P31325

PR
Gene name
Phkg2
Protein name
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
Names
PHK-gamma-LT, PHK-gamma-T, Phosphorylase kinase subunit gamma-2
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:140671
EC number
2.7.11.19: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

170-192 (Activation loop from InterPro)

Target domain

24-291 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P31325

Entry ID Method Resolution Chain Position Source
AF-P31325-F1 Predicted AlphaFoldDB

No variants for P31325

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P31325

No associated diseases with P31325

3 regional properties for P31325

Type Name Position InterPro Accession
domain Protein kinase domain 49 - 350 IPR000719
conserved_site Mitogen-activated protein (MAP) kinase, conserved site 84 - 187 IPR003527
binding_site Protein kinase, ATP binding site 55 - 79 IPR017441

Functions

Description
EC Number 2.7.11.19 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
enzyme binding Binding to an enzyme, a protein with catalytic activity.
phosphorylase kinase activity Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a.

4 GO annotations of biological process

Name Definition
glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
glycogen catabolic process The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
glycogen metabolic process The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.
protein phosphorylation The process of introducing a phosphate group on to a protein.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KJ16 PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Bos taurus (Bovine) PR
P15735 PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Homo sapiens (Human) PR
Q16816 PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Homo sapiens (Human) PR
P07934 Phkg1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Mus musculus (Mouse) SS
Q9DB30 Phkg2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Mus musculus (Mouse) PR
P31325 Phkg2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Rattus norvegicus (Rat) PR
P13286 Phkg1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Rattus norvegicus (Rat) SS
P08413 Camk2b Calcium/calmodulin-dependent protein kinase type II subunit beta Rattus norvegicus (Rat) SS
P11275 Camk2a Calcium/calmodulin-dependent protein kinase type II subunit alpha Rattus norvegicus (Rat) PR
P11730 Camk2g Calcium/calmodulin-dependent protein kinase type II subunit gamma Rattus norvegicus (Rat) SS
P15791 Camk2d Calcium/calmodulin-dependent protein kinase type II subunit delta Rattus norvegicus (Rat) SS
P20689 Mylk2 Myosin light chain kinase 2, skeletal/cardiac muscle Rattus norvegicus (Rat) SS
E9PT87 Mylk3 Myosin light chain kinase 3 Rattus norvegicus (Rat) SS
O70150 Pnck Calcium/calmodulin-dependent protein kinase type 1B Rattus norvegicus (Rat) PR
Q7TNJ7 Camk1g Calcium/calmodulin-dependent protein kinase type 1G Rattus norvegicus (Rat) SS
Q63092 Camkv CaM kinase-like vesicle-associated protein Rattus norvegicus (Rat) SS
Q63450 Camk1 Calcium/calmodulin-dependent protein kinase type 1 Rattus norvegicus (Rat) EV
10 20 30 40 50 60
MTLDVGPEDE LPDWAAAKEF YQKYDPKDII GRGVSSVVRR CVHRATGDEF AVKIMEVSAE
70 80 90 100 110 120
RLSLEQLEEV RDATRREMHI LRQVAGHPHI ITLIDSYESS SFMFLVFDLM RKGELFDYLT
130 140 150 160 170 180
EKVALSEKET RSIMRSLLEA VNFLHVNNIV HRDLKPENIL LDDNMQIRLS DFGFSCHLEP
190 200 210 220 230 240
GEKLRELCGT PGYLAPEILK CSMDETHPGY GKEVDLWACG VILFTLLAGS PPFWHRRQIL
250 260 270 280 290 300
MLRMIMEGQY QFSSPEWDDR SNTVKDLIAK LLQVDPNARL TAEQALQHPF FERCKGSQPW
310 320 330 340 350 360
NLTPRQRFRV AVWTILAAGR VALSSHRLRP LTKNALLRDP YALRPVRRLI DNCAFRLYGH
370 380 390 400
WVKKGEQQNR AALFQHQPPR PFPIIATDLE GDSSAITEDE VTLVRS