AiPD: Autoinhibited Protein Database

P31268

Gene name	HOXA7 (HOX1A)
Protein name	Homeobox protein Hox-A7
Names	Homeobox protein Hox 1.1, Homeobox protein Hox-1A
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3204
EC number
Protein Class

Descriptions

HoxA7 is a sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This protein possesses intrinsically disordered regions (IDRs) with large negative charge, some of which involve a consecutive sequence of aspartate (D) or glutamate (E) residues, known as D/E repeats. These D/E repeats can cause autoinhibition through intramolecular electrostatic interaction with HMG boxes and modulate binding to DNA. This autoinhibited state can transition into the uninhibited complex with DNA through an electrostatically driven induced-fit process, which accelerates the target DNA search kinetics in the presence of non-functional high-affinity ligands ('decoys').

Autoinhibitory domains (AIDs)

217-230 (D/E repeat) SS

Target domain	128-192 (DNA-binding domain)
Relief mechanism
Assay

AID

217-230 (D/E repeat)

Target domain

128-192 (DNA-binding domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P31268

Entry ID	Method	Resolution	Chain	Position	Source
AF-P31268-F1	Predicted				AlphaFoldDB

276 variants for P31268

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs149657061	2	S>G		No	ESP ExAC TOPMed gnomAD
rs781611799	2	S>I		No	ExAC gnomAD
rs781611799	2	S>N		No	ExAC gnomAD
rs757369844	3	S>Y		No	ExAC gnomAD
rs866752726	4	S>L		No	TOPMed gnomAD
rs751666779	4	S>P		No	ExAC TOPMed gnomAD
rs758495730	8	N>D		No	ExAC TOPMed gnomAD
rs765702602	9	A>G		No	ExAC gnomAD
rs907646153	9	A>T		No	TOPMed
rs1309115771	10	L>R		No	TOPMed gnomAD
rs759944196	12	S>I		No	ExAC TOPMed gnomAD
rs371532380	13	K>R		No	ESP ExAC gnomAD
rs377689779	14	Y>*		No	ESP ExAC TOPMed gnomAD
rs1161572722	15	T>A		No	gnomAD
rs1379798108	16	A>G		No	gnomAD
rs145778968	17	G>A		No	1000Genomes ESP ExAC TOPMed gnomAD
rs145778968	17	G>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs78410337	17	G>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs78410337	17	G>W		No	1000Genomes ESP ExAC TOPMed gnomAD
rs2301721	18	A>P		No	1000Genomes ESP ExAC TOPMed gnomAD
VAR_028001 rs2301721	18	A>T		No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs550774120	19	S>A		No	1000Genomes gnomAD
rs745678681	21	F>I		No	ExAC gnomAD
rs530671173	24	A>T		No	1000Genomes ExAC TOPMed gnomAD
rs1284749326	25	E>*		No	gnomAD
rs771200839	25	E>G		No	ExAC gnomAD
rs1284749326	25	E>Q		No	gnomAD
rs747255380	26	P>S		No	ExAC gnomAD
rs758448332	27	T>I		No	ExAC TOPMed gnomAD
rs758448332	27	T>S		No	ExAC TOPMed gnomAD
rs979099678	29	C>F		No	TOPMed
rs752752010	29	C>G		No	ExAC gnomAD
COSM4824345 rs755438662	30	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs866074728	32	A>V		No	Ensembl
rs761087427	33	P>R		No	ExAC TOPMed gnomAD
rs766593338	33	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs193124013	34	N>K		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1018055387	36	Q>R		No	TOPMed
rs1422982625	38	S>R		No	TOPMed gnomAD
rs765294385	39	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs765294385	39	G>R		No	ExAC gnomAD
rs765294385	39	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs139653572	39	G>V		No	ESP ExAC TOPMed gnomAD
rs770701724	40	Y>*		No	ExAC gnomAD
rs776620721	40	Y>H		No	ExAC TOPMed gnomAD
rs776620721	40	Y>N		No	ExAC TOPMed gnomAD
TCGA novel	41	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs746792177	41	G>R		No	ExAC TOPMed gnomAD
rs746792177	41	G>W		No	ExAC TOPMed gnomAD
rs748260443	42	A>V		No	ExAC gnomAD
rs1346956477	43	G>D		No	gnomAD
COSM3928998	44	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs778899843	44	A>V		No	ExAC gnomAD
rs1207033824	45	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
COSM6110128	46	A>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1233857798	46	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs879105208	47	F>V		No	Ensembl
rs756474411	48	A>G		No	ExAC TOPMed gnomAD
rs749850344	48	A>P		No	ExAC TOPMed gnomAD
rs749850344	48	A>T		No	ExAC TOPMed gnomAD
rs756474411	48	A>V		No	ExAC TOPMed gnomAD
rs878972024	49	S>A		No	Ensembl
rs750774350	49	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA
rs1029466417	51	V>A		No	Ensembl
rs764900202	52	P>Q		No	ExAC gnomAD
rs1457386778	53	G>S		No	gnomAD
rs759115973	53	G>V		No	ExAC
rs1172350298	55	Y>C		No	gnomAD
rs776477605	55	Y>H		No	ExAC gnomAD
rs766322170	56	N>K		No	ExAC gnomAD
rs1476627731	56	N>S		No	TOPMed gnomAD
TCGA novel	57	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs760410079	57	V>G		No	ExAC gnomAD
