AiPD: Autoinhibited Protein Database

P35241

Gene name	RDX
Protein name	Radixin
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5962
EC number
Protein Class

Descriptions

MSN is a moesin protein and belongs to the ezrin-radixin-moesin (ERM) protein family, directly involved in the cytoskeleton-membrane crosslinking. Functional N-terminal FERM domain of ERM attaches to the membrane by binding specific membrane proteins while the last 34 residues of the C-terminal tail domain bind actin filaments. The autoinhibitory domain is positions at the C-terminal tail domain of ERM, where FERM domain of ERM is bound tightly via phosphotyrosine binding (PTB), pleckstrin homology (PH), and Enabled/VASP Homology 1 (EVH1) domains, thus masking the binding sites for other molecules. ERM is activated through phosphorylation at Thr558 weakening the FERM/tail binding and, unmasks the binding sites of membrane protein and actin filaments in the presence of phospholipids.

Autoinhibitory domains (AIDs)

467-583 (Tail domain) SS

Target domain	5-295 (FERM domain)
Relief mechanism	PTM
Assay

AID

467-583 (Tail domain)

Target domain

5-295 (FERM domain)

Relief mechanism

PTM (Phosphorylation at Thr558)

Assay

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100

Pearson MA et al. (2000) "Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain", Cell, 101, 259-70

Austermann J et al. (2008) "Characterization of the Ca2+ -regulated ezrin-S100P interaction and its role in tumor cell migration", The Journal of biological chemistry, 283, 29331-40

Liu J et al. (2014) "Conserved sequence repeats of IQGAP1 mediate binding to Ezrin", Journal of proteome research, 13, 1156-66

Autoinhibited structure

Activated structure

1 structures for P35241

Entry ID	Method	Resolution	Chain	Position	Source
AF-P35241-F1	Predicted				AlphaFoldDB

