P36022
EV
Gene name |
DYN1 (DHC1, YKR054C) |
Protein name |
Dynein heavy chain, cytoplasmic |
Names |
Dynein heavy chain, cytosolic , DYHC |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YKR054C |
EC number |
|
Protein Class |
DYNEIN HEAVY CHAIN FAMILY PROTEIN (PTHR10676) |
Descriptions
Cytoplasmic dynein-1 (DYN1) is the main minus-end-directed microtubule motor responsible for transporting vesicles, protein complexes, RNAs, organelles, and viruses along microtubules. Lone, single dynein molecules are in an autoinhibited state, in which the two motor heads are stacked together. In this state, dynein moves diffusively along a microtubule with only a small bias towards the minus end of the microtubule. When the two heads were physically separated by a rigid rod, the movement of dynein molecules became directed and processive. In addition, assembly of multiple dynein molecules on a single cargo enables them to move unidirectionally and generate force cooperatively.
Autoinhibition of cytoplasmic dynein-1 is relieved by Lis1 acting as a molecular wedge. Lis1 is the only dynein regulator known to bind directly to dynein’s AAA+ motor domain, with two known binding sites: one on dynein’s motor domain between AAA3 and AAA4, and the other on dynein’s stalk, a long antiparallel coiled coil that leads to dynein’s microtubule-binding domain. This interaction with Lis1 induces significant conformational changes, facilitating the transition from an autoinhibited 'Phi' state to an active complex involving dynein, dynactin, and activating adapters.
Autoinhibitory domains (AIDs)
Target domain |
1758-3970 (Motor domain in other dynein-1) |
Relief mechanism |
Partner binding |
Assay |
Structural analysis, Mutagenesis experiment, Deletion assay |
Accessory elements
No accessory elements
References
- Karasmanis EP et al. (2023) "Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge", Nature structural & molecular biology, 30, 1357-1364
- Torisawa T et al. (2014) "Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein", Nature cell biology, 16, 1118-24
Autoinhibited structure
Activated structure
20 structures for P36022
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3J67 | EM | 3400 A | A | 1554-4092 | PDB |
| 3J68 | EM | 3000 A | A | 1554-4092 | PDB |
| 3QMZ | X-ray | 600 A | A/B | 1364-4092 | PDB |
| 4AI6 | X-ray | 340 A | A/B | 1364-4092 | PDB |
| 4AKG | X-ray | 330 A | A/B | 1364-4092 | PDB |
| 4AKH | X-ray | 360 A | A/B | 1364-4092 | PDB |
| 4AKI | X-ray | 370 A | A/B | 1364-4092 | PDB |
| 4W8F | X-ray | 354 A | PDB | ||
| 5AFR | X-ray | 500 A | A/B | 1-557 | PDB |
| 5VH9 | EM | 770 A | A | 1448-4092 | PDB |
| 5VLJ | EM | 1050 A | A | 1448-4092 | PDB |
| 6KIO | EM | 394 A | M | 3095-3224 | PDB |
| 6KIQ | EM | 362 A | M | 3095-3224 | PDB |
| 6KJN | NMR | - | A | 3095-3232 | PDB |
| 6KJO | NMR | - | A | 3095-3232 | PDB |
| 7MGM | EM | 310 A | A | 1219-4092 | PDB |
| 7MI1 | X-ray | 450 A | PDB | ||
| 7MI3 | EM | 350 A | PDB | ||
| 7MI6 | EM | 390 A | PDB | ||
| 7MI8 | EM | 370 A | PDB |
90 variants for P36022
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s11-547563 | 2 | C>F | No | SGRP | |
