AiPD: Autoinhibited Protein Database

P33981

Gene name	TTK (MPS1, MPS1L1)
Protein name	Dual specificity protein kinase TTK
Names	Phosphotyrosine picked threonine-protein kinase, PYT
Species	Homo sapiens (Human)
KEGG Pathway	hsa:7272
EC number	2.7.12.1: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class	MIXED LINEAGE PROTEIN KINASE (PTHR22974)

Descriptions

Monopolar spindle 1 (MPS1 or TTK) is a conserved apical kinase in the spindle assembly checkpoint (SAC) that ensures accurate segregation of chromosomes during mitosis. MPS1 undergoes extensive auto- and transphosphorylation. The N-terminal extension harbors multiple phosphorylation sites and is involved in dimerization and catalytic activation. Phosphorylation within the N-terminal extension contributes to MPS1 activation through relief of catalytic autoinhibition that is mediated by the N-terminal extension itself.

Autoinhibitory domains (AIDs)

Target domain	525-791 (Protein kinase domain)
Relief mechanism	PTM
Assay	Deletion assay, Mutagenesis experiment

AID

40-49 (N-terminal extension)

Target domain

525-791 (Protein kinase domain)

Relief mechanism

PTM (Phosphorylation in the N-terminal extension)

Assay

Deletion assay, Mutagenesis experiment

Accessory elements

663-688 (Activation loop from InterPro)

Target domain	525-791 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100

Combes G et al. (2018) "Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint", Current biology : CB, 28, 872-883.e5

Autoinhibited structure

Activated structure

79 structures for P33981

Entry ID	Method	Resolution	Chain	Position	Source
2X9E	X-ray	310 A	A	514-828	PDB
2ZMC	X-ray	314 A	A	510-857	PDB
2ZMD	X-ray	288 A	A	510-857	PDB
3CEK	X-ray	230 A	A	519-808	PDB
3DBQ	X-ray	270 A	A	515-857	PDB
3GFW	X-ray	274 A	A	519-808	PDB
3H9F	X-ray	260 A	A	519-808	PDB
3HMN	X-ray	270 A	A	510-809	PDB
3HMO	X-ray	240 A	A	510-809	PDB
3HMP	X-ray	230 A	A	510-809	PDB
3VQU	X-ray	240 A	A	516-820	PDB
3W1F	X-ray	270 A	A	516-820	PDB
3WYX	X-ray	290 A	A	516-820	PDB
3WYY	X-ray	305 A	A	516-820	PDB
3WZJ	X-ray	275 A	A	516-820	PDB
3WZK	X-ray	230 A	A	516-820	PDB
4B94	X-ray	220 A	A/B/C/D	62-239	PDB
4BHZ	X-ray	285 A	A	519-808	PDB
4BI0	X-ray	284 A	A	519-808	PDB
4BI1	X-ray	270 A	A	519-808	PDB
4BI2	X-ray	311 A	A	519-808	PDB
4C4E	X-ray	260 A	A	519-808	PDB
4C4F	X-ray	236 A	A	519-808	PDB
4C4G	X-ray	265 A	A	519-808	PDB
4C4H	X-ray	280 A	A	519-808	PDB
4C4I	X-ray	265 A	A	519-808	PDB
4C4J	X-ray	250 A	A	519-808	PDB
4CV8	X-ray	300 A	A	519-808	PDB
4CV9	X-ray	250 A	A	519-808	PDB
4CVA	X-ray	250 A	A	519-808	PDB
4D2S	X-ray	250 A	A	514-795	PDB
4H7X	X-ray	260 A	A/B	55-210	PDB
4H7Y	X-ray	180 A	A/B/C/D	55-210	PDB
4JS8	X-ray	194 A	A	515-795	PDB
4JT3	X-ray	220 A	A	515-795	PDB
4O6L	X-ray	238 A	A/B	515-795	PDB
4ZEG	X-ray	233 A	A	515-795	PDB
5AP0	X-ray	215 A	A	519-808	PDB
5AP1	X-ray	205 A	A	519-808	PDB
5AP2	X-ray	280 A	A	519-808	PDB
5AP3	X-ray	270 A	A	519-808	PDB
5AP4	X-ray	285 A	A	519-808	PDB
5AP5	X-ray	280 A	A	519-808	PDB
5AP6	X-ray	210 A	A	519-808	PDB
5AP7	X-ray	245 A	A	519-808	PDB
5EH0	X-ray	218 A	A	519-794	PDB
5EHL	X-ray	266 A	A	519-808	PDB
5EHO	X-ray	218 A	A	519-808	PDB
5EHY	X-ray	226 A	A	519-808	PDB
5EI2	X-ray	267 A	A	519-808	PDB
5EI6	X-ray	201 A	A	519-808	PDB
5EI8	X-ray	217 A	A	519-753	PDB
5LJJ	X-ray	300 A	A	519-808	PDB
5MRB	X-ray	220 A	A	519-808	PDB
5N7V	X-ray	252 A	A	519-808	PDB
5N84	X-ray	230 A	A	519-808	PDB
5N87	X-ray	229 A	A	519-808	PDB
5N93	X-ray	210 A	A	519-808	PDB
5N9S	X-ray	230 A	A	519-808	PDB
5NA0	X-ray	290 A	A	519-808	PDB
5NAD	X-ray	280 A	A	519-808	PDB
5NTT	X-ray	275 A	A	519-797	PDB
5O91	X-ray	320 A	A	519-808	PDB
6B4W	X-ray	290 A	A	515-795	PDB
6GVJ	X-ray	241 A	A	400-808	PDB
6H3K	X-ray	248 A	A	519-794	PDB
6N6O	X-ray	260 A	A	515-795	PDB
6TN9	X-ray	260 A	A	515-806	PDB
6TNB	X-ray	265 A	A	515-806	PDB
6TNC	X-ray	230 A	A	515-806	PDB
6TND	X-ray	258 A	A	515-806	PDB
7CHM	X-ray	265 A	A	515-795	PDB
7CHN	X-ray	240 A	A	515-795	PDB
7CHT	X-ray	240 A	A	515-795	PDB
7CIL	X-ray	230 A	A	515-795	PDB
7CJA	X-ray	249 A	A	515-795	PDB
7CLH	X-ray	290 A	A	515-795	PDB
7LQD	X-ray	195 A	A	519-808	PDB
AF-P33981-F1	Predicted				AlphaFoldDB