409 variants for P35241

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs770252893 RCV001102779 CA6270354	101	L>F	Autosomal recessive nonsyndromic hearing loss 24 [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
RCV000014074 rs121918380 CA256734	155	Q>*	Autosomal recessive nonsyndromic hearing loss 24 [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
RCV000778302 CA382868084 rs139960434	191	Y>*	Autosomal recessive nonsyndromic hearing loss 24 [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV000339086 RCV001289164 CA6270267 rs146019940	201	Y>C	Autosomal recessive nonsyndromic hearing loss 24 [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV000281752 CA10633388 rs150863373	279	R>L	Autosomal recessive nonsyndromic hearing loss 24 [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA229017469 RCV002223935 rs893826250 RCV000778301	304	Q>*	Autosomal recessive nonsyndromic hearing loss 24 [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
RCV002522178 CA6270150 rs377016439 RCV000374116	350	R>H	Autosomal recessive nonsyndromic hearing loss 24 [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1463925107 RCV001262022	370	R>*	Autosomal recessive nonsyndromic hearing loss 24 [ClinVar]	Yes	ClinVar dbSNP
rs146713867 RCV003165546 CA6270079 RCV001857751 RCV000218122	385	E>A	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs886047646 CA10637104 RCV000389591	399	A>T	Autosomal recessive nonsyndromic hearing loss 24 [ClinVar]	Yes	ClinGen ClinVar dbSNP gnomAD
CA183860 RCV000155954 rs572843421 RCV000922492 RCV002516139	428	I>V	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs727504709 RCV000155993	438	K>missing	Rare genetic deafness [ClinVar]	Yes	ClinVar dbSNP
RCV000014073 rs1372141763	469	A>missing	Autosomal recessive nonsyndromic hearing loss 24 [ClinVar]	Yes	ClinVar dbSNP
CA6269982 RCV000332763 rs138560358 RCV002520671	471	P>A	Autosomal recessive nonsyndromic hearing loss 24 [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV000037714 CA134769 RCV000275257 RCV000881421 rs74983220	496	A>V	Autosomal recessive nonsyndromic hearing loss 24 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1864714177 RCV001107353	499	E>Q	Autosomal recessive nonsyndromic hearing loss 24 [ClinVar]	Yes	ClinVar dbSNP
rs140180881 RCV002520670 CA6269961 RCV000367552	502	N>D	Inborn genetic diseases Autosomal recessive nonsyndromic hearing loss 24 [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs199573785 CA6269954 RCV001107352	516	T>I	Autosomal recessive nonsyndromic hearing loss 24 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC dbSNP gnomAD
RCV001104608 rs1864709166	526	K>R	Autosomal recessive nonsyndromic hearing loss 24 [ClinVar]	Yes	ClinVar dbSNP
VAR_036859 RCV000014072 rs121918379 CA256733	578	D>N	Variant assessed as Somatic; 0.0 impact. Autosomal recessive nonsyndromic hearing loss 24 DFNB24 [NCI-TCGA, ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt NCI-TCGA dbSNP gnomAD
rs763518071 CA6270454	2	P>L		No	ClinGen ExAC gnomAD
rs1180055130 CA382869801	3	K>E		No	ClinGen gnomAD
CA229019664 rs940919907	5	I>M		No	ClinGen TOPMed gnomAD
CA6270424 rs749170461	5	I>N		No	ClinGen ExAC gnomAD
CA229019663 rs533324168	6	N>D		No	ClinGen TOPMed gnomAD
rs193206883 CA382869478	6	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs777411187 CA6270423	6	N>S		No	ClinGen ExAC TOPMed gnomAD
CA6270420 rs142539598	7	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs142539598 CA6270421 CA382869476	7	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA382869458 rs1172573717	10	T>A		No	ClinGen gnomAD
CA6270419 rs758795848	11	T>A		No	ClinGen ExAC gnomAD
CA229019661 rs975220280	12	M>V		No	ClinGen Ensembl
rs1470002111 CA382869434	13	D>E		No	ClinGen gnomAD
CA229019660 rs200152052	15	E>A		No	ClinGen 1000Genomes
CA382869396 rs1190229511	18	F>L		No	ClinGen gnomAD
rs1484699609 CA382869384	19	A>G		No	ClinGen TOPMed gnomAD
rs1484699609 CA382869383	19	A>V		No	ClinGen TOPMed gnomAD
rs1412807538 CA382869375	20	I>T		No	ClinGen TOPMed
CA382869362 rs1333330754	21	Q>H		No	ClinGen TOPMed gnomAD
rs1376600655 CA382869357	22	P>R		No	ClinGen TOPMed
rs967856297 CA229019659	23	N>S		No	ClinGen gnomAD
rs1217488325 CA382869341	24	T>K		No	ClinGen TOPMed gnomAD
CA229019658 rs745448124	26	G>D		No	ClinGen Ensembl
CA229019657 rs570849275	27	K>R		No	ClinGen Ensembl
CA382869281 rs1221853098	31	D>G		No	ClinGen gnomAD
CA6270395 rs546913232	33	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1350793312 CA382869192	35	K>E		No	ClinGen TOPMed gnomAD
CA6270393 rs764655058	38	G>V		No	ClinGen ExAC gnomAD
CA6270392 rs756266812	40	R>C		No	ClinGen ExAC TOPMed gnomAD
rs771175890 CA6270390	40	R>H		No	ClinGen ExAC TOPMed gnomAD
rs771175890 CA6270391 RCV000608130	40	R>L		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs771175890 CA382869159	40	R>P		No	ClinGen ExAC TOPMed gnomAD
CA382869149 rs774408089	42	V>F		No	ClinGen ExAC TOPMed gnomAD
CA6270388 rs774408089	42	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1412883921 CA382869137	43	W>C		No	ClinGen TOPMed
CA382869140 rs1371794483	43	W>L		No	ClinGen TOPMed
rs766246489 CA6270387	45	F>L		No	ClinGen ExAC TOPMed gnomAD
CA382869106 rs1467025026	48	Q>R		No	ClinGen gnomAD
CA6270386 rs201338088	49	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1199209715 CA382869094	50	V>I		No	ClinGen gnomAD
