P35917
SS
Gene name |
Flt4 (Flt-4, Vegfr3) |
Protein name |
Vascular endothelial growth factor receptor 3 |
Names |
VEGFR-3 , EC 2.7.10.1 , Fms-like tyrosine kinase 4 , FLT-4 , Tyrosine-protein kinase receptor FLT4 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14257 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) play crucial roles in vasculogenesis and angiogenesis. The unphosphorylated juxtamembrane region of VEGFR2 autoinhibits kinase activity by interacting with the activation loop in the kinase domain. Like other receptor tyrosine kinases, VEGFRs may have other autoinhibitory regions.
Autoinhibitory domains (AIDs)
Target domain |
845-1171 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
1054-1079 (Activation loop)
Target domain |
845-1173 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100
- Roskoski R Jr (2008) "VEGF receptor protein-tyrosine kinases: structure and regulation", Biochemical and biophysical research communications, 375, 287-91
- Wang X et al. (2020) "Molecular Bases of VEGFR-2-Mediated Physiological Function and Pathological Role", Frontiers in cell and developmental biology, 8, 599281
- Shewchuk LM et al. (2000) "Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail", Structure (London, England : 1993), 8, 1105-13
- Stuttfeld E et al. (2009) "Structure and function of VEGF receptors", IUBMB life, 61, 915-22
- Hubbard SR (2004) "Juxtamembrane autoinhibition in receptor tyrosine kinases", Nature reviews. Molecular cell biology, 5, 464-71
- Chiara F et al. (2004) "Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail", The Journal of biological chemistry, 279, 19732-8
Autoinhibited structure
Activated structure
1 structures for P35917
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P35917-F1 | Predicted | AlphaFoldDB |
79 variants for P35917
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389140246 | 52 | R>M | No | EVA | |
| rs3389116652 | 54 | Q>* | No | EVA | |
| rs3389152924 | 58 | E>G | No | EVA | |
| rs3389091923 | 68 | L>M | No | EVA | |
| rs26959541 | 69 | T>S | No | EVA | |
| rs3389156283 | 88 | E>K | No | EVA | |
| rs3389165268 | 109 | Y>H | No | EVA | |
| rs26959540 | 122 | G>A | No | EVA | |
| rs240059055 | 126 | A>V | No | EVA | |
| rs3389091860 | 128 | T>A | No | EVA | |
| rs3389146401 | 152 | D>E | No | EVA | |
| rs3389151396 | 161 | S>Y | No | EVA | |
| rs3389148609 | 162 | I>N | No | EVA | |
| rs3389125001 | 174 | S>* | No | EVA | |
| rs26959536 | 175 | A>V | No | EVA | |
| rs3402293238 | 179 | D>G | No | EVA | |
| rs3389125048 | 182 | E>* | No | EVA | |
| rs3389158587 | 212 | D>E | No | EVA | |
| rs3401831568 | 234 | L>Q | No | EVA | |
| rs3389151388 | 278 | W>C | No | EVA | |
| rs3389140230 | 279 | V>I | No | EVA | |
| rs3412946417 | 318 | R>Q | No | EVA | |
| rs3389148641 | 330 | K>M | No | EVA | |
| rs3389152603 | 344 | E>A | No | EVA | |
| rs3389125029 | 344 | E>Q | No | EVA | |
| rs3389091857 | 348 | G>S | No | EVA | |
| rs3389152601 | 405 | A>E | No | EVA | |
| rs3389152438 | 414 | L>R | No | EVA | |
| rs3389124988 | 463 | W>S | No | EVA | |
| rs3402271219 | 477 | R>L | No | EVA | |
| rs3389152382 | 494 | T>I | No | EVA | |
| rs255082132 | 508 | T>M | No | EVA | |
| rs3389148634 | 531 | M>T | No | EVA | |
| rs3389146467 | 536 | V>I | No | EVA | |
| rs3389153068 | 538 | N>Y | No | EVA | |
| rs3389151347 | 540 | V>M | No | EVA | |
| rs3389091913 | 550 | Y>H | No | EVA | |
| rs3402188581 | 566 | E>K | No | EVA | |
| rs3402272817 | 569 | L>S | No | EVA | |
| rs3389151368 | 580 | A>T | No | EVA | |
| rs3389091929 | 584 | T>M | No | EVA | |
| rs3389158613 | 614 | H>Y | No | EVA | |
| rs3389148606 | 696 | E>* | No | EVA | |
| rs3389146436 | 736 | Q>H | No | EVA | |
| rs3389153124 | 739 | R>H | No | EVA | |
| rs3401831577 | 760 | S>T | No | EVA | |
| rs3402340950 | 765 | V>E | No | EVA | |
| rs3401831578 | 772 | G>D | No | EVA | |
| rs3389148613 | 790 | W>* | No | EVA | |
| rs3389125019 | 824 | L>* | No | EVA | |
| rs3389140217 | 830 | Y>N | No | EVA | |
| rs3389151334 | 844 | R>W | No | EVA | |
| rs3389152572 | 870 | G>D | No | EVA | |
| rs3402188610 | 872 | S>T | No | EVA | |
| rs3389158570 | 911 | N>Y | No | EVA | |
| rs3389153141 | 917 | T>A | No | EVA | |
| rs3389153047 | 927 | V>A | No | EVA | |
| rs3389124970 | 928 | E>K | No | EVA | |
| rs3401569733 | 967 | A>T | No | EVA | |
| rs3389153114 | 976 | S>G | No | EVA | |