655 variants for P33981

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV002244866 CA16603112 COSM84994 rs1057520011	697	D>Y	Neoplasm of the pancreas pancreas [ClinVar, Cosmic]	Yes	ClinGen cosmic curated ClinVar Ensembl dbSNP
TCGA novel	1	M>?	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA141873866 rs867311877	4	E>K		No	ClinGen TOPMed
rs772044461 CA3901676	5	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1035762334 CA141873899	7	S>N		No	ClinGen TOPMed gnomAD
rs1308105195 CA364635661	8	G>A		No	ClinGen gnomAD
TCGA novel	10	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3901677 rs775788767	13	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1218531522 CA364635745	16	I>V		No	ClinGen gnomAD
CA364635754 rs1430791863	17	M>T		No	ClinGen TOPMed
rs757845279 CA3901678	18	N>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3901679 rs765099875	18	N>K		No	ClinGen ExAC gnomAD
rs1004064525 CA141873942	18	N>S		No	ClinGen Ensembl
CA364635782 rs1212996087	21	R>I		No	ClinGen gnomAD
CA3901680 rs567093928	22	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs1472854078 CA364635818	25	N>S		No	ClinGen TOPMed gnomAD
TCGA novel	26	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	27	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762701284 CA3901681	28	K>Q		No	ClinGen ExAC gnomAD
CA364635885 rs1562008876	29	N>D		No	ClinGen Ensembl
TCGA novel	29	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1441870045 CA364635925	31	D>E		No	ClinGen gnomAD
CA364635923 rs1463272539	31	D>V		No	ClinGen TOPMed
rs751483992 CA141873962 CA3901683	34	D>E		No	ClinGen ExAC TOPMed gnomAD
CA364635999 rs1344083976	36	L>Q		No	ClinGen TOPMed
CA3901684 rs754548500	37	S>R		No	ClinGen ExAC TOPMed gnomAD
CA364636060 rs1359768634	40	K>E		No	ClinGen gnomAD
TCGA novel	40	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364636143 rs1447391810	45	T>I		No	ClinGen gnomAD
CA3901685 rs368624175	46	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA364636878 rs1314086478	47	D>E		No	ClinGen gnomAD
CA141875389 rs772861170	47	D>G		No	ClinGen Ensembl
CA364636889 rs1362436584	48	N>D		No	ClinGen gnomAD
rs747103890 CA3901718	49	S>L		No	ClinGen ExAC gnomAD
CA141875410 rs913087423	52	V>I		No	ClinGen Ensembl
CA141875411 rs967188136	53	N>H		No	ClinGen TOPMed gnomAD
rs200207796 CA3901721	53	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA141875427 rs868010271	54	Q>*		No	ClinGen Ensembl
rs1246462606 CA364637070	55	I>M		No	ClinGen gnomAD
CA141875436 rs978569988	55	I>T		No	ClinGen Ensembl
rs1284430157 CA364637076	56	M>V		No	ClinGen gnomAD
CA364637106 rs770723697	57	M>L		No	ClinGen ExAC TOPMed gnomAD
CA3901722 rs770723697	57	M>V		No	ClinGen ExAC TOPMed gnomAD
CA364637135 rs1218527440	58	M>T		No	ClinGen gnomAD
CA3901723 rs774081878	58	M>V		No	ClinGen ExAC gnomAD
rs1288755092 CA364637152	59	A>T		No	ClinGen gnomAD
CA3901724 rs759346384	60	N>S		No	ClinGen ExAC TOPMed gnomAD
rs775486276 CA3901726	63	E>D		No	ClinGen ExAC TOPMed gnomAD
rs767406007 CA3901725	63	E>V		No	ClinGen ExAC gnomAD
TCGA novel	64	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1425644700 CA364637316	66	L>W		No	ClinGen gnomAD
CA3901727 rs760172960	67	S>N		No	ClinGen ExAC gnomAD
rs763634581 CA3901728	70	L>F		No	ClinGen ExAC gnomAD
rs1161491003 CA364637409	71	K>R		No	ClinGen gnomAD
CA364637470 rs1420295336	74	K>E		No	ClinGen gnomAD
CA364637522 rs1373776576 COSM3176130 COSM3176129	76	S>G	liver [Cosmic]	No	ClinGen cosmic curated TOPMed
CA3901732 rs142681483	77	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3901733 rs367719510	78	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA364637567 rs367719510	78	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs747546403 CA3901735	79	L>P		No	ClinGen ExAC TOPMed gnomAD
CA141875549 rs923040563	81	D>V		No	ClinGen TOPMed
rs1474002310 CA364637647	82	A>T		No	ClinGen TOPMed
rs1244197911 CA364637675	83	L>F		No	ClinGen TOPMed gnomAD
CA364637733 rs1355032367	86	K>E		No	ClinGen gnomAD
CA141875618 rs1036094009	87	L>F		No	ClinGen gnomAD
rs748390988 CA3901738	87	L>W		No	ClinGen ExAC gnomAD
rs770044427 CA3901739	88	I>T		No	ClinGen ExAC gnomAD
rs1047423274 CA141875620	90	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA3901740 rs376160183	90	R>H	Variant assessed as Somatic; 4.622e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs745708448 CA3901741	92	S>R		No	ClinGen ExAC gnomAD
CA364637973 rs1239713358	94	A>G		No	ClinGen gnomAD
rs1440083356 CA364637999	95	I>S		No	ClinGen gnomAD
CA364637983 rs1270402844	95	I>V		No	ClinGen TOPMed
CA364638016 rs1229650680	96	E>K		No	ClinGen TOPMed
CA3901742 VAR_037141 rs2230513	97	A>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1582085855 CA364638091	99	P>A		No	ClinGen Ensembl
CA3901746 rs776244342	101	D>E		No	ClinGen ExAC TOPMed gnomAD
rs368277234 CA3901747	102	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA141875684 rs749680365	103	Y>C		No	ClinGen Ensembl
TCGA novel	105	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs56051245 CA141875691	107	E>K		No	ClinGen gnomAD
CA364638323 rs1391204580	108	S>I		No	ClinGen gnomAD
rs750072933 CA3901749	110	A>T		No	ClinGen ExAC TOPMed gnomAD
CA364638403 rs1562010147	111	R>G		No	ClinGen Ensembl
CA364638439 rs1562010152	112	I>N		No	ClinGen Ensembl
CA364638452 rs1314512247	113	Q>E		No	ClinGen TOPMed gnomAD
rs1255547191 CA364638594	120	K>E		No	ClinGen gnomAD
TCGA novel	121	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3901751 rs766698455	121	A>V		No	ClinGen ExAC TOPMed gnomAD
CA3901770 rs766675492	126	D>G		No	ClinGen ExAC gnomAD
rs751911841 CA3901771	129	R>C		No	ClinGen ExAC gnomAD
TCGA novel rs1582086296 CA364638838	129	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
CA364638878 rs1210284726	131	Y>C		No	ClinGen gnomAD
TCGA novel	140	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3901773 rs372511572	140	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA141876069 rs201365987	142	F>L		No	ClinGen Ensembl
TCGA novel	143	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364639142 rs1195271914	144	F>C		No	ClinGen gnomAD
rs919014661 CA141876071	145	V>I		No	ClinGen Ensembl
rs759057062 CA141876073	146	H>D		No	ClinGen Ensembl
CA364639182 rs759057062	146	H>N		No	ClinGen Ensembl
rs1423895846 CA364639199	147	I>V		No	ClinGen gnomAD
CA3901775 rs145266061	148	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs753199840 CA3901774	148	S>P		No	ClinGen ExAC gnomAD
CA3901777 rs144032191	149	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA364639299 rs1305159114	151	Q>K		No	ClinGen TOPMed
CA141876136 rs867154764	152	F>S		No	ClinGen gnomAD
rs867154764 CA364639333	152	F>Y		No	ClinGen gnomAD
rs1435867625 CA364639400	155	S>L		No	ClinGen TOPMed
CA364639413 rs1278989642	156	Q>K		No	ClinGen gnomAD
CA3901808 rs781074484	158	N>D		No	ClinGen ExAC TOPMed gnomAD