| s11-547497 | 24 | K>R | No | SGRP | |
| s11-547459 | 37 | Y>H | No | SGRP | |
| s11-547364 | 68 | E>D | No | SGRP | |
| s11-547216 | 118 | I>L | No | SGRP | |
| s11-546979 | 197 | K>E | No | SGRP | |
| s11-546718 | 284 | A>T | No | SGRP | |
| s11-546606 | 321 | V>A | No | SGRP | |
| s11-546594 | 325 | S>N | No | SGRP | |
| s11-546576 | 331 | Q>L | No | SGRP | |
| s11-546519 | 350 | P>Q | No | SGRP | |
| s11-546505 | 355 | V>I | No | SGRP | |
| s11-546344 | 408 | L>F | No | SGRP | |
| s11-546201 | 456 | S>N | No | SGRP | |
| s11-546045 | 508 | T>M | No | SGRP | |
| s11-546029 | 513 | M>I | No | SGRP | |
| s11-545763 | 602 | Q>L | No | SGRP | |
| s11-545605 | 655 | T>A | No | SGRP | |
| s11-545506 | 688 | S>G | No | SGRP | |
| s11-545253 | 772 | C>F | No | SGRP | |
| s11-545079 | 830 | A>V | No | SGRP | |
| s11-545058 | 837 | T>I | No | SGRP | |
| s11-545047 | 841 | T>A | No | SGRP | |
| s11-544927 | 881 | N>D | No | SGRP | |
| s11-544794 | 925 | T>N | No | SGRP | |
| s11-544709 | 953 | I>M | No | SGRP | |
| s11-544498 | 1024 | R>S | No | SGRP | |
| s11-544440 | 1043 | E>G | No | SGRP | |
| s11-544406 | 1054 | N>K | No | SGRP | |
| s11-544324 | 1082 | V>L | No | SGRP | |
| s11-544297 | 1091 | D>Y | No | SGRP | |
| s11-544222 | 1116 | V>I | No | SGRP | |
| s11-544101 | 1156 | N>T | No | SGRP | |
| s11-544015 | 1185 | K>E | No | SGRP | |
| s11-544012 | 1186 | I>L | No | SGRP | |
| s11-543825 | 1248 | T>I | No | SGRP | |
| s11-543766 | 1268 | F>I | No | SGRP | |
| s11-543661 | 1303 | V>M | No | SGRP | |
| s11-543483 | 1362 | Q>R | No | SGRP | |
| s11-543441 | 1376 | K>I | No | SGRP | |
| s11-543408 | 1387 | E>G | No | SGRP | |
| s11-543370 | 1400 | V>I | No | SGRP | |
| s11-542845 | 1575 | L>F | No | SGRP | |
| s11-542835 | 1578 | F>S | No | SGRP | |
| s11-542643 | 1642 | K>T | No | SGRP | |
| s11-542566 | 1668 | Q>E | No | SGRP | |
| s11-542239 | 1777 | I>V | No | SGRP | |
| s11-541618 | 1984 | I>V | No | SGRP | |
| s11-541441 | 2043 | Q>K | No | SGRP | |
| s11-541434 | 2045 | S>N | No | SGRP | |
| s11-541213 | 2119 | L>V | No | SGRP | |
| s11-540996 | 2191 | R>H | No | SGRP | |
| s11-540697 | 2291 | A>T | No | SGRP | |
| s11-540675 | 2298 | Y>C | No | SGRP | |
| s11-540643 | 2309 | S>C | No | SGRP | |
| s11-540588 | 2327 | A>V | No | SGRP | |
| s11-540546 | 2341 | T>I | No | SGRP | |
| s11-540517 | 2351 | Q>E | No | SGRP | |
| s11-540447 | 2374 | E>G | No | SGRP | |
| s11-540277 | 2431 | A>S | No | SGRP | |
| s11-540247 | 2441 | V>I | No | SGRP | |
| s11-539968 | 2534 | A>T | No | SGRP | |
| s11-539739 | 2610 | G>A | No | SGRP | |
| s11-539133 | 2812 | R>H | No | SGRP | |
| s11-538762 | 2936 | I>V | No | SGRP | |
| s11-538744 | 2942 | D>N | No | SGRP | |
| s11-538699 | 2957 | P>S | No | SGRP | |
| s11-538575 | 2998 | A>V | No | SGRP | |
| s11-538382 | 3062 | E>D | No | SGRP | |
| s11-538292 | 3092 | E>D | No | SGRP | |
| s11-538268 | 3100 | D>E | No | SGRP | |
| s11-538237 | 3111 | G>C | No | SGRP | |
| s11-537969 | 3200 | N>S | No | SGRP | |
| s11-537819 | 3250 | A>V | No | SGRP | |
| s11-537771 | 3266 | R>Q | No | SGRP | |
| s11-537540 | 3343 | A>G | No | SGRP | |
| s11-537349 | 3407 | L>F | No | SGRP | |