| rs3389156259 | 991 | S>C | No | EVA | |
| rs219623797 | 1001 | A>T | No | EVA | |
| rs3389146419 | 1075 | R>Q | No | EVA | |
| rs3389165337 | 1104 | L>Q | No | EVA | |
| rs3389152558 | 1108 | F>L | No | EVA | |
| rs3389156279 | 1129 | K>R | No | EVA | |
| rs3389165269 | 1148 | M>L | No | EVA | |
| rs3389158597 | 1171 | D>N | No | EVA | |
| rs3389156234 | 1179 | Q>* | No | EVA | |
| rs3389151394 | 1182 | E>* | No | EVA | |
| rs1132162427 | 1185 | R>H | No | EVA | |
| rs3389163933 | 1188 | L>M | No | EVA | |
| rs3389140202 | 1190 | S>I | No | EVA | |
| rs3389158560 | 1226 | L>P | No | EVA | |
| rs3389125020 | 1279 | L>M | No | EVA | |
| rs26959470 | 1293 | P>Q | No | EVA | |
| rs3389148645 | 1303 | G>S | No | EVA | |
| rs3402183918 | 1326 | A>S | No | EVA | |
| rs3389152585 | 1357 | F>S | No | EVA |
No associated diseases with P35917
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| growth factor binding | Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| protein phosphatase binding | Binding to a protein phosphatase. |
| vascular endothelial growth factor receptor activity | Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
25 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| blood vessel morphogenesis | The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. |
| lung alveolus development | The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. |
| lymph vessel development | The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure. |
| lymphangiogenesis | Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| positive regulation of cell growth | Any process that activates or increases the frequency, rate, extent or direction of cell growth. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of endothelial cell migration | Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. |
| positive regulation of endothelial cell proliferation | Any process that activates or increases the rate or extent of endothelial cell proliferation. |
| positive regulation of ERK1 and ERK2 cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| positive regulation of JNK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. |
| positive regulation of protein kinase C signaling | Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. |
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
| positive regulation of vascular endothelial growth factor production | Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| regulation of blood vessel remodeling | Any process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels. |
| regulation of MAPK cascade | Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. |
| respiratory gaseous exchange by respiratory system | The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. |
| respiratory system process | A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. |
| sprouting angiogenesis | The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation. |
| vascular endothelial growth factor receptor signaling pathway | The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| vascular endothelial growth factor signaling pathway | The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| vasculature development | The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. |
101 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43481 | KIT | Mast/stem cell growth factor receptor Kit | Bos taurus (Bovine) | SS |
| Q06805 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Bos taurus (Bovine) | PR |
| Q06807 | TEK | Angiopoietin-1 receptor | Bos taurus (Bovine) | SS |
| Q28889 | KIT | Mast/stem cell growth factor receptor Kit | Felis catus (Cat) (Felis silvestris catus) | SS |
| P13369 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Felis catus (Cat) (Felis silvestris catus) | SS |
| P18460 | FGFR3 | Fibroblast growth factor receptor 3 | Gallus gallus (Chicken) | SS |
| P21804 | FGFR1 | Fibroblast growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| Q9PUF6 | PDGFRA | Platelet-derived growth factor receptor alpha | Gallus gallus (Chicken) | SS |
| Q08156 | KIT | Mast/stem cell growth factor receptor Kit | Gallus gallus (Chicken) | SS |
| Q8QHL3 | FLT1 | Vascular endothelial growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| P18461 | FGFR2 | Fibroblast growth factor receptor 2 | Gallus gallus (Chicken) | SS |
