P35508

SS
Gene name
CSNK1D (HCKID)
Protein name
Casein kinase I isoform delta
Names
CKI-delta , CKId , EC 2.7.11.1 , Tau-protein kinase CSNK1D , EC 2.7.11.26
Species
Bos taurus (Bovine)
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

Casein kinase I epsilon (CSNK1E) is a member of CKI family and is involved in signaling, circadian clock, DNA repair, and metabolism. The tail of autophosphorylated CKIε interacts with the kinase domain and blocks the active site. Proteolytic lysis of the C-terminal region relieves autoinhibition.

Autoinhibitory domains (AIDs)

306-415 (C-terminal domain) SS

Target domain

9-287 (Protein kinase domain)

Relief mechanism

Cleavage, PTM

Assay

Accessory elements

148-178 (Activation loop from InterPro)

Target domain

9-287 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P35508

Entry ID Method Resolution Chain Position Source
AF-P35508-F1 Predicted AlphaFoldDB

100 variants for P35508

Variant ID(s) Position Change Description Diseaes Association Provenance
rs478902736 2 E>D No EVA
rs440474408 5 V>G No EVA
rs458917029 12 G>S No EVA
rs450914046 13 R>G No EVA
rs469466758 14 K>E No EVA
rs467143478 17 S>R No EVA
rs452022764 19 S>A No EVA
rs464013710 19 S>C No EVA
rs437523106 20 F>L No EVA
rs474677525 21 G>R No EVA
rs453883350 22 D>A No EVA
rs472521429 22 D>E No EVA
rs453883350 22 D>G No EVA
rs439505396 23 I>F No EVA
rs444379764 24 Y>* No EVA
rs470998560 24 Y>S No EVA
rs463013419 25 L>F No EVA
rs481557239 25 L>P No EVA
rs448619522 26 G>R No EVA
rs450938106 118 Y>H No EVA
rs461312418 157 R>L No EVA
rs480093960 175 G>E No EVA
rs440580991 176 T>A No EVA
rs451072466 184 T>R No EVA
rs477486823 184 T>S No EVA
rs481043344 185 H>P No EVA
rs481043344 185 H>R No EVA
rs454824421 189 E>D No EVA
rs473404216 192 R>Q No EVA
rs434091763 193 R>M No EVA
rs452449532 193 R>S No EVA
rs471013547 194 D>A No EVA
rs444596033 195 D>A No EVA
rs463126777 198 S>A No EVA
rs442278111 204 M>L No EVA
rs460113566 206 F>V No EVA
rs447832670 253 N>T No EVA
rs435814138 253 N>Y No EVA
rs466336918 281 G>R No EVA
rs433477137 286 Y>H No EVA
rs440666092 296 G>A No EVA
rs476849320 298 S>I No EVA
rs481200673 301 A>G No EVA
rs462682158 301 A>S No EVA
rs448135561 303 D>Y No EVA
rs466778430 304 A>T No EVA
rs433758152 305 E>K No EVA
rs446001403 307 E>D No EVA
rs464441216 308 R>G No EVA
rs457289403 309 R>G No EVA
rs475813170 311 R>* No EVA
rs454970472 312 E>G No EVA
rs473451800 315 L>W No EVA
rs459120413 317 H>N No EVA
rs471088793 317 H>P No EVA
rs444700508 322 A>D No EVA
rs462539997 323 T>P No EVA
rs441697830 324 R>P No EVA
rs460223792 326 L>R No EVA
rs478839614 330 A>T No EVA
rs445841134 331 S>W No EVA
rs483003767 332 G>C No EVA
rs449923820 334 L>P No EVA
rs436387388 335 R>G No EVA
rs454985957 336 G>R No EVA
rs466889467 337 T>A No EVA
rs452614273 340 V>G No EVA
rs470975083 341 A>S No EVA
rs444703560 345 P>L No EVA
rs444703560 345 P>R No EVA
rs456774360 347 T>S No EVA
rs474659394 349 T>A No EVA
rs441588022 349 T>I No EVA
rs474659394 349 T>P No EVA
rs474659394 349 T>S No EVA
rs478727013 351 H>R No EVA
rs443581966 355 T>P No EVA
rs462268070 358 R>S No EVA
rs459945067 365 R>K No EVA
rs478355181 369 V>E No EVA
rs445575031 370 S>R No EVA
rs470467377 374 H>P No EVA
rs481905636 374 H>Q No EVA
rs434456453 377 A>D No EVA
rs467165681 377 A>T No EVA
rs452841415 378 P>T No EVA
rs465045484 379 V>F No EVA
rs432162490 384 S>A No EVA
rs475686026 388 G>R No EVA
rs455746254 390 Q>* No EVA
rs474152302 390 Q>H No EVA
rs441343988 392 T>P No EVA
rs441343988 392 T>S No EVA
rs459836608 393 S>C No EVA
rs472067489 395 M>I No EVA
rs438970715 397 T>A No EVA
rs474122831 404 V>G No EVA
rs434649923 405 A>E No EVA
rs454043500 408 G>C No EVA
rs472628291 414 H>Q No EVA

