P37276
SS
Gene name |
Dhc64C (cDhc, CG7507) |
Protein name |
Dynein heavy chain, cytoplasmic |
Names |
Dynein heavy chain, cytosolic , DYHC |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG7507 |
EC number |
|
Protein Class |
|
Descriptions
Cytoplasmic dynein (dynein hereafter) is an AAA+ motor responsible for nearly all motility and force generation towards the microtubule (MT) minus-end and involved in a wide variety of cellular functions, such as positioning of intracellular organelles, breakdown of the nuclear envelope and assembly of the mitotic spindle. The partial loss of dynein function has been implicated in a range of neurodegenerative and neurodevelopmental conditions, including spinal muscular atrophy, amyotrophic lateral sclerosis, Alzheimer's disease, and schizophrenia. <br>The core of the dynein complex is a homodimer of two heavy chains, the C-terminal motor domain of which is a catalytic ring of six AAA modules (AAA1-6). Dynein's MT binding domain is separated from the catalytic domain by a coiled-coil stalk. When dynein is not bound to its cargo, it forms two distinct conformations, the phi-particle, and open conformations, both of which move poorly along MTs. Formation of a dynein-dynactin-cargo adaptor complex aligns the dynein motor domains in a parallel conformation and activates processive motility along MTs. <br>Lissencephaly-1 (Lis-1) promotes the formation of the active complex with dynactin and also favors the recruitment of two dyneins to dynactin, resulting in increased velocity, higher force production and more effective competition against kinesin. Lis-1 binds to release dynein from its autoinhibited state and dissociates form motile complexes, indicating that its primary role is to orchestrate the assembly of the transport machinery.
Autoinhibitory domains (AIDs)
Target domain |
1890-3080 (Motor domain) |
Relief mechanism |
Partner binding |
Assay |
|
Target domain |
1890-3080 (Motor domain) |
Relief mechanism |
Partner binding |
Assay |
|
Target domain |
1857-4205 (Motor domain in other dynein-1) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
References
- Reimer JM et al. (2023) "Structures of human dynein in complex with the lissencephaly 1 protein, LIS1", eLife, 12,
- Zhang K et al. (2017) "Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated", Cell, 169, 1303-1314.e18
- Elshenawy MM et al. (2020) "Lis1 activates dynein motility by modulating its pairing with dynactin", Nature cell biology, 22, 570-578
- Karasmanis EP et al. (2023) "Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge", Nature structural & molecular biology, 30, 1357-1364
- Torisawa T et al. (2014) "Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein", Nature cell biology, 16, 1118-24
Autoinhibited structure
Activated structure
0 structures for P37276
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|
No variants for P37276
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P37276 | |||||
No associated diseases with P37276
15 regional properties for P37276
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AAA+ ATPase domain | 1890 - 2039 | IPR003593-1 |
| domain | AAA+ ATPase domain | 2202 - 2353 | IPR003593-2 |
| domain | AAA+ ATPase domain | 2572 - 2722 | IPR003593-3 |
| domain | AAA+ ATPase domain | 2914 - 3080 | IPR003593-4 |
| domain | Dynein heavy chain region D6 P-loop domain | 4020 - 4128 | IPR004273 |
