AiPD: Autoinhibited Protein Database

P31323

Gene name	PRKAR2B
Protein name	cAMP-dependent protein kinase type II-beta regulatory subunit
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5577
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

29-156 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

29-156 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P31323

Entry ID	Method	Resolution	Chain	Position	Source
AF-P31323-F1	Predicted				AlphaFoldDB

186 variants for P31323

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	56	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368937554 rs1584397394	82	Q>R		No	ClinGen Ensembl
rs1436699482 CA368937564	84	D>N		No	TOPMed ClinGen
rs1330114726 CA368937577	85	S>C		No	TOPMed ClinGen
CA164660360 rs936000837	86	E>G		No	TOPMed ClinGen
CA368937585 rs1417462170	87	D>N		No	ClinGen TOPMed gnomAD
rs1031523798 CA4429823	88	G>E		No	ClinGen TOPMed gnomAD
CA368937593 rs1349918280	88	G>R		No	ClinGen gnomAD
CA368937606 rs1292233393	90	E>K		No	gnomAD ClinGen
rs368313660 CA4429826	92	E>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs775932235 CA4429827	93	A>V		No	ExAC gnomAD ClinGen
CA368937639 rs1308958978	94	A>V		No	ClinGen gnomAD
CA368937642 rs1478425629	95	P>S		No	ClinGen TOPMed
CA368937647 rs1290865073	96	A>S		No	ClinGen gnomAD
CA368937651 rs1197111787	96	A>V		No	ClinGen TOPMed
rs1286490210 CA368937660	98	A>S		No	ClinGen TOPMed
rs891292930 CA164660371	98	A>V		No	ClinGen TOPMed
rs1007188401 CA164660373	99	G>E		No	TOPMed ClinGen
TCGA novel	100	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368937689 rs1219279254	102	N>K		No	ClinGen TOPMed
CA4429830 rs568215467	102	N>S		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA4429844 rs748684280	106	I>V		No	ExAC gnomAD ClinGen
rs1477864517 COSM744232 CA368937738	108	R>*	lung Variant assessed as Somatic; 0.0 impact. endometrium [Cosmic, NCI-TCGA]	No	gnomAD ClinGen cosmic curated NCI-TCGA
rs775824400 CA4429846	108	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1034952052 CA164665976	110	T>I		No	Ensembl ClinGen
rs1326909416 CA368937764	112	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	117	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	121	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4429861 rs777219859	126	E>D		No	ExAC TOPMed gnomAD ClinGen
rs1399701337 CA368823085	126	E>K		No	gnomAD ClinGen
rs1380123627 CA368823096	126	E>V		No	ClinGen TOPMed
CA368823143 rs1347522011	128	D>V		No	gnomAD ClinGen
rs748864990 CA4429863	129	A>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	129	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748864990 CA4429862	129	A>V		No	ClinGen ExAC TOPMed gnomAD
CA368823215 rs1435893803	131	S>C		No	TOPMed ClinGen
rs149865268 CA4429864	132	R>G		No	ESP ExAC ClinGen
rs200951450 CA4429882	134	I>M		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	138	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1357784770 CA368824647	140	D>H		No	ClinGen TOPMed gnomAD
rs776909179 CA164160716	142	R>I		No	ClinGen Ensembl
rs1562865559 CA368824700	143	N>S		No	ClinGen Ensembl
CA368824694 rs1209902990	143	N>Y		No	gnomAD ClinGen
TCGA novel	148	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4429884 rs769300018	149	C>F		No	ExAC gnomAD ClinGen
CA4429885 rs559030584	150	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4429886 rs748545506	151	D>N		No	ClinGen ExAC gnomAD
CA368824831 rs1400376735	152	I>N		No	ClinGen TOPMed
CA368824840 rs1239120460	153	L>M		No	ClinGen gnomAD
CA368824847 rs1562865573	153	L>P		No	Ensembl ClinGen
rs773593350 CA368824878	155	F>L		No	ClinGen ExAC gnomAD
CA164160774 rs371768848	160	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ESP gnomAD ClinGen NCI-TCGA
rs371768848 CA164160768	160	P>R		No	ClinGen ESP gnomAD
CA164160763 rs946674589	160	P>T		No	ClinGen Ensembl