CA364641334 rs1359954464	158	N>S		No	ClinGen gnomAD
CA3901811 rs748116446	160	K>E		No	ClinGen ExAC gnomAD
CA364641393 rs1380258298	162	S>G		No	ClinGen TOPMed gnomAD
rs751135082	162	S>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs751135082	162	S>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1409135346 CA364641425	164	Q>K		No	ClinGen gnomAD
CA3901813 rs777540164	166	L>I		No	ClinGen ExAC TOPMed gnomAD
rs748887464 CA3901814	168	K>R		No	ClinGen ExAC TOPMed gnomAD
CA141878383 rs975019437	169	A>T		No	ClinGen Ensembl
TCGA novel	171	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772451937 CA3901818	172	R>C		No	ClinGen ExAC gnomAD
CA141878421 rs772102753	172	R>H		No	ClinGen TOPMed gnomAD
CA364641482 rs772102753	172	R>L		No	ClinGen TOPMed gnomAD
rs772451937 CA364641480	172	R>S		No	ClinGen ExAC gnomAD
rs1260898018 CA364641489	174	A>T		No	ClinGen gnomAD
TCGA novel	181	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3901823 rs151265706	185	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3901822 rs142356650	185	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1264711807 CA364641563	186	N>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs934998687 CA141878454	187	L>*		No	ClinGen TOPMed gnomAD
CA3901825 rs750685395	188	N>K		No	ClinGen ExAC gnomAD
CA364641590 rs1562011725	190	Q>K		No	ClinGen Ensembl
CA3901828 rs767449958	191	K>I		No	ClinGen ExAC gnomAD
rs1335082917 CA364641607	192	K>*		No	ClinGen gnomAD
CA364641606 rs1335082917	192	K>E		No	ClinGen gnomAD
CA364641618 rs1284885333	193	Q>L		No	ClinGen TOPMed
rs1276550387 CA364641627	195	L>F		No	ClinGen TOPMed gnomAD
rs752579117 CA3901829	198	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1280945388 CA364641662	200	K>E		No	ClinGen gnomAD
rs1562011766 CA364641667	200	K>N		No	ClinGen Ensembl
CA364641680 rs1319602298	202	N>T		No	ClinGen gnomAD
CA364641690 rs1196738291 CA364641691	203	L>F		No	ClinGen TOPMed gnomAD
TCGA novel	203	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759463818 CA141879134	205	A>G		No	ClinGen Ensembl
rs978297040 CA141878493	205	A>P		No	ClinGen TOPMed gnomAD
CA3901853 rs370932587	207	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1230825 COSM1230826 CA364641729 rs1317171782	208	V>A	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA364641725 rs1382324268	208	V>I		No	ClinGen gnomAD
CA3901855 rs779744771	209	L>*		No	ClinGen ExAC TOPMed gnomAD
rs746572464 CA3901856	210	T>I		No	ClinGen ExAC gnomAD
rs1180481429 CA364641747	211	A>V		No	ClinGen gnomAD
rs1029122027 CA141879168	212	Q>P		No	ClinGen TOPMed
rs200060897 CA141879184	213	E>K		No	ClinGen gnomAD
CA141879193 rs955610385	215	F>L		No	ClinGen Ensembl
rs1212716656 CA364641771	215	F>S		No	ClinGen TOPMed
CA141879202 rs865796322	216	S>F		No	ClinGen Ensembl
rs770461559 CA3901860	217	G>D		No	ClinGen ExAC gnomAD
CA3901859 rs748719753	217	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA364641792 rs1278547079	219	L>F		No	ClinGen TOPMed
CA3901861 rs201291359	219	L>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3901862 rs763183104	220	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3901863 rs374261143	221	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA364641802 rs1399060216	221	H>Y		No	ClinGen TOPMed
rs1243462256 CA364641808	222	L>V		No	ClinGen gnomAD
CA3901864 rs774728669	223	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA3901865 rs759629265	223	Q>H		No	ClinGen ExAC gnomAD
CA3901866 rs763982055	224	N>S		No	ClinGen ExAC gnomAD
CA3901867 rs763982055	224	N>T		No	ClinGen ExAC gnomAD
CA364641826 rs1466374113	225	R>G		No	ClinGen TOPMed
CA3901868 rs377726791	225	R>K		No	ClinGen ESP ExAC gnomAD
rs985195988 CA141879270	227	N>K		No	ClinGen TOPMed gnomAD
rs371130809 CA3901869	228	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA141879282 rs750351998	231	S>C		No	ClinGen ExAC TOPMed gnomAD
CA3901870 rs750351998	231	S>F		No	ClinGen ExAC TOPMed gnomAD
CA141879322 rs989385425	232	R>G		No	ClinGen Ensembl
TCGA novel	233	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1477513887 CA364641883	233	G>E		No	ClinGen TOPMed
CA141879325 rs200827307	236	T>A		No	ClinGen gnomAD
CA364641913 rs1259938544	238	A>T		No	ClinGen TOPMed
CA364641921 rs1259095781	239	R>K		No	ClinGen TOPMed gnomAD
rs914916834 CA141879329	239	R>S		No	ClinGen TOPMed gnomAD
CA364641922 rs1259095781	239	R>T		No	ClinGen TOPMed gnomAD
CA3901873 rs751245021	241	L>S		No	ClinGen ExAC TOPMed gnomAD
rs375558420 CA3901874	242	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA3901875 rs780864953	243	G>A		No	ClinGen ExAC gnomAD
rs1441940118 CA364641997	244	E>K		No	ClinGen TOPMed
CA3901893 rs150274294	246	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141417041 CA3901894	249	Q>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201650148 CA3901895	250	D>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3901896 rs145134547	253	I>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1260017521 CA364642139	254	G>D		No	ClinGen TOPMed gnomAD
rs1479283240 CA364642155	255	Y>*		No	ClinGen gnomAD
CA3901897 rs189153762	255	Y>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199898922 CA364642159	256	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs368343290 CA3901900	256	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs368343290 CA3901899	256	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs199898922 CA3901898	256	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA364642171 rs1461818937	257	N>I		No	ClinGen gnomAD
CA3901901 rs193272979	258	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA364642221 rs1405629645	261	Q>E		No	ClinGen gnomAD
CA364642226 rs1302694600	261	Q>H		No	ClinGen gnomAD
CA3901904 rs745996197	263	N>D		No	ClinGen ExAC
rs1216481378 CA364642285	266	K>E	Variant assessed as Somatic; 4.631e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA141879980 rs972413463	274	V>I		No	ClinGen TOPMed gnomAD
CA364642436 rs972413463	274	V>L		No	ClinGen TOPMed gnomAD
TCGA novel	275	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs145815187 CA3901922	276	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1562012507 CA364642489	278	L>P		No	ClinGen Ensembl
rs1582090139 CA364642495	279	L>V		No	ClinGen Ensembl
CA364642514 rs780129118	280	N>K		No	ClinGen ExAC TOPMed gnomAD
CA364642509 rs1361340211	280	N>S		No	ClinGen gnomAD
rs1327833754 CA364642530	281	S>R		No	ClinGen gnomAD
CA364642539 rs1319384309	282	P>L		No	ClinGen gnomAD
rs1290985303 CA364642536	282	P>S		No	ClinGen gnomAD
rs931231327 CA141880010	283	D>G		No	ClinGen TOPMed
TCGA novel	283	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	283	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1242337078 CA364642569	284	C>F		No	ClinGen gnomAD
