P35293
Gene name |
Rab18 |
Protein name |
Ras-related protein Rab-18 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:19330 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P35293
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P35293-F1 | Predicted | AlphaFoldDB |
4 variants for P35293
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3408103396 | 103 | L>* | No | EVA | |
| rs3389493469 | 105 | E>A | No | EVA | |
| rs3389434466 | 177 | E>G | No | EVA | |
| rs3389501811 | 178 | S>N | No | EVA |
No associated diseases with P35293
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| endoplasmic reticulum tubular network | A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GDP binding | Binding to GDP, guanosine 5'-diphosphate. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| endoplasmic reticulum tubular network organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section. |
| eye development | The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. |
| import into nucleus | The directed movement of substances into the nucleus. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| lipid droplet organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0IIG8 | RAB18 | Ras-related protein Rab-18 | Bos taurus (Bovine) | PR |
| Q5ZLG1 | RAB18 | Ras-related protein Rab-18 | Gallus gallus (Chicken) | PR |
| Q9NP72 | RAB18 | Ras-related protein Rab-18 | Homo sapiens (Human) | PR |
| P61294 | Rab6b | Ras-related protein Rab-6B | Mus musculus (Mouse) | PR |
| P35279 | Rab6a | Ras-related protein Rab-6A | Mus musculus (Mouse) | PR |
| P35294 | Rab19 | Ras-related protein Rab-19 | Mus musculus (Mouse) | PR |
| Q8CFP6 | Dnajc27 | DnaJ homolog subfamily C member 27 | Mus musculus (Mouse) | PR |
| Q5EB77 | Rab18 | Ras-related protein Rab-18 | Rattus norvegicus (Rat) | PR |
| Q6DHC1 | rab18b | Ras-related protein Rab-18-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDEDVLTTLK | ILIIGESGVG | KSSLLLRFTD | DTFDPELAAT | IGVDFKVKTI | SVDGNKAKLA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IWDTAGQERF | RTLTPSYYRG | AQGVILVYDV | TRRDTFVKLD | NWLNELETYC | TRNDIVNMLV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GNKIDKENRE | VDRNEGLKFA | RKHSMLFIEA | SAKTCDGVQC | AFEELVEKII | QTPGLWESEN |
| 190 | 200 | ||||
| QNKGVKLSHR | EESRGGGACG | GYCSVL |