P34529

PR
Gene name
dcr-1
Protein name
Endoribonuclease dcr-1
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_K12H4.8
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

142-235 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P34529

Entry ID Method Resolution Chain Position Source
AF-P34529-F1 Predicted AlphaFoldDB

No variants for P34529

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P34529

No associated diseases with P34529

9 regional properties for P34529

Type Name Position InterPro Accession
domain Ribonuclease III domain 1381 - 1610 IPR000999-1
domain Ribonuclease III domain 1643 - 1828 IPR000999-2
domain Helicase, C-terminal 371 - 542 IPR001650
domain PAZ domain 847 - 1027 IPR003100
domain Dicer dimerisation domain 571 - 667 IPR005034
domain Helicase/UvrB, N-terminal 12 - 182 IPR006935
domain Helicase superfamily 1/2, ATP-binding domain 9 - 218 IPR014001
domain Double-stranded RNA-binding domain 1833 - 1896 IPR014720
domain Dicer, double-stranded RNA-binding domain 1832 - 1895 IPR044441

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RISC complex A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
deoxyribonuclease I activity Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
metal ion binding Binding to a metal ion.
ribonuclease III activity Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
RNA binding Binding to an RNA molecule or a portion thereof.

15 GO annotations of biological process

Name Definition
apoptotic DNA fragmentation The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
defense response to Gram-positive bacterium Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
DNA catabolic process, endonucleolytic The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
gonad morphogenesis The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.
ncRNA processing Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules.
nematode larval development The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
olfactory learning Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.
positive regulation of primary miRNA processing Any process that activates or increases the frequency, rate or extent of primary microRNA processing.
pre-miRNA processing A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule.
regulation of development, heterochronic Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached.
reproduction The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.
RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
RNA phosphodiester bond hydrolysis The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
siRNA processing A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6TUI4 DICER1 Endoribonuclease Dicer Bos taurus (Bovine) SS
Q25BN1 DICER1 Endoribonuclease Dicer Gallus gallus (Chicken) SS
Q9UPY3 DICER1 Endoribonuclease Dicer Homo sapiens (Human) EV
Q9BYX4 IFIH1 Interferon-induced helicase C domain-containing protein 1 Homo sapiens (Human) PR
Q96C10 DHX58 ATP-dependent RNA helicase DHX58 Homo sapiens (Human) PR
O95786 RIGI Antiviral innate immune response receptor RIG-I Homo sapiens (Human) EV
Q8R5F7 Ifih1 Interferon-induced helicase C domain-containing protein 1 Mus musculus (Mouse) PR
Q6Q899 Ddx58 Antiviral innate immune response receptor RIG-I Mus musculus (Mouse) SS