TCGA novel	284	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1346790448 CA364642582	285	D>V		No	ClinGen TOPMed
rs768903901 CA3901926	286	V>A		No	ClinGen ExAC gnomAD
rs758287992 CA3901927	288	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1256525948 CA364642628	289	D>G		No	ClinGen TOPMed
CA364642626 rs1245281728	289	D>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA364642638 rs1273731372	290	D>N		No	ClinGen gnomAD
CA3901929 rs543283063	295	C>S		No	ClinGen 1000Genomes ExAC gnomAD
CA3901930 rs774160816	296	F>L		No	ClinGen ExAC TOPMed gnomAD
CA3901931 rs759469255	297	M>L		No	ClinGen ExAC TOPMed gnomAD
CA141880037 rs759469255	297	M>V		No	ClinGen ExAC TOPMed gnomAD
rs771514849 CA3901932	298	K>E		No	ClinGen ExAC gnomAD
rs770654454 CA3901949	301	T>I		No	ClinGen ExAC gnomAD
rs770654454 CA364643853	301	T>N		No	ClinGen ExAC gnomAD
CA364643876 rs1582091298	302	S>F		No	ClinGen Ensembl
CA364643882 rs1284768524	303	R>G		No	ClinGen gnomAD
rs745620512 CA3901951	303	R>K		No	ClinGen ExAC TOPMed gnomAD
CA3901952 rs772097975	304	S>L		No	ClinGen ExAC gnomAD
CA364643915 rs1246168569	305	E>K		No	ClinGen gnomAD
rs760331674 CA3901954 COSM1081917 COSM1596499	307	R>Q	endometrium Variant assessed as Somatic; 4.653e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA3901956 rs776441338	309	L>F		No	ClinGen ExAC gnomAD
rs761475326 CA3901957	310	V>F		No	ClinGen ExAC gnomAD
rs887912168 CA141881140	311	V>M		No	ClinGen TOPMed gnomAD
CA3901959 rs750836089	312	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1276558518 CA364644080	314	S>F		No	ClinGen TOPMed
TCGA novel	314	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3901960 rs148971862	316	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA141881182 rs1003243926	318	G>E		No	ClinGen TOPMed
CA3901962 rs370307286	319	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA364644179 rs1224438929	320	D>N		No	ClinGen Ensembl
rs755056087 CA3901963	321	S>T		No	ClinGen ExAC gnomAD
TCGA novel	322	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3901980 rs763443323	330	V>L		No	ClinGen ExAC TOPMed gnomAD
CA364644426 rs1358796410	332	N>D		No	ClinGen gnomAD
CA364644429 rs1208180715	332	N>S		No	ClinGen gnomAD
CA141882308 rs113049830	333	S>G		No	ClinGen gnomAD
rs1243624938 CA364644439	333	S>R		No	ClinGen TOPMed
rs1447855404 CA364644440	334	H>N		No	ClinGen gnomAD
TCGA novel	336	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3901981 rs766664618	338	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1188347192 CA364644472	338	P>T		No	ClinGen TOPMed
rs1276859759 CA364644484	340	V>L		No	ClinGen TOPMed
CA141882334 rs1027743661	343	E>G		No	ClinGen Ensembl
rs774853711 CA3901982	343	E>K		No	ClinGen ExAC gnomAD
rs759995763 CA3901983	344	K>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	344	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	344	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3901984 rs767981193	344	K>R		No	ClinGen ExAC gnomAD
CA141882346 rs200901836	345	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1161017053 CA364644531	347	E>G		No	ClinGen TOPMed gnomAD
rs1456939019 CA364644528	347	E>Q		No	ClinGen gnomAD
rs752869981 CA3901986	349	I>T		No	ClinGen ExAC gnomAD
rs756132806 CA3901987	350	I>T		No	ClinGen ExAC TOPMed gnomAD
rs764440902 CA3901988	352	D>G		No	ClinGen ExAC TOPMed gnomAD
rs764440902 CA364644563	352	D>V		No	ClinGen ExAC TOPMed gnomAD
rs1285242580 CA364644575	354	I>K		No	ClinGen TOPMed
rs1454964783 COSM3784735 COSM3784734 CA364644572	354	I>V	pancreas [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1316313546 CA364644584	355	T>I		No	ClinGen gnomAD
CA3901989 rs61735783	356	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3901990 rs199645793	360	T>M		No	ClinGen ExAC TOPMed gnomAD
rs199645793 CA3901991	360	T>R		No	ClinGen ExAC TOPMed gnomAD
CA3901993 rs755010075	361	E>K		No	ClinGen ExAC gnomAD
rs1204729678 CA364644634	363	S>T		No	ClinGen gnomAD
CA3901995 rs747754489	365	L>P		No	ClinGen ExAC gnomAD
CA3901994 rs781256573	365	L>V		No	ClinGen ExAC TOPMed gnomAD
CA364644652 rs1243670930	366	A>V		No	ClinGen gnomAD
CA364644676 rs1185337262	370	E>K		No	ClinGen gnomAD
rs200662710 CA3902016	373	E>G		No	ClinGen ExAC TOPMed gnomAD
CA141886914 rs994039518	373	E>K		No	ClinGen Ensembl
rs182726489 CA3902017	375	Q>E		No	ClinGen 1000Genomes ExAC gnomAD
CA141886923 rs774928701	376	E>G		No	ClinGen TOPMed
CA364645736 rs1347475436	378	E>D		No	ClinGen gnomAD
COSM3697972 COSM3697973 rs1162243458 CA364645752	380	P>A	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs746296225 CA3902019	381	E>G		No	ClinGen ExAC TOPMed gnomAD
CA364645784 rs1311368817	382	S>N		No	ClinGen gnomAD
rs1230852592 CA364645796	383	N>D		No	ClinGen gnomAD
rs1388139099 CA364645816	384	Q>P		No	ClinGen TOPMed gnomAD
rs368838577 COSM1081921 COSM1596498 CA3902021	386	Q>R	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	391	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776075114 CA3902023	394	E>V		No	ClinGen ExAC gnomAD
CA3902025 rs768808118	395	C>F		No	ClinGen ExAC gnomAD
rs761034842 CA3902024	395	C>R		No	ClinGen ExAC TOPMed gnomAD
rs61735782 CA3902026	396	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA364646013 rs1374126913	400	P>R		No	ClinGen gnomAD
rs1173069682 CA364646012	400	P>S		No	ClinGen gnomAD
TCGA novel	401	A>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	401	A>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761965510 CA3902027	401	A>G		No	ClinGen ExAC gnomAD
CA364646016 rs1481343179	401	A>T		No	ClinGen TOPMed
rs148231017 CA3902028	402	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA364646051 rs1562017808	406	H>D		No	ClinGen Ensembl
CA3902031 rs188887854	408	Q>H		No	ClinGen 1000Genomes ExAC gnomAD
rs752704358 CA3902032	410	P>L		No	ClinGen ExAC TOPMed gnomAD
CA3902034 rs777743321	413	A>V		No	ClinGen ExAC TOPMed gnomAD
CA3902036 rs141520128	414	R>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141520128 CA3902035	414	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3902037 rs778540061 COSM1081923 COSM1154708	414	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs547856836 CA141887002	418	T>I		No	ClinGen 1000Genomes TOPMed
CA364646232 rs547856836	418	T>K		No	ClinGen 1000Genomes TOPMed
TCGA novel	419	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745463615 CA3902038	419	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1376319319 CA364646541	420	Q>R		No	ClinGen gnomAD
CA3902065 rs773385884	422	H>R		No	ClinGen ExAC gnomAD
rs770018604 CA3902064	422	H>Y		No	ClinGen ExAC
CA364646622 rs1226208659	425	F>L		No	ClinGen TOPMed gnomAD
CA3902067 rs771116223	426	E>K		No	ClinGen ExAC gnomAD
rs774627664 CA3902068	428	P>R		No	ClinGen ExAC gnomAD
rs976509206 CA364646661	428	P>S		No	ClinGen TOPMed gnomAD
rs976509206 CA141888812	428	P>T		No	ClinGen TOPMed gnomAD
