Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P33726

Entry ID Method Resolution Chain Position Source
AF-P33726-F1 Predicted AlphaFoldDB

No variants for P33726

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P33726

1 associated diseases with P33726

Without disease ID

5 regional properties for P33726

Type Name Position InterPro Accession
domain 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 481 - 814 IPR002073
domain GAF domain 71 - 230 IPR003018-1
domain GAF domain 252 - 439 IPR003018-2
domain HD/PDEase domain 554 - 741 IPR003607
conserved_site 3'5'-cyclic nucleotide phosphodiesterase, conserved site 597 - 608 IPR023174

Functions

Description
EC Number 3.1.4.35 Phosphoric diester hydrolases
Subcellular Localization
  • Membrane ; Lipid-anchor
  • Cell projection, cilium, photoreceptor outer segment
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
photoreceptor outer segment membrane The membrane surrounding the outer segment of a vertebrate photoreceptor.

3 GO annotations of molecular function

Name Definition
3',5'-cyclic-GMP phosphodiesterase activity Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+.
3',5'-cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate.
metal ion binding Binding to a metal ion.

5 GO annotations of biological process

Name Definition
detection of light stimulus The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal.
entrainment of circadian clock by photoperiod The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
retina development in camera-type eye The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P23439 PDE6B Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Bos taurus (Bovine) PR
O77746 PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase Canis lupus familiaris (Dog) (Canis familiaris) SS
Q9VJ79 Pde11 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 Drosophila melanogaster (Fruit fly) SS
P35913 PDE6B Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Homo sapiens (Human) PR
P23440 Pde6b Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Mus musculus (Mouse) PR
10 20 30 40 50 60
MSLSEEQVQH FLDQNPDFTD QYFGKTLSPE HVAGACGDGQ PTDCASFREL CQVEESAALF
70 80 90 100 110 120
ELVQDMQESV NMERVVFKIL RRLCTILRAD RCSLFMYRQR NGVAELATRL FSVQPGSALE
130 140 150 160 170 180
DCLVPPDSEI VFPLDIGVVG HVAQTKKMVN VQDVTECPHF SPFADELTGY ETRNILATPI
190 200 210 220 230 240
MNGKDVVAVI MALNKLDGPC FTSEDEDVFL KYLNFGTLNL KIYHLSYLHN CETRRGQVLL
250 260 270 280 290 300
WSANKVFEEL TDIERQFHKA FYTVRAYLNC DRYSVGLLDM TKEKEFFDVW PVLMGEAQPY
310 320 330 340 350 360
SGPRTPDGRE IVFYKVIDYI LHGKEDIKVI PSPPADHWAL ASGLPTYVAE SGFICNIMNT
370 380 390 400 410 420
AADEMFTFQE GPLDDSGWVI KNVLSMPIVN KKEEIVGVAT FYNRKDGKPF DEQDEVLMES
430 440 450 460 470 480
LTQFLGWSVL NTDTYDKMNK LENRKDIAQD MVLYHVRCDK DEIQLILPTR ERLGKEPADC
490 500 510 520 530 540
EEDELGILLK EVLPGPSKFD IYEFHFSDLE CTELELVKCG IQMYYELGVV RKFQIPQEVL
550 560 570 580 590 600
VRFLFSVSKG YRRITYHNWR HGFNVAQTMF TLLTTGKLKS YYTDLEAFAM VTAGLCHDID
610 620 630 640 650 660
HRGTNNLYQM KSQNPLAKLH GSSILERHHL EFGKFLLSEE TLNIYQNLNR RQHEHVIHLM
670 680 690 700 710 720
DIAIIATDLA LYFKKRTMFQ KIVDESKNYE DRKSWVEYLS LETTRKEIVM AMMMTACDLS
730 740 750 760 770 780
AITKPWEVQS KVALLVAAEF WEQGDLERTV LDQQPIPMMD RNKAAELPKL QVGFIDFVCT
790 800 810 820 830 840
FVYKEFSRFH EEILPMFDRL QNNRKEWKAL ADEYEAKLKA LEEEKQQQED RTTAKKAGTE
850
ICNGGPAPKS STCCIL