TCGA novel	162	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs903870287 CA164169638	163	M>T		No	TOPMed ClinGen
rs1244149180 CA368828784	164	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1424238319 CA368828800	165	Q>E		No	ClinGen gnomAD
rs757942408 CA4429904	165	Q>H		No	ClinGen ExAC gnomAD
rs748643069 CA4429906	169	A>T		No	ClinGen ExAC gnomAD
rs1456962757 CA368828931	169	A>V		No	ClinGen TOPMed
CA368828938 rs1255579209	170	M>V		No	ClinGen TOPMed
rs756637383 CA4429907	174	L>F		No	ExAC TOPMed gnomAD ClinGen
rs1396204031 CA368829036	174	L>M		No	ClinGen gnomAD
CA368829111 rs1352953019	177	D>G		No	gnomAD ClinGen
rs771144413 CA4429910	180	H>R		No	ExAC gnomAD ClinGen
rs3729873 CA164169725	187	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs3729873 CA4429913	187	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA368829325 rs1562869146	188	G>S		No	ClinGen Ensembl
rs1184185951 CA368831775	201	I>T		No	TOPMed ClinGen
rs1158900282 CA368831769	201	I>V		No	gnomAD ClinGen
rs761724038 CA4429936	205	C>R		No	ExAC gnomAD ClinGen
rs761724038 CA4429937	205	C>S		No	ExAC gnomAD ClinGen
rs1392080606 CA368831884	206	D>G		No	gnomAD ClinGen
rs773136065 CA4429938	206	D>N		No	ClinGen ExAC gnomAD
rs762750038 CA4429939	207	G>S		No	ClinGen ExAC TOPMed gnomAD
CA164174417 rs1044637262	208	V>I		No	TOPMed ClinGen
TCGA novel	209	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766071087 CA4429940	210	R>G		No	ExAC gnomAD ClinGen
rs756975609 CA4429941	211	C>R		No	ExAC TOPMed gnomAD ClinGen
TCGA novel	215	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1469923855 CA368832074	216	D>H		No	TOPMed ClinGen
rs764527123 CA4429943	216	D>V		No	ExAC gnomAD ClinGen
rs1213025838 CA368832118	218	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA4429944 rs754413619	218	R>H		No	ClinGen ExAC gnomAD
rs751394789 CA164174483	220	S>N		No	ClinGen gnomAD
CA368832177 rs1266150485	221	F>S		No	ClinGen gnomAD
CA164174503 rs202187974	228	Y>C		No	Ensembl ClinGen
rs374034733 CA164174525	229	N>S		No	ESP TOPMed gnomAD ClinGen
CA368832413 rs1442441796	230	T>I		No	TOPMed ClinGen
CA368832426 rs1371140480	231	P>A		No	ClinGen TOPMed
rs1178801826 CA368832492	236	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	237	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368832510 rs1405310138	237	T>S		No	ClinGen TOPMed
CA368832528 rs1245228594 COSM3831567	239	T>A	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA4429950 rs747089861	241	P>L		No	ExAC gnomAD ClinGen
rs530887023 CA4429951	243	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA164142774 rs1048544863	256	I>T		No	ClinGen TOPMed
CA368818520 rs1319876189	260	N>S		No	gnomAD ClinGen
COSM744228 rs777810830 CA4429972	261	A>S	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	263	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1271963939 CA368818579	264	R>S		No	ClinGen gnomAD
CA4429974 rs770804316	266	M>I		No	ClinGen ExAC TOPMed gnomAD
rs749115000 CA4429973	266	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA368818641 rs1237712646	269	S>G		No	gnomAD ClinGen
rs773983070 CA164142777	269	S>N		No	ClinGen ExAC TOPMed gnomAD
CA4429975 rs773983070	269	S>T		No	ExAC TOPMed gnomAD ClinGen
CA164142781 rs922652968	280	L>V		No	gnomAD ClinGen
rs1204029640 CA368818911	285	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
rs746545398 CA4429998	285	R>L		No	ExAC gnomAD ClinGen
COSM1263056 rs768206192 CA368818919	287	K>E	oesophagus [Cosmic]	No	ExAC TOPMed gnomAD ClinGen cosmic curated
CA4429999 rs768206192	287	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA4430000 rs776089075	288	V>I		No	ClinGen ExAC gnomAD
rs148976844 CA164143677	291	V>A		No	ESP TOPMed gnomAD ClinGen
rs375279955 CA164143692	293	G>S		No	ESP gnomAD ClinGen
CA164143696 rs947463536	294	T>S		No	ClinGen Ensembl
rs1562873042 CA368818968	295	K>E		No	Ensembl ClinGen