rs760389560 CA3902069	429	V>A		No	ClinGen ExAC gnomAD
CA3902070 rs763889955	431	S>T		No	ClinGen ExAC gnomAD
rs1213808321 CA364646718	432	V>F		No	ClinGen TOPMed
rs74677005 CA141888828	433	S>*		No	ClinGen TOPMed gnomAD
rs74677005 CA364646734	433	S>L		No	ClinGen TOPMed gnomAD
rs922312211 CA141888833	435	Q>*		No	ClinGen TOPMed
rs1183068671 CA364646772	435	Q>L		No	ClinGen gnomAD
CA141888840 rs373723443	439	I>M		No	ClinGen ESP TOPMed
CA364646810 rs1471700231	439	I>V		No	ClinGen gnomAD
CA364646835 rs1178855820	440	S>L		No	ClinGen gnomAD
rs761696133 CA3902072	441	T>I		No	ClinGen ExAC gnomAD
CA3902073 rs567403155	442	S>C		No	ClinGen ExAC TOPMed gnomAD
rs567403155 CA364646858	442	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs749981250 CA3902074	445	F>Y		No	ClinGen ExAC gnomAD
CA3902075 rs757916581	446	D>G		No	ClinGen ExAC gnomAD
rs1357425626 CA364646925	446	D>N		No	ClinGen gnomAD
rs766016669 CA3902076	447	P>R		No	ClinGen ExAC gnomAD
rs931459514 CA141888859	449	S>F		No	ClinGen Ensembl
rs144749454 CA3902077	450	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA364647016 rs1237625949	451	C>F		No	ClinGen TOPMed
rs1050439599 CA141888865	451	C>R		No	ClinGen Ensembl
CA364647031 rs1373135808	452	K>E		No	ClinGen TOPMed
rs1326415749 CA364647048	452	K>R		No	ClinGen TOPMed
rs755314310 CA3902078	453	T>A		No	ClinGen ExAC gnomAD
CA141888874 rs867273086	453	T>I		No	ClinGen Ensembl
CA141888881 rs1044965914	455	S>N		No	ClinGen TOPMed gnomAD
rs376931234 CA3902079	455	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1277109339 CA364647108	456	S>N		No	ClinGen gnomAD
CA364647124 rs1366561970	457	N>S		No	ClinGen gnomAD
rs370218926 COSM1230823 CA141888892 COSM1230824	458	T>A	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP TOPMed
rs370218926 CA141888890	458	T>P		No	ClinGen ESP TOPMed
CA364647179 rs1364787277	460	D>G		No	ClinGen TOPMed
CA364647169 rs1251084014	460	D>N		No	ClinGen gnomAD
rs1482131782 CA364647219	462	Y>*		No	ClinGen gnomAD
CA3902081 rs756727109	463	M>V		No	ClinGen ExAC gnomAD
CA3902082 rs112880049	464	S>G		No	ClinGen ExAC gnomAD
rs1478230933 CA364647249	464	S>T		No	ClinGen gnomAD
rs544489952 CA3902096	469	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA364647299 rs1402074591	470	V>L		No	ClinGen TOPMed
TCGA novel	472	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1341585680 CA364647319	473	N>H		No	ClinGen TOPMed
CA141889399 rs191381064	474	D>E		No	ClinGen 1000Genomes
COSM95417 CA364647326 rs1447124383	474	D>N	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA3902098 rs751194719	475	F>L		No	ClinGen ExAC gnomAD
rs767247672 CA3902100	476	P>L		No	ClinGen ExAC gnomAD
rs759190571 CA3902099	476	P>T		No	ClinGen ExAC gnomAD
TCGA novel	477	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1294162290 CA364647345	477	P>S		No	ClinGen TOPMed gnomAD
rs753161549 CA3902101	478	A>T		No	ClinGen ExAC gnomAD
rs199565621 CA3902102	480	Q>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs778429201 CA3902103	481	L>F		No	ClinGen ExAC gnomAD
rs1436331076 CA364647373	481	L>S		No	ClinGen gnomAD
TCGA novel	482	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3902104 rs754311204	483	T>A		No	ClinGen ExAC gnomAD
CA141889422 rs757305495	484	P>H		No	ClinGen ExAC TOPMed gnomAD
CA3902105 rs757305495	484	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1001925787 CA364647411	487	Q>H		No	ClinGen TOPMed
rs1355774310 CA364647409	487	Q>R		No	ClinGen gnomAD
CA364647413 rs1208242863	488	P>T		No	ClinGen gnomAD
CA141889432 rs1054771533	490	C>G		No	ClinGen TOPMed gnomAD
rs979040862 CA141889438	494	Q>E		No	ClinGen Ensembl
CA3902107 rs745902594	495	Q>E		No	ClinGen ExAC gnomAD
rs772325809 CA3902108	496	H>P		No	ClinGen ExAC gnomAD
rs139605395 CA3902110	499	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	499	L>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3902111 rs769516769	500	A>D		No	ClinGen ExAC gnomAD
rs1191280219 CA364647497	500	A>T		No	ClinGen TOPMed
rs773040133 CA3902112	502	P>S		No	ClinGen ExAC gnomAD
TCGA novel	504	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	505	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA141889466 rs200609571	506	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1413807388 CA364647545	507	Q>R		No	ClinGen gnomAD
rs775303379 CA3902136	508	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1256503280 CA364648117	512	S>P		No	ClinGen gnomAD
CA3902138 rs760362405	513	S>L		No	ClinGen ExAC gnomAD
rs866971521 CA141891189	514	A>E		No	ClinGen Ensembl
rs777100194 CA3902140	514	A>T		No	ClinGen ExAC gnomAD
CA3902141 rs762067127	515	N>D		No	ClinGen ExAC gnomAD
rs56007972 CA3902142	515	N>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs56007972 CA364648174	515	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA364648210 rs1392514269	517	C>G		No	ClinGen TOPMed
rs144229618 CA3902144	519	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA3902146 rs200239131	523	R>I		No	ClinGen ExAC TOPMed gnomAD
CA364648454 rs1483341123	531	I>M		No	ClinGen TOPMed
TCGA novel	532	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1429245362 CA364648501 COSM389581 COSM3411303	534	G>E	lung central_nervous_system [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA3902149 rs781251041	537	S>G		No	ClinGen ExAC gnomAD
CA141891232 rs183642720	538	K>N		No	ClinGen 1000Genomes TOPMed gnomAD
CA364648844 rs1249050722	542	V>L		No	ClinGen gnomAD
CA364648857 rs1582112282	544	N>D		No	ClinGen Ensembl
CA141892852 rs922357788	549	I>L		No	ClinGen TOPMed gnomAD
rs922357788 CA364648897	549	I>V		No	ClinGen TOPMed gnomAD
CA364648906 rs1415994902	550	Y>C		No	ClinGen gnomAD
rs560320481 CA3902179	551	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1164311405 CA364648921	552	I>M		No	ClinGen TOPMed gnomAD
TCGA novel	553	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs55988913 CA3902180	554	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	555	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364648947 rs767981089	556	N>I		No	ClinGen ExAC TOPMed gnomAD
CA3902182 rs767981089	556	N>S		No	ClinGen ExAC TOPMed gnomAD
CA3902183 rs532047071	560	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs182107453 CA141892865	561	D>G		No	ClinGen 1000Genomes gnomAD
CA141892868 rs182107453	561	D>V		No	ClinGen 1000Genomes gnomAD
rs866301407 CA141892874	562	N>D		No	ClinGen Ensembl
CA364649007 rs1287066981	565	L>F		No	ClinGen gnomAD
TCGA novel	565	L>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364649022 rs1380677129	567	S>N		No	ClinGen gnomAD
rs1562024331 CA364649034	568	Y>*		No	ClinGen Ensembl
CA3902184 rs201042481	569	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA141892880 rs1041923854	569	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
