P35294
Gene name |
Rab19 |
Protein name |
Ras-related protein Rab-19 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:19331 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P35294
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P35294-F1 | Predicted | AlphaFoldDB |
11 variants for P35294
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388830750 | 17 | L>M | No | EVA | |
| rs223173616 | 20 | V>I | No | EVA | |
| rs3388830713 | 27 | N>D | No | EVA | |
| rs3396592383 | 55 | T>P | No | EVA | |
| rs3388824169 | 57 | R>S | No | EVA | |
| rs3388821304 | 65 | K>N | No | EVA | |
| rs3388830691 | 126 | M>I | No | EVA | |
| rs3388810613 | 145 | A>G | No | EVA | |
| rs3388810531 | 170 | E>D | No | EVA | |
| rs1135362581 | 191 | S>N | No | EVA | |
| rs3388827234 | 204 | L>H | No | EVA |
No associated diseases with P35294
1 regional properties for P35294
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 16 - 175 | IPR005225 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagosome assembly | The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3ZC27 | RAB19 | Ras-related protein Rab-19 | Bos taurus (Bovine) | PR |
| Q5ZHV1 | RAB33B | Ras-related protein Rab-33B | Gallus gallus (Chicken) | PR |
| Q9H082 | RAB33B | Ras-related protein Rab-33B | Homo sapiens (Human) | PR |
| A4D1S5 | RAB19 | Ras-related protein Rab-19 | Homo sapiens (Human) | PR |
| O35963 | Rab33b | Ras-related protein Rab-33B | Mus musculus (Mouse) | PR |
| P61294 | Rab6b | Ras-related protein Rab-6B | Mus musculus (Mouse) | PR |
| P35279 | Rab6a | Ras-related protein Rab-6A | Mus musculus (Mouse) | PR |
| P35293 | Rab18 | Ras-related protein Rab-18 | Mus musculus (Mouse) | PR |
| Q8CFP6 | Dnajc27 | DnaJ homolog subfamily C member 27 | Mus musculus (Mouse) | PR |
| Q5M7U5 | Rab19 | Ras-related protein Rab-19 | Rattus norvegicus (Rat) | PR |
| Q20365 | rab-33 | Ras-related protein Rab-33 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQFSSSSRTS | DENVDYLFKV | ILIGDSNVGK | TCVVQHFKSG | VYSESQQNTI | GVDFTVRSLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IDGKKVKMQV | WDTAGQERFR | TITQSYYRSA | HAAIIAYDLT | RRSTFESVPH | WIHEIEKYGA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ANLVIMLIGN | KSDLWEKRHV | LFEDACTLAE | KHGLLAVLET | SAKESRNIDE | VFVLMAKELI |
| 190 | 200 | 210 | |||
| ARNSLHLYGE | SAQQGLSQDS | SPVLVAQVPN | ESTRCTC |