rs1246719462 CA382869084	51	D>V		No	ClinGen TOPMed
rs191491207 CA6270385	52	S>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA
CA382869064 rs1268700666	54	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs769654968 CA6270384	54	G>V		No	ClinGen ExAC gnomAD
rs1026218136 CA229018654	56	S>C		No	ClinGen Ensembl
CA382869052 rs1292861284	56	S>P		No	ClinGen gnomAD
CA229018653 rs759999873	57	T>A		No	ClinGen Ensembl
CA382869037 rs1184962249	58	W>*		No	ClinGen Ensembl
rs12575547 CA229018652	61	L>V		No	ClinGen Ensembl
CA229018651 rs997405742	62	N>H		No	ClinGen Ensembl
CA382869005 rs1276316036	63	K>R		No	ClinGen gnomAD
CA382868981 rs1171957975	65	V>I		No	ClinGen gnomAD
CA382868979 rs1171957975	65	V>L		No	ClinGen gnomAD
CA6270366 rs766473708	66	T>S		No	ClinGen ExAC gnomAD
rs903287405 CA229018595	67	Q>L		No	ClinGen Ensembl
CA6270365 rs762814919	68	Q>H		No	ClinGen ExAC gnomAD
CA6270364 rs750130636	69	D>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA382868949 rs1420722740	70	V>I		No	ClinGen gnomAD
CA229018594 rs928846227	71	K>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA229018593 rs1046298143	75	P>S		No	ClinGen TOPMed gnomAD
CA6270362 rs570197235	76	L>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1024390508 CA229018592	76	L>V		No	ClinGen TOPMed gnomAD
rs948868930 CA229018591	78	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1346670512 CA382868884	79	K>R		No	ClinGen gnomAD
CA229018590 rs915988891	80	F>L		No	ClinGen TOPMed
CA6270359 rs760060345	85	F>I		No	ClinGen ExAC TOPMed gnomAD
RCV000219753 CA6270358 rs376418131	86	P>A		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1359079462 CA382868832	86	P>L		No	ClinGen TOPMed
rs376418131 CA382868836	86	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs550717233 CA6270357	89	V>I		No	ClinGen 1000Genomes ExAC gnomAD
rs528974802 CA6270356	91	E>G		No	ClinGen 1000Genomes ExAC gnomAD
CA6270355 rs778347694	94	I>V		No	ClinGen ExAC gnomAD
rs748714954 CA6270353	101	L>R		No	ClinGen ExAC gnomAD
CA6270351 rs755117227	102	F>L		No	ClinGen ExAC gnomAD
CA382868706 rs758609386	105	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs758609386 CA6270348	105	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA6270349 rs758609386	105	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA382868673 rs1419991939	109	A>V		No	ClinGen gnomAD
CA6270347 rs765061992	110	I>F		No	ClinGen ExAC gnomAD
CA6270346 rs765061992	110	I>V		No	ClinGen ExAC gnomAD
CA6270345 rs753800892	113	D>E		No	ClinGen ExAC TOPMed gnomAD
CA229018588 rs561699385	114	E>K		No	ClinGen 1000Genomes
CA229018587 rs919237920	115	I>M		No	ClinGen TOPMed gnomAD
rs763870351 CA6270343	116	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs1229959067 CA382868622	117	C>Y		No	ClinGen TOPMed
rs1210684516 CA382868596	121	T>A		No	ClinGen TOPMed
CA382868591 rs1257568242	122	A>T		No	ClinGen TOPMed
rs200090161 CA6270340	126	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA382868562 rs1188215593	126	A>V		No	ClinGen TOPMed
rs1246038476 CA382868558	127	S>C		No	ClinGen gnomAD
CA6270339 rs774125184	128	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs770307768 CA6270338	131	Q>H		No	ClinGen ExAC gnomAD
rs376337012 CA382868516	133	K>N		No	ClinGen ESP ExAC gnomAD
CA6270335 rs768988858	134	Y>C		No	ClinGen ExAC gnomAD
CA6270336 rs777285617	134	Y>H		No	ClinGen ExAC gnomAD
rs1424460559 CA382868506	135	G>E		No	ClinGen TOPMed
CA229018585 rs201598955	136	D>G		No	ClinGen gnomAD
CA382868503 rs1384571095	136	D>N		No	ClinGen TOPMed gnomAD
rs1022001914 CA229018584	137	Y>C		No	ClinGen TOPMed
rs190296143 CA6270334	138	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1396587120 CA382868454	142	H>R		No	ClinGen gnomAD
CA6270333 rs780068896	143	K>N		No	ClinGen ExAC TOPMed gnomAD
CA382868439 rs1319544788	144	P>L		No	ClinGen TOPMed
CA6270332 rs758479232	145	G>A		No	ClinGen ExAC TOPMed gnomAD
CA382868435 rs758479232	145	G>D		No	ClinGen ExAC TOPMed gnomAD
rs746106701 CA6270331	146	Y>H		No	ClinGen ExAC gnomAD
CA382868416 rs1194831380	148	A>V		No	ClinGen gnomAD
CA229018583 rs892144169	149	N>T		No	ClinGen TOPMed
rs1426337057 CA382868405	150	D>A		No	ClinGen gnomAD
rs1426337057 CA382868404	150	D>G		No	ClinGen gnomAD
CA229018582 rs1031071840	151	R>K		No	ClinGen TOPMed
CA382868395 rs779065310	151	R>S		No	ClinGen ExAC gnomAD
CA382868389 rs1210797282	152	L>R		No	ClinGen gnomAD
CA382868368 rs1213643220	156	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA6270328 rs753570699	156	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1470753928 CA601962164	158	L>FK*		No	ClinGen gnomAD
rs930558988 CA229017886	159	E>D		No	ClinGen TOPMed
CA6270295 rs762764289	161	H>N		No	ClinGen ExAC
CA6270294 rs772892808	162	K>R		No	ClinGen ExAC gnomAD
rs1180308372 CA382868297	164	T>I		No	ClinGen gnomAD
CA6270293 rs761056787	165	K>E		No	ClinGen ExAC TOPMed gnomAD
rs761056787 CA6270292	165	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA6270291 rs775863166	166	E>D		No	ClinGen ExAC gnomAD
rs772506958 CA6270290	167	Q>E		No	ClinGen ExAC gnomAD
CA229017885 rs532467334	167	Q>R		No	ClinGen TOPMed
rs760022115 CA6270289	170	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1279952599 CA382868250	171	R>K		No	ClinGen gnomAD
CA6270288 rs774479712	172	I>K		No	ClinGen ExAC gnomAD
rs1278022845 CA382868235	173	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA382868214 rs1236827750	176	H>N		No	ClinGen gnomAD
