P32892

PR
Gene name
DRS1 (YLL008W, L1345)
Protein name
ATP-dependent RNA helicase DRS1
Names
Deficiency of ribosomal subunits protein 1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YLL008W
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

83-243 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P32892

Entry ID Method Resolution Chain Position Source
AF-P32892-F1 Predicted AlphaFoldDB

8 variants for P32892

Variant ID(s) Position Change Description Diseaes Association Provenance
s12-131735 3 V>A No SGRP
s12-131875 50 K>E No SGRP
s12-132143 139 V>E No SGRP
s12-132218 164 G>E No SGRP
s12-132259 178 K>E No SGRP
s12-132367 214 D>N No SGRP
s12-133030 435 V>I No SGRP
s12-133715 663 K>R No SGRP

No associated diseases with P32892

No regional properties for P32892

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P32892

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

2 GO annotations of biological process

Name Definition
ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P10081 TIF2 ATP-dependent RNA helicase eIF4A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P15424 MSS116 ATP-dependent RNA helicase MSS116, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P53166 MRH4 ATP-dependent RNA helicase MRH4, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q03532 HAS1 ATP-dependent RNA helicase HAS1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q06218 DBP9 ATP-dependent RNA helicase DBP9 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P20448 HCA4 ATP-dependent RNA helicase HCA4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P21372 PRP5 Pre-mRNA-processing ATP-dependent RNA helicase PRP5 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) EV
P45818 ROK1 ATP-dependent RNA helicase ROK1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MVVGTKKYSN LDFVPTISDS EDDVPILDSS DDEKVEAKKT TKKRKGKNNK KKVSEGDNLD
70 80 90 100 110 120
EDVHEDLDAG FKFDLDADDT TSNFQGWNFL AEGESNKDDA EAFVKKDVDL DKIIRRKGGL
130 140 150 160 170 180
VKMAHIDSKQ EEETEKEKVE KENDSDDEEL AMDGFGMGAP MNNGDENQSE EEEEEEEKEE
190 200 210 220 230 240
EEEEEEEQEE MTLEKGGKDD EIDEEDDSEE AKADFYAPET EGDEAKKQMY ENFNSLSLSR
250 260 270 280 290 300
PVLKGLASLG YVKPSPIQSA TIPIALLGKD IIAGAVTGSG KTAAFMIPII ERLLYKPAKI
310 320 330 340 350 360
ASTRVIVLLP TRELAIQVAD VGKQIARFVS GITFGLAVGG LNLRQQEQML KSRPDIVIAT
370 380 390 400 410 420
PGRFIDHIRN SASFNVDSVE ILVMDEADRM LEEGFQDELN EIMGLLPSNR QNLLFSATMN
430 440 450 460 470 480
SKIKSLVSLS LKKPVRIMID PPKKAATKLT QEFVRIRKRD HLKPALLFNL IRKLDPTGQK
490 500 510 520 530 540
RIVVFVARKE TAHRLRIIMG LLGMSVGELH GSLTQEQRLD SVNKFKNLEV PVLICTDLAS
550 560 570 580 590 600
RGLDIPKIEV VINYDMPKSY EIYLHRVGRT ARAGREGRSV TFVGESSQDR SIVRAAIKSV
610 620 630 640 650 660
EENKSLTQGK ALGRNVDWVQ IEETNKLVES MNDTIEDILV EEKEEKEILR AEMQLRKGEN
670 680 690 700 710 720
MLKHKKEIQA RPRRTWFQSE SDKKNSKVLG ALSRNKKVTN SKKRKREEAK ADGNGARSYR
730 740 750
KTKTDRIADQ ERTFKKQKST NSNKKKGFKS RR