| s11-537258 | 3437 | V>A | No | SGRP | |
| s11-537238 | 3444 | I>V | No | SGRP | |
| s11-536901 | 3556 | K>R | No | SGRP | |
| s11-536587 | 3661 | S>P | No | SGRP | |
| s11-536506 | 3688 | T>A | No | SGRP | |
| s11-536359 | 3737 | T>A | No | SGRP | |
| s11-536344 | 3742 | N>D | No | SGRP | |
| s11-535885 | 3895 | F>V | No | SGRP | |
| s11-535750 | 3940 | T>A | No | SGRP | |
| s11-535587 | 3994 | Y>F | No | SGRP | |
| s11-535501 | 4023 | I>V | No | SGRP | |
| s11-535455 | 4038 | E>A | No | SGRP | |
| s11-535354 | 4072 | N>D | No | SGRP |
No associated diseases with P36022
13 regional properties for P36022
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AAA+ ATPase domain | 1788 - 2114 | IPR003593-1 |
| domain | AAA+ ATPase domain | 2410 - 2560 | IPR003593-2 |
| domain | AAA+ ATPase domain | 2752 - 2918 | IPR003593-3 |
| domain | Dynein heavy chain region D6 P-loop domain | 3792 - 3894 | IPR004273 |
| domain | Dynein heavy chain, tail | 220 - 763 | IPR013594 |
| domain | Dynein heavy chain, linker | 1221 - 1626 | IPR013602 |
| domain | Dynein heavy chain, AAA module D4 | 2732 - 2935 | IPR024317 |
| domain | Dynein heavy chain, coiled coil stalk | 3018 - 3346 | IPR024743 |
| domain | Dynein heavy chain, hydrolytic ATP-binding dynein motor region | 1758 - 2081 | IPR035699 |
| domain | Dynein heavy chain, ATP-binding dynein motor region | 3378 - 3597 | IPR035706 |
| domain | Dynein heavy chain 3, AAA+ lid domain | 2608 - 2681 | IPR041589 |
| domain | Dynein heavy chain AAA lid domain | 3929 - 4016 | IPR041658 |
| domain | DYN1, AAA+ ATPase lid domain | 2223 - 2358 | IPR048404 |
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR10676 | DYNEIN HEAVY CHAIN FAMILY PROTEIN |
| PANTHER Subfamily | PTHR10676:SF314 | CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1 |
| PANTHER Protein Class |
microtubule binding motor protein
microtubule or microtubule-binding cytoskeletal protein |
|
| PANTHER Pathway Category |
Huntington disease Dynein complex |
|
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| astral microtubule | Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. |
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic dynein complex | Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains. |
| cytoplasmic microtubule | Any microtubule in the cytoplasm of a cell. |
| spindle pole body | The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction |
| dynein intermediate chain binding | Binding to an intermediate chain of the dynein complex. |
| dynein light intermediate chain binding | Binding to a light intermediate chain of the dynein complex. |
| minus-end-directed microtubule motor activity | A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cytoplasmic microtubule organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. |
| establishment of mitotic spindle localization | The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs. |
| establishment of mitotic spindle orientation | A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. |
| karyogamy | The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. |