CA6270287 rs770966763	176	H>R		No	ClinGen ExAC TOPMed gnomAD
CA382868207 rs1312933297	177	E>K		No	ClinGen gnomAD
rs1373231261 CA382868190	179	H>D		No	ClinGen gnomAD
CA382868165 rs1311898195	182	M>T		No	ClinGen gnomAD
rs760956967 CA382868128	185	E>D		No	ClinGen ExAC TOPMed gnomAD
CA382868116 rs1167744965	187	S>A		No	ClinGen gnomAD
RCV000595667 CA6270273 CA6270272 rs141888853	188	M>I		No	ClinGen ESP ExAC TOPMed gnomAD ClinVar dbSNP
CA6270274 rs753162328	188	M>V		No	ClinGen ExAC TOPMed gnomAD
rs977975801 CA229017871	190	E>G		No	ClinGen Ensembl
rs1395517131 CA382868062	195	A>T		No	ClinGen TOPMed
CA382868052 rs1190745874	196	Q>R		No	ClinGen gnomAD
CA382868043 rs1430107242	197	D>V		No	ClinGen TOPMed
CA6270270 rs771021876	198	L>V		No	ClinGen ExAC gnomAD
rs763049581 CA6270269	200	M>V		No	ClinGen ExAC TOPMed gnomAD
CA6270268 rs200979844	201	Y>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA229017868 rs999025809	203	V>I		No	ClinGen TOPMed
CA382868000 rs1270058032	204	N>S		No	ClinGen TOPMed
CA6270266 rs748307983	208	I>V		No	ClinGen ExAC gnomAD
CA229017867 rs1033344762	209	K>R		No	ClinGen TOPMed
CA6270264 rs768543778	211	K>R		No	ClinGen ExAC TOPMed
CA6270263 rs746996085	212	K>E		No	ClinGen ExAC gnomAD
CA6270261 rs757983014	217	W>G		No	ClinGen ExAC gnomAD
CA382867898 rs1591158664	218	L>P		No	ClinGen Ensembl
rs1171207515 CA382867874	222	A>S		No	ClinGen gnomAD
rs1256221880 CA382867860	224	G>D		No	ClinGen TOPMed
CA382867858 rs1256221880	224	G>V		No	ClinGen TOPMed
CA382867855 rs1417549341	225	L>P		No	ClinGen gnomAD
CA6270256 rs767917915	226	N>S		No	ClinGen ExAC gnomAD
rs759844390 CA6270255	229	E>D		No	ClinGen ExAC gnomAD
CA382867820 rs1195313309	230	H>R		No	ClinGen TOPMed gnomAD
CA6270254 rs752091940	232	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6270230 rs759013014	235	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA229017605 rs1015257930	238	I>T		No	ClinGen TOPMed
rs750867106 CA6270229	239	G>R		No	ClinGen ExAC gnomAD
rs1420781644 CA382867724	242	W>*		No	ClinGen gnomAD
rs761754434 CA6270227	242	W>G		No	ClinGen ExAC gnomAD
CA6270226 rs776993573	243	S>R		No	ClinGen ExAC TOPMed gnomAD
CA6270225 rs764350321	248	I>T		No	ClinGen ExAC gnomAD
rs1475251489 CA382867668	250	F>L		No	ClinGen gnomAD
rs1259104257 CA382867657	251	N>S		No	ClinGen gnomAD
rs760963268 CA6270224	252	D>G		No	ClinGen ExAC gnomAD
rs760963268 CA382867649	252	D>V		No	ClinGen ExAC gnomAD
CA6270223 rs775489692	253	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1315647125 CA382867626	255	F>C		No	ClinGen gnomAD
CA6270220 rs745866179	256	V>G		No	ClinGen ExAC TOPMed gnomAD
rs771731527 CA6270221	256	V>L		No	ClinGen ExAC gnomAD
CA6270218 rs770505660	259	P>S		No	ClinGen ExAC gnomAD
CA229017604 rs997759369	260	I>T		No	ClinGen TOPMed
RCV000155275 RCV000766845 rs138116275 CA182496	260	I>V		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1386279803 CA382867591	261	D>A		No	ClinGen gnomAD
rs1455213377 CA382867594	261	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
RCV000214012 rs201031650 CA6270214	264	A>P		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA6270215 rs201031650	264	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs567486858 CA229017602	265	P>R		No	ClinGen Ensembl
rs762865437 CA6270200	266	D>G		No	ClinGen ExAC TOPMed gnomAD
rs774350060 CA6270201	266	D>N		No	ClinGen ExAC gnomAD
rs762865437 CA6270199	266	D>V		No	ClinGen ExAC TOPMed gnomAD
CA382867517 rs1320616517	270	Y>H		No	ClinGen TOPMed
CA382867508 rs1222145324	271	A>S		No	ClinGen TOPMed
CA382867499 rs1415646714	272	P>L		No	ClinGen gnomAD
CA382867504 rs1427063445	272	P>T		No	ClinGen gnomAD
CA6270198 rs370869036	273	R>C		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs142346566 CA6270197	273	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA229017474 rs962472148	275	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA382867483 rs962472148	275	R>K		No	ClinGen TOPMed gnomAD
rs1238810329 CA382867474	276	I>S		No	ClinGen TOPMed
CA6270196 rs367959168	277	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA382867460 rs1185421880	278	K>M		No	ClinGen TOPMed
CA6270194 rs150863373	279	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6270195 rs17854426	279	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA382867454 rs1174111572	280	I>V		No	ClinGen TOPMed
rs779319068 CA6270192	281	L>S		No	ClinGen ExAC gnomAD
CA382867438 rs1180466589	282	A>G		No	ClinGen gnomAD
CA229017472 rs370138199	283	L>F		No	ClinGen ESP TOPMed gnomAD
rs899794374 CA229017471	284	C>R		No	ClinGen Ensembl
rs754363355 CA6270190	288	H>R		No	ClinGen ExAC gnomAD
CA382867386 rs1483135162	289	E>D		No	ClinGen gnomAD
rs778047006 CA6270189	291	Y>H		No	ClinGen ExAC gnomAD
rs767569356 CA6270186	292	M>L		No	ClinGen ExAC gnomAD
rs767569356 CA6270187	292	M>V		No	ClinGen ExAC gnomAD
CA6270185 rs759389484	293	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA6270184 rs147732690	297	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1174649339 CA382867326	299	T>A		No	ClinGen gnomAD
CA6270183 rs766193519	299	T>N		No	ClinGen ExAC gnomAD
CA6270182 rs762920481	300	I>T		No	ClinGen ExAC
rs1212547271 CA382867321	300	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs769318918 CA6270180	303	Q>P		No	ClinGen ExAC gnomAD
rs951352621 CA229017468	305	M>I		No	ClinGen TOPMed
