P32871
PR
Gene name |
PIK3CA |
Protein name |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
Names |
PI3-kinase subunit alpha, PI3K-alpha, PI3Kalpha, PtdIns-3-kinase subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha, PtdIns-3-kinase subunit p110-alpha, p110alpha, Phosphoinositide-3-kinase catalytic alpha polypeptide, Serine/threonine protein kinase PIK3CA |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:282306 |
EC number |
2.7.1.137: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
933-957 (Activation loop from InterPro)
Target domain |
695-1064 (Catalytic domain of Class IA Phosphoinositide 3-kinase alpha) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
2 structures for P32871
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2V1Y | X-ray | 240 A | A | 1-108 | PDB |
| AF-P32871-F1 | Predicted | AlphaFoldDB |
77 variants for P32871
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs470616753 | 11 | W>G | No | EVA | |
| rs442275607 | 23 | E>G | No | EVA | |
| rs476852391 | 25 | L>I | No | EVA | |
| rs463133323 | 27 | P>Q | No | EVA | |
| rs440338931 | 70 | F>L | No | EVA | |
| rs452003600 | 70 | F>Y | No | EVA | |
| rs473266203 | 71 | V>I | No | EVA | |
| rs436171900 | 72 | S>G | No | EVA | |
| rs432441072 | 95 | F>C | No | EVA | |
| rs457281810 | 95 | F>I | No | EVA | |
| rs465418683 | 95 | F>L | No | EVA | |
| rs446783171 | 102 | I>L | No | EVA | |
| rs437484320 | 123 | M>R | No | EVA | |
| rs472340445 | 134 | P>T | No | EVA | |
| rs455491990 | 135 | E>* | No | EVA | |
| rs435451388 | 150 | A>S | No | EVA | |
| rs451917430 | 246 | Y>D | No | EVA | |
| rs450242729 | 272 | Y>D | No | EVA | |
| rs137072391 | 291 | E>K | No | EVA | |
| rs135217082 | 296 | Q>H | No | EVA | |
| rs458108993 | 323 | S>C | No | EVA | |
| rs483164154 | 323 | S>T | No | EVA | |
| rs472533865 | 334 | L>H | No | EVA | |
| rs460873627 | 336 | I>R | No | EVA | |
| rs442242161 | 337 | K>* | No | EVA | |
| rs477425825 | 340 | C>* | No | EVA | |
| rs475041067 | 345 | N>H | No | EVA | |
| rs456551593 | 345 | N>T | No | EVA | |
| rs481238980 | 410 | K>E | No | EVA | |
| rs469172366 | 416 | K>R | No | EVA | |
| rs451213964 | 417 | E>* | No | EVA | |
| rs477755781 | 417 | E>A | No | EVA | |
| rs469054408 | 457 | N>T | No | EVA | |
| rs462116390 | 552 | W>* | No | EVA | |
| rs443937418 | 553 | S>I | No | EVA | |
| rs472154293 | 593 | I>M | No | EVA | |
| rs474502587 | 598 | A>T | No | EVA | |
| rs454060722 | 600 | E>Q | No | EVA | |
| rs435461171 | 614 | F>L | No | EVA | |
| rs439313298 | 641 | Y>S | No | EVA | |
| rs472217794 | 647 | N>T | No | EVA | |
| rs460134731 | 649 | L>F | No | EVA | |
| rs441948902 | 650 | V>E | No | EVA | |
| rs474919290 | 653 | L>* | No | EVA | |
| rs437809318 | 664 | G>A | No | EVA | |
| rs452522075 | 669 | W>C | No | EVA | |
| rs470771928 | 669 | W>L | No | EVA | |
| rs466850362 | 670 | H>Q | No | EVA | |
| rs434029346 | 670 | H>Y | No | EVA | |
| rs436348589 | 672 | K>Q | No | EVA | |
| rs469665776 | 672 | K>R | No | EVA | |
| rs444337654 | 676 | H>Q | No | EVA | |
| rs477098719 | 677 | N>H | No | EVA | |
| rs458632477 | 680 | V>G | No | EVA | |
| rs440162686 | 682 | Q>* | No | EVA | |
| rs442892416 | 690 | S>T | No | EVA | |
| rs475856496 | 704 | R>M | No | EVA | |
| rs445403900 | 739 | M>I | No | EVA | |
| rs459797389 | 742 | P>S | No | EVA | |
| rs441244938 | 747 | A>T | No | EVA | |
| rs480644225 | 750 | G>V | No | EVA | |
| rs462463532 | 756 | N>K | No | EVA | |
| rs439571281 | 828 | G>D | No | EVA | |
| rs432578922 | 838 | C>G | No | EVA | |
| rs465542996 | 843 | D>N | No | EVA | |
| rs133094348 | 873 | N>T | No | EVA | |
| rs445812590 | 880 | W>* | No | EVA | |
| rs433661590 | 885 | N>K | No | EVA | |
| rs466587511 | 887 | G>R | No | EVA | |
| rs481051163 | 888 | E>* | No | EVA | |
| rs462698109 | 888 | E>A | No | EVA | |
| rs436045308 | 892 | A>S | No | EVA | |
| rs456783061 | 894 | I>T | No | EVA | |
| rs465291830 | 896 | L>V | No | EVA | |
| rs443751522 | 978 | E>A | No | EVA | |
| rs462297408 | 980 | F>V | No | EVA | |
| rs450274383 | 982 | E>A | No | EVA |
No associated diseases with P32871
