P32031

PR
Gene name
slp2 (CG2939)
Protein name
Fork head domain transcription factor slp2
Names
Sloppy paired locus protein 2
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG2939
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

253-361 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P32031

Entry ID Method Resolution Chain Position Source
AF-P32031-F1 Predicted AlphaFoldDB

No variants for P32031

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P32031

No associated diseases with P32031

3 regional properties for P32031

Type Name Position InterPro Accession
domain Fork head domain 178 - 274 IPR001766
conserved_site Fork head domain conserved site1 180 - 193 IPR018122
conserved_site Fork head domain conserved site 2 224 - 230 IPR030456

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

2 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
segment polarity determination Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O15353 FOXN1 Forkhead box protein N1 Homo sapiens (Human) PR
Q96NZ1 FOXN4 Forkhead box protein N4 Homo sapiens (Human) PR
Q08050 FOXM1 Forkhead box protein M1 Homo sapiens (Human) EV
Q12948 FOXC1 Forkhead box protein C1 Homo sapiens (Human) PR
Q8K3Q3 Foxn4 Forkhead box protein N4 Mus musculus (Mouse) PR
Q61572 Foxc1 Forkhead box protein C1 Mus musculus (Mouse) PR
O08696 Foxm1 Forkhead box protein M1 Mus musculus (Mouse) PR
P97691 Foxm1 Forkhead box protein M1 Rattus norvegicus (Rat) PR
Q28H65 foxn5 Forkhead box protein N5 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
A2BGM5 foxn4 Forkhead box protein N4 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MVKIEEGLPS SEISAHSLHF QHHHHPLPPT THHSALQSPH PVGLNLTNLM KMARTPHLKS
70 80 90 100 110 120
SFSINSILPE TVEHHDEDEE EDVEKKSPAK FPPNHNNNNL NTTNWGSPED HEAESDPESD
130 140 150 160 170 180
LDVTSMSPAP VANPNESDPD EVDEEFVEED IECDGETTDG DAENKSNDGK PVKDKKGNEK
190 200 210 220 230 240
PPYSYNALIM MAIRQSSEKR LTLNGIYEYI MTNHPYYRDN KQGWQNSIRH NLSLNKCFVK
250 260 270 280 290 300
VPRHYDDPGK GNYWMLDPSA EDVFIGGSTG KLRRRTTAAS RSRLAAFKRS LIGPMFPGLA
310 320 330 340 350 360
AYPQFGQFLT YPPTAPSLLA SMYQRYNPFA PKGGPGHPGL PPGLPGLPGP PGPQGPPGPP
370 380 390 400 410 420
PPPFVAPPTS SELYQRLQYQ QLLHQHAAAA ALAAHQRQLS VAAASAASQP PPTHHHPHLA
430 440 450
VGQAPLSPGG DSPGPSPQPL HKPVTVVSRN S