| domain | Dynein heavy chain, tail | 242 - 826 | IPR013594 |
| domain | Dynein heavy chain, linker | 1312 - 1710 | IPR013602 |
| domain | Dynein heavy chain, AAA module D4 | 2893 - 3171 | IPR024317 |
| domain | Dynein heavy chain, coiled coil stalk | 3186 - 3518 | IPR024743 |
| domain | Dynein heavy chain, hydrolytic ATP-binding dynein motor region | 1857 - 2217 | IPR035699 |
| domain | Dynein heavy chain, ATP-binding dynein motor region | 3547 - 3766 | IPR035706 |
| domain | Dynein heavy chain, C-terminal domain | 4323 - 4633 | IPR041228 |
| domain | Dynein heavy chain, AAA 5 extension domain | 2412 - 2535 | IPR041466 |
| domain | Dynein heavy chain AAA lid domain | 4161 - 4315 | IPR041658 |
| domain | Dynein 2 heavy chain 1, cytoplasmic, ATPase lid domain | 2736 - 2828 | IPR054354 |
13 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon cytoplasm | Any cytoplasm that is part of a axon. |
| axonemal dynein complex | A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. |
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic dynein complex | Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains. |
| cytoplasmic microtubule | Any microtubule in the cytoplasm of a cell. |
| dynein complex | Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity. |
| fusome | A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| kinetochore | A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
| microtubule associated complex | Any multimeric complex connected to a microtubule. |
| posterior cell cortex | The region that lies just beneath the plasma membrane in the part of a cell that is closest to the posterior as defined by the developing, or existing, anterior/posterior axis. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction |
| dynein intermediate chain binding | Binding to an intermediate chain of the dynein complex. |
| dynein light intermediate chain binding | Binding to a light intermediate chain of the dynein complex. |
| microtubule motor activity | A motor activity that generates movement along a microtubule, driven by ATP hydrolysis. |
| minus-end-directed microtubule motor activity | A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis. |
41 GO annotations of biological process
| Name | Definition |
|---|---|
| axo-dendritic transport | The directed movement of organelles or molecules along microtubules in neuron projections. |
| border follicle cell migration | The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster. |
| cellularization | The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development. |
| centrosome cycle | The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle. |
| centrosome localization | Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell. |
| chitin-based cuticle development | Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster. |
| cystoblast division | Any of the rounds of incomplete mitosis undergone by a cystoblast to form a cyst of interconnected cells. |
| cytoplasmic microtubule organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. |
| dendrite morphogenesis | The process in which the anatomical structures of a dendrite are generated and organized. |
| establishment of epithelial cell apical/basal polarity | The specification and formation of the apicobasal polarity of an epithelial cell. |
