 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent activity, acting on DNA Catalytic activity that acts to modify DNA, driven by ATP hydrolysis.
ATP-dependent chromatin remodeler activity An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling.
helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
nucleosome binding Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
rDNA binding Binding to a DNA sequence encoding a ribosomal RNA.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

11 GO annotations of biological process

Name Definition
chromatin remodeling A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.
DNA-templated transcription elongation The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.
negative regulation of histone exchange Any process that stops, prevents or reduces the frequency, rate or extent of histone exchange.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of chromatin organization Any process that modulates the frequency, rate or extent of chromatin organization.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcriptional start site selection at RNA polymerase II promoter Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
sister chromatid cohesion The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
termination of RNA polymerase I transcription A transcription termination process that completes the production of a ribosomal RNA transcript. RNAP I termination requires binding of a terminator protein to specific sequences downstream of the transcription unit.
termination of RNA polymerase II transcription A transcription termination process that completes the production of a primary RNA polymerase II transcript.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P31380 FUN30 ATP-dependent helicase FUN30 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P32597 STH1 Nuclear protein STH1/NPS1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q24368 Iswi Chromatin-remodeling complex ATPase chain Iswi Drosophila melanogaster (Fruit fly) SS
P28370 SMARCA1 Probable global transcription activator SNF2L1 Homo sapiens (Human) SS
O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 Homo sapiens (Human) EV
Q6PGB8 Smarca1 Probable global transcription activator SNF2L1 Mus musculus (Mouse) SS
Q91ZW3 Smarca5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 Mus musculus (Mouse) SS
Q7G8Y3 Os01g0367900 Probable chromatin-remodeling complex ATPase chain Oryza sativa subsp japonica (Rice) PR
P41877 isw-1 Chromatin-remodeling complex ATPase chain isw-1 Caenorhabditis elegans SS
Q8RWY3 CHR11 ISWI chromatin-remodeling complex ATPase CHR11 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAYMLAIANF HFFKFYTRMR KKHENNSCNE KDKDENLFKI ILAIFLQEKK KYDCISSGSI
70 80 90 100 110 120
MTASEEYLEN LKPFQVGLPP HDPESNKKRY LLKDANGKKF DLEGTTKRFE HLLSLSGLFK
130 140 150 160 170 180
HFIESKAAKD PKFRQVLDVL EENKANGKGK GKHQDVRRRK TEHEEDAELL KEEDSDDDES
190 200 210 220 230 240
IEFQFRESPA YVNGQLRPYQ IQGVNWLVSL HKNKIAGILA DEMGLGKTLQ TISFLGYLRY
250 260 270 280 290 300
IEKIPGPFLV IAPKSTLNNW LREINRWTPD VNAFILQGDK EERAELIQKK LLGCDFDVVI
310 320 330 340 350 360
ASYEIIIREK SPLKKINWEY IIIDEAHRIK NEESMLSQVL REFTSRNRLL ITGTPLQNNL
370 380 390 400 410 420
HELWALLNFL LPDIFSDAQD FDDWFSSEST EEDQDKIVKQ LHTVLQPFLL RRIKSDVETS
430 440 450 460 470 480
LLPKKELNLY VGMSSMQKKW YKKILEKDLD AVNGSNGSKE SKTRLLNIMM QLRKCCNHPY
490 500 510 520 530 540
LFDGAEPGPP YTTDEHLVYN AAKLQVLDKL LKKLKEEGSR VLIFSQMSRL LDILEDYCYF
550 560 570 580 590 600
RNYEYCRIDG STAHEDRIQA IDDYNAPDSK KFVFLLTTRA GGLGINLTSA DVVVLYDSDW
610 620 630 640 650 660
NPQADLQAMD RAHRIGQKKQ VKVFRLVTDN SVEEKILERA TQKLRLDQLV IQQNRTSLKK
670 680 690 700 710 720
KENKADSKDA LLSMIQHGAA DVFKSGTSTG SAGTPEPGSG EKGDDIDLDE LLLKSENKTK
730 740 750 760 770 780
SLNAKYETLG LDDLQKFNQD SAYEWNGQDF KKKIQRDIIS PLLLNPTKRE RKENYSIDNY
790 800 810 820 830 840
YKDVLNTGRS STPSHPRMPK PHVFHSHQLQ PPQLKVLYEK ERMWTAKKTG YVPTMDDVKA
850 860 870 880 890 900
AYGDISDEEE KKQKLELLKL SVNNSQPLTE EEEKMKADWE SEGFTNWNKL EFRKFITVSG
910 920 930 940 950 960
KYGRNSIQAI ARELAPGKTL EEVRAYAKAF WSNIERIEDY EKYLKIIENE EEKIKRVKMQ
970 980 990 1000 1010 1020
QEALRRKLSE YKNPFFDLKL KHPPSSNNKR TYSEEEDRFI LLMLFKYGLD RDDVYELVRD
1030 1040 1050 1060 1070 1080
EIRDCPLFEL DFYFRSRTPV ELARRGNTLL QCLEKEFNAG IVLDDATKDR MKKEDENGKR
1090 1100 1110 1120
IREEFADQTA NEKENVDGVE SKKAKIEDTS NVGTEQLVAE KIPENETTH