COSM1088874	57	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs772288938	58	N>D		No	ExAC TOPMed gnomAD
rs1269033672	58	N>S		No	gnomAD
COSM1312998	58	N>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1209746860	59	S>N		No	gnomAD
rs748309582	59	S>R		No	ExAC TOPMed gnomAD
rs1562738126	60	P>T		No	Ensembl
rs1253448405	61	L>F		No	gnomAD
rs1344928638	63	Q>H		No	Ensembl
rs559354439	64	S>N		No	1000Genomes ExAC gnomAD
rs768791120	64	S>R		No	ExAC TOPMed gnomAD
COSM1088873	65	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM600783 COSM6110130 rs1384986017	65	P>T	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic NCI-TCGA TOPMed
rs1038275564	67	A>V		No	Ensembl
rs756592104	69	G>C		No	ExAC gnomAD
rs1006250755	69	G>V		No	TOPMed
rs1359389813	70	Y>N		No	TOPMed
rs781551044	71	G>D		No	ExAC gnomAD
TCGA novel	72	L>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1274092644	74	A>G		No	TOPMed
rs752468389	74	A>T		No	ExAC gnomAD
rs1583421468	75	D>A		No	Ensembl
COSM746308	75	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1399312973	76	A>T		No	gnomAD
rs529254085	76	A>V		No	ExAC TOPMed gnomAD
rs563708052	77	Y>*		No	ExAC gnomAD
rs766259696 COSM1088872	78	G>D	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs753340327	78	G>S		No	ExAC gnomAD
rs760595034	79	N>D		No	ExAC
TCGA novel	79	N>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1420195665	79	N>I		No	TOPMed gnomAD
rs1420195665	79	N>S		No	TOPMed gnomAD
rs750200293 COSM1088871	82	C>*	Variant assessed as Somatic; HIGH impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs750200293	82	C>W		No	ExAC TOPMed gnomAD
rs1434462964	83	A>T		No	gnomAD
rs921688382	83	A>V		No	TOPMed
rs144742215	84	S>A		No	ESP gnomAD
rs144742215	84	S>T		No	ESP gnomAD
rs974835724	85	Y>*		No	TOPMed
rs1450272157	86	D>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs767355645	86	D>N		No	ExAC TOPMed gnomAD
rs1469095750	87	Q>R		No	TOPMed
rs761589955	89	I>M		No	ExAC gnomAD
TCGA novel	89	I>P	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1045191807	90	P>A		No	gnomAD
rs1239787579	90	P>L		No	TOPMed gnomAD
rs1045191807	90	P>S		No	gnomAD
COSM400291	91	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1311317501	91	G>W		No	gnomAD
rs762960362	93	C>S		No	ExAC TOPMed gnomAD
rs762960362	93	C>Y		No	ExAC TOPMed gnomAD
rs1056530813	94	S>G		No	gnomAD
rs1337197232	95	D>A		No	gnomAD
rs1171656723	99	G>D		No	gnomAD
rs1342947011	99	G>S		No	TOPMed
rs746326146	100	A>T		No	ExAC gnomAD
rs781764041	100	A>V		No	ExAC TOPMed gnomAD
rs377596605	101	C>*		No	ESP ExAC gnomAD
rs935605212	101	C>Y		No	gnomAD
rs1439661851	102	D>N		No	gnomAD
rs747359929	103	K>E		No	ExAC gnomAD
rs35510017 COSM452920	103	K>R	breast [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs754637278	104	T>M		No	ExAC gnomAD
rs769859237	105	D>E		No	ExAC TOPMed gnomAD
rs1222044457	105	D>N		No	TOPMed
rs750440722	106	E>D		No	ExAC TOPMed gnomAD
rs779561079	106	E>Q		No	ExAC gnomAD
rs1000360737	108	A>S		No	TOPMed gnomAD
rs1000360737	108	A>T		No	TOPMed gnomAD
TCGA novel	108	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs761645013	109	L>P		No	ExAC gnomAD
TCGA novel	110	H>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1338494214	111	G>V		No	gnomAD
rs769984771	112	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1295878557	114	E>A		No	gnomAD
rs1562737958	114	E>Q		No	Ensembl
rs777330616	115	A>T		No	ExAC gnomAD
rs771520037	115	A>V		No	ExAC gnomAD
rs1471991218	117	F>S		No	gnomAD
rs1196973946	118	R>G		No	TOPMed
rs778216909	118	R>L		No	ExAC TOPMed gnomAD
rs778216909	118	R>P		No	ExAC TOPMed gnomAD
rs1277880163	120	Y>N		No	gnomAD
rs779567620	121	P>H		No	ExAC
rs749030294	121	P>S		No	ExAC gnomAD
rs755689640	122	W>R		No	ExAC gnomAD
rs1216063088	123	M>L		No	gnomAD
rs544001319	124	R>P		No	1000Genomes ExAC gnomAD
rs544001319	124	R>Q		No	1000Genomes ExAC gnomAD
rs865788066	124	R>W		No	gnomAD
rs1401927444	125	S>F		No	TOPMed
rs772553123	127	G>A		No	ExAC
TCGA novel	127	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs900847750	128	P>L		No	Ensembl
rs1036671085	129	D>E		No	TOPMed gnomAD
TCGA novel	130	R>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs939771927	132	R>Q		No	Ensembl
rs1562737529	132	R>W		No	Ensembl
rs745409883	133	G>D		No	ExAC gnomAD
rs780609860	134	R>L		No	ExAC TOPMed gnomAD
rs1276150189	136	T>P		No	gnomAD
rs982907728	137	Y>C		No	TOPMed
rs1331097182	138	T>M		No	TOPMed gnomAD
rs762508295	139	R>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs1407134241	139	R>S		No	gnomAD
rs747004706	141	Q>*		No	ExAC gnomAD
rs747004706	141	Q>E		No	ExAC gnomAD