rs761276998 CA6270179	305	M>K		No	ClinGen ExAC gnomAD
CA382867268 rs1194199542	307	A>V		No	ClinGen gnomAD
CA382867245 rs1482842876	311	E>Q		No	ClinGen gnomAD
CA6270177 rs200709947	314	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA382867206 rs1283154489	316	K>E		No	ClinGen TOPMed
CA229016779 rs983104500	322	Q>K		No	ClinGen Ensembl
rs17854427 CA229016778 VAR_036857	328	K>E		No	ClinGen UniProt Ensembl dbSNP
CA382867090 rs1565313533	329	K>N		No	ClinGen Ensembl
rs576461351 CA6270164	329	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs533107164 CA6270162 RCV001562098 RCV000218314	332	I>T		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs761720838 CA6270161	333	A>T		No	ClinGen ExAC gnomAD
rs1237181088 CA382867057	334	E>V		No	ClinGen gnomAD
rs776049009 CA6270159	336	E>G		No	ClinGen ExAC gnomAD
rs763659660 CA6270158	338	E>K		No	ClinGen ExAC gnomAD
CA382867014 rs1269884778	340	I>K		No	ClinGen TOPMed gnomAD
rs1472479600 CA382867011	340	I>M		No	ClinGen TOPMed
rs1030064754 CA229016776	342	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs760305656 CA6270157	342	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1273246492 CA382866996	343	E>K		No	ClinGen gnomAD
rs1565313478 CA382866990	344	K>Q		No	ClinGen Ensembl
rs775152694 CA6270156	345	E>K		No	ClinGen ExAC gnomAD
RCV001358542 rs141462728 RCV000600590 CA6270155	346	E>A		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs770471737 CA6270152	349	E>G		No	ClinGen ExAC gnomAD
CA6270153 rs773878373	349	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs748656504 CA6270151	350	R>C		No	ClinGen ExAC TOPMed gnomAD
CA6270149 rs747206359	354	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1415001942 CA382866916	355	E>Q		No	ClinGen gnomAD
rs762915826 CA382866890	358	T>I		No	ClinGen TOPMed
CA229016775 rs762915826	358	T>K		No	ClinGen TOPMed
CA382866885 rs1413266757	359	I>V		No	ClinGen TOPMed gnomAD
rs1249628120 CA382866854	363	K>R		No	ClinGen gnomAD
CA6270091 rs762103695	367	E>Q		No	ClinGen ExAC gnomAD
CA6270090 rs201399984	369	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
RCV001858412 CA6270089 RCV000826031 rs201399984	369	T>S		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA382574020 rs1463925107	370	R>G		No	ClinGen gnomAD
rs1379848461 CA382574017	370	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA228498841 rs199534450	371	K>E		No	ClinGen 1000Genomes
CA6270087 rs761232127	376	D>E		No	ClinGen ExAC TOPMed gnomAD
CA382573964 rs1214332223	376	D>G		No	ClinGen TOPMed gnomAD
rs772146113 CA382573929	379	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed
CA6270084 rs759574395	379	R>L		No	ClinGen ExAC gnomAD
CA382573927 rs759574395	379	R>Q		No	ClinGen ExAC gnomAD
CA382573909 rs1308348441	381	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs774459596 CA382573908	381	R>P		No	ClinGen ExAC TOPMed gnomAD
rs774459596 CA6270083	381	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs376810025 CA6270081	382	A>P		No	ClinGen ESP ExAC gnomAD
rs376810025 CA6270080	382	A>T		No	ClinGen ESP ExAC gnomAD
CA6270078 rs748108220	387	E>K		No	ClinGen ExAC gnomAD
CA6270077 rs754563690	388	R>*		No	ClinGen ExAC TOPMed gnomAD
CA382573844 rs1477005471	388	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1291327971 CA382573833	389	L>H		No	ClinGen gnomAD
rs746466609 CA6270075	390	E>G		No	ClinGen ExAC gnomAD
rs779405847 CA6270074	391	K>E		No	ClinGen ExAC gnomAD
CA6270073 rs727505297 CA382573803	392	E>D		No	ClinGen ExAC TOPMed gnomAD
rs750035123 CA6270072	393	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs764536750 CA6270071	393	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed
CA6270070 rs756407279	394	R>*		No	ClinGen ExAC TOPMed gnomAD
CA6270069 rs780679073	394	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1209373602 CA382573733	400	K>M		No	ClinGen gnomAD
rs767965188 CA228498689	401	S>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel rs1591137281 CA382573727	401	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
CA6270068 rs767965188	401	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA6270067 rs373960715	402	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs369202684 CA6270066	404	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6270065 rs766364205	408	A>V		No	ClinGen ExAC gnomAD
rs769714594 CA6270062	409	D>N		No	ClinGen ExAC TOPMed gnomAD
CA382573632 rs1298544556	410	Q>R		No	ClinGen gnomAD
CA6270060 rs776729174	411	M>I		No	ClinGen ExAC gnomAD
rs747909378 CA6270061	411	M>R		No	ClinGen ExAC gnomAD
rs1428169066 CA382573615	412	K>Q		No	ClinGen gnomAD
CA382573609 rs1370371596	412	K>R		No	ClinGen gnomAD
rs768760004 CA382573601	413	N>I		No	ClinGen ExAC gnomAD
rs768760004 CA6270059	413	N>S		No	ClinGen ExAC gnomAD
CA228498643 rs930575497	414	Q>K		No	ClinGen TOPMed
CA6270058 rs746885384	414	Q>L		No	ClinGen ExAC gnomAD
rs1350109120 CA382573586	415	E>K		No	ClinGen TOPMed
CA6270057 rs779676296	417	L>V		No	ClinGen ExAC TOPMed gnomAD
rs200525150 CA6270037	418	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA382573273 rs1187916181	419	A>G		No	ClinGen gnomAD
rs1277665435 CA382573262	420	E>V		No	ClinGen TOPMed
CA382573240 rs1253939697	422	A>V		No	ClinGen gnomAD
CA382573186 rs1226107324	427	K>N		No	ClinGen gnomAD
rs770612865 CA6270033	427	K>R		No	ClinGen ExAC gnomAD
rs375938363 CA228497759	428	I>T		No	ClinGen ESP