| establishment of Golgi localization | The directed movement of the Golgi to a specific location. |
| establishment of mitotic spindle localization | The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs. |
| establishment or maintenance of epithelial cell apical/basal polarity | Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell. |
| fusome organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells. |
| germ-line cyst formation | Formation of a group of interconnected cells derived from a single gonial founder cell. |
| germarium-derived oocyte fate determination | The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster. |
| intracellular mRNA localization | Any process in which mRNA is transported to, or maintained in, a specific location within the cell. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| lumen formation, open tracheal system | Creation of the central hole of a tube in an open tracheal system through which gases flow. |
| maintenance of RNA location | Any process in which RNA is maintained in a location and prevented from moving elsewhere. |
| melanotic encapsulation of foreign target | Formation of a multilayered, melanized sheath of cells around a foreign invader. |
| microtubule-based movement | A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. |
| mitochondrion distribution | Any process that establishes the spatial arrangement of mitochondria between and within cells. |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
| mitotic spindle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. |
| mushroom body development | The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells. |
| neuroblast proliferation | The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. |
| nuclear migration | The directed movement of the nucleus to a specific location within a cell. |
| oocyte nucleus migration involved in oocyte dorsal/ventral axis specification | The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster. |
| oogenesis | The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. |
| ovarian fusome organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions. |
| pole cell formation | Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells. |
| positive regulation of mitotic centrosome separation | Any process that activates or increases the frequency, rate or extent of centrosome separation. |
| positive regulation of neuron remodeling | Any process that activates or increases the frequency, rate or extent of neuron remodeling. |
| protein localization to kinetochore | Any process in which a protein is transported to, or maintained at, the kinetochore. |
| regulation of mitotic metaphase/anaphase transition | Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. |
| retrograde axonal transport | The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons. |
| retrograde axonal transport of mitochondrion | The directed movement of mitochondria along microtubules in axons towards the cell body and away from the presynapse. |
| RNA transport | The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| spindle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart. |
| stress granule assembly | The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P36022 | DYN1 | Dynein heavy chain, cytoplasmic | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | EV |