COSM168487 CA3902186 rs773610148 COSM1596533	571	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	572	I>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364649064 rs1174646561	573	A>G		No	ClinGen TOPMed gnomAD
CA364649060 rs1269120787	573	A>T		No	ClinGen TOPMed gnomAD
CA3902187 rs763281952	576	N>S		No	ClinGen ExAC gnomAD
TCGA novel	577	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771485877 CA3902188	577	K>T		No	ClinGen ExAC gnomAD
CA3902191 rs767444929	579	Q>R		No	ClinGen ExAC gnomAD
rs903330524 CA141892907	581	H>D		No	ClinGen Ensembl
CA141892911 rs61738280 COSM3430903 COSM3430904	582	S>G	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA141892915 rs55951238	583	D>A		No	ClinGen Ensembl
CA364649129 rs1254190060	583	D>N		No	ClinGen gnomAD
CA3902192 rs369548504	585	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA141892922 rs186705357	586	I>F		No	ClinGen 1000Genomes
CA141892928 rs936242020	586	I>M		No	ClinGen gnomAD
rs760846337 CA3902193	586	I>T		No	ClinGen ExAC gnomAD
rs764385212 CA3902194	587	R>*		No	ClinGen ExAC TOPMed gnomAD
rs750297262 CA3902195 COSM197053	587	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA3902196 rs758261126	588	L>H		No	ClinGen ExAC TOPMed gnomAD
CA364649157 rs1360890215	588	L>I		No	ClinGen gnomAD
rs751549680 CA3902216	592	E>A		No	ClinGen ExAC gnomAD
CA364649206 rs1233431626	593	I>V		No	ClinGen TOPMed
rs1582112625 CA364649213	594	T>A		No	ClinGen Ensembl
rs1005091833 CA141893027	594	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1219102759 CA364649220	595	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs767471019 CA3902218	596	Q>H		No	ClinGen ExAC gnomAD
CA3902219 rs556742505	597	Y>N		No	ClinGen 1000Genomes ExAC gnomAD
rs1362531121 CA364649242	598	I>T		No	ClinGen TOPMed
rs191416444 CA3902221	599	Y>*		No	ClinGen 1000Genomes ExAC gnomAD
CA364649249 rs1399462699	599	Y>C		No	ClinGen TOPMed
rs1436234412 CA364649246	599	Y>H		No	ClinGen gnomAD
TCGA novel COSM197054 rs757647603 CA3902223	600	M>I	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC gnomAD NCI-TCGA
rs748883691 CA3902222	600	M>V		No	ClinGen ExAC gnomAD
rs1358638673 CA364649285	604	C>Y		No	ClinGen TOPMed
TCGA novel	606	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3902225 rs746220162	607	I>F		No	ClinGen ExAC gnomAD
CA3902226 rs574618987	607	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA3902227 rs540538876	609	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1369410864 CA364649368	611	S>G		No	ClinGen gnomAD
rs747061200 CA3902228	611	S>N		No	ClinGen ExAC TOPMed gnomAD
CA3902230 rs1801351	614	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3902231 rs762089919	615	K>E		No	ClinGen ExAC gnomAD
CA3902232 rs765529954	615	K>R		No	ClinGen ExAC gnomAD
TCGA novel	617	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3902233 rs774066834	618	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3902234 rs759362914	619	I>T		No	ClinGen ExAC gnomAD
rs767420588 CA3902235	621	P>L		No	ClinGen ExAC TOPMed gnomAD
rs767420588 CA364649550	621	P>R		No	ClinGen ExAC TOPMed gnomAD
COSM1446086 COSM1446085 rs200822002 CA141893096	624	R>C	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1260979404 COSM1446087 COSM1446088 CA364649604	624	R>H	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1290908223 CA364649664	627	Y>*		No	ClinGen gnomAD
rs1200695694 CA364649679	628	W>*		No	ClinGen TOPMed
CA141893102 rs867898181	629	K>E		No	ClinGen Ensembl
CA364649704 rs1212897510	629	K>N		No	ClinGen gnomAD
CA364649721 rs1250918401	630	N>K		No	ClinGen TOPMed gnomAD
CA141893105 rs975093444	631	M>I		No	ClinGen TOPMed gnomAD
rs201661746 CA3902238	634	A>E		No	ClinGen 1000Genomes ExAC gnomAD
COSM1446089 CA3902239 COSM1446090 rs763552829	637	T>A	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA364649843 rs1254402872	638	I>T		No	ClinGen TOPMed gnomAD
CA364649860 rs1164609977	639	H>Q		No	ClinGen gnomAD
CA3902241 rs756952502	639	H>R		No	ClinGen ExAC TOPMed gnomAD
CA3902242 rs778614606	641	H>R		No	ClinGen ExAC gnomAD
rs533668607 CA3902259	642	G>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs533668607 CA3902258	642	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	645	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1416665544 CA364650044	646	S>R		No	ClinGen gnomAD
CA3902261 rs764798180	651	A>G		No	ClinGen ExAC gnomAD
CA364650138 rs1354931603	653	F>S		No	ClinGen gnomAD
CA141893608 rs920672186	655	I>L		No	ClinGen TOPMed
CA3902262 rs750032024	656	V>I		No	ClinGen ExAC
CA141893615 rs750032024	656	V>L		No	ClinGen ExAC
CA364650220 CA141893623 rs1035835841	659	M>I		No	ClinGen gnomAD
CA364650255 rs1257846328	662	L>R		No	ClinGen TOPMed
CA364650259 rs1182028263	663	I>V		No	ClinGen TOPMed
CA364650270 rs1228854582	664	D>A		No	ClinGen gnomAD
TCGA novel	664	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3902264 rs780429336	666	G>V		No	ClinGen ExAC gnomAD
rs751945146 CA3902265	669	N>K		No	ClinGen ExAC gnomAD
rs1348385222 CA364650306	669	N>S		No	ClinGen gnomAD
CA3902266 rs755594526	670	Q>*		No	ClinGen ExAC gnomAD
rs1485087083 CA364650333	673	P>A		No	ClinGen gnomAD
rs930668121 CA141893640	673	P>R		No	ClinGen TOPMed gnomAD
CA3902267 rs781762318	674	D>G		No	ClinGen ExAC gnomAD
CA364650357 rs1240997116	677	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1473114560 CA364650366	678	V>F		No	ClinGen gnomAD
CA3902268 rs185300112	679	V>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs185300112 CA3902269	679	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA141893649 rs185300112	679	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs372645109 CA3902270	681	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA141893653 rs57363908	681	D>N		No	ClinGen Ensembl
CA3902271 rs749479683	682	S>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	682	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1226778611 CA364650387	682	S>T		No	ClinGen TOPMed
rs909226958 CA141893661	683	Q>*		No	ClinGen Ensembl
rs777871742 CA3902290	685	G>S		No	ClinGen ExAC gnomAD
CA3902291 rs749303494	687	V>I		No	ClinGen ExAC TOPMed gnomAD
rs771241505 CA3902292	689	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs746807190 CA3902294	690	M>L		No	ClinGen ExAC gnomAD
rs1299124272 CA364627833	692	P>T		No	ClinGen gnomAD
CA364627844 rs1203947781	693	E>G		No	ClinGen TOPMed
rs1463041126 CA364627847	694	A>T		No	ClinGen TOPMed
rs1307590360 CA364627857	695	I>T		No	ClinGen gnomAD
rs768378142 CA3902295	697	D>G		No	ClinGen ExAC TOPMed gnomAD
rs776568921 CA3902296	698	M>T		No	ClinGen ExAC gnomAD
TCGA novel	699	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs372900516 CA3902297	702	R>G		No	ClinGen ESP ExAC gnomAD
rs769590044 CA3902298	704	N>S		No	ClinGen ExAC TOPMed gnomAD
rs772831205 CA3902299	705	G>R		No	ClinGen ExAC TOPMed gnomAD