Q8R418 Dicer1 Endoribonuclease Dicer Mus musculus (Mouse) SS
Q6ATG6 Os05g0271300 Ribonuclease 3-like protein 2 Oryza sativa subsp japonica (Rice) PR
B3DLA6 dicer1 Endoribonuclease Dicer Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q6TV19 dicer1 Endoribonuclease Dicer Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MVRVRADLQC FNPRDYQVEL LDKATKKNTI VQLGTGSGKT FIAVLLLKEY GVQLFAPLDQ
70 80 90 100 110 120
GGKRAFFVVE KVNLVEQQAI HIEVHTSFKV GQVHGQTSSG LWDSKEQCDQ FMKRHHVVVI
130 140 150 160 170 180
TAQCLLDLIR HAYLKIEDMC VLIFDECHHA LGSQHPYRSI MVDYKLLKKD KPVPRVLGLT
190 200 210 220 230 240
ASLIKAKVAP EKLMEQLKKL ESAMDSVIET ASDLVSLSKY GAKPYEVVII CKDFEIGCLG
250 260 270 280 290 300
IPNFDTVIEI FDETVAFVNT TTEFHPDLDL DPRRPIKDSL KTTRAVFRQL GPWAAWRTAQ
310 320 330 340 350 360
VWEKELGKII KSQVLPDKTL RFLNMAKTSM ITIKRLLEPE MKKIKSIEAL RPYVPQRVIR
370 380 390 400 410 420
LFEILETFNP EFQKERMKLE KAEHLSAIIF VDQRYIAYSL LLMMRHIKSW EPKFKFVNPD
430 440 450 460 470 480
YVVGASGRNL ASSDSQGLHK RQTEVLRRFH RNEINCLIAT SVLEEGVDVK QCNLVIKFDR
490 500 510 520 530 540
PLDMRSYVQS KGRARRAGSR YVITVEEKDT AACDSDLKDF QQIEKILLSR HRTVNNPIED
550 560 570 580 590 600
DSDRFEEFDV DSQMEPYVVE KTGATLKMST AIALINRYCS KLPSDIFTRL VPHNQIIPIE
610 620 630 640 650 660
ENGVTKYCAE LLLPINSPIK HAIVLKNPMP NKKTAQMAVA LEACRQLHLE GELDDNLLPK
670 680 690 700 710 720
GRESIAKLLE HIDEEPDEYA PGIAAKVGSS KRKQLYDKKI ARALNESFVE ADKECFIYAF
730 740 750 760 770 780
ELERFREAEL TLNPKRRKFE DPFNYEYCFG FLSAKEIPKI PPFPVFLRQG NMKVRLIVAP
790 800 810 820 830 840
KKTTVTAAQL QEIQLFHNYL FTQVLQMCKT GNLEFDGTSN APLNTLIVPL NKRKDDMSYT
850 860 870 880 890 900
INMKYVSEVV ANMENMPRIP KDEVRRQYKF NAEDYKDAIV MPWYRNLEQP VFYYVAEILP
910 920 930 940 950 960
EWRPSSKFPD THFETFNEYF IKKYKLEIYD QNQSLLDVDF TSTRLNLLQP RIQNQPRRSR
970 980 990 1000 1010 1020
TVSNSSTSNI PQASASDSKE SNTSVPHSSQ RQILVPELMD IHPISATLWN VIAALPSIFY
1030 1040 1050 1060 1070 1080
RVNQLLLTDE LRETILVKAF GKEKTKLDDN VEWNSLAYAT EYEEKQTIIV KKIQQLRDLN
1090 1100 1110 1120 1130 1140
QKSIEDQERE TRENDKIDDG EELFNIGVWD PEEAVRIGVE ISSRDDRMDG EDQDTVGLTQ
1150 1160 1170 1180 1190 1200
GLHDGNISDE DDELPFVMHD YTARLTSNRN GIGAWSGSES IVPSGWGDWD GPEPDNSPMP
1210 1220 1230 1240 1250 1260
FQILGGPGGL NVQALMADVG RVFDPSTASS SLSQTVQEST VSPPKQLTKE EEQFKKLQND
1270 1280 1290 1300 1310 1320
LLKQAKERLE ALEMSEDMEK PRRLEDTVNL EDYGDDQENQ EDENTPTNFP KTIDEEIEEL
1330 1340 1350 1360 1370 1380
SIGARKKQEI DDNAAKTDVL ERENCEVLPV AINEKSRSFS FEKESKAING RLIRQRSEEY
1390 1400 1410 1420 1430 1440
VSHIDSDIGL GVSPCLLLTA LTTSNAADGM SLERFETIGD SFLKFATTDY LYHTLLDQHE
1450 1460 1470 1480 1490 1500
GKLSFARSKE VSNCNLYRLG KKLGIPQLIV ANKFDAHDSW LPPCYIPTCD FKAPNTDDAE
1510 1520 1530 1540 1550 1560
EKDNEIERIL DGQVIEEKPE NKTGWDIGGD VSKSTTDGIE TITFPKQARV GNDDISPLPY
1570 1580 1590 1600 1610 1620
NLLTQQHISD KSIADAVEAL IGVHLLTLGP NPTLKVMNWM GLKVIQKDQK SDVPSPLLRF
1630 1640 1650 1660 1670 1680
IDTPTNPNAS LNFLNNLWQQ FQFTQLEEKI GYRFKERAYL VQAFTHASYI NNRVTGCYQR
1690 1700 1710 1720 1730 1740
LEFLGDAVLD YMITRYLFED SRQYSPGVLT DLRSALVNNT IFASLAVKFE FQKHFIAMCP
1750 1760 1770 1780 1790 1800
GLYHMIEKFV KLCSERNFDT NFNAEMYMVT TEEEIDEGQE EDIEVPKAMG DIFESVAGAI
1810 1820 1830 1840 1850 1860
YLDSGRNLDT TWQVIFHMMR GTIELCCANP PRSPIRELME FEQSKVRFSK MERILESGKV
1870 1880 1890 1900
RVTVEVVNNM RFTGMGRNYR IAKATAAKRA LKYLHQIEQQ RRQSPSLTTV