P35546
SS
Gene name |
Ret |
Protein name |
Proto-oncogene tyrosine-protein kinase receptor Ret |
Names |
EC 2.7.10.1 , Proto-oncogene c-Ret [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:19713 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Proto-oncogene tyrosine-protein kinase receptor Ret is a receptor tyrosine kinase for the glial cell line-derived neurotrophic factor family of ligands. RET signaling is essential for development, survival, and regeneration of many neuronal populations in the enteric and sympathetic nervous systems and the kidney. Within the RET intracellular domain, there is no cis-inhibitory domain. Instead, there are alternative inhibitory mechanisms, possibly in trans, for the autoregulation of RET kinase activity. The first contact area within the dimer involves residues 763-767. The residues 763-767 in an extended conformation masks the substrate-binding site of the second molecule. A second contact area in the dimer involves helix αN (residues 712-714) interacting with the side chains of the second molecule. The dimer structure represents a trans-inhibited state.
Autoinhibitory domains (AIDs)
Target domain |
725-1017 (Protein kinase domain) |
Relief mechanism |
Ligand binding, PTM |
Assay |
|
Target domain |
725-1017 (Protein kinase domain) |
Relief mechanism |
Ligand binding, PTM |
Assay |
|
Accessory elements
No accessory elements
References
- Knowles PP et al. (2006) "Structure and chemical inhibition of the RET tyrosine kinase domain", The Journal of biological chemistry, 281, 33577-87
- Uchikawa E et al. (2019) "Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex", eLife, 8,
- Nielsen J et al. (2022) "Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling", Journal of molecular biology, 434, 167458
- Chen YS et al. (2021) "Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone-receptor activation", Proceedings of the National Academy of Sciences of the United States of America, 118,
- Craddock BP et al. (2007) "Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region", FEBS letters, 581, 3235-40
- Huang X et al. (2009) "Structural insights into the inhibited states of the Mer receptor tyrosine kinase", Journal of structural biology, 165, 88-96
Autoinhibited structure
Activated structure
2 structures for P35546
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1UEF | X-ray | 250 A | C/D | 1055-1067 | PDB |
| AF-P35546-F1 | Predicted | AlphaFoldDB |
61 variants for P35546
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388857525 | 63 | V>M | No | EVA | |
| rs3388847767 | 69 | G>S | No | EVA | |
| rs3388835545 | 78 | T>I | No | EVA | |
| rs3388847738 | 124 | Q>H | No | EVA | |
| rs3397028619 | 124 | Q>P | No | EVA | |
| rs3388835586 | 142 | C>Y | No | EVA | |
| rs3388856372 | 147 | F>L | No | EVA | |
| rs3388817774 | 167 | I>N | No | EVA | |
| rs234354620 | 176 | V>I | No | EVA | |
| rs3388855111 | 193 | V>M | No | EVA | |
| rs3388856360 | 197 | C>Y | No | EVA | |
| rs38784258 | 208 | G>E | No | EVA | |
| rs217416601 | 215 | R>H | No | EVA | |
| rs3388854665 | 235 | E>V | No | EVA | |
| rs3412845549 | 251 | N>T | No | EVA | |
| rs3544782715 | 270 | A>V | No | EVA | |
| rs3544754388 | 280 | A>T | No | EVA | |
| rs3388844863 | 295 | A>V | No | EVA | |
| rs3544832744 | 337 | I>V | No | EVA | |
| rs3388847715 | 350 | A>T | No | EVA | |
| rs213956039 | 351 | T>I | No | EVA | |
| rs3388817738 | 359 | L>P | No | EVA | |
| rs3388839987 | 360 | N>H | No | EVA | |
| rs387219223 | 374 | A>S | No | EVA | |
| rs3388854599 | 382 | F>L | No | EVA | |
| rs3388835582 | 383 | Q>E | No | EVA | |
| rs3388854661 | 384 | G>V | No | EVA | |
| rs3388852642 | 384 | G>W | No | EVA | |
| rs3388831164 | 385 | P>H | No | EVA | |
| rs3388855078 | 385 | P>T | No | EVA | |
| rs214374778 | 392 | V>I | No | EVA | |
| rs250076540 | 395 | F>V | No | EVA | |
| rs3397331027 | 397 | V>M | No | EVA | |
| rs253891802 | 438 | V>I | No | EVA | |
| rs241413917 | 449 | I>T | No | EVA | |
| rs3388847781 | 478 | P>H | No | EVA | |
| rs225841295 | 481 | T>N | No | EVA | |
| rs246619719 | 486 | T>M | No | EVA | |
| rs3388831149 | 497 | Q>E | No | EVA | |
| rs36505070 | 512 | T>A | No | EVA | |
| rs3388844866 | 515 | V>I | No | EVA | |
| rs3388854608 | 556 | N>T | No | EVA | |
| rs3388849830 | 580 | A>D | No | EVA | |
| rs3388852482 | 584 | P>L | No | EVA | |
| rs3388817754 | 628 | Q>H | No | EVA | |
