P32582

PR
Gene name
CYS4 (STR4, YGR155W, G6667)
Protein name
Cystathionine beta-synthase
Names
Beta-thionase, Serine sulfhydrase, Sulfur transfer protein 4
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YGR155W
EC number
4.2.1.22: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

27-104 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P32582

Entry ID Method Resolution Chain Position Source
6C2H X-ray 149 A A 1-353 PDB
6C2Q X-ray 217 A A 1-353 PDB
6C2Z X-ray 137 A A 1-353 PDB
6C4P X-ray 230 A A 1-353 PDB
AF-P32582-F1 Predicted AlphaFoldDB

3 variants for P32582

Variant ID(s) Position Change Description Diseaes Association Provenance
s07-799077 177 R>K No SGRP
s07-800058 504 S>N strain: UCD932 [UniProt] No SGRP
s07-800066 507 A>T No SGRP

No associated diseases with P32582

5 regional properties for P32582

Type Name Position InterPro Accession
domain CBS domain 369 - 432 IPR000644-1
domain CBS domain 461 - 507 IPR000644-2
binding_site Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site 42 - 60 IPR001216
domain Tryptophan synthase beta chain-like, PALP domain 17 - 319 IPR001926
domain Cystathionine beta-synthase, C-terminal domain 366 - 505 IPR046353

Functions

Description
EC Number 4.2.1.22 Hydro-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
cystathionine beta-synthase activity Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

6 GO annotations of biological process

Name Definition
cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid.
cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine.
cysteine biosynthetic process via cystathionine The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine.
hydrogen sulfide biosynthetic process The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S.
transsulfuration The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes.
traversing start control point of mitotic cell cycle A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P35520 CBS Cystathionine beta-synthase Homo sapiens (Human) EV
Q91WT9 Cbs Cystathionine beta-synthase Mus musculus (Mouse) SS
P32232 Cbs Cystathionine beta-synthase Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MTKSEQQADS RHNVIDLVGN TPLIALKKLP KALGIKPQIY AKLELYNPGG SIKDRIAKSM
70 80 90 100 110 120
VEEAEASGRI HPSRSTLIEP TSGNTGIGLA LIGAIKGYRT IITLPEKMSN EKVSVLKALG
130 140 150 160 170 180
AEIIRTPTAA AWDSPESHIG VAKKLEKEIP GAVILDQYNN MMNPEAHYFG TGREIQRQLE
190 200 210 220 230 240
DLNLFDNLRA VVAGAGTGGT ISGISKYLKE QNDKIQIVGA DPFGSILAQP ENLNKTDITD
250 260 270 280 290 300
YKVEGIGYDF VPQVLDRKLI DVWYKTDDKP SFKYARQLIS NEGVLVGGSS GSAFTAVVKY
310 320 330 340 350 360
CEDHPELTED DVIVAIFPDS IRSYLTKFVD DEWLKKNNLW DDDVLARFDS SKLEASTTKY
370 380 390 400 410 420
ADVFGNATVK DLHLKPVVSV KETAKVTDVI KILKDNGFDQ LPVLTEDGKL SGLVTLSELL
430 440 450 460 470 480
RKLSINNSNN DNTIKGKYLD FKKLNNFNDV SSYNENKSGK KKFIKFDENS KLSDLNRFFE
490 500
KNSSAVITDG LKPIHIVTKM DLLSYLA