P36004
Gene name |
KKQ8 (YKL168C, YKL632) |
Protein name |
Probable serine/threonine-protein kinase KKQ8 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YKL168C |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P36004
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P36004-F1 | Predicted | AlphaFoldDB |
26 variants for P36004
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s11-133352 | 39 | I>T | No | SGRP | |
| s11-133277 | 64 | T>I | No | SGRP | |
| s11-133256 | 71 | D>G | No | SGRP | |
| s11-133232 | 79 | Q>R | No | SGRP | |
| s11-133200 | 90 | G>S | No | SGRP | |
| s11-132990 | 160 | S>P | No | SGRP | |
| s11-132970 | 166 | M>I | No | SGRP | |
| s11-132816 | 218 | P>T | No | SGRP | |
| s11-132804 | 222 | F>I | No | SGRP | |
| s11-132792 | 226 | R>G | No | SGRP | |
| s11-132734 | 245 | F>S | No | SGRP | |
| s11-132726 | 248 | A>T | No | SGRP | |
| s11-132606 | 288 | A>T | No | SGRP | |
| s11-132605 | 288 | A>V | No | SGRP | |
| s11-132590 | 293 | S>L | No | SGRP | |
| s11-132575 | 298 | R>I | No | SGRP | |
| s11-132509 | 320 | L>S | No | SGRP | |
| s11-132455 | 338 | G>D | No | SGRP | |
| s11-132447 | 341 | P>S | No | SGRP | |
| s11-132428 | 347 | S>N | No | SGRP | |
| s11-132413 | 352 | G>E | No | SGRP | |
| s11-132257 | 404 | A>V | No | SGRP | |
| s11-132219 | 417 | L>V | No | SGRP | |
| s11-131867 | 534 | R>Q | No | SGRP | |
| s11-131622 | 616 | D>Y | No | SGRP | |
| s11-131544 | 642 | Y>H | No | SGRP |
No associated diseases with P36004
4 regional properties for P36004
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Homeobox domain | 264 - 328 | IPR001356 |
| domain | Zinc finger, LIM-type | 51 - 112 | IPR001781-1 |
| domain | Zinc finger, LIM-type | 113 - 175 | IPR001781-2 |
| conserved_site | Homeobox, conserved site | 299 - 322 | IPR017970 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular cation homeostasis | Any process involved in the maintenance of an internal steady state of cations at the level of a cell. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P28708 | PRR1 | Serine/threonine-protein kinase PRR1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P47116 | PTK2 | Serine/threonine-protein kinase PTK2/STK2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P06782 | SNF1 | Carbon catabolite-derepressing protein kinase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | EV |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVMQEEKKRQ | QPVTRRVRSF | SESFKNLFRP | PRSRDSSPIN | VTRIPYRSSS | TSPKRSSEPP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RRSTVSAQIL | DPKNSPIRQR | SYTLKCCTPG | LSHPFRQTGS | GASNSPTRHR | SISGEEQEIV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NSLPEYKRSA | SHTFHGIRRP | RSRSSSVSSC | DSSNGTTSSS | DSQWAMDSLL | DDSDNDLTPY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RGSNKDILKS | KDRAPYNYID | DYNKKALRRA | TSYPNPLPSK | QFYNERLYTR | RSHPDEESLE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLPRFAGADV | QCIIEQNGFK | VYEDGSHEHN | IKLSGVIAKL | EKGNSLPAHR | QGSLSRPRLG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ITLSGLFKHH | KNECDIENAL | SLLPNVEKSQ | TNHEKRTGQS | PNDSNRSSPT | QGREDYLKIV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NPDASLGSDE | LKLINSLSSR | IHKSLQNYLQ | EKNLKPAECI | GEQAPTFQDN | YGHPVGLVGA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GAYGEVKLCA | RLRNEKDSPP | FETYHDSKYI | YYAVKELKPK | PDSDLEKFCT | KITSEFIIGH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SLSHYHKNGK | KPAPNILNVF | DILEDSSSFI | EVMEFCPAGD | LYGMLVGKSK | LKGRLHPLEA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DCFMKQLLHG | VKFMHDHGIA | HCDLKPENIL | FYPHGLLKIC | DFGTSSVFQT | AWERRVHAQK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GIIGSEPYVA | PEEFVDGEYY | DPRLIDCWSC | GVVYITMILG | HYLWKVASRE | KDMSYDEFYK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EMQRKNQFRV | FEELKHVNSE | LATNRKIALY | RIFQWEPRKR | ISVGKLLDMQ | WMKSTNCCLI |
| YDST |