| mitotic sister chromatid segregation | The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. |
| mitotic spindle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. |
| nuclear migration | The directed movement of the nucleus to a specific location within a cell. |
| nuclear migration along microtubule | The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P37276 | Dhc64C | Dynein heavy chain, cytoplasmic | Drosophila melanogaster (Fruit fly) | SS |
| Q14204 | DYNC1H1 | Cytoplasmic dynein 1 heavy chain 1 | Homo sapiens (Human) | EV |
| Q9JHU4 | Dync1h1 | Cytoplasmic dynein 1 heavy chain 1 | Mus musculus (Mouse) | SS |
| P38650 | Dync1h1 | Cytoplasmic dynein 1 heavy chain 1 | Rattus norvegicus (Rat) | SS |
| Q19020 | dhc-1 | Dynein heavy chain, cytoplasmic | Caenorhabditis elegans | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MCKNEARLAN | ELIEFVAATV | TGIKNSPKEN | EQAFIDYLHC | QYLERFQFFL | GLLDGREFDT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LFVFLFEELD | RTIVTIDIGE | EAIYDANLAN | KKYSTLLIIK | SRSVIVDAEP | IATQISAIYL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PGPVNAGNLA | SIITHGVSSV | FGQLIKSDTK | TYSVETIDKT | RRKLDDISKQ | FQQLHTSIET |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PDLLAMVPSI | IKLAVSKGAT | SHDYANYLPS | NDLESMRFLN | ILQSIANKWF | LVLKQTLAID |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RDIKNGSFLD | EVEFWSNFYE | VLKSLIEQTQ | SQEFQVCLSV | LTNAKRFHNL | TNLLNEGSLS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DKFKLADKYN | QFLSSIPIDE | VRQASNLEDL | QELFPVLASS | LKKFRYSGYP | VQRFVVLMDK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ISQEVMDAIL | SNLSDLFQLE | YGSFLGLYEK | SAGMIEEWDD | IVQDVNLLIR | EDLRKRAPQE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLIQKLTFTS | ASVKATLDEI | LSTRKRFFSL | AETIKSISPS | TYHEEIQRLY | HPFEQIHDIS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VNFRLKLEQA | ESEFSKNMLD | LEKKLQNTLA | SFMDSDHCPT | EKLSYLVKFK | PLMELCPRIK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VKVLENQQIL | LLEIKKDIRQ | LETGLELLPK | ILHVEALNNI | PPISARISYF | LNVQSRIDNI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VQYLEALFGS | NWNDTLEGRS | ISTSIVQLRK | ETNPHDVFLH | WLGNFPEKAT | ANLLTTPILK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LIRNNEDDYE | LKVNFDFALA | AAYSELRSLT | YMAFQVPSHI | VRIARTYMYL | YPRAINLVEL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IQTFFSLSKS | LSYTFYTNIF | LKRNVQTVWL | LLQQILITPW | ESLQEESSEM | SCSVHSLARL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EKSIDGILSD | YQILKNSEPQ | FAKEFSGLKS | FDGTADDLHE | VEEIISNIQA | IFENLFTKGL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TNVSDHISTF | NNLIISIILE | KVRLNLKKMH | FPKHVLKLSF | NEGRITSSPS | LAAMKRSLLK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| DIEALLNKVV | LINFLHDPDH | PLSTTLTFNS | LVIKLKDDIQ | NCIEQVQNLH | CKINSYVKEW |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| QKMEFLWQIT | EEAFLEVVDN | STQRCFGILK | GLLDSQSKFD | LIISRNNFSK | NLVLHTEDAQ |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| RHIRSKMDSW | ILYVSKHLLT | IYERDARKLH | EDMNRDREAV | EDMDINFTSL | KNITVIIEAV |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| NVNKRHLTER | DIQIKLLGSV | MRALTKLKVR | FPSHFVYIDQ | LDNDFSSLRQ | SLSYVEQELQ |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| KHRVVIAKSL | EEGVENINNL | SQSLNESWSV | RKPISPTLTP | PEALKILEFF | NESITKLKKK |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| MHSVAAAAKM | LLIPVVLNDQ | LTHVVEEVKT | YDLVWRSIKN | LWEDVQRTFE | TPWCRVDVLL |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| LQSDLANFLR | RADELPRAVK | QFEMYKSLFS | QVNMLTSVNK | ILVELKDGAL | KPRHWNMIFR |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| DIGKRQIQKN | LLDKLEFSLK | DVMVLNLTLN | EILLTKIIER | AQKEFVIEKS | LNRIKKFWKE |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| AQYEVIEHSS | GLKLVREWDV | LEQACKEDLE | ELVSMKASNY | YKIFEQDCLD | LESKLTKLSE |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| IQVNWVEVQF | YWLDLYGILG | ENLDIQNFLP | LETSKFKSLT | SEYKMITTRA | FQLDTTIEVI |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| HIPNFDTTLK | LTIDSLKMIK | SSLSTFLERQ | RRQFPRFYFL | GNDDLLKIIG | SGKHHDQVSK |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| FMKKMFGSIE | SIIFLEDFIT | GVRSVEGEVL | NLNEKIELKD | SIQAQEWLNI | LDTEIKLSVF |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| TQFRDCLGQL | KDGTDIEVVV | SKYIFQAILL | SAQVMWTELV | EKCLQTNQFS | KYWKEVDMKI |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| KGLLDKLNKS | SDNVKKKIEA | LLVEYLHFNN | VIGQLKNCST | KEEARLLWAK | VQKFYQKNDT |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| LDDLNSVFIS | QSGYLLQYKF | EYIGIPERLI | YTPLLLIGFA | TLTDSLHQKY | GGCFFGPAGT |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| GKTETVKAFG | QNLGRVVVVF | NCDDSFDYQV | LSRLLVGITQ | IGAWGCFDEF | NRLDEKVLSA |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| VSANIQQIQN | GLQVGKSHIT | LLEEETPLSP | HTAVFITLNP | GYNGRSELPE | NLKKSFREFS |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| MKSPQSGTIA | EMILQIMGFE | DSKSLASKIV | HFLELLSSKC | SSMNHYHFGL | RTLKGVLRNC |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| SPLISEFGEG | EKTVVESLKR | VILPSLGDTD | ELVFKDELSK | IFDSAGTPLN | SKAIVQCLKD |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| AGQRSGFSMS | EEFLKKCMQF | YYMQKTQQAL | ILVGKAGCGK | TATWKTVIDA | MAIFDGHANV |
| 2110 | 2120 | 2130 | 2140 | 2150 | 2160 |
| VYVIDTKVLT | KESLYGSMLK | ATLEWRDGLF | TSILRRVNDD | ITGTFKNSRI | WVVFDSDLDP |
| 2170 | 2180 | 2190 | 2200 | 2210 | 2220 |
| EYVEAMNSVL | DDNKILTLPN | GERLPIPPNF | RILFETDNLD | HTTPATITRC | GLLWFSTDVC |
| 2230 | 2240 | 2250 | 2260 | 2270 | 2280 |
| SISSKIDHLL | NKSYEALDNK | LSMFELDKLK | DLISDSFDMA | SLTNIFTCSN | DLVHILGVRT |
| 2290 | 2300 | 2310 | 2320 | 2330 | 2340 |
| FNKLETAVQL | AVHLISSYRQ | WFQNLDDKSL | KDVITLLIKR | SLLYALAGDS | TGESQRAFIQ |
| 2350 | 2360 | 2370 | 2380 | 2390 | 2400 |
| TINTYFGHDS | QELSDYSTIV | IANDKLSFSS | FCSEIPSVSL | EAHEVMRPDI | VIPTIDTIKH |
| 2410 | 2420 | 2430 | 2440 | 2450 | 2460 |
| EKIFYDLLNS | KRGIILCGPP | GSGKTMIMNN | ALRNSSLYDV | VGINFSKDTT | TEHILSALHR |
| 2470 | 2480 | 2490 | 2500 | 2510 | 2520 |
| HTNYVTTSKG | LTLLPKSDIK | NLVLFCDEIN | LPKLDKYGSQ | NVVLFLRQLM | EKQGFWKTPE |
| 2530 | 2540 | 2550 | 2560 | 2570 | 2580 |
| NKWVTIERIH | IVGACNPPTD | PGRIPMSERF | TRHAAILYLG | YPSGKSLSQI | YEIYYKAIFK |