8 regional properties for P32871
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain | 173 - 292 | IPR000341 |
| domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | 765 - 1065 | IPR000403 |
| domain | Phosphoinositide 3-kinase, accessory (PIK) domain | 517 - 704 | IPR001263 |
| domain | C2 phosphatidylinositol 3-kinase-type domain | 322 - 487 | IPR002420 |
| domain | Phosphatidylinositol 3-kinase, adaptor-binding domain | 16 - 108 | IPR003113 |
| conserved_site | Phosphatidylinositol 3/4-kinase, conserved site | 801 - 815 | IPR018936-1 |
| conserved_site | Phosphatidylinositol 3/4-kinase, conserved site | 900 - 920 | IPR018936-2 |
| domain | PI3Kalpha, catalytic domain | 695 - 1064 | IPR037704 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.137 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| intercalated disc | A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. |
| lamellipodium | A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| phosphatidylinositol 3-kinase complex | A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too. |
| phosphatidylinositol 3-kinase complex, class IA | A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways. |
| phosphatidylinositol 3-kinase complex, class IB | A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
11 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-phosphatidylinositol-3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+). |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| insulin receptor substrate binding | Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. |
| phosphatidylinositol 3-kinase activity | Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring. |
| phosphatidylinositol kinase activity | Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. |
| phosphatidylinositol-3,4-bisphosphate 5-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+). |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+). |
| protein kinase activator activity | Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
31 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| adipose tissue development | The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. |
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| cardiac muscle cell contraction | The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
| cellular response to glucose stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. |
| cellular response to hydrostatic pressure | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it. |
| energy homeostasis | Any process involved in the balance between food intake (energy input) and energy expenditure. |
| glucose metabolic process | The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. |
| hypomethylation of CpG island | An decrease in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes. |
| liver development | The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. |
| negative regulation of actin filament depolymerization | Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization. |
| negative regulation of anoikis | Any process that stops, prevents or reduces the frequency, rate or extent of anoikis. |
| negative regulation of fibroblast apoptotic process | Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process. |
| negative regulation of neuron apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. |
| phagocytosis | A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. |
| phosphatidylinositol 3-kinase signaling | A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions. |
| phosphatidylinositol phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. |
| phosphatidylinositol-3-phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position. |
| phosphatidylinositol-mediated signaling | The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| positive regulation of lamellipodium assembly | Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. |
| positive regulation of peptidyl-serine phosphorylation | Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. |