CA228497740 rs866703297	429	A>S		No	ClinGen gnomAD
CA382573171 rs866703297	429	A>T		No	ClinGen gnomAD
rs755277132 CA6270031	430	L>F		No	ClinGen ExAC TOPMed gnomAD
CA6270030 rs752109745	434	A>P		No	ClinGen ExAC gnomAD
rs752109745 CA382573124	434	A>T		No	ClinGen ExAC gnomAD
CA6270028 rs758524429	435	K>E		No	ClinGen ExAC
rs750514673 CA382573106	435	K>N		No	ClinGen ExAC gnomAD
CA228497698 rs1000629842	437	K>T		No	ClinGen TOPMed
rs1565306762 CA382573046	440	E>D		No	ClinGen Ensembl
CA382573035 rs1591135650	441	E>G		No	ClinGen Ensembl
CA382573019 rs1165246963	443	T>A		No	ClinGen gnomAD
rs754058941 CA6270023	445	W>C		No	ClinGen ExAC gnomAD
CA177716 rs727503393 RCV000151738	447	H>Q		No	ClinGen ClinVar Ensembl dbSNP
rs763990381 CA6270022	447	H>R		No	ClinGen ExAC gnomAD
CA382572961 rs1182813603	448	K>E		No	ClinGen gnomAD
rs1352385377 CA382572662	449	A>G		No	ClinGen gnomAD
CA382572630 rs1565305499	451	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA382572628 rs1422141289	452	A>T		No	ClinGen TOPMed
rs759449465 CA6269995	454	E>*		No	ClinGen ExAC
RCV000156494 RCV001850160 rs727505062 CA184951	455	D>A		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA382572583 rs201761918	455	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6269991 rs762407915	466	V>E		No	ClinGen ExAC gnomAD
rs769377191 CA6269989	467	M>I		No	ClinGen ExAC gnomAD
CA382572433 rs1231807337	469	A>V		No	ClinGen TOPMed gnomAD
CA6269986 rs772465918	470	P>R		No	ClinGen ExAC
rs754733997 CA6269978	471	P>H		No	ClinGen ExAC gnomAD
CA6269980 rs754733997	471	P>L	Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA6269979 rs754733997	471	P>R		No	ClinGen ExAC gnomAD
RCV000401456 CA6269983 rs138560358	471	P>S		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs138560358 CA6269981	471	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs766253404 CA6269974	474	P>L		No	ClinGen ExAC TOPMed gnomAD
rs772746054 CA6269970	481	P>A		No	ClinGen ExAC gnomAD
CA6269968 rs761425561	485	E>K		No	ClinGen ExAC gnomAD
CA6269966 rs772357302	487	D>N		No	ClinGen ExAC TOPMed gnomAD
CA228495695 rs201741843	488	E>G		No	ClinGen 1000Genomes
CA382572207 rs1411872584	489	H>Q		No	ClinGen gnomAD
CA228495681 rs961196966	490	D>G		No	ClinGen TOPMed gnomAD
CA134767 RCV000037713 RCV001571007 rs34471100 VAR_036858	490	D>N		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA382572193 rs961196966	490	D>V		No	ClinGen TOPMed gnomAD
rs1191086578 CA382572166	492	N>H		No	ClinGen TOPMed
rs149915672 CA6269962	499	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA228495648 rs889509891	501	S>P		No	ClinGen TOPMed
rs140180881 CA6269960	502	N>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs781434721 CA6269959	504	G>R		No	ClinGen ExAC gnomAD
rs146734750 CA6269958	506	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA382571958 rs1239679893	508	H>R		No	ClinGen gnomAD
CA6269957 rs751403876	508	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA6269955 rs758394158	511	E>K		No	ClinGen ExAC gnomAD
rs894093123 CA228495628	513	E>K		No	ClinGen TOPMed gnomAD
CA228495623 rs1019544317	514	R>C		No	ClinGen TOPMed
CA228495619 rs758006766	514	R>H		No	ClinGen gnomAD
rs1327254539 CA382571889	515	V>I		No	ClinGen TOPMed gnomAD
CA382571873 rs1379664354	517	E>K		No	ClinGen gnomAD
CA6269952 rs761349279	519	Q>H		No	ClinGen ExAC gnomAD
CA6269951 rs753458211	522	E>K		No	ClinGen ExAC gnomAD
rs763861122 CA6269950	523	R>C		No	ClinGen ExAC gnomAD
rs374217847 CA6269949	523	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs374217847 CA6269948	523	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6269947 rs771409632	527	Q>L		No	ClinGen ExAC gnomAD
CA228494808 rs768846725	536	A>T		No	ClinGen gnomAD
rs143401385 CA382571118	540	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA6269931 rs143401385	540	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs760462619 CA382571073	542	T>I		No	ClinGen ExAC TOPMed gnomAD
rs760462619 CA6269930	542	T>N		No	ClinGen ExAC TOPMed gnomAD
rs763338823 CA6269927	546	Q>E		No	ClinGen ExAC gnomAD
CA228494783 rs200726776	550	L>F		No	ClinGen 1000Genomes TOPMed gnomAD
CA228494786 rs200726776	550	L>I		No	ClinGen 1000Genomes TOPMed gnomAD
rs1489548023 CA382570838	555	V>I		No	ClinGen gnomAD
rs958586956 CA228494775	556	K>N		No	ClinGen TOPMed gnomAD
CA6269925 rs770379250	557	A>V		No	ClinGen ExAC TOPMed gnomAD
CA6269924 rs528380395	559	R>C		No	ClinGen ExAC TOPMed gnomAD
rs776835361 CA6269923	559	R>H		No	ClinGen ExAC gnomAD
rs1324635029 CA382570763	560	D>G		No	ClinGen gnomAD
rs139896690 CA6269922	563	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA382570704 rs1179716581	564	T>A		No	ClinGen TOPMed
rs762658340 CA228494742	566	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA382570649 rs1369269011	567	Q>R		No	ClinGen gnomAD
rs868305531 CA228494733	569	R>*		No	ClinGen Ensembl
rs780179741 CA6269920	569	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1371513238 CA382570590	572	N>D		No	ClinGen gnomAD
rs1170898250 CA382570567	573	T>A		No	ClinGen gnomAD
CA382570533 rs1232437292	575	Q>E		No	ClinGen TOPMed
rs745727415 CA6269918	577	I>T		No	ClinGen ExAC gnomAD
RCV000826030 CA6269919 rs370958814	577	I>V		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA6269916 rs757290634	582	A>V		No	ClinGen ExAC gnomAD
CA382570407 rs1483519462	583	M>T		No	ClinGen gnomAD
CA6269915 rs753707089	583	M>V		No	ClinGen ExAC gnomAD