rs1289685923 CA368818972	295	K>N		No	TOPMed ClinGen
CA164143704 rs941339348	295	K>R		No	TOPMed gnomAD ClinGen
CA164143709 rs143772610	296	V>G		No	ESP TOPMed ClinGen
CA4430004 rs759778020	296	V>L		No	ExAC gnomAD ClinGen
rs1324127724 CA368818979	297	Y>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs756370975 CA4430007	299	D>N		No	ExAC gnomAD ClinGen
rs1049700324 CA164143720	301	E>D		No	Ensembl ClinGen
COSM276898 rs201018627 CA4430030	309	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	311	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1195799073 CA368819350	312	S>Y		No	gnomAD ClinGen
CA368819387 rs1166000566	315	I>T		No	gnomAD ClinGen
rs1461306991 CA368819382	315	I>V		No	ClinGen gnomAD
rs991319621 CA164145333	317	E>V		No	Ensembl ClinGen
TCGA novel	320	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368819504 rs1562874375	324	T>A		No	Ensembl ClinGen
rs1311725863 CA368819511	325	M>V		No	ClinGen gnomAD
CA4430034 rs758303446	327	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	328	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4430051 rs762889848	330	K>R		No	ClinGen ExAC gnomAD
CA4430053 rs751385940	333	V>A		No	ExAC gnomAD ClinGen
rs932569758 CA164145419	334	E>G		No	ClinGen TOPMed
CA164145421 VAR_046549 rs3729881 CA368819659	335	E>D		No	ClinGen TOPMed UniProt dbSNP
rs1484299990 CA368819666	336	N>S		No	TOPMed gnomAD ClinGen
CA4430054 rs754717990	337	G>D		No	ClinGen ExAC gnomAD
CA4430055 rs547463316	339	V>L		No	1000Genomes ExAC gnomAD ClinGen
TCGA novel	340	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	340	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1269965585 CA368819713	341	I>V		No	TOPMed ClinGen
rs1269115229 CA368819723	342	A>T		No	gnomAD ClinGen
rs1489977996 CA368819733	343	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	TOPMed ClinGen NCI-TCGA
rs1031585694 CA164145430	343	R>L		No	Ensembl ClinGen
CA4430059 rs777203428	345	S>L		No	ClinGen ExAC TOPMed gnomAD
CA4430058 rs777203428	345	S>W		No	ClinGen ExAC TOPMed gnomAD
CA368819763 rs1350023361	346	R>W		No	ClinGen TOPMed
rs536349158 CA4430061	348	Q>H		No	1000Genomes ExAC gnomAD ClinGen
rs1159165961 CA368819801	349	Y>F		No	gnomAD ClinGen
CA368819842 rs1362730841	353	L>F		No	ClinGen TOPMed gnomAD
rs747403181 CA4430062	354	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1048371348 CA164145444	354	A>V		No	ClinGen TOPMed
rs1295807932	361	R>P		No	gnomAD
TCGA novel	365	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1379361464	367	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
TCGA novel	367	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1224595549	368	I>T		No	gnomAD
rs1184321840	368	I>V		No	TOPMed gnomAD
rs1306322995	371	V>A		No	gnomAD
TCGA novel	374	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770045302	374	L>F		No	ExAC gnomAD
rs749489513 CA4430091	375	A>V		No	ExAC gnomAD ClinGen
rs1426148175 CA368820363	376	M>I		No	TOPMed gnomAD ClinGen
CA368820359 rs1562875259	376	M>T		No	ClinGen Ensembl
rs771035954 CA4430092	379	Q>K		No	ClinGen ExAC gnomAD
CA164146369 rs78421605	386	G>E		No	Ensembl ClinGen
rs774406745	389	M>L		No	ExAC gnomAD
TCGA novel	391	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs79974757	392	M>I		No	Ensembl
TCGA novel	394	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1584459566	395	N>S		No	Ensembl
rs76105568	397	A>S		No	ExAC TOPMed gnomAD
rs76105568	397	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD NCI-TCGA
rs1319176311	405	A>T		No	TOPMed
TCGA novel	406	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201946496	409	T>M		No	gnomAD
rs763679888	411	M>L		No	ExAC gnomAD
rs763679888	411	M>V		No	ExAC gnomAD
rs376761898	412	D>G		No	ESP ExAC TOPMed gnomAD
rs1280371411	413	I>F		No	TOPMed gnomAD
rs367760989	414	V>I		No	ESP TOPMed gnomAD
rs764908290	419	A>G		No	ExAC gnomAD