| positive regulation of protein kinase B signaling | Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| protein kinase B signaling | A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. |
| regulation of cellular respiration | Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds. |
| regulation of genetic imprinting | Any process that modulates the frequency, rate or extent of genetic imprinting. |
| regulation of multicellular organism growth | Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. |
| relaxation of cardiac muscle | The process in which the extent of cardiac muscle contraction is reduced. |
| response to muscle stretch | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length. |
| vascular endothelial growth factor signaling pathway | The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O02810 | PI4KB | Phosphatidylinositol 4-kinase beta | Bos taurus (Bovine) | PR |
| P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Homo sapiens (Human) | PR |
| P48736 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Homo sapiens (Human) | PR |
| O00329 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Homo sapiens (Human) | PR |
| P42336 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Homo sapiens (Human) | PR |
| Q8BTI9 | Pik3cb | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Mus musculus (Mouse) | PR |
| Q9JHG7 | Pik3cg | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Mus musculus (Mouse) | PR |
| O35904 | Pik3cd | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Mus musculus (Mouse) | PR |
| P42337 | Pik3ca | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Mus musculus (Mouse) | PR |
| O02697 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Sus scrofa (Pig) | PR |
| Q9Z1L0 | Pik3cb | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Rattus norvegicus (Rat) | PR |
| Q94125 | age-1 | Phosphatidylinositol 3-kinase age-1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPPRPSSGEL | WGIHLMPPRI | LVECLLPNGM | IVTLECLREA | TLITIKHELF | KEARKYPLHQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLQDESSYIF | VSVTQEAERE | EFFDETRRLC | DLRLFQPFLK | VIEPVGNREE | KILNREIGFA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IGMPVCEFDM | VKDPEVQDFR | RNILNVCKEA | VDLRDLNSPH | SRAMYVYPPN | VESSPELPKH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IYNKLDKGQI | IVVIWVIVSP | NNDKQKYTLK | INHDCVPEQV | IAEAIRKKTR | SMLLSSEQLK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LCVLEYQGKY | ILKVCGCDEY | FLEKYPLSQY | KYIRSCIMLG | RMPNLMLMAK | ESLYSQLPMD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CFTMPSYSRR | ISTATPYMNG | ETSTKSLWVI | NSALRIKILC | ATYVNVNIRD | IDKIYVRTGI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YHGGEPLCDN | VNTQRVPCSN | PRWNEWLNYD | IYIPDLPRAA | RLCLSICSVK | GRKGAKEEHC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PLAWGNINLF | DYTDTLVSGK | MALNLWPVPH | GLEDLLNPIG | VTGSNPNKET | PCLELEFDWF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SSVVKFPDMS | VIEEHANWSV | SREAGFSYSH | AGLSNRLARD | NELRENDKEQ | LRAICTRDPL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SEITEQEKDF | LWSHRHYCVT | IPEILPKLLL | SVKWNSRDEV | AQMYCLVKDW | PPIKPEQAME |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LLDCNYPDPM | VRGFAVRCLE | KYLTDDKLSQ | YLIQLVQVLK | YEQYLDNLLV | RFLLKKALTN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QRIGHFFFWH | LKSEMHNKTV | SQRFGLLLES | YCRACGMYLK | HLNRQVEAME | KLINLTDILK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QEKKDETQKV | QMKFLVEQMR | RPDFMDALQG | FLSPLNPAHQ | LGNLRLEECR | IMSSAKRPLW |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LNWENPDIMS | ELLFQNNEII | FKNGDDLRQD | MLTLQIIRIM | ENIWQNQGLD | LRMLPYGCLS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IGDCVGLIEV | VRNSHTIMQI | QCKGGLKGAL | QFNSHTLHQW | LKDKNKGEIY | DAAIDLFTRS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| CAGYCVATFI | LGIGDRHNSN | IMVKDDGQLF | HIDFGHFLDH | KKKKFGYKRE | RVPFVLTQDF |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LIVISKGAQE | CTKTREFERF | QEMCYKAYLA | IRQHANLFIN | LFSMMLGSGM | PELQSFDDIA |
| 1030 | 1040 | 1050 | 1060 | ||
| YIRKTLALDK | TEQEALEYFM | KQMNDAHHGG | WTTKMDWIFH | TIKQHALN |