| Q07407 | htl | Fibroblast growth factor receptor homolog 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q6J9G0 | STYK1 | Tyrosine-protein kinase STYK1 | Homo sapiens (Human) | PR |
| P36888 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (Human) | EV |
| P16234 | PDGFRA | Platelet-derived growth factor receptor alpha | Homo sapiens (Human) | EV |
| P09619 | PDGFRB | Platelet-derived growth factor receptor beta | Homo sapiens (Human) | EV |
| P35968 | KDR | Vascular endothelial growth factor receptor 2 | Homo sapiens (Human) | EV |
| P17948 | FLT1 | Vascular endothelial growth factor receptor 1 | Homo sapiens (Human) | SS |
| P07333 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Homo sapiens (Human) | SS |
| P10721 | KIT | Mast/stem cell growth factor receptor Kit | Homo sapiens (Human) | EV |
| P22455 | FGFR4 | Fibroblast growth factor receptor 4 | Homo sapiens (Human) | SS |
| P22607 | FGFR3 | Fibroblast growth factor receptor 3 | Homo sapiens (Human) | EV |
| P07949 | RET | Proto-oncogene tyrosine-protein kinase receptor Ret | Homo sapiens (Human) | EV |
| P35590 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Homo sapiens (Human) | PR |
| Q02763 | TEK | Angiopoietin-1 receptor | Homo sapiens (Human) | SS |
| P11362 | FGFR1 | Fibroblast growth factor receptor 1 | Homo sapiens (Human) | EV |
| P21802 | FGFR2 | Fibroblast growth factor receptor 2 | Homo sapiens (Human) | EV |
| P35916 | FLT4 | Vascular endothelial growth factor receptor 3 | Homo sapiens (Human) | SS |
| Q91V87 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Mus musculus (Mouse) | PR |
| Q6J9G1 | Styk1 | Tyrosine-protein kinase STYK1 | Mus musculus (Mouse) | PR |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| P35546 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| Q62371 | Ddr2 | Discoidin domain-containing receptor 2 | Mus musculus (Mouse) | SS |
| Q03146 | Ddr1 | Epithelial discoidin domain-containing receptor 1 | Mus musculus (Mouse) | SS |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| P97793 | Alk | ALK tyrosine kinase receptor | Mus musculus (Mouse) | SS |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q62190 | Mst1r | Macrophage-stimulating protein receptor | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| P70424 | Erbb2 | Receptor tyrosine-protein kinase erbB-2 | Mus musculus (Mouse) | SS |
| Q61527 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Mus musculus (Mouse) | SS |
| Q61526 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Mus musculus (Mouse) | SS |
| Q01279 | Egfr | Epidermal growth factor receptor | Mus musculus (Mouse) | SS |
| Q01887 | Ryk | Tyrosine-protein kinase RYK | Mus musculus (Mouse) | PR |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| P16056 | Met | Hepatocyte growth factor receptor | Mus musculus (Mouse) | PR |
| Q2HWD6 | KIT | Mast/stem cell growth factor receptor Kit | Sus scrofa (Pig) | SS |
| Q7TQM3 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Rattus norvegicus (Rat) | PR |
| P53767 | Flt1 | Vascular endothelial growth factor receptor 1 | Rattus norvegicus (Rat) | PR |
| P20786 | Pdgfra | Platelet-derived growth factor receptor alpha | Rattus norvegicus (Rat) | SS |
| Q04589 | Fgfr1 | Fibroblast growth factor receptor 1 | Rattus norvegicus (Rat) | SS |
| G3V9H8 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Rattus norvegicus (Rat) | SS |
| Q498D6 | Fgfr4 | Fibroblast growth factor receptor 4 | Rattus norvegicus (Rat) | PR |
| Q05030 | Pdgfrb | Platelet-derived growth factor receptor beta | Rattus norvegicus (Rat) | SS |
| O08775 | Kdr | Vascular endothelial growth factor receptor 2 | Rattus norvegicus (Rat) | SS |
| Q91ZT1 | Flt4 | Vascular endothelial growth factor receptor 3 | Rattus norvegicus (Rat) | SS |
| Q17833 | old-1 | Tyrosine-protein kinase receptor old-1 | Caenorhabditis elegans | PR |
| Q19238 | F09A5.2 | Putative tyrosine-protein kinase F09A5.2 | Caenorhabditis elegans | SS |
| Q10656 | egl-15 | Myoblast growth factor receptor egl-15 | Caenorhabditis elegans | PR |
| P34892 | kin-16 | Receptor-like tyrosine-protein kinase kin-16 | Caenorhabditis elegans | PR |
| G5ED65 | ver-1 | Protein ver-1 | Caenorhabditis elegans | PR |