rs199764540 CA3902300	706	K>N		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	709	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364628801 rs1187524521	711	I>M		No	ClinGen gnomAD
CA364628858 rs1173453784	715	S>G		No	ClinGen TOPMed
rs1420084218 CA364628905	718	W>S		No	ClinGen gnomAD
CA141845553 rs917945629	719	S>A		No	ClinGen Ensembl
rs770508314 CA3902321	720	L>S		No	ClinGen ExAC gnomAD
rs940005678 CA141845554	720	L>V		No	ClinGen gnomAD
rs1345780743 CA364628953	722	C>Y		No	ClinGen gnomAD
rs774170186 CA3902322	723	I>V		No	ClinGen ExAC gnomAD
rs1390521116 CA364628986	724	L>F		No	ClinGen TOPMed
CA3902323 rs150451663	726	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	726	Y>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA364629002 rs1286546879	726	Y>H		No	ClinGen gnomAD
TCGA novel	727	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775979132 CA3902325	730	G>R		No	ClinGen ExAC TOPMed gnomAD
CA3902326 rs760942299	731	K>E		No	ClinGen ExAC gnomAD
rs1056924665 CA141845583	731	K>R		No	ClinGen TOPMed gnomAD
CA141845591 rs867949681	733	P>Q		No	ClinGen Ensembl
TCGA novel	736	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1237151385 CA364629166	737	I>T		No	ClinGen TOPMed
rs141223517 CA3902329	738	I>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs141223517 CA3902328	738	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1257782523 CA364629235	742	S>F		No	ClinGen gnomAD
TCGA novel	742	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1210396536 CA364629256	744	L>S		No	ClinGen gnomAD
CA3902330 rs757376723	744	L>V		No	ClinGen ExAC gnomAD
rs765258198 CA364629267	745	H>P		No	ClinGen ExAC TOPMed gnomAD
rs765258198 CA3902331	745	H>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	746	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3902332 rs750468084	747	I>V		No	ClinGen ExAC gnomAD
rs1444364339 CA364629311	748	I>T		No	ClinGen gnomAD
rs1184015262 CA364629332	750	P>A		No	ClinGen TOPMed gnomAD
CA141845642 rs1049369074	751	N>H		No	ClinGen Ensembl
CA364629371 rs1228401098	753	E>K		No	ClinGen TOPMed
rs200382179 CA3902333	757	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA364629444 rs2230512	758	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs2230512 CA3902335 COSM197055 VAR_037142	758	D>N	large_intestine [Cosmic]	No	ClinGen cosmic curated UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1582117309 CA364629468	759	I>S		No	ClinGen Ensembl
rs755802728 CA3902336	760	P>L		No	ClinGen ExAC gnomAD
rs777964068 CA141845674	761	E>A		No	ClinGen Ensembl
CA364629520 rs1311892415	763	D>G		No	ClinGen gnomAD
CA3902337 rs777779837	764	L>P		No	ClinGen ExAC gnomAD
CA364629552 rs1300826991	765	Q>H		No	ClinGen Ensembl
CA364629546 rs1377756474	765	Q>R		No	ClinGen TOPMed
CA364629574 rs1280462227	767	V>E		No	ClinGen gnomAD
rs1411281840 CA364629568	767	V>M		No	ClinGen TOPMed gnomAD
rs1010370319 CA141845695	769	K>M		No	ClinGen TOPMed
rs763018821 CA3902353	771	C>G		No	ClinGen ExAC TOPMed gnomAD
rs1215363692	774	R>G	Variant assessed as Somatic; 4.691e-05 impact. [NCI-TCGA]	No	NCI-TCGA
CA141846017 rs945817978	774	R>G		No	ClinGen TOPMed gnomAD
rs923193250 CA141846041	775	D>N		No	ClinGen TOPMed gnomAD
rs1191023541 CA364629732	776	P>S		No	ClinGen TOPMed
rs1202255666 CA364629794	780	I>M		No	ClinGen gnomAD
rs368619103 CA3902354	781	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs200871965 CA3902355	782	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA141846054 rs945237871	783	P>A		No	ClinGen TOPMed gnomAD
rs755960167 CA3902356	784	E>Q		No	ClinGen ExAC gnomAD
rs753639607 CA3902358	787	A>G		No	ClinGen ExAC TOPMed gnomAD
rs375013020 CA3902359	788	H>Y		No	ClinGen ESP ExAC gnomAD
rs17849351 CA141846089	789	P>Q		No	ClinGen Ensembl
rs1435699865 CA364629936	791	V>I		No	ClinGen TOPMed
TCGA novel	791	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779778484 CA3902363	792	Q>R		No	ClinGen ExAC gnomAD
rs866800095 CA141846105	797	P>R		No	ClinGen Ensembl
CA3902382 rs746504223	798	V>D		No	ClinGen ExAC TOPMed gnomAD
rs780895297 CA3902384	804	G>E		No	ClinGen ExAC gnomAD
CA3902385 rs748518043	809	M>L		No	ClinGen ExAC gnomAD
rs748518043 CA364630345	809	M>V		No	ClinGen ExAC gnomAD
rs1390162506 CA364630397	811	Y>C		No	ClinGen TOPMed
CA3902387 rs773730783	812	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA364630418 rs1429657653	813	L>M		No	ClinGen gnomAD
rs749759214 CA3902388	814	G>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	814	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774346835 CA3902390	817	V>F		No	ClinGen ExAC TOPMed gnomAD
CA3902391 rs55901486	818	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs767635121 CA3902392	822	P>L		No	ClinGen ExAC TOPMed gnomAD
rs61735784 CA364630564	823	N>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV000888599 CA3902393 rs61735784	823	N>H		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA364630594 rs1209675271	824	S>Y		No	ClinGen TOPMed
rs1375011323 CA364630621	826	L>S		No	ClinGen gnomAD
TCGA novel	826	L>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761719966 CA3902395	830	K>*		No	ClinGen ExAC TOPMed gnomAD
CA141846481 rs894905802	830	K>I		No	ClinGen Ensembl
rs772138855 CA3902414	831	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1252769825 CA364631007	833	Y>C		No	ClinGen TOPMed gnomAD
CA3902415 rs775882099	836	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs775882099 CA364631031	836	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs764389041 CA3902418	839	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs141280630 CA3902419	840	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA3902420 rs762802143	841	S>R		No	ClinGen ExAC gnomAD
CA364631072 rs1373913644	842	H>Q		No	ClinGen gnomAD
rs766233509 CA3902421	842	H>R		No	ClinGen ExAC gnomAD
CA3902422 rs751457789	844	S>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	844	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	845	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1397887316 CA364631115	849	T>A		No	ClinGen gnomAD
rs752175870 CA3902428	851	E>G		No	ClinGen ExAC TOPMed gnomAD
rs766975134 CA3902427	851	E>K		No	ClinGen ExAC TOPMed
rs1384629564 CA364631145	853	K>R		No	ClinGen gnomAD
rs539988632 COSM252896 CA3902430	854	R>K	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	854	R>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763254614	854	R>G	Variant assessed as Somatic; 4.921e-05 impact. [NCI-TCGA]	No	NCI-TCGA
COSM1081942 rs755816263 CA3902429 COSM1154709	854	R>G	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA3902432 rs757581628	855	G>R		No	ClinGen ExAC TOPMed gnomAD
rs779307641 CA3902434	856	K>R		No	ClinGen ExAC gnomAD
rs768996038	857	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs772671513 CA3902436	858	K>C		No	ClinGen ExAC TOPMed
rs1467184173 CA364631178	858	K>L		No	ClinGen gnomAD