rs777542472	142	T>A		No	ExAC gnomAD
rs1170206862	142	T>M		No	gnomAD
TCGA novel	146	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs878859385	149	F>Y		No	Ensembl
rs1477746824 COSM3880409	150	H>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs765531291	153	R>G		No	ExAC TOPMed gnomAD
rs1179211280	153	R>P		No	gnomAD
rs765531291	153	R>S		No	ExAC TOPMed gnomAD
rs1583420652	154	Y>S		No	Ensembl
rs753980676	155	L>P		No	ExAC gnomAD
rs766627218	156	T>A		No	ExAC gnomAD
COSM3880408 rs559344881	156	T>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs559344881	156	T>R		No	1000Genomes ExAC TOPMed gnomAD
rs774535792	157	R>G		No	ExAC TOPMed gnomAD
rs1343684367 COSM317468	157	R>L	lung [Cosmic]	No	cosmic curated TOPMed gnomAD
rs1343684367	157	R>Q		No	TOPMed gnomAD
rs774535792	157	R>W		No	ExAC TOPMed gnomAD
rs769491087	158	R>C		No	ExAC TOPMed gnomAD
rs1449685607	158	R>H		No	gnomAD
rs576810987	159	R>H		No	1000Genomes ExAC gnomAD
COSM746309	159	R>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM184301 rs1361050955	160	R>H	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA gnomAD
rs1368746193	160	R>S		No	TOPMed
rs919990927	161	I>T		No	TOPMed
COSM333707 rs201959803	161	I>V	lung [Cosmic]	No	cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs375101630	163	I>V		No	ESP ExAC TOPMed gnomAD
rs758229054	166	A>P		No	ExAC gnomAD
TCGA novel	166	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM1568450	166	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs754810820	170	T>A		No	ExAC TOPMed gnomAD
rs1335089145	170	T>S		No	TOPMed
rs780389627 COSM4414555	172	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs1562737385	172	R>H		No	Ensembl
TCGA novel	174	I>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs750418651	175	K>R		No	ExAC gnomAD
COSM1450195	176	I>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs768096835	177	W>*		No	ExAC TOPMed gnomAD
rs768096835	177	W>C		No	ExAC TOPMed gnomAD
rs1309185969	179	Q>H		No	gnomAD
rs751967060	181	R>G		No	ExAC gnomAD
COSM1254349	181	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1562737367	181	R>L		No	Ensembl
rs764422900 COSM1088869	182	R>H	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs764422900	182	R>L		No	ExAC TOPMed gnomAD
COSM1088868	184	K>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs927986090	184	K>N		No	TOPMed
COSM1088867	186	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1301265808	187	K>T		No	gnomAD
rs374828544	189	H>R		No	ESP
rs776316860	190	K>N		No	ExAC gnomAD
rs1378345862	191	D>H		No	gnomAD
COSM3637739 rs770523270	192	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA
rs1031543455	193	G>D		No	TOPMed gnomAD
rs760210246	193	G>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1031543455	193	G>V		No	TOPMed gnomAD
rs571549143	194	P>L		No	ExAC gnomAD
rs978085273	195	T>I		No	TOPMed
rs772065138	196	A>G		No	ExAC TOPMed gnomAD
COSM1088866	196	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs147555041	197	A>S		No	1000Genomes ExAC gnomAD
rs749066787	200	P>A		No	ExAC gnomAD
rs749066787	200	P>S		No	ExAC gnomAD
rs200468253	201	E>K		No	ExAC TOPMed gnomAD
rs200468253	201	E>Q		No	ExAC TOPMed gnomAD
rs371795704	203	A>S		No	ESP gnomAD
rs750517268	203	A>V		No	ExAC TOPMed gnomAD
rs757346004	204	V>L		No	ExAC gnomAD
rs1341434143	205	P>L		No	gnomAD
rs764552031	206	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA
rs954358815	207	A>V		No	Ensembl
rs368771286	208	A>P		No	ESP ExAC TOPMed gnomAD
rs368771286	208	A>S		No	ESP ExAC TOPMed gnomAD
rs138411797	209	A>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1342151391	209	A>V		No	TOPMed
rs1423826860	212	A>G		No	gnomAD
rs1423826860	212	A>V		No	gnomAD
rs370998918	213	A>E		No	ESP ExAC TOPMed gnomAD
rs760187331	213	A>S		No	ExAC gnomAD
rs760187331	213	A>T		No	ExAC gnomAD
rs370998918	213	A>V		No	ESP ExAC TOPMed gnomAD
rs771551984	214	D>N		No	ExAC gnomAD
rs115619001	215	K>N		No	1000Genomes ESP ExAC TOPMed gnomAD
rs370786847	217	D>E		No	ESP ExAC TOPMed gnomAD
rs140671509	217	D>N		No	ESP ExAC TOPMed gnomAD
rs140671509	217	D>Y		No	ESP ExAC TOPMed gnomAD
rs565645084	218	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs565645084	218	E>Q		No	1000Genomes ExAC TOPMed gnomAD
rs757318981	219	E>D		No	ExAC TOPMed gnomAD
rs781471186	219	E>G		No	ExAC gnomAD
COSM1241276	219	E>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs200815896	221	D>E		No	ExAC TOPMed gnomAD
rs1265710721	221	D>V		No	TOPMed
rs146964934	225	E>D		No	1000Genomes ESP TOPMed gnomAD
rs778284810	227	D>N		No	ExAC TOPMed gnomAD
rs143079352	228	E>K		No	ESP ExAC gnomAD
rs1562737167	229	E>D		No	Ensembl