| Q9S9M2 | WAKL4 | Wall-associated receptor kinase-like 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q7X8C5 | WAKL2 | Wall-associated receptor kinase-like 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VYA3 | WAKL10 | Wall-associated receptor kinase-like 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C9L5 | WAKL9 | Wall-associated receptor kinase-like 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M092 | WAKL17 | Wall-associated receptor kinase-like 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNY5 | WAKL18 | Wall-associated receptor kinase-like 18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8AXB3 | kdrl | Vascular endothelial growth factor receptor kdr-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5GIT4 | kdr | Vascular endothelial growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73791 | tek | Angiopoietin-1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90Z00 | fgfr1a | Fibroblast growth factor receptor 1-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JG38 | fgfr2 | Fibroblast growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8N6 | csf1r | Macrophage colony-stimulating factor 1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90413 | fgfr4 | Fibroblast growth factor receptor 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DE49 | pdgfra | Platelet-derived growth factor receptor alpha | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JFR5 | kita | Mast/stem cell growth factor receptor kita | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5MD89 | flt4 | Vascular endothelial growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQPGAALNLR | LWLCLGLLQG | LANGYSMTPP | TLNITEDSYV | IDTGDSLSIS | CRGQHPLEWT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WPGAQEVLTT | GGKDSEDTRV | VHDCEGTEAR | PYCKVLLLAQ | THANNTGSYH | CYYKYIKARI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EGTTAASTYV | FVRDFKHPFI | NKPDTLLVNR | KDSMWVPCLV | SIPGLNITLR | SQSSALHPDG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QEVLWDDRRG | MRVPTQLLRD | ALYLQCETTW | GDQNFLSNLF | VVHITGNELY | DIQLYPKKSM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ELLVGEKLVL | NCTVWAEFDS | GVTFDWDYPG | KQAERAKWVP | ERRSQQTHTE | LSSILTIHNV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SQNDLGPYVC | EANNGIQRFR | ESTEVIVHEK | PFISVEWLKG | PVLEATAGDE | LVKLPVKLAA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YPPPEFQWYK | DRKAVTGRHN | PHALVLKEVT | EASAGVYTLA | LWNSAAGLRQ | NISLELVVNV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PPHIHEKEAS | SPSIYSRHSR | QTLTCTAYGV | PQPLSVQWHW | RPWTPCKTFA | QRSLRRRQQR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DGMPQCRDWK | EVTTQDAVNP | IESLDSWTEF | VEGKNKTVSK | LVIQDANVSA | MYKCVVVNKV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GQDERLIYFY | VTTIPDGFSI | ESEPSEDPLE | GQSVRLSCRA | DNYTYEHLRW | YRLNLSTLHD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AQGNPLLLDC | KNVHLFATPL | EANLEEAEPG | ARHATLSLNI | PRVAPEDEGD | YVCEVQDRRS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QDKHCHKKYL | SVQALEAPRL | TQNLTDLLVN | VSDSLEMRCP | VAGAHVPSIV | WYKDERLLEK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ESGIDLADSN | QRLSIQRVRE | EDAGRYLCSV | CNAKGCVNSS | ASVAVEGSED | KGSMEIVILI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GTGVIAVFFW | VLLLLIFCNM | KRPAHADIKT | GYLSIIMDPG | EVPLEEQCEY | LSYDASQWEF |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PRERLHLGRV | LGHGAFGKVV | EASAFGINKG | SSCDTVAVKM | LKEGATASEH | RALMSELKIL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| IHIGNHLNVV | NLLGACTKPN | GPLMVIVEFC | KYGNLSNFLR | VKRDTFNPYA | EKSPEQRRRF |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| RAMVEGAKAD | RRRPGSSDRA | LFTRFLMGKG | SARRAPLVQE | AEDLWLSPLT | MEDLVCYSFQ |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| VARGMEFLAS | RKCIHRDLAA | RNILLSESDI | VKICDFGLAR | DIYKDPDYVR | KGSARLPLKW |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| MAPESIFDKV | YTTQSDVWSF | GVLLWEIFSL | GASPYPGVQI | NEEFCQRLKD | GTRMRAPELA |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| TPAIRHIMQS | CWSGDPKARP | AFSDLVEILG | DLLQGGGWQE | EEEERMALHS | SQSSEEDGFM |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| QASTTALHIT | EADADDSPPS | MHCHSLAARY | YNCVSFPGRL | ARGTKTPGSS | RMKTFEELPM |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| TPTTYKASMD | NQTDSGMVLA | SEEFEELESR | HRPEGSFSCK | GPGQHMDIPR | GHPDPQGRRR |
| 1330 | 1340 | 1350 | 1360 | ||
| RPTQGAQGGK | VFYNNEYGEV | SQPCTEGDCC | PSAGSTFFAD | SSY |