No associated diseases with P33981

4 regional properties for P33981

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	525 - 791	IPR000719
active_site	Serine/threonine-protein kinase, active site	643 - 655	IPR008271
binding_site	Protein kinase, ATP binding site	531 - 553	IPR017441
domain	Protein kinase Mps1 family, catalytic domain	523 - 791	IPR027084

Functions

		Description
EC Number	2.7.12.1	Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
PANTHER Family	PTHR22974	MIXED LINEAGE PROTEIN KINASE
PANTHER Subfamily	PTHR22974:SF21	DUAL SPECIFICITY PROTEIN KINASE TTK
PANTHER Protein Class	non-receptor serine/threonine protein kinase protein modifying enzyme
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
kinetochore	A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle	The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

7 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding	Binding to an identical protein or proteins.
kinetochore binding	Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

14 GO annotations of biological process

Name	Definition
chromosome segregation	The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
chromosome separation	The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II).
female meiosis chromosome segregation	The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female.
meiotic spindle assembly checkpoint signaling	A signal transduction process that contributes to a meiotic spindle assembly checkpoint, that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle.
mitotic spindle assembly checkpoint signaling	A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
mitotic spindle organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of pathway-restricted SMAD protein phosphorylation	Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein localization to kinetochore	Any process in which a protein is transported to, or maintained at, the kinetochore.
protein localization to meiotic spindle midzone	A process in which a protein is transported to, or maintained in, a location within a meiotic spindle midzone.
spindle organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P35761	Ttk	Dual specificity protein kinase TTK	Mus musculus (Mouse)	SS
Q84VX4	MPS1	Serine/threonine-protein kinase MPS1	Arabidopsis thaliana (Mouse-ear cress)	SS
Q8AYG3	ttk	Dual specificity protein kinase Ttk	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MESEDLSGRE	LTIDSIMNKV	RDIKNKFKNE	DLTDELSLNK	ISADTTDNSG	TVNQIMMMAN
70	80	90	100	110	120
NPEDWLSLLL	KLEKNSVPLS	DALLNKLIGR	YSQAIEALPP	DKYGQNESFA	RIQVRFAELK
130	140	150	160	170	180
AIQEPDDARD	YFQMARANCK	KFAFVHISFA	QFELSQGNVK	KSKQLLQKAV	ERGAVPLEML
190	200	210	220	230	240
EIALRNLNLQ	KKQLLSEEEK	KNLSASTVLT	AQESFSGSLG	HLQNRNNSCD	SRGQTTKARF
250	260	270	280	290	300
LYGENMPPQD	AEIGYRNSLR	QTNKTKQSCP	FGRVPVNLLN	SPDCDVKTDD	SVVPCFMKRQ
310	320	330	340	350	360
TSRSECRDLV	VPGSKPSGND	SCELRNLKSV	QNSHFKEPLV	SDEKSSELII	TDSITLKNKT
370	380	390	400	410	420
ESSLLAKLEE	TKEYQEPEVP	ESNQKQWQSK	RKSECINQNP	AASSNHWQIP	ELARKVNTEQ
430	440	450	460	470	480
KHTTFEQPVF	SVSKQSPPIS	TSKWFDPKSI	CKTPSSNTLD	DYMSCFRTPV	VKNDFPPACQ
490	500	510	520	530	540
LSTPYGQPAC	FQQQQHQILA	TPLQNLQVLA	SSSANECISV	KGRIYSILKQ	IGSGGSSKVF
550	560	570	580	590	600
QVLNEKKQIY	AIKYVNLEEA	DNQTLDSYRN	EIAYLNKLQQ	HSDKIIRLYD	YEITDQYIYM
610	620	630	640	650	660
VMECGNIDLN	SWLKKKKSID	PWERKSYWKN	MLEAVHTIHQ	HGIVHSDLKP	ANFLIVDGML
670	680	690	700	710	720
KLIDFGIANQ	MQPDTTSVVK	DSQVGTVNYM	PPEAIKDMSS	SRENGKSKSK	ISPKSDVWSL
730	740	750	760	770	780
GCILYYMTYG	KTPFQQIINQ	ISKLHAIIDP	NHEIEFPDIP	EKDLQDVLKC	CLKRDPKQRI
790	800	810	820	830	840
SIPELLAHPY	VQIQTHPVNQ	MAKGTTEEMK	YVLGQLVGLN	SPNSILKAAK	TLYEHYSGGE
850
SHNSSSSKTF	EKKRGKK