| rs3388831213 | 658 | V>D | No | EVA | |
| rs3388852638 | 677 | F>Y | No | EVA | |
| rs3388849850 | 701 | T>M | No | EVA | |
| rs3388855104 | 703 | N>I | No | EVA | |
| rs3396857860 | 756 | V>A | No | EVA | |
| rs3388849863 | 757 | A>T | No | EVA | |
| rs3388852631 | 768 | S>T | No | EVA | |
| rs3388817718 | 778 | N>I | No | EVA | |
| rs3388855079 | 779 | L>F | No | EVA | |
| rs3388849898 | 827 | Y>C | No | EVA | |
| rs3388847784 | 937 | S>F | No | EVA | |
| rs3388835553 | 943 | W>* | No | EVA | |
| rs3388849869 | 959 | E>G | No | EVA | |
| rs3388838885 | 987 | Q>R | No | EVA | |
| rs3388835555 | 1014 | R>I | No | EVA | |
| rs3388835559 | 1105 | S>L | No | EVA |
No associated diseases with P35546
12 regional properties for P35546
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 582 - 852 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 584 - 848 | IPR001245 |
| domain | Immunoglobulin subtype | 94 - 189 | IPR003599-1 |
| domain | Immunoglobulin subtype | 198 - 276 | IPR003599-2 |
| domain | Fibronectin type III | 279 - 376 | IPR003961-1 |
| domain | Fibronectin type III | 379 - 478 | IPR003961-2 |
| domain | Immunoglobulin-like domain | 86 - 181 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 192 - 268 | IPR007110-2 |
| active_site | Tyrosine-protein kinase, active site | 714 - 726 | IPR008266 |
| domain | Immunoglobulin-like beta-sandwich domain | 98 - 173 | IPR013151 |
| binding_site | Protein kinase, ATP binding site | 588 - 614 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 582 - 849 | IPR020635 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| plasma membrane protein complex | Any protein complex that is part of the plasma membrane. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
34 GO annotations of biological process
| Name | Definition |
|---|---|
| anatomical structure morphogenesis | The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. |
| cellular response to retinoic acid | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. |
| embryonic epithelial tube formation | The morphogenesis of an embryonic epithelium into a tube-shaped structure. |
| enteric nervous system development | The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. |
| glial cell-derived neurotrophic factor receptor signaling pathway | The series of molecular signals initiated by a ligand binding to a glial cell-derived neurotrophic factor receptor. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| innervation | The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue. |
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers |
| membrane protein proteolysis | The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| neural crest cell migration | The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. |
| neuron cell-cell adhesion | The attachment of a neuron to another cell via adhesion molecules. |
| neuron differentiation | The process in which a relatively unspecialized cell acquires specialized features of a neuron. |
| neuron maturation | A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. |
| Peyer's patch morphogenesis | The process in which a Peyer's patch is generated and organized. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| positive regulation of cell adhesion mediated by integrin | Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| positive regulation of cell size | Any process that increases cell size. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| positive regulation of metanephric glomerulus development | Any process that increases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros. |
| positive regulation of neuron maturation | Any process that activates or increases the frequency, rate or extent of neuron maturation. |
| positive regulation of neuron projection development | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| positive regulation of peptidyl-serine phosphorylation of STAT protein | Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. |
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| regulation of axonogenesis | Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. |
| response to pain | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. |
| response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| retina development in camera-type eye | The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| ureter maturation | A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut. |