1 associated diseases with P35241

[MIM: 611022]: Deafness, autosomal recessive, 24 (DFNB24)

A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. . Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. . Note=The disease is caused by variants affecting the gene represented in this entry.

5 regional properties for P35241

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	249 - 500	IPR000719
active_site	Serine/threonine-protein kinase, active site	364 - 376	IPR008271
binding_site	Protein kinase, ATP binding site	255 - 278	IPR017441
domain	p21 activated kinase binding domain	72 - 117	IPR033923
domain	p21-activated kinase 2, catalytic domain	229 - 524	IPR035064

Functions

		Description
EC Number
Subcellular Localization	Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cytoskeleton Cleavage furrow Cell projection, microvillus Cell projection, stereocilium	Enriched at the stereocilium base with very low levels in the shaft of stereociliary bundles (By similarity) Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

17 GO annotations of cellular component

Name	Definition
adherens junction	A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
apical part of cell	The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
cell periphery	The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures.
cell tip	The region at the end of the longest axis of a cylindrical or elongated cell.
cleavage furrow	The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
cortical actin cytoskeleton	The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
filopodium	Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
lamellipodium	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
microvillus	Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
stereocilium base	The tapered base of the stereocilium adjacent to where it joins the hair cell body. This region contains a rootlet comprised of bundled actin filaments which spans the joint and stabilizes the stereocilium.
T-tubule	Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.

6 GO annotations of molecular function

Name	Definition
actin binding	Binding to monomeric or multimeric forms of actin, including actin filaments.
ATPase binding	Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
cell adhesion molecule binding	Binding to a cell adhesion molecule.
protein kinase A binding	Binding to a protein kinase A.
RNA binding	Binding to an RNA molecule or a portion thereof.

