P33726
Gene name |
PDE6B |
Protein name |
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta |
Names |
GMP-PDE beta |
Species |
Canis lupus familiaris (Dog) (Canis familiaris) |
KEGG Pathway |
cfa:399653 |
EC number |
3.1.4.35: Phosphoric diester hydrolases |
Protein Class |
|

Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure

Activated structure

1 structures for P33726
Entry ID | Method | Resolution | Chain | Position | Source |
---|---|---|---|---|---|
AF-P33726-F1 | Predicted | AlphaFoldDB |
No variants for P33726
Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
---|---|---|---|---|---|
No variants for P33726 |
1 associated diseases with P33726
Without disease ID
5 regional properties for P33726
Type | Name | Position | InterPro Accession |
---|---|---|---|
domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 481 - 814 | IPR002073 |
domain | GAF domain | 71 - 230 | IPR003018-1 |
domain | GAF domain | 252 - 439 | IPR003018-2 |
domain | HD/PDEase domain | 554 - 741 | IPR003607 |
conserved_site | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | 597 - 608 | IPR023174 |
Functions
Description | ||
---|---|---|
EC Number | 3.1.4.35 | Phosphoric diester hydrolases |
Subcellular Localization |
|
|
PANTHER Family | ||
PANTHER Subfamily | ||
PANTHER Protein Class | ||
PANTHER Pathway Category | No pathway information available |
1 GO annotations of cellular component
Name | Definition |
---|---|
photoreceptor outer segment membrane | The membrane surrounding the outer segment of a vertebrate photoreceptor. |
3 GO annotations of molecular function
Name | Definition |
---|---|
3',5'-cyclic-GMP phosphodiesterase activity | Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+. |
3',5'-cyclic-nucleotide phosphodiesterase activity | Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate. |
metal ion binding | Binding to a metal ion. |
5 GO annotations of biological process
Name | Definition |
---|---|
detection of light stimulus | The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. |
entrainment of circadian clock by photoperiod | The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night). |
retina development in camera-type eye | The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. |
signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
visual perception | The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. |
5 homologous proteins in AiPD
UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
---|---|---|---|---|
P23439 | PDE6B | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta | Bos taurus (Bovine) | PR |
O77746 | PDE5A | cGMP-specific 3',5'-cyclic phosphodiesterase | Canis lupus familiaris (Dog) (Canis familiaris) | SS |
Q9VJ79 | Pde11 | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 | Drosophila melanogaster (Fruit fly) | SS |
P35913 | PDE6B | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta | Homo sapiens (Human) | PR |
P23440 | Pde6b | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta | Mus musculus (Mouse) | PR |
10 | 20 | 30 | 40 | 50 | 60 |
MSLSEEQVQH | FLDQNPDFTD | QYFGKTLSPE | HVAGACGDGQ | PTDCASFREL | CQVEESAALF |
70 | 80 | 90 | 100 | 110 | 120 |
ELVQDMQESV | NMERVVFKIL | RRLCTILRAD | RCSLFMYRQR | NGVAELATRL | FSVQPGSALE |
130 | 140 | 150 | 160 | 170 | 180 |
DCLVPPDSEI | VFPLDIGVVG | HVAQTKKMVN | VQDVTECPHF | SPFADELTGY | ETRNILATPI |
190 | 200 | 210 | 220 | 230 | 240 |
MNGKDVVAVI | MALNKLDGPC | FTSEDEDVFL | KYLNFGTLNL | KIYHLSYLHN | CETRRGQVLL |
250 | 260 | 270 | 280 | 290 | 300 |
WSANKVFEEL | TDIERQFHKA | FYTVRAYLNC | DRYSVGLLDM | TKEKEFFDVW | PVLMGEAQPY |
310 | 320 | 330 | 340 | 350 | 360 |
SGPRTPDGRE | IVFYKVIDYI | LHGKEDIKVI | PSPPADHWAL | ASGLPTYVAE | SGFICNIMNT |
370 | 380 | 390 | 400 | 410 | 420 |
AADEMFTFQE | GPLDDSGWVI | KNVLSMPIVN | KKEEIVGVAT | FYNRKDGKPF | DEQDEVLMES |
430 | 440 | 450 | 460 | 470 | 480 |
LTQFLGWSVL | NTDTYDKMNK | LENRKDIAQD | MVLYHVRCDK | DEIQLILPTR | ERLGKEPADC |
490 | 500 | 510 | 520 | 530 | 540 |
EEDELGILLK | EVLPGPSKFD | IYEFHFSDLE | CTELELVKCG | IQMYYELGVV | RKFQIPQEVL |
550 | 560 | 570 | 580 | 590 | 600 |
VRFLFSVSKG | YRRITYHNWR | HGFNVAQTMF | TLLTTGKLKS | YYTDLEAFAM | VTAGLCHDID |
610 | 620 | 630 | 640 | 650 | 660 |
HRGTNNLYQM | KSQNPLAKLH | GSSILERHHL | EFGKFLLSEE | TLNIYQNLNR | RQHEHVIHLM |
670 | 680 | 690 | 700 | 710 | 720 |
DIAIIATDLA | LYFKKRTMFQ | KIVDESKNYE | DRKSWVEYLS | LETTRKEIVM | AMMMTACDLS |
730 | 740 | 750 | 760 | 770 | 780 |
AITKPWEVQS | KVALLVAAEF | WEQGDLERTV | LDQQPIPMMD | RNKAAELPKL | QVGFIDFVCT |
790 | 800 | 810 | 820 | 830 | 840 |
FVYKEFSRFH | EEILPMFDRL | QNNRKEWKAL | ADEYEAKLKA | LEEEKQQQED | RTTAKKAGTE |
850 | |||||
ICNGGPAPKS | STCCIL |