| Q14204 | DYNC1H1 | Cytoplasmic dynein 1 heavy chain 1 | Homo sapiens (Human) | EV |
| Q9JHU4 | Dync1h1 | Cytoplasmic dynein 1 heavy chain 1 | Mus musculus (Mouse) | SS |
| P38650 | Dync1h1 | Cytoplasmic dynein 1 heavy chain 1 | Rattus norvegicus (Rat) | SS |
| Q19020 | dhc-1 | Dynein heavy chain, cytoplasmic | Caenorhabditis elegans | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGDSLENPDT | SVDPIVNLSI | ANYDAFANYL | RKAVTILLPE | DDVVPASLND | ALDDPVNQDT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IRKFLSDPQV | QALYVQRNCI | KEDDSEQPAE | GEDEKEQVTY | QISNDVHFTN | SRMASLACIK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RGLVVEADKS | IHSQLRLINF | SDGSPYETLH | AFISKSLAPY | FKSYVKESGR | ADRDGDKMAP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SVEKKLAELE | MGLLHLQQNI | DIPEITLTAH | QTVNNVIRKC | AEENRKAKVA | DFGDKVEDSS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FLNLLQNGVN | RWIAEIKKVT | KLNRDPGSGT | ALQEISFWLN | LERALYRIQE | KRESPEVALT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LDILKHGKRF | HATVSFDTDT | GLKQALATVA | DYNPLMKDFP | INDLLSATEL | EKIRPAVQQI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FAHLRKVRNT | KYPIQRCLKL | IEAISRDLSQ | QLLKVLGTRR | LMHIPFDEFE | RVMNQCFEIF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SCWDDEYDKL | QGLLRDIVKK | KRDEHLKMVW | RVSPAHKKLQ | TRMEHMRKFR | RQHEQLRTVI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LRVLRPTKPA | VGDDGNVVET | KQPYSLDAAD | ANAIEEVNLA | YENVKEVDCL | DITKEGSEAW |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EAAVKRYEEK | IDRVETRITA | HLRDQLGTAK | NANEMFRIFS | RFNALFVRPH | IRGAIREYQT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QLIQRVKDDI | EALHEKFKVQ | YPQSKSCRLS | SVRDLPPVAG | SIIWARQIDN | QLTMYLKRVE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DVLGKGWETH | IEGQKLKADG | DSFRAKLSIS | DVFHEWARKV | QERNFGSTGR | IFTIESTRSR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IGRGNVLRLR | VNFLPEIITL | AKEVRNIKNL | GFRVPLTIVN | KAHQANQIYP | YAISLIESVR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TYERTLEKIE | DRASIVPLVA | GLRKDVLNLV | SEGIGLIWES | YKLDPYVIRL | SECVTQFQEK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VDDLLVVEEQ | LDVDVRSLET | CPYSAATFVE | ILSKIQHAVD | DLSLRQYSNL | SVWVTRLDEE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VEKKLALRLQ | AGIQAWTEAL | TGNKKEVDTS | MDTDAPAQPT | HKLGGDPQIQ | NAVHEIRITN |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| QQMYLYPSIE | EARFQIMQQF | FAWQAIVTSQ | VRLQSTRYQV | GLEKHVSQTY | RNLLTKLPEG |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| KILENAYGAI | EQKVSEVRNY | VDEWLRYQSL | WDLQADMLYG | RLGEDVNLWI | KCLNDIKQSR |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| TTFDTSDTRR | AYGPIIIDYA | KVQAKVTLKY | DSWHKEALGK | FGTLLGTEMT | SFHSKVSKSR |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| TDLEMQSIEA | ASTSDAVSFI | TYVQSLKKDM | IAWDKQVEVF | REAQRILERQ | RFQFPNTWLH |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| VDNIEGEWSA | FNEIIKRKDT | AIQTQVASLQ | AKIVAEDKAV | ETRTVDFLND | WEKTKPTGGK |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| IRPDDALQQL | QIFESKYSRL | KEERDNVVKA | KEALELQESA | VPNNSAERMN | VALEELQDLR |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| GVWSELSKVW | TQIDETREKP | WLSVQPRKLR | QQLEAMMAQL | KELPARLRMY | ESYEYVKKLI |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| QSYIKVNMLI | VELKSDALKE | RHWKQLTKQL | RVNWVLSDLS | LGQVWDVNLQ | KNEGIVKDII |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| LVAQGEMALE | EFLKQVRESW | QNYELDLINY | QNKCRIIRGW | DDLFNKVKEH | INSVAAMKLS |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| PYYKVFEEEA | LTWEEKLNRI | NALFDVWIDV | QRRWVYLEGI | FSGSADIKTL | LPVETSRFQS |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| ISSEFLGLMK | KVTKSPKVMD | VLNIPAVQRS | LERLADLLGK | IQKALGEYLE | RERTSFPRFY |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| FVGDEDLLEI | IGNSKNIARL | QKHFKKMFAG | VAAILLNEEN | NVILGISSRE | GEEVHFMNPV |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| STVEHPKINE | WLSLVEKQMR | FTLASLLAQA | VQDIKQFRDG | KIDPQAYMEW | CDKYQAQIVV |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| LAAQILWSED | VESALQQASE | NNQSKPMQRV | LGNVESTLNV | LADSVLQEQP | PLRRRKLEHL |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| INEFVHKRTV | TRRLLNNGVT | SPKSFQWLCE | MRFYFDPRQT | EVLQQLTIHM | ANARFFYGFE |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| YLGVQDRLVQ | TPLTDRCYLT | MTQALESRLG | GSPFGPAGTG | KTESVKALGN | QLGRFVLVFN |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| CDETFDFQAM | GRIFVGLCQV | GAWGCFDEFN | RLEERMLSAC | SQQIQTIQEA | LKYEMDSNKE |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| SITVELVGKQ | VRVSPDMAIF | ITMNPGYAGR | SNLPDNLKKL | FRSLAMTTPD | RQLIAEVMLF |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| SQGFRSAEKL | ACKIVPFFKL | CDEQLSNQSH | YDFGLRALKS | VLISAGNVKR | DRIMKIKEQM |
| 2110 | 2120 | 2130 | 2140 | 2150 | 2160 |
| KQRGDENIDE | ASVAENLPEQ | EILIQSVCET | MVPKLVAEDI | PLLFSLLSDV | FPNVGYTRAE |
| 2170 | 2180 | 2190 | 2200 | 2210 | 2220 |
| MKGLKEEIRK | VCQEDYLVCG | EGDEQGAAWM | EKVLQLYQIS | NLNHGLMMVG | PSGSGKSTAW |
| 2230 | 2240 | 2250 | 2260 | 2270 | 2280 |
| KTLLKALERF | EGVEGVAHVI | DPKAISKEAL | YGVLDPNTRE | WTDGLFTHIL | RKIIDNVRGE |
| 2290 | 2300 | 2310 | 2320 | 2330 | 2340 |
| INKRQWIIFD | GDVDPEWVEN | LNSVLDDNKL | LTLPNGERLS | LPPNVRVMFE | VQDLKFATLA |
| 2350 | 2360 | 2370 | 2380 | 2390 | 2400 |
| TVSRCGMVWF | SEDVLSTEMI | FENYLSRLRS | IPLEDGDEDF | VGVIKPAKDK | EEEVSPSLQV |
| 2410 | 2420 | 2430 | 2440 | 2450 | 2460 |
| QRDIALLLLP | FFSADGIVVR | TLEYAMDQEH | IMDFTRLRAL | SSLFSMLNQA | ARNVLTFNAQ |
| 2470 | 2480 | 2490 | 2500 | 2510 | 2520 |
| HPDFPCSADQ | LEHYIPKALV | YSVLWSFAGD | AKLKVRIDLG | DFVRSVTTVP | LPGAAGAPII |
| 2530 | 2540 | 2550 | 2560 | 2570 | 2580 |
| DYEVNMSGDW | VPWSNKVPVI | EVETHKVASP | DIVVPTLDTV | RHESLLYTWL | AEHKPLVLCG |
| 2590 | 2600 | 2610 | 2620 | 2630 | 2640 |
| PPGSGKTMTL | FSALRALPDM | EVVGLNFSSA | TTPELLLKTF | DHYCEYRKTP | NGVVLSPVQI |
| 2650 | 2660 | 2670 | 2680 | 2690 | 2700 |
| GKWLVLFCDE | INLPDMDSYG | TQRVISFLRQ | LVEHKGFYRA | SDQAWVSLER | IQFVGACNPP |
| 2710 | 2720 | 2730 | 2740 | 2750 | 2760 |
| TDPGRKPLSH | RFLRHVPIIY | VDYPGETSLK | QIYGTFSRAM | LRLMPALRGY | AEPLTNAMVE |
| 2770 | 2780 | 2790 | 2800 | 2810 | 2820 |
| FYLASQDRFT | QDMQPHYVYS | PREMTRWVRG | ICEAIRPLDS | LPVEGLVRLW | AHEALRLFQD |
| 2830 | 2840 | 2850 | 2860 | 2870 | 2880 |
| RLVDDSERRW | TNENIDLVGQ | KHFPGINQEE | ALQRPILYSN | WLSKDYMPVN | REELREYVHA |
| 2890 | 2900 | 2910 | 2920 | 2930 | 2940 |
| RLKVFYEEEL | DVPLVLFDEV | LDHVLRIDRI | FRQPQGHLLL | IGVSGAGKTT | LSRFVAWMNG |
| 2950 | 2960 | 2970 | 2980 | 2990 | 3000 |
| LSIFQIKVHN | KYTSEDFDED | LRCVLRRSGC | KDEKIAFILD | ESNVLDSGFL | ERMNTLLANG |