| ureteric bud development | The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure. |
95 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43481 | KIT | Mast/stem cell growth factor receptor Kit | Bos taurus (Bovine) | SS |
| Q06805 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Bos taurus (Bovine) | PR |
| Q06807 | TEK | Angiopoietin-1 receptor | Bos taurus (Bovine) | SS |
| Q28889 | KIT | Mast/stem cell growth factor receptor Kit | Felis catus (Cat) (Felis silvestris catus) | SS |
| P13369 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Felis catus (Cat) (Felis silvestris catus) | SS |
| P18460 | FGFR3 | Fibroblast growth factor receptor 3 | Gallus gallus (Chicken) | SS |
| P21804 | FGFR1 | Fibroblast growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| Q9PUF6 | PDGFRA | Platelet-derived growth factor receptor alpha | Gallus gallus (Chicken) | SS |
| Q08156 | KIT | Mast/stem cell growth factor receptor Kit | Gallus gallus (Chicken) | SS |
| Q8QHL3 | FLT1 | Vascular endothelial growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| P18461 | FGFR2 | Fibroblast growth factor receptor 2 | Gallus gallus (Chicken) | SS |
| Q07407 | htl | Fibroblast growth factor receptor homolog 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q6J9G0 | STYK1 | Tyrosine-protein kinase STYK1 | Homo sapiens (Human) | PR |
| P36888 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (Human) | EV |
| P16234 | PDGFRA | Platelet-derived growth factor receptor alpha | Homo sapiens (Human) | EV |
| P09619 | PDGFRB | Platelet-derived growth factor receptor beta | Homo sapiens (Human) | EV |
| P35916 | FLT4 | Vascular endothelial growth factor receptor 3 | Homo sapiens (Human) | SS |
| P35968 | KDR | Vascular endothelial growth factor receptor 2 | Homo sapiens (Human) | EV |
| P17948 | FLT1 | Vascular endothelial growth factor receptor 1 | Homo sapiens (Human) | SS |
| P07333 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Homo sapiens (Human) | SS |
| P10721 | KIT | Mast/stem cell growth factor receptor Kit | Homo sapiens (Human) | EV |
| P22455 | FGFR4 | Fibroblast growth factor receptor 4 | Homo sapiens (Human) | SS |
| P22607 | FGFR3 | Fibroblast growth factor receptor 3 | Homo sapiens (Human) | EV |
| P35590 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Homo sapiens (Human) | PR |
| Q02763 | TEK | Angiopoietin-1 receptor | Homo sapiens (Human) | SS |
| P11362 | FGFR1 | Fibroblast growth factor receptor 1 | Homo sapiens (Human) | EV |
| P21802 | FGFR2 | Fibroblast growth factor receptor 2 | Homo sapiens (Human) | EV |
| P07949 | RET | Proto-oncogene tyrosine-protein kinase receptor Ret | Homo sapiens (Human) | EV |
| Q91V87 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Mus musculus (Mouse) | PR |
| Q6J9G1 | Styk1 | Tyrosine-protein kinase STYK1 | Mus musculus (Mouse) | PR |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| Q62371 | Ddr2 | Discoidin domain-containing receptor 2 | Mus musculus (Mouse) | SS |
| Q03146 | Ddr1 | Epithelial discoidin domain-containing receptor 1 | Mus musculus (Mouse) | SS |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| P97793 | Alk | ALK tyrosine kinase receptor | Mus musculus (Mouse) | SS |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q62190 | Mst1r | Macrophage-stimulating protein receptor | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| P70424 | Erbb2 | Receptor tyrosine-protein kinase erbB-2 | Mus musculus (Mouse) | SS |
| Q61527 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Mus musculus (Mouse) | SS |
| Q61526 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Mus musculus (Mouse) | SS |
| Q01279 | Egfr | Epidermal growth factor receptor | Mus musculus (Mouse) | SS |
| Q01887 | Ryk | Tyrosine-protein kinase RYK | Mus musculus (Mouse) | PR |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| P16056 | Met | Hepatocyte growth factor receptor | Mus musculus (Mouse) | PR |
| Q2HWD6 | KIT | Mast/stem cell growth factor receptor Kit | Sus scrofa (Pig) | SS |
| Q7TQM3 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Rattus norvegicus (Rat) | PR |
| P53767 | Flt1 | Vascular endothelial growth factor receptor 1 | Rattus norvegicus (Rat) | PR |
