P35279
PR
Gene name |
Rab6a (Rab6, MNCb-1660) |
Protein name |
Ras-related protein Rab-6A |
Names |
Rab-6 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:19346 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P35279
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P35279-F1 | Predicted | AlphaFoldDB |
7 variants for P35279
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388926677 | 83 | I>T | No | EVA | |
| rs3397922169 | 118 | D>H | No | EVA | |
| rs3388926405 | 133 | K>N | No | EVA | |
| rs3388931083 | 149 | N>K | No | EVA | |
| rs3398324320 | 154 | E>V | No | EVA | |
| rs3398504251 | 155 | T>S | No | EVA | |
| rs3388928912 | 186 | E>K | No | EVA |
No associated diseases with P35279
1 regional properties for P35279
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 13 - 169 | IPR005225 |
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| acrosomal membrane | The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endosome to plasma membrane transport vesicle | A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to deliver lipids and membrane proteins to the plasma membrane and to release various cargo molecules, such as proteins or hormones, by exocytosis. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| presynapse | The part of a synapse that is part of the presynaptic cell. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATPase activator activity | Binds to and increases the activity of an ATP hydrolysis activity. |
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| myosin V binding | Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. |
| protein domain specific binding | Binding to a specific domain of a protein. |
| protein N-terminus binding | Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| antigen processing and presentation | The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. |
| early endosome to Golgi transport | The directed movement of substances from early endosomes to the Golgi. |
| intra-Golgi vesicle-mediated transport | The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| peptidyl-cysteine methylation | The methylation of peptidyl-cysteine to form peptidyl-S-methyl-L-cysteine. |
| protein localization to Golgi apparatus | A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. |
| protein localization to Golgi membrane | A process in which a protein is transported to, or maintained in, a location within a Golgi membrane. |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
| retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A6QR46 | RAB6B | Ras-related protein Rab-6B | Bos taurus (Bovine) | PR |
| Q1KME6 | RAB6A | Ras-related protein Rab-6A | Gallus gallus (Chicken) | PR |
| O18334 | Rab6 | Ras-related protein Rab6 | Drosophila melanogaster (Fruit fly) | PR |
| O95755 | RAB36 | Ras-related protein Rab-36 | Homo sapiens (Human) | PR |
| Q9BZG1 | RAB34 | Ras-related protein Rab-34 | Homo sapiens (Human) | PR |
| Q5JT25 | RAB41 | Ras-related protein Rab-41 | Homo sapiens (Human) | PR |
| Q9NRW1 | RAB6B | Ras-related protein Rab-6B | Homo sapiens (Human) | PR |
| P20340 | RAB6A | Ras-related protein Rab-6A | Homo sapiens (Human) | PR |
| Q8CAM5 | Rab36 | Ras-related protein Rab-36 | Mus musculus (Mouse) | PR |
| P61294 | Rab6b | Ras-related protein Rab-6B | Mus musculus (Mouse) | PR |
| P35293 | Rab18 | Ras-related protein Rab-18 | Mus musculus (Mouse) | PR |
| P35294 | Rab19 | Ras-related protein Rab-19 | Mus musculus (Mouse) | PR |
| Q8CFP6 | Dnajc27 | DnaJ homolog subfamily C member 27 | Mus musculus (Mouse) | PR |
| Q9WVB1 | Rab6a | Ras-related protein Rab-6A | Rattus norvegicus (Rat) | PR |
| P34213 | rab-6.1 | Ras-related protein rab-6.1 | Caenorhabditis elegans | PR |
| Q22782 | rab-6.2 | Ras-related protein rab-6.2 | Caenorhabditis elegans | PR |
| Q9LFT9 | RABH1E | Ras-related protein RABH1e | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O80501 | RABH1B | Ras-related protein RABH1b | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SMR4 | RABH1C | Ras-related protein RABH1c | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LV79 | RABH1A | Ras-related protein RABH1a | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAGGDFGNP | LRKFKLVFLG | EQSVGKTSLI | TRFMYDSFDN | TYQATIGIDF | LSKTMYLEDR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TVRLQLWDTA | GQERFRSLIP | SYIRDSTVAV | VVYDITNVNS | FQQTTKWIDD | VRTERGSDVI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IMLVGNKTDL | ADKRQVSIEE | GERKAKELNV | MFIETSAKAG | YNVKQLFRRV | AAALPGMEST |
| 190 | 200 | ||||
| QDRSREDMID | IKLEKPQEQP | VNEGGCSC |