No associated diseases with P31268

No regional properties for P31268

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P31268

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name	Definition
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor binding	Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific DNA binding	Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

12 GO annotations of biological process

Name	Definition
angiogenesis	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
anterior/posterior pattern specification	The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
embryonic skeletal system morphogenesis	The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.
negative regulation of cell-matrix adhesion	Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of keratinocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation.
negative regulation of leukocyte migration	Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.
negative regulation of monocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
stem cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.

11 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P23459	HOXD8	Homeobox protein Hox-D8	Gallus gallus (Chicken)	PR
A2T6Z0	HOXB1	Homeobox protein Hox-B1	Pan troglodytes (Chimpanzee)	SS
P10105	lab	Homeotic protein labial	Drosophila melanogaster (Fruit fly)	EV
P49639	HOXA1	Homeobox protein Hox-A1	Homo sapiens (Human)	SS
P14653	HOXB1	Homeobox protein Hox-B1	Homo sapiens (Human)	SS
P09022	Hoxa1	Homeobox protein Hox-A1	Mus musculus (Mouse)	SS
O08656	Hoxa1	Homeobox protein Hox-A1	Rattus norvegicus (Rat)	SS
A2D649	HOXB1	Homeobox protein Hox-B1	Macaca mulatta (Rhesus macaque)	SS
Q28IU6	hoxd1	Homeobox protein Hox-D1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	SS
Q8JH55	hoxb8b	Homeobox protein Hox-B8b	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
F1Q4R9	meox1	Homeobox protein MOX-1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MSSSYYVNAL	FSKYTAGASL	FQNAEPTSCS	FAPNSQRSGY	GAGAGAFAST	VPGLYNVNSP
70	80	90	100	110	120
LYQSPFASGY	GLGADAYGNL	PCASYDQNIP	GLCSDLAKGA	CDKTDEGALH	GAAEANFRIY
130	140	150	160	170	180
PWMRSSGPDR	KRGRQTYTRY	QTLELEKEFH	FNRYLTRRRR	IEIAHALCLT	ERQIKIWFQN
190	200	210	220
RRMKWKKEHK	DEGPTAAAAP	EGAVPSAAAT	AAADKADEED	DDEEEEDEEE