P36006
PR
Gene name |
MYO3 (YKL129C) |
Protein name |
Myosin-3 |
Names |
Actin-dependent myosin-I MYO3, Class I unconventional myosin MYO3, Type I myosin MYO3 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YKL129C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P36006
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1RUW | X-ray | 180 A | A | 1121-1189 | PDB |
| 1VA7 | X-ray | 290 A | A/B/C/D | 1121-1189 | PDB |
| 2BTT | NMR | - | A | 1121-1189 | PDB |
| AF-P36006-F1 | Predicted | AlphaFoldDB |
24 variants for P36006
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s11-200052 | 38 | I>V | No | SGRP | |
| s11-199509 | 219 | G>S | No | SGRP | |
| s11-199439 | 242 | K>R | No | SGRP | |
| s11-199433 | 244 | M>T | No | SGRP | |
| s11-199289 | 293 | I>N | No | SGRP | |
| s11-199268 | 300 | I>N | No | SGRP | |
| s11-198815 | 451 | R>K | No | SGRP | |
| s11-198797 | 457 | T>I | No | SGRP | |
| s11-198535 | 544 | Q>H | No | SGRP | |
| s11-198032 | 712 | D>G | No | SGRP | |
| s11-197499 | 890 | S>P | No | SGRP | |
| s11-197363 | 935 | S>L | No | SGRP | |
| s11-197328 | 947 | I>V | No | SGRP | |
| s11-197169 | 1000 | H>N | No | SGRP | |
| s11-197010 | 1053 | H>N | No | SGRP | |
| s11-196965 | 1068 | A>T | No | SGRP | |
| s11-196915 | 1084 | M>I | No | SGRP | |
| s11-196913 | 1085 | P>Q | No | SGRP | |
| s11-196805 | 1121 | K>R | No | SGRP | |
| s11-196799 | 1123 | P>L | No | SGRP | |
| s11-196623 | 1182 | D>Y | No | SGRP | |
| s11-196559 | 1203 | S>L | No | SGRP | |
| s11-196403 | 1255 | A>V | No | SGRP | |
| s11-196394 | 1258 | A>V | No | SGRP |
No associated diseases with P36006
5 regional properties for P36006
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SH3 domain | 1120 - 1182 | IPR001452 |
| domain | Myosin head, motor domain | 30 - 716 | IPR001609 |
| domain | Class I myosin tail homology domain | 760 - 961 | IPR010926 |
| domain | Fungal myosin-I, SH3 domain | 1125 - 1179 | IPR035535 |
| domain | Class I myosin, motor domain | 50 - 702 | IPR036072 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cortical patch | An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae. |
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| cell periphery | The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. |
| cell tip | The region at the end of the longest axis of a cylindrical or elongated cell. |
| myosin complex | A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. |
| microfilament motor activity | A motor activity that generates movement along a microfilament, driven by ATP hydrolysis. |
| myosin binding | Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cortical patch localization | Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells. |
| actin filament organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. |
| bipolar cellular bud site selection | The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell. |
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| fungal-type cell wall organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall. |
| positive regulation of Arp2/3 complex-mediated actin nucleation | Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation. |
| response to osmotic stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. |
| vesicle transport along actin filament | Movement of a vesicle along an actin filament, mediated by motor proteins. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVIKKGARR | KDVKEPKKRS | AKIKKATFDA | NKKKEVGISD | LTLLSKISDE | SINENLKKRF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KNGIIYTYIG | HVLISVNPFR | DLGIYTNAVL | ESYKGKNRLE | VPPHVFAIAE | SMYYNLKSYN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ENQCVIISGE | SGAGKTEAAK | RIMQYIAAAS | NSHSESIGKI | KDMVLATNPL | LESFGCAKTL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RNNNSSRHGK | YLEIKFNSQF | EPCAGNITNY | LLEKQRVVGQ | IKNERNFHIF | YQFTKGASDT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YKQMFGVQMP | EQYIYTAAAG | CTTADTIDDV | KDYEGTLEAM | RTIGLVQEEQ | DQIFRMLAAI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LWIGNISFIE | NEEGNAQVGD | TSVTDFVAYL | LQVDASLLVK | CLVERIMQTS | HGMKRGSVYH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VPLNPVQATA | VRDALAKAIY | NNLFDWIVDR | VNVSLQAFPG | ADKSIGILDI | YGFEIFEHNS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FEQICINYVN | EKLQQIFIQL | TLKAEQETYE | REKIKWTPIK | YFDNKVVCDL | IEAKNPPGIL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AAMNDSIATA | HADSNAADQA | FAQRLNLFNS | NPYFELRANK | FVIKHYAGDV | TYDINGITDK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NKDQLQKDLI | ELIGTTTNTF | LSTIFPDDVD | KDSKRRPPTA | GDKIIKSANE | LVETLSKAEP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SYIRTIKPNQ | TKSPNDYDDH | QVLHQVKYLG | LQENVRIRRA | GFAYRQTFEK | FVERFYLLSP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DCSYAGDYTW | DGDTLEAVKL | ILRDAMIPEK | EFQLGVTSVF | IKTPESLFAL | EDMRDKYWYN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| MAARIQRAWR | RFLQRRIDAA | IKIQRTIREK | KGGNKYVKLR | DYGTKLLAGK | KERRSMSLLG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| YRAFMGDYLS | CNESKTKGSY | IRRQVGIKDK | VVFSIKGECL | HSKFGRSAQR | LKKVFILTKK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TFYIIGQTRE | QNAMKYTQDY | KIDVGKIKQV | SLTNLQDDWM | GVILVNSTQS | DPLINTPFKT |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ELMTRLKKLN | EKIMIKVGPT | IEYHKQPNKL | HTVRSKISDS | APKYGDIYKS | STIYVRRGHP |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| ANSKSNKKPK | NPGGLSGKPI | KSKKSKHKST | HKHTHSHRSH | RDAAKKQPLP | SQKPVNPLSL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| AATAAQAAYN | PKPDKTVPIK | SSAIPAAKVS | SKHSSKPSSK | EKVAVKKASS | SHKSSSAKQN |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| QVSMPPSKGV | EKNKEPLKET | TATATANIPI | PPPPPPMGQP | KDPKFEAAYD | FPGSGSSSEL |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| PLKKGDIVFI | SRDEPSGWSL | AKLLDGSKEG | WVPTAYMTPY | KDTRNTVPVA | ATGAVNDVTN |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| QKSSQIDNTI | SSAQEGVQFG | SATVGPTSDN | QSNPVGTFSD | GLASALAARA | NKMRAESADD |
| 1270 | |||||
| DDNDDGDDDD | DW |