No associated diseases with P35508

3 regional properties for P35508

Type Name Position InterPro Accession
domain Protein kinase domain 299 - 569 IPR000719
active_site Serine/threonine-protein kinase, active site 422 - 434 IPR008271
binding_site Protein kinase, ATP binding site 305 - 328 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Cytoplasm, perinuclear region
  • Cell membrane
  • Cytoplasm, cytoskeleton, spindle
  • Golgi apparatus
  • Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells
  • Recruited to the spindle apparatus and the centrosomes in response to DNA-damage
  • Correct subcellular localization requires kinase activity (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
spindle microtubule Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction
protein serine kinase activity Catalysis of the reactions
protein serine/threonine kinase activity Catalysis of the reactions
tau-protein kinase activity Catalysis of the reaction

17 GO annotations of biological process

Name Definition
circadian regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle.
Golgi organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
microtubule nucleation The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).
non-motile cilium assembly The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
positive regulation of canonical Wnt signaling pathway Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
protein localization to centrosome A process in which a protein is transported to, or maintained at, the centrosome.
protein localization to cilium A process in which a protein is transported to, or maintained in, a location within a cilium.
protein localization to Golgi apparatus A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of circadian rhythm Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
spindle assembly The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P29295 HRR25 Casein kinase I homolog HRR25 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q5ZLL1 CSNK1E Casein kinase I isoform epsilon Gallus gallus (Chicken) SS
Q86Y07 VRK2 Serine/threonine-protein kinase VRK2 Homo sapiens (Human) PR
P49674 CSNK1E Casein kinase I isoform epsilon Homo sapiens (Human) EV
P48730 CSNK1D Casein kinase I isoform delta Homo sapiens (Human) SS
Q8BN21 Vrk2 Serine/threonine-protein kinase VRK2 Mus musculus (Mouse) PR
Q9JMK2 Csnk1e Casein kinase I isoform epsilon Mus musculus (Mouse) SS
Q9DC28 Csnk1d Casein kinase I isoform delta Mus musculus (Mouse) PR
Q06486 Csnk1d Casein kinase I isoform delta Rattus norvegicus (Rat) PR
P42169 C03C10.2 Putative casein kinase I C03C10.2 Caenorhabditis elegans PR
P34516 K06H7.8 Putative serine/threonine-protein kinase K06H7.1 Caenorhabditis elegans PR
Q6P647 csnk1d Casein kinase I isoform delta Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q7T2E3 csnk1da Casein kinase I isoform delta-A Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q7ZUS1 vrk1 Serine/threonine-protein kinase VRK1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q6P3K7 csnk1db Casein kinase I isoform delta-B Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH IESKIYKMMQ
70 80 90 100 110 120
GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH
130 140 150 160 170 180
SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA
190 200 210 220 230 240
SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL
250 260 270 280 290 300
CKGYPSEFAT YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA
310 320 330 340 350 360
ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS HTANTSPRPV
370 380 390 400 410
SGMERERKVS MRLHRGAPVN ISSSDLTGRQ DTSRMSTSQI PGRVASSGLQ SVVHR