| 2590 | 2600 | 2610 | 2620 | 2630 | 2640 |
| LVPEFRSYTE | PFARASVHLY | NECKARYSTG | LQSHYLFSPR | ELTRLVRGVY | TAINTGPRQT |
| 2650 | 2660 | 2670 | 2680 | 2690 | 2700 |
| LRSLIRLWAY | EAWRIFADRL | VGVKEKNSFE | QLLYETVDKY | LPNQDLGNIS | STSLLFSGLL |
| 2710 | 2720 | 2730 | 2740 | 2750 | 2760 |
| SLDFKEVNKT | DLVNFIEERF | KTFCDEELEV | PMVIHESMVD | HILRIDRALK | QVQGHMMLIG |
| 2770 | 2780 | 2790 | 2800 | 2810 | 2820 |
| ASRTGKTILT | RFVAWLNGLK | IVQPKIHRHS | NLSDFDMILK | KAISDCSLKE | SRTCLIIDES |
| 2830 | 2840 | 2850 | 2860 | 2870 | 2880 |
| NILETAFLER | MNTLLANADI | PDLFQGEEYD | KLLNNLRNKT | RSLGLLLDTE | QELYDWFVGE |
| 2890 | 2900 | 2910 | 2920 | 2930 | 2940 |
| IAKNLHVVFT | ICDPTNNKSS | AMISSPALFN | RCIINWMGDW | DTKTMSQVAN | NMVDVIPMEF |
| 2950 | 2960 | 2970 | 2980 | 2990 | 3000 |
| TDFIVPEVNK | ELVFTEPIQT | IRDAVVNILI | HFDRNFYQKM | KVGVNPRSPG | YFIDGLRALV |
| 3010 | 3020 | 3030 | 3040 | 3050 | 3060 |
| KLVTAKYQDL | QENQRFVNVG | LEKLNESVLK | VNELNKTLSK | KSTELTEKEK | EARSTLDKML |
| 3070 | 3080 | 3090 | 3100 | 3110 | 3120 |
| MEQNESERKQ | EATEEIKKIL | KVQEEDIRKR | KEVVMKSIQD | IEPTILEAQR | GVKNIKKQQL |
| 3130 | 3140 | 3150 | 3160 | 3170 | 3180 |
| TEIRSMVNPP | SGVKIVMEAV | CAILGYQFSN | WRDIQQFIRK | DDFIHNIVHY | DTTLHMKPQI |
| 3190 | 3200 | 3210 | 3220 | 3230 | 3240 |
| RKYMEEEFLS | DPNFTYETIN | RASKACGPLY | QWVNAQINFS | KVLENVDPLR | QEMKRIEFES |
| 3250 | 3260 | 3270 | 3280 | 3290 | 3300 |
| LKTKANLLAA | EEMTQDLEAS | IEVSKRKYSL | LIRDVEAIKT | EMSNVQANLD | RSISLVKSLT |
| 3310 | 3320 | 3330 | 3340 | 3350 | 3360 |
| FEKERWLNTT | KQFSKTSQEL | IGNCIISSIY | ETYFGHLNER | ERADMLVILK | RLLGKFAVKY |
| 3370 | 3380 | 3390 | 3400 | 3410 | 3420 |
| DVNYRFIDYL | VTLDEKMKWL | ECGLDKNDYF | LENMSIVMNS | QDAVPFLLDP | SSHMITVISN |
| 3430 | 3440 | 3450 | 3460 | 3470 | 3480 |
| YYGNKTVLLS | FLEEGFVKRL | ENAIRFGSVV | IIQDGEFFDP | IISRLISREF | NHAGNRVTVE |
| 3490 | 3500 | 3510 | 3520 | 3530 | 3540 |
| IGDHEVDVSG | DFKLFIHSCD | PSGDIPIFLR | SRVRLVHFVT | NKESIETRIF | DITLTEENAE |
| 3550 | 3560 | 3570 | 3580 | 3590 | 3600 |
| MQRKREDLIK | LNTEYKLKLK | NLEKRLLEEL | NNSQGNMLEN | DELMVTLNNL | KKEAMNIEKK |
| 3610 | 3620 | 3630 | 3640 | 3650 | 3660 |
| LSESEEFFPQ | FDNLVEEYSI | IGKHSVKIFS | MLEKFGQFHW | FYGISIGQFL | SCFKRVFIKK |
| 3670 | 3680 | 3690 | 3700 | 3710 | 3720 |
| SRETRAARTR | VDEILWLLYQ | EVYCQFSTAL | DKKFKMIMAM | TMFCLYKFDI | ESEQYKEAVL |
| 3730 | 3740 | 3750 | 3760 | 3770 | 3780 |
| TMIGVLSESS | DGVPKLTVDT | NNDLRYLWDY | VTTKSYISAL | NWFKNEFFVD | EWNIADVVAN |
| 3790 | 3800 | 3810 | 3820 | 3830 | 3840 |
| SENNYFTMAS | ERDVDGTFKL | IELAKASKES | LKIIPLGSIE | NLNYAQEEIS | KSKIEGGWIL |
| 3850 | 3860 | 3870 | 3880 | 3890 | 3900 |
| LQNIQMSLSW | VKTYLHKHVE | ETKAAEEHEK | FKMFMTCHLT | GDKLPAPLLQ | RTDRFVYEDI |
| 3910 | 3920 | 3930 | 3940 | 3950 | 3960 |
| PGILDTVKDL | WGSQFFTGKI | SGVWSVYCTF | LLSWFHALIT | ARTRLVPHGF | SKKYYFNDCD |
| 3970 | 3980 | 3990 | 4000 | 4010 | 4020 |
| FQFASVYLEN | VLATNSTNNI | PWAQVRDHIA | TIVYGGKIDE | EKDLEVVAKL | CAHVFCGSDN |
| 4030 | 4040 | 4050 | 4060 | 4070 | 4080 |
| LQIVPGVRIP | QPLLQQSEEE | ERARLTAILS | NTIEPADSLS | SWLQLPRESI | LNYERLQAKE |
| 4090 | |||||
| VASSTEQLLQ | EM |