P34722

PR
Gene name
tpa-1 (B0545.1)
Protein name
Protein kinase C-like 1
Names
PKC, Tetradecanoyl phorbol acetate-resistant protein 1
Species
Caenorhabditis elegans
KEGG Pathway
EC number
2.7.11.13: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

101-180 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

516-540 (Activation loop from InterPro)

Target domain

375-634 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P34722

Entry ID Method Resolution Chain Position Source
AF-P34722-F1 Predicted AlphaFoldDB

No variants for P34722

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P34722

No associated diseases with P34722

11 regional properties for P34722

Type Name Position InterPro Accession
domain Protein kinase domain 375 - 634 IPR000719
domain AGC-kinase, C-terminal 635 - 704 IPR000961
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 165 - 217 IPR002219-1
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 237 - 289 IPR002219-2
active_site Serine/threonine-protein kinase, active site 495 - 507 IPR008271
binding_site Protein kinase, ATP binding site 381 - 404 IPR017441
domain Protein kinase, C-terminal 655 - 697 IPR017892
domain Diacylglycerol/phorbol-ester binding 163 - 177 IPR020454-1
domain Diacylglycerol/phorbol-ester binding 179 - 188 IPR020454-2
domain Diacylglycerol/phorbol-ester binding 192 - 203 IPR020454-3
domain Diacylglycerol/phorbol-ester binding 276 - 288 IPR020454-4

Functions

Description
EC Number 2.7.11.13 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium-dependent protein kinase C activity Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
metal ion binding Binding to a metal ion.
mitogen-activated protein kinase kinase kinase binding Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

7 GO annotations of biological process

Name Definition
defense response to fungus Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
positive regulation of axon regeneration Any process that activates, maintains or increases the rate of axon regeneration.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
response to wounding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

31 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P24583 PKC1 Protein kinase C-like 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
A1A4I4 PKN1 Serine/threonine-protein kinase N1 Bos taurus (Bovine) SS
A1Z7T0 Pkn Serine/threonine-protein kinase N Drosophila melanogaster (Fruit fly) SS
P83099 Pkcdelta Putative protein kinase C delta type homolog Drosophila melanogaster (Fruit fly) PR
Q6P5Z2 PKN3 Serine/threonine-protein kinase N3 Homo sapiens (Human) SS
Q96LW2 RSKR Ribosomal protein S6 kinase-related protein Homo sapiens (Human) PR
Q02156 PRKCE Protein kinase C epsilon type Homo sapiens (Human) SS
P24723 PRKCH Protein kinase C eta type Homo sapiens (Human) SS
Q16512 PKN1 Serine/threonine-protein kinase N1 Homo sapiens (Human) EV
Q16513 PKN2 Serine/threonine-protein kinase N2 Homo sapiens (Human) EV
Q04759 PRKCQ Protein kinase C theta type Homo sapiens (Human) PR
Q05655 PRKCD Protein kinase C delta type Homo sapiens (Human) SS
P70268 Pkn1 Serine/threonine-protein kinase N1 Mus musculus (Mouse) SS
P23298 Prkch Protein kinase C eta type Mus musculus (Mouse) PR
Q8BWW9 Pkn2 Serine/threonine-protein kinase N2 Mus musculus (Mouse) SS
Q8K045 Pkn3 Serine/threonine-protein kinase N3 Mus musculus (Mouse) SS
P16054 Prkce Protein kinase C epsilon type Mus musculus (Mouse) PR
Q02111 Prkcq Protein kinase C theta type Mus musculus (Mouse) PR
P28867 Prkcd Protein kinase C delta type Mus musculus (Mouse) PR
Q63433 Pkn1 Serine/threonine-protein kinase N1 Rattus norvegicus (Rat) SS
Q64617 Prkch Protein kinase C eta type Rattus norvegicus (Rat) PR
P09216 Prkce Protein kinase C epsilon type Rattus norvegicus (Rat) PR
O08874 Pkn2 Serine/threonine-protein kinase N2 Rattus norvegicus (Rat) SS
P09215 Prkcd Protein kinase C delta type Rattus norvegicus (Rat) PR
Q9Y1J3 pdk-1 3-phosphoinositide-dependent protein kinase 1 Caenorhabditis elegans SS
Q19266 pkc-3 Protein kinase C-like 3 Caenorhabditis elegans SS
P90980 pkc-2 Protein kinase C-like 2 Caenorhabditis elegans SS
Q9XTG7 akt-2 Serine/threonine-protein kinase akt-2 Caenorhabditis elegans SS
Q17941 akt-1 Serine/threonine-protein kinase akt-1 Caenorhabditis elegans PR
Q2L6W9 sax-1 Serine/threonine-protein kinase sax-1 Caenorhabditis elegans SS
A7MBL8 pkn2 Serine/threonine-protein kinase N2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MAQAENACRL KLLRADVPVD LLPAGCSATD LQPAVNVKEK IEVNGESRLV QKKKTLYPEW
70 80 90 100 110 120
EKCWDTAVAE GRILQIVLMF NQTPVVEATM RLEDIISKCK SDAITHIWIN TKPNGRILAQ
130 140 150 160 170 180
TRHLKNAPDD DHPVEDIMTS RSNSGPGIQR RRGAIKHARV HEIRGHQFVA TFFRQPHFCS
190 200 210 220 230 240
LCSDFMWGLN KQGYQCQLCS AAVHKKCHEK VIMQCPGSAK NTKETMALKE RFKVDIPHRF
250 260 270 280 290 300
KTYNFKSPTF CDHCGSMLYG LFKQGLRCEV CNVACHHKCE RLMSNLCGVN QKQLSEMYHE
310 320 330 340 350 360
IKRGTHATAS CPPNIANLHL NGETSKNNGS LPNKLKNLFK SHQYSVEEQK ETDEYMDNIW
370 380 390 400 410 420
GGGDGPVKKF ALPHFNLLKV LGKGSFGKVM LVELKGKNEF YAMKCLKKDV ILEDDDTECT
430 440 450 460 470 480
YIERRVLILA SQCPFLCQLF CSFQTNEYLF FVMEYLNGGD LMHHIQQIKK FDEARTRFYA
490 500 510 520 530 540
CEIVVALQFL HTNNIIYRDL KLDNVLLDCD GHIKLADFGM AKTEMNRENG MASTFCGTPD
550 560 570 580 590 600
YISPEIIKGQ LYNEAVDFWS FGVLMYEMLV GQSPFHGEGE DELFDSILNE RPYFPKTISK
610 620 630 640 650 660
EAAKCLSALF DRNPNTRLGM PECPDGPIRQ HCFFRGVDWK RFENRQVPPP FKPNIKSNSD
670 680 690 700
ASNFDDDFTN EKAALTPVHD KNLLASIDPE AFLNFSYTNP HFSK