No associated diseases with P31323

3 regional properties for P31323

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	5 - 261	IPR000719
active_site	Serine/threonine-protein kinase, active site	120 - 132	IPR008271
binding_site	Protein kinase, ATP binding site	11 - 34	IPR017441

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Cell membrane	Colocalizes with PJA2 in the cytoplasm and at the cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

13 GO annotations of cellular component

Name	Definition
cAMP-dependent protein kinase complex	An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
ciliary base	Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendritic shaft	Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
dendritic spine	A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
membrane raft	Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name	Definition
cAMP binding	Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
cAMP-dependent protein kinase inhibitor activity	Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase.
cAMP-dependent protein kinase regulator activity	Modulation of the activity of the enzyme cAMP-dependent protein kinase.
protein domain specific binding	Binding to a specific domain of a protein.
protein kinase A catalytic subunit binding	Binding to one or both of the catalytic subunits of protein kinase A.
ubiquitin protein ligase binding	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

7 GO annotations of biological process

Name	Definition
fatty acid metabolic process	The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
learning	Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
modulation of chemical synaptic transmission	Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
negative regulation of cAMP-dependent protein kinase activity	Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity.
response to antipsychotic drug	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antipsychotic drug stimulus. Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.
response to clozapine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clozapine stimulus.

23 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P07278	BCY1	cAMP-dependent protein kinase regulatory subunit	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	SS
P00514	PRKAR1A	cAMP-dependent protein kinase type I-alpha regulatory subunit	Bos taurus (Bovine)	EV
P00515	PRKAR2A	cAMP-dependent protein kinase type II-alpha regulatory subunit	Bos taurus (Bovine)	EV
P31322	PRKAR2B	cAMP-dependent protein kinase type II-beta regulatory subunit	Bos taurus (Bovine)	EV
Q5ZM91	PRKAR1A	cAMP-dependent protein kinase type I-alpha regulatory subunit	Gallus gallus (Chicken)	SS
P16905	Pka-R1	cAMP-dependent protein kinase type I regulatory subunit	Drosophila melanogaster (Fruit fly)	PR
P81900	Pka-R2	cAMP-dependent protein kinase type II regulatory subunit	Drosophila melanogaster (Fruit fly)	PR
Q96M20	CNBD2	Cyclic nucleotide-binding domain-containing protein 2	Homo sapiens (Human)	PR
P10644	PRKAR1A	cAMP-dependent protein kinase type I-alpha regulatory subunit	Homo sapiens (Human)	EV
P31321	PRKAR1B	cAMP-dependent protein kinase type I-beta regulatory subunit	Homo sapiens (Human)	EV
P13861	PRKAR2A	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (Human)	PR
P12367	Prkar2a	cAMP-dependent protein kinase type II-alpha regulatory subunit	Mus musculus (Mouse)	PR
Q9D5U8	Cnbd2	Cyclic nucleotide-binding domain-containing protein 2	Mus musculus (Mouse)	PR
P12849	Prkar1b	cAMP-dependent protein kinase type I-beta regulatory subunit	Mus musculus (Mouse)	PR
Q9DBC7	Prkar1a	cAMP-dependent protein kinase type I-alpha regulatory subunit [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed]	Mus musculus (Mouse)	SS
P31324	Prkar2b	cAMP-dependent protein kinase type II-beta regulatory subunit	Mus musculus (Mouse)	PR
P05207	PRKAR2A	cAMP-dependent protein kinase type II-alpha regulatory subunit	Sus scrofa (Pig)	SS
P07802	PRKAR1A	cAMP-dependent protein kinase type I-alpha regulatory subunit	Sus scrofa (Pig)	SS
P81377	Prkar1b	cAMP-dependent protein kinase type I-beta regulatory subunit	Rattus norvegicus (Rat)	PR
P09456	Prkar1a	cAMP-dependent protein kinase type I-alpha regulatory subunit	Rattus norvegicus (Rat)	SS
P12368	Prkar2a	cAMP-dependent protein kinase type II-alpha regulatory subunit	Rattus norvegicus (Rat)	PR
P12369	Prkar2b	cAMP-dependent protein kinase type II-beta regulatory subunit	Rattus norvegicus (Rat)	PR
P30625	kin-2	cAMP-dependent protein kinase regulatory subunit	Caenorhabditis elegans	SS

10	20	30	40	50	60
MSIEIPAGLT	ELLQGFTVEV	LRHQPADLLE	FALQHFTRLQ	QENERKGTAR	FGHEGRTWGD
70	80	90	100	110	120
LGAAAGGGTP	SKGVNFAEEP	MQSDSEDGEE	EEAAPADAGA	FNAPVINRFT	RRASVCAEAY
130	140	150	160	170	180
NPDEEEDDAE	SRIIHPKTDD	QRNRLQEACK	DILLFKNLDP	EQMSQVLDAM	FEKLVKDGEH
190	200	210	220	230	240
VIDQGDDGDN	FYVIDRGTFD	IYVKCDGVGR	CVGNYDNRGS	FGELALMYNT	PRAATITATS
250	260	270	280	290	300
PGALWGLDRV	TFRRIIVKNN	AKKRKMYESF	IESLPFLKSL	EFSERLKVVD	VIGTKVYNDG
310	320	330	340	350	360
EQIIAQGDSA	DSFFIVESGE	VKITMKRKGK	SEVEENGAVE	IARCSRGQYF	GELALVTNKP
370	380	390	400	410
RAASAHAIGT	VKCLAMDVQA	FERLLGPCME	IMKRNIATYE	EQLVALFGTN	MDIVEPTA