25 GO annotations of biological process

Name	Definition
apical protein localization	Any process in which a protein is transported to, or maintained in, apical regions of the cell.
barbed-end actin filament capping	The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
cellular response to platelet-derived growth factor stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.
cellular response to thyroid hormone stimulus	A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
establishment of endothelial barrier	The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.
establishment of protein localization to plasma membrane	The directed movement of a protein to a specific location in a plasma membrane.
negative regulation of adherens junction organization	Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization.
negative regulation of cell size	Any process that reduces cell size.
negative regulation of GTPase activity	Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
negative regulation of homotypic cell-cell adhesion	Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion.
positive regulation of cell migration	Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of early endosome to late endosome transport	Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport.
positive regulation of G1/S transition of mitotic cell cycle	Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of protein catabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
positive regulation of protein localization to early endosome	Any process that activates or increases the frequency, rate or extent of protein localization to early endosome.
protein kinase A signaling	A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
protein localization to plasma membrane	A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
regulation of actin filament bundle assembly	Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles.
regulation of cell shape	Any process that modulates the surface configuration of a cell.
regulation of cell size	Any process that modulates the size of a cell.
regulation of GTPase activity	Any process that modulates the rate of GTP hydrolysis by a GTPase.
regulation of organelle assembly	Any process that modulates the frequency, rate or extent of organelle assembly.
regulation of Rap protein signal transduction	Any process that modulates the frequency, rate or extent of Rap protein signal transduction.
regulation of ruffle assembly	Any process that modulates the frequency, rate or extent of ruffle assembly.

21 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P31976	EZR	Ezrin	Bos taurus (Bovine)	PR
Q2HJ49	MSN	Moesin	Bos taurus (Bovine)	PR
Q32LP2	RDX	Radixin	Bos taurus (Bovine)	SS
Q9PU45	RDX	Radixin	Gallus gallus (Chicken)	PR
Q24564	Mer	Moesin/ezrin/radixin homolog 2	Drosophila melanogaster (Fruit fly)	SS
P46150	Moe	Moesin/ezrin/radixin homolog 1	Drosophila melanogaster (Fruit fly)	SS
Q3KP66	INAVA	Innate immunity activator protein	Homo sapiens (Human)	PR
P35240	NF2	Merlin	Homo sapiens (Human)	EV
P26038	MSN	Moesin	Homo sapiens (Human)	EV
P15311	EZR	Ezrin	Homo sapiens (Human)	EV
A2AD83	Frmd7	FERM domain-containing protein 7	Mus musculus (Mouse)	PR
P26040	Ezr	Ezrin	Mus musculus (Mouse)	SS
P26041	Msn	Moesin	Mus musculus (Mouse)	SS
P46662	Nf2	Merlin	Mus musculus (Mouse)	SS
P26043	Rdx	Radixin	Mus musculus (Mouse)	SS
P26042	MSN	Moesin	Sus scrofa (Pig)	PR
P26044	RDX	Radixin	Sus scrofa (Pig)	SS
Q63648	Nf2	Merlin	Rattus norvegicus (Rat)	SS
O35763	Msn	Moesin	Rattus norvegicus (Rat)	SS
P31977	Ezr	Ezrin	Rattus norvegicus (Rat)	SS
Q6Q413	nf2b	NF2, moesin-ezrin-radixin-like	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MPKPINVRVT	TMDAELEFAI	QPNTTGKQLF	DQVVKTVGLR	EVWFFGLQYV	DSKGYSTWLK
70	80	90	100	110	120
LNKKVTQQDV	KKENPLQFKF	RAKFFPEDVS	EELIQEITQR	LFFLQVKEAI	LNDEIYCPPE
130	140	150	160	170	180
TAVLLASYAV	QAKYGDYNKE	IHKPGYLAND	RLLPQRVLEQ	HKLTKEQWEE	RIQNWHEEHR
190	200	210	220	230	240
GMLREDSMME	YLKIAQDLEM	YGVNYFEIKN	KKGTELWLGV	DALGLNIYEH	DDKLTPKIGF
250	260	270	280	290	300
PWSEIRNISF	NDKKFVIKPI	DKKAPDFVFY	APRLRINKRI	LALCMGNHEL	YMRRRKPDTI
310	320	330	340	350	360
EVQQMKAQAR	EEKHQKQLER	AQLENEKKKR	EIAEKEKERI	EREKEELMER	LKQIEEQTIK
370	380	390	400	410	420
AQKELEEQTR	KALELDQERK	RAKEEAERLE	KERRAAEEAK	SAIAKQAADQ	MKNQEQLAAE
430	440	450	460	470	480
LAEFTAKIAL	LEEAKKKKEE	EATEWQHKAF	AAQEDLEKTK	EELKTVMSAP	PPPPPPPVIP
490	500	510	520	530	540
PTENEHDEHD	ENNAEASAEL	SNEGVMNHRS	EEERVTETQK	NERVKKQLQA	LSSELAQARD
550	560	570	580
ETKKTQNDVL	HAENVKAGRD	KYKTLRQIRQ	GNTKQRIDEF	EAM