| P20786 | Pdgfra | Platelet-derived growth factor receptor alpha | Rattus norvegicus (Rat) | SS |
| Q91ZT1 | Flt4 | Vascular endothelial growth factor receptor 3 | Rattus norvegicus (Rat) | SS |
| Q04589 | Fgfr1 | Fibroblast growth factor receptor 1 | Rattus norvegicus (Rat) | SS |
| Q498D6 | Fgfr4 | Fibroblast growth factor receptor 4 | Rattus norvegicus (Rat) | PR |
| Q05030 | Pdgfrb | Platelet-derived growth factor receptor beta | Rattus norvegicus (Rat) | SS |
| O08775 | Kdr | Vascular endothelial growth factor receptor 2 | Rattus norvegicus (Rat) | SS |
| G3V9H8 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Rattus norvegicus (Rat) | SS |
| Q17833 | old-1 | Tyrosine-protein kinase receptor old-1 | Caenorhabditis elegans | PR |
| Q19238 | F09A5.2 | Putative tyrosine-protein kinase F09A5.2 | Caenorhabditis elegans | SS |
| Q10656 | egl-15 | Myoblast growth factor receptor egl-15 | Caenorhabditis elegans | PR |
| P34892 | kin-16 | Receptor-like tyrosine-protein kinase kin-16 | Caenorhabditis elegans | PR |
| G5ED65 | ver-1 | Protein ver-1 | Caenorhabditis elegans | PR |
| Q8AXB3 | kdrl | Vascular endothelial growth factor receptor kdr-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5GIT4 | kdr | Vascular endothelial growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73791 | tek | Angiopoietin-1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90Z00 | fgfr1a | Fibroblast growth factor receptor 1-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JG38 | fgfr2 | Fibroblast growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8N6 | csf1r | Macrophage colony-stimulating factor 1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90413 | fgfr4 | Fibroblast growth factor receptor 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DE49 | pdgfra | Platelet-derived growth factor receptor alpha | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JFR5 | kita | Mast/stem cell growth factor receptor kita | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5MD89 | flt4 | Vascular endothelial growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKATSGAAG | LGLKLILLLP | LLGEAPLGLY | FSRDAYWERL | YVDQPAGTPL | LYVHALRDAP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GEVPSFRLGQ | HLYGVYRTRL | HENDWIRINE | TTGLLYLNQS | LDHSSWEQLS | IRNGGFPLLT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IFLQVFLGST | AQREGECHWP | GCTRVYFSFI | NDTFPNCSSF | KAQDLCIPET | AVSFRVRENR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PPGTFYHFHM | LPVQFLCPNI | SVKYSLLGGD | SLPFRCDPDC | LEVSTRWALD | RELREKYVLE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ALCIVAGPGA | NKETVTLSFP | VTVYDEDDSA | PTFSGGVGTA | SAVVEFKRKE | GTVVATLQVF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DADVVPASGE | LVRRYTNTLL | SGDSWAQQTF | RVEHSPIETL | VQVNNNSVRA | TMHNYKLILN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RSLSISESRV | LQLAVLVNDS | DFQGPGAGGI | LVLHFNVSVL | PVTLNLPRAY | SFPVNKRARR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YAQIGKVCVE | NCQEFSGVSI | QYKLQPSSIN | CTALGVVTSP | EDTSGTLFVN | DTEALRRPEC |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TKLQYTVVAT | DRQTRRQTQA | SLVVTVEGTS | ITEEVGCPKS | CAVNKRRPEC | EECGGLGSPT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GRCEWRQGDG | KGITRNFSTC | SPSTRTCPDG | HCDAVESRDA | NICPQDCLRA | DIVGGHERGE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RQGIKAGYGI | CNCFPDEKKC | FCEPEDSQGP | LCDALCRTII | TAALFSLIIS | ILLSIFCVCH |
| 670 | 680 | 690 | 700 | 710 | 720 |
| HHKHGHKPPI | ASAEMTFCRP | AQGFPISYSS | SGTRRPSLDS | TENQVPVDSF | KIPEDPKWEF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PRKNLVLGKT | LGEGEFGKVV | KATAFRLKGR | AGYTTVAVKM | LKENASQSEL | RDLLSEFNLL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KQVNHPHVIK | LYGACSQDGP | LLLIVEYAKY | GSLRGFLRDS | RKIGPAYVSG | GGSRNSSSLD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| HPDERVLTMG | DLISFAWQIS | RGMQYLAEMK | LVHRDLAARN | ILVAEGRKMK | ISDFGLSRDV |
| 910 | 920 | 930 | 940 | 950 | 960 |
| YEEDSYVKKS | KGRIPVKWMA | IESLFDHIYT | TQSDVWSFGV | LLWEIVTLGG | NPYPGIPPER |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LFNLLKTGHR | MERPDNCSEE | MYRLMLQCWK | QEPDKRPVFA | DISKDLEKMM | VKSRDYLDLA |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ASTPSDSLLY | DDGLSEEETP | LVDCNNAPLP | RSLPSTWIEN | KLYGMSDPNW | PGESPVPLTR |
| 1090 | 1100 | 1110 | |||
| ADGTSTGFPR | YANDSVYANW | MVSPSAAKLM | DTFDS |