| 3010 | 3020 | 3030 | 3040 | 3050 | 3060 |
| EVPGLFEGDE | YTTLMTQCKE | GAQREGLMLD | SSDELYKWFT | QQVMRNLHVV | FTMNPSTDGL |
| 3070 | 3080 | 3090 | 3100 | 3110 | 3120 |
| KDRAATSPAL | FNRCVLNWFG | DWSDSALFQV | GKEFTTRVDL | EKPNWHAPDF | FPSVCPLVPA |
| 3130 | 3140 | 3150 | 3160 | 3170 | 3180 |
| NPTHRDAVIN | SCVYVHQTLH | QANARLAKRG | GRTMAVTPRH | YLDFIHHFVK | LYNEKRSDLE |
| 3190 | 3200 | 3210 | 3220 | 3230 | 3240 |
| EQQLHLNVGL | NKIAETVEQV | EEMQKSLAVK | KQELQAKNEA | ANAKLKQMFQ | DQQEAEKKKI |
| 3250 | 3260 | 3270 | 3280 | 3290 | 3300 |
| QSQEIQIRLA | DQTVKIEEKR | KYVMADLAQV | EPAVIDAQAA | VKSIRKQQLV | EVRTMANPPS |
| 3310 | 3320 | 3330 | 3340 | 3350 | 3360 |
| VVKLALESIC | LLLGENATDW | KSIRAVIMRE | NFINSIVSNF | GTENITDDVR | EKMKSKYLSN |
| 3370 | 3380 | 3390 | 3400 | 3410 | 3420 |
| PDYNFEKVNR | ASMACGPMVK | WAIAQIEYAD | MLKRVEPLRE | ELRSLEEQAD | VNLASAKETK |
| 3430 | 3440 | 3450 | 3460 | 3470 | 3480 |
| DLVEQLERSI | AAYKEEYAQL | ISQAQAIKTD | LENVQAKVDR | SIALLKSLNI | ERERWESTSE |
| 3490 | 3500 | 3510 | 3520 | 3530 | 3540 |
| TFKSQMSTII | GDVLLSAAFI | AYGGYFDQHY | RLNLFTTWSQ | HLQAASIQYR | ADIARTEYLS |
| 3550 | 3560 | 3570 | 3580 | 3590 | 3600 |
| NPDERLRWQA | NALPTDDLCT | ENAIMLKRFN | RYPLIIDPSG | QATTFLLNEY | AGKKITKTSF |
| 3610 | 3620 | 3630 | 3640 | 3650 | 3660 |
| LDDSFRKNLE | SALRFGNPLL | VQDVENYDPI | LNPVLNRELR | RTGGRVLITL | GDQDIDLSPS |
| 3670 | 3680 | 3690 | 3700 | 3710 | 3720 |
| FVIFLSTRDP | TVEFPPDICS | RVTFVNFTVT | RSSLQSQCLN | QVLKAERPDI | DEKRSDLLKL |
| 3730 | 3740 | 3750 | 3760 | 3770 | 3780 |
| QGEFRLRLRQ | LEKSLLQALN | DAKGKILDDD | SVITTLETLK | KEAYDINQKV | DETDKVIAEI |
| 3790 | 3800 | 3810 | 3820 | 3830 | 3840 |
| ETVSQQYLPL | SVACSNIYFT | MDSLNQVHFL | YQYSLKMFLD | IFSTVLYNNP | KLEGRTDHSE |
| 3850 | 3860 | 3870 | 3880 | 3890 | 3900 |
| RLGIVTRDLF | QVCYERVARG | MIHIDRLTFA | LLMCKIHLKG | TSESNLDAEF | NFFLRSREGL |
| 3910 | 3920 | 3930 | 3940 | 3950 | 3960 |
| LANPTPVEGL | SAEQIESVNR | LALRLPIFRK | LLEKVRSIPE | LGAWLQQSSP | EQVVPQLWDE |
| 3970 | 3980 | 3990 | 4000 | 4010 | 4020 |
| SKALSPIASS | VHQLLLIQAF | RPDRVIAAAH | NVVNTVLGED | FMPNAEQELD | FTSVVDKQLN |
| 4030 | 4040 | 4050 | 4060 | 4070 | 4080 |
| CNTPALLCSV | PGFDASGRVD | DLAAEQNKQI | SSIAIGSAEG | FNQAERAINM | ACKTGRWVLL |
| 4090 | 4100 | 4110 | 4120 | 4130 | 4140 |
| KNVHLAPQWL | VQLEKKMHSL | QPHSGFRLFL | TMEINPKVPV | NLLRAGRIFV | FEPPPGIRAN |
| 4150 | 4160 | 4170 | 4180 | 4190 | 4200 |
| LLRTFSTVPA | ARMMKTPSER | ARLYFLLAWF | HAIVQERLRY | VPLGWAKKYE | FNESDLRVAC |
| 4210 | 4220 | 4230 | 4240 | 4250 | 4260 |
| DTLDTWIDTT | AMGRTNLPPE | KVPWDALVTL | LSQSIYGGKI | DNDFDQRLLT | SFLKKLFTAR |
| 4270 | 4280 | 4290 | 4300 | 4310 | 4320 |
| SFEADFALVA | NVDGASGGLR | HITMPDGTRR | DHFLKWIENL | TDRQTPSWLG | LPNNAEKVLL |
| 4330 | 4340 | 4350 | 4360 | 4370 | 4380 |
| TTRGTDLVSK | LLKMQQLEDD | DELAYSVEDQ | SEQSAVGRGE | DGRPSWMKTL | HNSATAWLEL |
| 4390 | 4400 | 4410 | 4420 | 4430 | 4440 |
| LPKNLQVLKR | TVENIKDPLY | RYFEREVTSG | SRLLQTVILD | LQDVVLICQG | EKKQTNHHRS |
| 4450 | 4460 | 4470 | 4480 | 4490 | 4500 |
| MLSELVRGII | PKGWKRYTVP | AGCTVIQWIT | DFSNRVQQLQ | KVSQLVSQAG | AKELQGFPVW |
| 4510 | 4520 | 4530 | 4540 | 4550 | 4560 |
| LGGLLNPEAY | ITATRQCVAQ | ANSWSLEELA | LDVTITDAGL | KNDQKDCCFG | VTGLKLQGAQ |
| 4570 | 4580 | 4590 | 4600 | 4610 | 4620 |
| CKNNELLLAS | TIMMDLPVTI | LKWIKISSEP | RISKLTLPVY | LNSTRTELLF | TVDLAVAAGQ |
| 4630 | |||||
| ESHSFYERGV | AVLTSTALN |